JP2024545584A - ペイロード分子を気道上皮に送達するための組成物 - Google Patents

ペイロード分子を気道上皮に送達するための組成物 Download PDF

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JP2024545584A
JP2024545584A JP2024527672A JP2024527672A JP2024545584A JP 2024545584 A JP2024545584 A JP 2024545584A JP 2024527672 A JP2024527672 A JP 2024527672A JP 2024527672 A JP2024527672 A JP 2024527672A JP 2024545584 A JP2024545584 A JP 2024545584A
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alkyl
mol
nanoparticles
lipid
nanoparticle
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JP2024545584A5 (https=
Inventor
ピレス，アナ カデテ
シー ソン，ジャン
コーネビス，マーク
フルカッチ，ジェフリー
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ModernaTx Inc
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ModernaTx Inc
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2024527672A 2021-11-12 2022-11-10 ペイロード分子を気道上皮に送達するための組成物 Pending JP2024545584A (ja)

Applications Claiming Priority (3)

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US202163278973P 2021-11-12 2021-11-12
US63/278,973 2021-11-12
PCT/US2022/049537 WO2023086465A1 (en) 2021-11-12 2022-11-10 Compositions for the delivery of payload molecules to airway epithelium

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JP2024545584A true JP2024545584A (ja) 2024-12-10
JP2024545584A5 JP2024545584A5 (https=) 2025-11-18

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US (1) US20250049727A1 (https=)
EP (1) EP4429644A1 (https=)
JP (1) JP2024545584A (https=)
CN (1) CN118829423A (https=)
WO (1) WO2023086465A1 (https=)

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WO2026003403A1 (en) 2024-06-28 2026-01-02 Certest Biotec, S.L. Ionizable lipids and lipid nanoparticles containing them for extrahepatic delivery

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EP4429644A1 (en) 2024-09-18
CN118829423A (zh) 2024-10-22
WO2023086465A9 (en) 2024-08-22
WO2023086465A1 (en) 2023-05-19
US20250049727A1 (en) 2025-02-13

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