JP2024518437A - 細胞以下の分解能での時空間分解トランスクリプトミクス - Google Patents

細胞以下の分解能での時空間分解トランスクリプトミクス Download PDF

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JP2024518437A
JP2024518437A JP2023568525A JP2023568525A JP2024518437A JP 2024518437 A JP2024518437 A JP 2024518437A JP 2023568525 A JP2023568525 A JP 2023568525A JP 2023568525 A JP2023568525 A JP 2023568525A JP 2024518437 A JP2024518437 A JP 2024518437A
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oligonucleotide probe
oligonucleotide
disease
nucleic acid
barcode sequence
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JP2024518437A5 (enExample
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ワン，シャオ
レン，ジンイー
ゼン，フー
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Broad Institute Inc
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Broad Institute Inc
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    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2023568525A 2021-05-07 2022-05-06 細胞以下の分解能での時空間分解トランスクリプトミクス Pending JP2024518437A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163185511P 2021-05-07 2021-05-07
US63/185,511 2021-05-07
US202263314873P 2022-02-28 2022-02-28
US63/314,873 2022-02-28
PCT/US2022/028012 WO2022236011A1 (en) 2021-05-07 2022-05-06 Spatiotemporally resolved transcriptomics at subcellular resolution

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JP2024518437A true JP2024518437A (ja) 2024-05-01
JP2024518437A5 JP2024518437A5 (enExample) 2025-05-15

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US (1) US20240254545A1 (enExample)
EP (1) EP4334471A1 (enExample)
JP (1) JP2024518437A (enExample)
KR (1) KR20240005872A (enExample)
AU (1) AU2022269663A1 (enExample)
CA (1) CA3218089A1 (enExample)
IL (1) IL308267A (enExample)
WO (1) WO2022236011A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7783672B1 (ja) * 2025-02-03 2025-12-10 バイオ － セラピー、フィジオロジカル システムズ フォー ヘルス ソシエタ ペル アチオニ 治療用又は有益な製品の生物学的効果の発現、持続及び消失を特徴付けるための方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12359253B2 (en) 2018-04-09 2025-07-15 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing
US12497651B2 (en) 2020-11-23 2025-12-16 Pleno, Inc. Encoded dual-probe endonuclease assays
WO2022246242A1 (en) * 2021-05-21 2022-11-24 The Board Of Trustees Of The Leland Stanford Junior University Scalable distributed processing software for next-generation in situ sequencing
WO2024167929A1 (en) * 2023-02-06 2024-08-15 Applied Materials, Inc. Target probes with landmark sequences for localizing gene transcripts by fluorescence in situ hybridization
WO2025059443A1 (en) 2023-09-15 2025-03-20 The Broad Institute, Inc. Untargeted multiplexed in situ rna profiling and the uses and means therefor
WO2025136916A1 (en) 2023-12-18 2025-06-26 The Board Institute, Inc. Thick tissue transcriptomics and translatomics
WO2025189030A1 (en) 2024-03-07 2025-09-12 Stellaromics, Inc. Methods and systems for volumetric imaging

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012612A2 (en) 2010-07-23 2012-01-26 University Of Delaware Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes
US12359253B2 (en) 2018-04-09 2025-07-15 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7783672B1 (ja) * 2025-02-03 2025-12-10 バイオ － セラピー、フィジオロジカル システムズ フォー ヘルス ソシエタ ペル アチオニ 治療用又は有益な製品の生物学的効果の発現、持続及び消失を特徴付けるための方法

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US20240254545A1 (en) 2024-08-01
KR20240005872A (ko) 2024-01-12
EP4334471A1 (en) 2024-03-13
WO2022236011A1 (en) 2022-11-10
CA3218089A1 (en) 2022-11-10
IL308267A (en) 2024-01-01
AU2022269663A1 (en) 2023-11-23

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