JP2024527939A - 脂質ナノ粒子組成物を調製するためのプロセス - Google Patents

脂質ナノ粒子組成物を調製するためのプロセス Download PDF

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Publication number
JP2024527939A
JP2024527939A JP2024504833A JP2024504833A JP2024527939A JP 2024527939 A JP2024527939 A JP 2024527939A JP 2024504833 A JP2024504833 A JP 2024504833A JP 2024504833 A JP2024504833 A JP 2024504833A JP 2024527939 A JP2024527939 A JP 2024527939A
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JP
Japan
Prior art keywords
lipid
composition
lipid nanoparticle
nanoparticle composition
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2024504833A
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English (en)
Japanese (ja)
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JPWO2023009421A5 (https=
JP2024527939A5 (https=
Inventor
エイチ スミス，マイケル
スード，ニミル
ティアン，チャン
ダブリュー ドハーティ，ダニエル
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ModernaTx Inc
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ModernaTx Inc
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Publication date
Application filed by ModernaTx Inc filed Critical ModernaTx Inc
Publication of JP2024527939A publication Critical patent/JP2024527939A/ja
Publication of JPWO2023009421A5 publication Critical patent/JPWO2023009421A5/ja
Publication of JP2024527939A5 publication Critical patent/JP2024527939A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024504833A 2021-07-26 2022-07-25 脂質ナノ粒子組成物を調製するためのプロセス Pending JP2024527939A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163225815P 2021-07-26 2021-07-26
US63/225,815 2021-07-26
PCT/US2022/038151 WO2023009421A1 (en) 2021-07-26 2022-07-25 Processes for preparing lipid nanoparticle compositions

Publications (3)

Publication Number Publication Date
JP2024527939A true JP2024527939A (ja) 2024-07-26
JPWO2023009421A5 JPWO2023009421A5 (https=) 2025-08-04
JP2024527939A5 JP2024527939A5 (https=) 2025-08-04

Family

ID=82899410

Family Applications (1)

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JP2024504833A Pending JP2024527939A (ja) 2021-07-26 2022-07-25 脂質ナノ粒子組成物を調製するためのプロセス

Country Status (6)

Country Link
US (1) US20240335393A1 (https=)
EP (1) EP4376814A1 (https=)
JP (1) JP2024527939A (https=)
CN (1) CN118019527A (https=)
TW (1) TW202320736A (https=)
WO (1) WO2023009421A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019046809A1 (en) 2017-08-31 2019-03-07 Modernatx, Inc. METHODS OF MANUFACTURING LIPID NANOPARTICLES
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
TW202539706A (zh) * 2023-11-14 2025-10-16 大陸商上海瑞宏迪醫藥有限公司 一種脂質奈米粒的製備方法和應用
CN121099987A (zh) * 2024-04-08 2025-12-09 苏州艾博生物科技有限公司 脂质纳米颗粒制剂及其制备方法
GB202414932D0 (en) 2024-10-10 2024-11-27 Apoha Ltd Method and apparatus

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
WO2006044660A2 (en) * 2004-10-14 2006-04-27 Vanderbilt University Functionalized solid lipid nanoparticles and methods of making and using same
CA2816925C (en) * 2009-11-04 2023-01-10 The University Of British Columbia Nucleic acid-containing lipid particles and related methods
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
CA2824526C (en) 2011-01-11 2020-07-07 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
WO2013103659A1 (en) 2012-01-04 2013-07-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Stabilizing rna by incorporating chain-terminating nucleosides at the 3'-terminus
WO2014093924A1 (en) 2012-12-13 2014-06-19 Moderna Therapeutics, Inc. Modified nucleic acid molecules and uses thereof
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US20160022840A1 (en) 2013-03-09 2016-01-28 Moderna Therapeutics, Inc. Heterologous untranslated regions for mrna
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CA2906732C (en) 2013-03-15 2023-08-08 The University Of British Columbia Lipid nanoparticles for transfection and related methods
WO2017031232A1 (en) * 2015-08-17 2017-02-23 Modernatx, Inc. Methods for preparing particles and related compositions
EP4286012A3 (en) * 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
HRP20220652T1 (hr) 2015-12-10 2022-06-24 Modernatx, Inc. Pripravci i postupci unosa terapijskih sredstava
CN112437767B (zh) * 2018-05-24 2023-10-27 川斯勒佰尔公司 硫酯阳离子脂质
CN113166783B (zh) * 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
AU2020350759A1 (en) * 2019-09-19 2022-03-31 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents

Also Published As

Publication number Publication date
EP4376814A1 (en) 2024-06-05
WO2023009421A1 (en) 2023-02-02
US20240335393A1 (en) 2024-10-10
CN118019527A (zh) 2024-05-10
TW202320736A (zh) 2023-06-01

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