JP2024522167A - 肝疾患の処置のための併用療法 - Google Patents

肝疾患の処置のための併用療法 Download PDF

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JP2024522167A
JP2024522167A JP2023575549A JP2023575549A JP2024522167A JP 2024522167 A JP2024522167 A JP 2024522167A JP 2023575549 A JP2023575549 A JP 2023575549A JP 2023575549 A JP2023575549 A JP 2023575549A JP 2024522167 A JP2024522167 A JP 2024522167A
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seq
pnpla3
receptor
glp
inhibitor
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JP2024522167A5 (https=
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リンデン，ダニエル
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AstraZeneca AB
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AstraZeneca AB
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/22—Hormones
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    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01002—Arylesterase (3.1.1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01051—1-Acylglycerol-3-phosphate O-acyltransferase (2.3.1.51)

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JP2023575549A 2021-06-08 2022-06-07 肝疾患の処置のための併用療法 Withdrawn JP2024522167A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163208299P 2021-06-08 2021-06-08
US63/208,299 2021-06-08
PCT/IB2022/055292 WO2022259145A1 (en) 2021-06-08 2022-06-07 Combination therapies for treatment of liver diseases

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JP2024522167A true JP2024522167A (ja) 2024-06-11
JP2024522167A5 JP2024522167A5 (https=) 2025-06-13

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JP2023575549A Withdrawn JP2024522167A (ja) 2021-06-08 2022-06-07 肝疾患の処置のための併用療法

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US (1) US20250122504A1 (https=)
EP (1) EP4352223A1 (https=)
JP (1) JP2024522167A (https=)
KR (1) KR20240019796A (https=)
CN (1) CN117441017A (https=)
AU (1) AU2022289514A1 (https=)
CA (1) CA3221482A1 (https=)
IL (1) IL308974A (https=)
MX (1) MX2023014723A (https=)
TW (1) TW202313974A (https=)
WO (1) WO2022259145A1 (https=)
ZA (1) ZA202400228B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20260022948A (ko) * 2023-06-09 2026-02-20 썬 파마슈티컬 인더스트리스 리미티드 Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제
TW202539705A (zh) * 2024-04-03 2025-10-16 瑞典商阿斯特捷利康公司 Ｐｎｐｌａ３表現之抑制劑的劑量依賴性投予

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
WO1990006952A1 (fr) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
SI2173890T1 (sl) 2007-06-21 2011-06-30 Univ Muenchen Tech Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost
TWI617574B (zh) 2012-12-11 2018-03-11 梅迪繆思有限公司 用於治療肥胖之升糖素與ｇｌｐ－１共促效劑
TW202542311A (zh) * 2018-09-19 2025-11-01 美商Ionis製藥公司 Pnpla3表現之調節劑
WO2021074772A1 (en) * 2019-10-14 2021-04-22 Astrazeneca Ab Modulators of pnpla3 expression
WO2021126734A1 (en) * 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof

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Publication number Publication date
KR20240019796A (ko) 2024-02-14
EP4352223A1 (en) 2024-04-17
ZA202400228B (en) 2024-09-25
MX2023014723A (es) 2024-01-16
TW202313974A (zh) 2023-04-01
IL308974A (en) 2024-01-01
WO2022259145A1 (en) 2022-12-15
AU2022289514A1 (en) 2024-01-25
CN117441017A (zh) 2024-01-23
CA3221482A1 (en) 2022-12-15
US20250122504A1 (en) 2025-04-17

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