JP2024546438A - 癒着胎盤に関連するバイオマーカーについてサンプルを調製および分析する方法 - Google Patents

癒着胎盤に関連するバイオマーカーについてサンプルを調製および分析する方法 Download PDF

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JP2024546438A
JP2024546438A JP2024528448A JP2024528448A JP2024546438A JP 2024546438 A JP2024546438 A JP 2024546438A JP 2024528448 A JP2024528448 A JP 2024528448A JP 2024528448 A JP2024528448 A JP 2024528448A JP 2024546438 A JP2024546438 A JP 2024546438A
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protein
biomarkers
biomarker
sample
microparticle
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JP2024546438A5 (https=
Inventor
トーマス エフ. マケルラス
ケビン ピー. ローゼンブラット
ブライアン ディー. ブローマン
プレム ピー. グルナニ
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Brigham and Womens Hospital Inc
NX Prenatal Inc
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Brigham and Womens Hospital Inc
NX Prenatal Inc
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Publication of JP2024546438A publication Critical patent/JP2024546438A/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • G01N2030/8809Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
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    • G01N2800/368Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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    • G01N30/62Detectors specially adapted therefor
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    • G01N30/02Column chromatography
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Primary Health Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
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  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
JP2024528448A 2021-11-11 2022-11-14 癒着胎盤に関連するバイオマーカーについてサンプルを調製および分析する方法 Pending JP2024546438A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163278456P 2021-11-11 2021-11-11
US63/278,456 2021-11-11
PCT/US2022/079835 WO2023087004A2 (en) 2021-11-11 2022-11-14 Methods of preparing and analyzing samples for biomarkers associated with placenta accreta

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JP2024546438A true JP2024546438A (ja) 2024-12-24
JP2024546438A5 JP2024546438A5 (https=) 2025-11-07

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JP2024528448A Pending JP2024546438A (ja) 2021-11-11 2022-11-14 癒着胎盤に関連するバイオマーカーについてサンプルを調製および分析する方法

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US (1) US20250102482A1 (https=)
EP (1) EP4430406A4 (https=)
JP (1) JP2024546438A (https=)
CN (1) CN118451327A (https=)
WO (1) WO2023087004A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119230113A (zh) * 2024-09-30 2024-12-31 常州市妇幼保健院 胎盘植入性疾病早期识别及严重程度预测的分类器及其训练系统

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8068990B2 (en) * 2003-03-25 2011-11-29 Hologic, Inc. Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids
US20130237442A1 (en) * 2012-03-07 2013-09-12 University Of Miami Methods and Compositions for Diagnosis of Non-Viable Early Pregnancy
EP3175239A1 (en) * 2014-07-30 2017-06-07 Matthew Cooper Methods and compositions for diagnosing, prognosing, and confirming preeclampsia
WO2017096405A1 (en) * 2015-12-04 2017-06-08 Nx Prenatal Inc. Use of circulating microparticles to stratify risk of spontaneous preterm birth
EP3746087A4 (en) * 2018-01-31 2022-02-09 Nx Prenatal Inc. METHODS FOR EARLY DETECTION AND PREVENTION OF PREECLAMPIA USING CIRCULATION MICROPARTICLE-ASSOCIATED BIOMARKERS
US20230118097A1 (en) * 2020-01-22 2023-04-20 Beth Israel Deaconess Medical Center, Inc. Biomarkers for placenta accreta spectrum (pas) disorders

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US20250102482A1 (en) 2025-03-27
CN118451327A (zh) 2024-08-06
EP4430406A2 (en) 2024-09-18
WO2023087004A2 (en) 2023-05-19
EP4430406A4 (en) 2025-10-15
WO2023087004A3 (en) 2023-06-22

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