JP2024531314A - 小児ｍｓを治療するためのオファツムマブ - Google Patents

小児ｍｓを治療するためのオファツムマブ Download PDF

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Publication number
JP2024531314A
JP2024531314A JP2024509123A JP2024509123A JP2024531314A JP 2024531314 A JP2024531314 A JP 2024531314A JP 2024509123 A JP2024509123 A JP 2024509123A JP 2024509123 A JP2024509123 A JP 2024509123A JP 2024531314 A JP2024531314 A JP 2024531314A
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JP
Japan
Prior art keywords
ofatumumab
treatment
patient
use according
fingolimod
Prior art date
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Pending
Application number
JP2024509123A
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English (en)
Japanese (ja)
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JP2024531314A5 (cg-RX-API-DMAC10.html
Inventor
バガー，モルテン
グラハム，ゴードン
エイドリアン ヘリング，ディーター
メルシュヘムケ，マルチン
スー，ウェンディ
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ノバルティス アーゲー
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Publication date
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2024531314A publication Critical patent/JP2024531314A/ja
Publication of JP2024531314A5 publication Critical patent/JP2024531314A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024509123A 2021-08-16 2022-07-27 小児ｍｓを治療するためのオファツムマブ Pending JP2024531314A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163233524P 2021-08-16 2021-08-16
US63/233,524 2021-08-16
US202163254684P 2021-10-12 2021-10-12
US63/254,684 2021-10-12
EP21206466 2021-11-04
EP21206466.1 2021-11-04
PCT/EP2022/071132 WO2023020802A1 (en) 2021-08-16 2022-07-27 Ofatumumab for treating pediatric ms

Publications (2)

Publication Number Publication Date
JP2024531314A true JP2024531314A (ja) 2024-08-29
JP2024531314A5 JP2024531314A5 (cg-RX-API-DMAC10.html) 2025-08-07

Family

ID=82940064

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024509123A Pending JP2024531314A (ja) 2021-08-16 2022-07-27 小児ｍｓを治療するためのオファツムマブ

Country Status (7)

Country Link
US (1) US20240343821A1 (cg-RX-API-DMAC10.html)
EP (1) EP4387999A1 (cg-RX-API-DMAC10.html)
JP (1) JP2024531314A (cg-RX-API-DMAC10.html)
KR (1) KR20240046200A (cg-RX-API-DMAC10.html)
CA (1) CA3229704A1 (cg-RX-API-DMAC10.html)
IL (1) IL310813A (cg-RX-API-DMAC10.html)
WO (1) WO2023020802A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4252847A3 (en) 2016-08-15 2023-11-15 Novartis AG Regimens and methods of treating multiple sclerosis using ofatumumab
US20220389109A1 (en) * 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients
WO2021204994A1 (en) * 2020-04-09 2021-10-14 Novartis Ag Ofatumumab for treating ms while maintaining serum igg

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100944575B1 (ko) 2002-10-17 2010-02-25 젠맵 에이/에스 Ｃｄ20에 대한 인간 모노클로날 항체
UA107557C2 (xx) 2007-07-06 2015-01-26 Композиція антитіла офатумумабу
US20220389109A1 (en) * 2019-09-11 2022-12-08 Novartis Ag Management of conditions other than multiple sclerosis in ofatumumab-treated patients

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Efficacy andSafety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric PatientsWith Mult", CLINICALTRIALS.GOV[ONLINE], JPN6026030849, 14 June 2021 (2021-06-14), ISSN: 0005913101 *

Also Published As

Publication number Publication date
EP4387999A1 (en) 2024-06-26
WO2023020802A1 (en) 2023-02-23
IL310813A (en) 2024-04-01
KR20240046200A (ko) 2024-04-08
US20240343821A1 (en) 2024-10-17
CA3229704A1 (en) 2023-02-23

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