JP2024533426A - 糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 - Google Patents
糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 Download PDFInfo
- Publication number
- JP2024533426A JP2024533426A JP2024515577A JP2024515577A JP2024533426A JP 2024533426 A JP2024533426 A JP 2024533426A JP 2024515577 A JP2024515577 A JP 2024515577A JP 2024515577 A JP2024515577 A JP 2024515577A JP 2024533426 A JP2024533426 A JP 2024533426A
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- JP
- Japan
- Prior art keywords
- compound
- disease
- diseases
- methyl
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163243539P | 2021-09-13 | 2021-09-13 | |
| US63/243,539 | 2021-09-13 | ||
| PCT/US2022/076360 WO2023039600A1 (en) | 2021-09-13 | 2022-09-13 | Drug conjugates of sugar derivatives and uses thereof as senolytic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024533426A true JP2024533426A (ja) | 2024-09-12 |
| JP2024533426A5 JP2024533426A5 (https=) | 2025-09-22 |
Family
ID=85507744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024515577A Pending JP2024533426A (ja) | 2021-09-13 | 2022-09-13 | 糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20230137021A1 (https=) |
| EP (1) | EP4380575A4 (https=) |
| JP (1) | JP2024533426A (https=) |
| CN (1) | CN118475356A (https=) |
| AU (1) | AU2022342245A1 (https=) |
| CA (1) | CA3232213A1 (https=) |
| WO (1) | WO2023039600A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023039292A2 (en) * | 2021-09-13 | 2023-03-16 | Rubedo Life Sciences, Inc. | Novel sugar derivatives and uses thereof to prepare novel senolytic agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2710322T3 (es) * | 2012-08-28 | 2019-04-24 | Univ Tuebingen Medizinische Fakultaet | Trazadores de la senescencia |
| IL286427B2 (en) * | 2014-01-28 | 2024-08-01 | Mayo Found Medical Education & Res | Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease |
| US20210180013A1 (en) * | 2018-04-23 | 2021-06-17 | Agex Therapeutics, Inc. | Improved methods for inducing tissue regeneration and senolysis in mammalian cells |
| US11026963B2 (en) * | 2018-07-11 | 2021-06-08 | Rubedo Life Sciences, Inc. | Senolytic compositions and uses thereof |
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2022
- 2022-09-13 EP EP22868391.8A patent/EP4380575A4/en active Pending
- 2022-09-13 US US17/943,824 patent/US20230137021A1/en not_active Abandoned
- 2022-09-13 CA CA3232213A patent/CA3232213A1/en active Pending
- 2022-09-13 AU AU2022342245A patent/AU2022342245A1/en active Pending
- 2022-09-13 WO PCT/US2022/076360 patent/WO2023039600A1/en not_active Ceased
- 2022-09-13 JP JP2024515577A patent/JP2024533426A/ja active Pending
- 2022-09-13 CN CN202280072208.7A patent/CN118475356A/zh active Pending
-
2024
- 2024-05-06 US US18/655,834 patent/US20240299555A1/en active Pending
-
2025
- 2025-02-10 US US19/049,614 patent/US20250222115A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023039600A1 (en) | 2023-03-16 |
| AU2022342245A1 (en) | 2024-03-28 |
| CA3232213A1 (en) | 2023-03-16 |
| EP4380575A4 (en) | 2025-07-23 |
| US20250222115A1 (en) | 2025-07-10 |
| EP4380575A1 (en) | 2024-06-12 |
| CN118475356A (zh) | 2024-08-09 |
| US20230137021A1 (en) | 2023-05-04 |
| US20240299555A1 (en) | 2024-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250911 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250911 |