JP2024515459A - アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法 - Google Patents

アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法 Download PDF

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JP2024515459A
JP2024515459A JP2023558203A JP2023558203A JP2024515459A JP 2024515459 A JP2024515459 A JP 2024515459A JP 2023558203 A JP2023558203 A JP 2023558203A JP 2023558203 A JP2023558203 A JP 2023558203A JP 2024515459 A JP2024515459 A JP 2024515459A
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eye
unit dose
raav particles
weeks
seq
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JP2024515459A5 (https=
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ジュリー クラーク，
スコット ウィットカップ，
アダム トゥルプク，
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アドヴェラム バイオテクノロジーズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023558203A 2021-04-27 2022-04-26 アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法 Pending JP2024515459A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163180646P 2021-04-27 2021-04-27
US63/180,646 2021-04-27
PCT/US2022/071937 WO2022232790A1 (en) 2021-04-27 2022-04-26 Methods of treating ocular diseases using aav2 variants encoding aflibercept

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JP2024515459A true JP2024515459A (ja) 2024-04-10
JP2024515459A5 JP2024515459A5 (https=) 2025-04-28

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JP2023558203A Pending JP2024515459A (ja) 2021-04-27 2022-04-26 アフリベルセプトをコードするａａｖ２バリアントを使用する眼疾患の治療方法

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US (1) US20240197915A1 (https=)
EP (1) EP4329721A1 (https=)
JP (1) JP2024515459A (https=)
KR (1) KR20240005764A (https=)
CN (1) CN117222400A (https=)
BR (1) BR112023019056A2 (https=)
CA (1) CA3215855A1 (https=)
MX (1) MX2023012410A (https=)
WO (1) WO2022232790A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4364724T3 (da) 2018-05-10 2025-12-22 Regeneron Pharma Formuleringer med høj koncentration af VEGF-receptorfusionsprotein
EP3886946A1 (en) 2019-06-05 2021-10-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
KR20260005446A (ko) 2024-07-03 2026-01-12 김성훈 김치 제조 장치
KR20260006393A (ko) 2024-07-04 2026-01-13 김성훈 가정용 김치 제조 장치
WO2026019885A1 (en) * 2024-07-16 2026-01-22 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105755044A (zh) 2011-04-22 2016-07-13 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体及其使用方法
AU2017257169B2 (en) * 2016-04-29 2021-07-08 Adverum Biotechnologies, Inc. Evasion of neutralizing antibodies by a recombinant adeno-associated virus
ES2840059T3 (es) * 2016-06-16 2021-07-06 Adverum Biotechnologies Inc Tratamiento de la DMRE mediante el uso de la variante AAV2 con aflibercept
EP4653536A3 (en) 2017-03-17 2026-02-25 Adverum Biotechnologies, Inc. Compositions and methods for enhanced gene expression
CA3147843A1 (en) * 2019-09-11 2021-03-18 Mehdi Gasmi Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
WO2021050094A1 (en) 2019-09-11 2021-03-18 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
HRP20260137T1 (hr) 2019-09-11 2026-03-13 Adverum Biotechnologies, Inc. Liječenje očnih neovaskularnih bolesti upotrebom aav2 varijanti koje kodiraju aflibercept

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CA3215855A1 (en) 2022-11-03
US20240197915A1 (en) 2024-06-20
BR112023019056A2 (pt) 2024-01-16
WO2022232790A1 (en) 2022-11-03
EP4329721A1 (en) 2024-03-06
CN117222400A (zh) 2023-12-12
MX2023012410A (es) 2023-10-31
KR20240005764A (ko) 2024-01-12

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