JP2024534442A - ネオ抗原アジュバント及び維持療法 - Google Patents

ネオ抗原アジュバント及び維持療法 Download PDF

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JP2024534442A
JP2024534442A JP2024516893A JP2024516893A JP2024534442A JP 2024534442 A JP2024534442 A JP 2024534442A JP 2024516893 A JP2024516893 A JP 2024516893A JP 2024516893 A JP2024516893 A JP 2024516893A JP 2024534442 A JP2024534442 A JP 2024534442A
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sequence
expression system
nucleic acid
antigen
based expression
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JP2024534442A5 (https=
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ラファエル ルソー
アンドリュー ファーガスン
カリン ヨース
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グリットストーン バイオ インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
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  • Toxicology (AREA)
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  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2024516893A 2021-09-17 2022-09-19 ネオ抗原アジュバント及び維持療法 Pending JP2024534442A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163245663P 2021-09-17 2021-09-17
US63/245,663 2021-09-17
US202163281027P 2021-11-18 2021-11-18
US63/281,027 2021-11-18
US202263320685P 2022-03-16 2022-03-16
US63/320,685 2022-03-16
PCT/US2022/076678 WO2023044492A2 (en) 2021-09-17 2022-09-19 Neoantigen adjuvant and maintenance therapy

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Publication Number Publication Date
JP2024534442A true JP2024534442A (ja) 2024-09-20
JP2024534442A5 JP2024534442A5 (https=) 2025-09-29

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JP2024516893A Pending JP2024534442A (ja) 2021-09-17 2022-09-19 ネオ抗原アジュバント及び維持療法

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US (1) US20240216501A1 (https=)
EP (1) EP4401765A4 (https=)
JP (1) JP2024534442A (https=)
KR (1) KR20240099144A (https=)
AU (1) AU2022347452A1 (https=)
CA (1) CA3231295A1 (https=)
IL (1) IL311252A (https=)
WO (1) WO2023044492A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025207975A1 (en) * 2024-03-27 2025-10-02 Seattle Project Corp. Personalized cancer vaccines and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3743102A1 (en) * 2018-01-26 2020-12-02 Nantcell, Inc. Compositions and methods for combination cancer vaccine and immunologic adjuvant therapy
WO2021092095A1 (en) * 2019-11-04 2021-05-14 Gritstone Oncology, Inc. Neoantigen vaccine therapy
WO2021119545A1 (en) * 2019-12-11 2021-06-17 Gritstone Bio, Inc. Durable vaccination

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EP4401765A4 (en) 2025-11-12
US20240216501A1 (en) 2024-07-04
WO2023044492A3 (en) 2023-05-11
IL311252A (en) 2024-05-01
AU2022347452A1 (en) 2024-04-11
KR20240099144A (ko) 2024-06-28
WO2023044492A2 (en) 2023-03-23
CA3231295A1 (en) 2023-03-23
EP4401765A2 (en) 2024-07-24

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