JP2024521767A - Ｈ因子ファミリータンパク質のための阻害性核酸 - Google Patents

Ｈ因子ファミリータンパク質のための阻害性核酸 Download PDF

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JP2024521767A
JP2024521767A JP2023572717A JP2023572717A JP2024521767A JP 2024521767 A JP2024521767 A JP 2024521767A JP 2023572717 A JP2023572717 A JP 2023572717A JP 2023572717 A JP2023572717 A JP 2023572717A JP 2024521767 A JP2024521767 A JP 2024521767A
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nucleic acid
complement
nucleotide sequence
agent
fhr1
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JP2024521767A5 (enExample
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クラーク，サイモン
ムンエ，ムスタファ
ラティ，ソニカ
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コンプリメント・セラピューティクス・リミテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2023572717A 2021-05-27 2022-05-26 Ｈ因子ファミリータンパク質のための阻害性核酸 Pending JP2024521767A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2107586.6 2021-05-27
GBGB2107586.6A GB202107586D0 (en) 2021-05-27 2021-05-27 Inhibitory nucleic acids for Factor H family proteins
PCT/EP2022/064376 WO2022248651A2 (en) 2021-05-27 2022-05-26 Inhibitory nucleic acids for factor h family proteins

Publications (2)

Publication Number Publication Date
JP2024521767A true JP2024521767A (ja) 2024-06-04
JP2024521767A5 JP2024521767A5 (enExample) 2025-06-03

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JP2023572717A Pending JP2024521767A (ja) 2021-05-27 2022-05-26 Ｈ因子ファミリータンパク質のための阻害性核酸

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US (1) US20240209367A1 (enExample)
EP (1) EP4347030A2 (enExample)
JP (1) JP2024521767A (enExample)
CN (1) CN118632711A (enExample)
AU (1) AU2022279580A1 (enExample)
CA (1) CA3219247A1 (enExample)
GB (1) GB202107586D0 (enExample)
WO (1) WO2022248651A2 (enExample)

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Publication number Priority date Publication date Assignee Title
WO2024165568A2 (en) * 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibitors of expression and/or function

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7217807B2 (en) * 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
US20050118625A1 (en) * 2003-10-02 2005-06-02 Mounts William M. Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
WO2005116204A1 (ja) * 2004-05-11 2005-12-08 Rnai Co., Ltd. Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
US7745389B2 (en) 2005-02-14 2010-06-29 University Of Iowa Research Foundation Methods for treatment of age-related macular degeneration
GB0611606D0 (en) 2006-06-13 2006-07-19 Univ Belfast Protection against and treatment of age related macular degeneration
WO2009059321A2 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
US9598733B2 (en) 2011-02-17 2017-03-21 The Trustees Of Columbia University In The City Of New York Methods for identifying subjects with a genetic risk for developing IgA nephropathy
US20150157675A1 (en) 2012-04-02 2015-06-11 Sung Kyun Biotech Co., Ltd. Composition comprising eupatorium spp. extract as active ingredient for preventing and treating obesity and metabolic bone disease
EP2858679B2 (en) 2012-06-08 2024-06-05 Translate Bio, Inc. Pulmonary delivery of mrna to non-lung target cells
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
GB201709222D0 (en) 2017-06-09 2017-07-26 Univ Manchester C3b Inactivating Polypeptide
WO2019051443A1 (en) 2017-09-11 2019-03-14 Insideoutbio, Inc. METHODS AND COMPOSITIONS FOR IMPROVING IMMUNOGENICITY OF TUMORS
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
WO2019215330A1 (en) 2018-05-10 2019-11-14 The University Of Manchester Methods for assessing macular degeneration
EP4214515A1 (en) 2020-09-16 2023-07-26 Complement Therapeutics Limited Complementome assay

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AU2022279580A1 (en) 2024-01-04
EP4347030A2 (en) 2024-04-10
US20240209367A1 (en) 2024-06-27
CN118632711A (zh) 2024-09-10
WO2022248651A3 (en) 2023-02-02
CA3219247A1 (en) 2022-12-01
WO2022248651A2 (en) 2022-12-01
GB202107586D0 (en) 2021-07-14

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