JP2024504981A - 新規の操作されたヌクレアーゼおよびキメラヌクレアーゼ - Google Patents
新規の操作されたヌクレアーゼおよびキメラヌクレアーゼ Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N9/14—Hydrolases (3)
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03015—(S)-2-Hydroxy-acid oxidase (1.1.3.15)
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- C07K2319/00—Fusion polypeptide
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
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- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US202163140620P | 2021-01-22 | 2021-01-22 | |
| US63/140,620 | 2021-01-22 | ||
| US202163237484P | 2021-08-26 | 2021-08-26 | |
| US63/237,484 | 2021-08-26 | ||
| PCT/US2022/013396 WO2022159758A1 (en) | 2021-01-22 | 2022-01-21 | Novel engineered and chimeric nucleases |
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| JP2024504981A true JP2024504981A (ja) | 2024-02-02 |
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| WO (1) | WO2022159758A1 (pt) |
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| CA3174557A1 (en) | 2020-03-06 | 2021-09-10 | Metagenomi, Inc. | Class ii, type v crispr systems |
| EP4392561A1 (en) * | 2021-08-27 | 2024-07-03 | Metagenomi, Inc. | Enzymes with ruvc domains |
| WO2024026499A2 (en) * | 2022-07-29 | 2024-02-01 | Metagenomi, Inc. | Class ii, type v crispr systems |
| WO2024156085A1 (en) * | 2023-01-27 | 2024-08-02 | Syngenta Crop Protection Ag | Mb2cas12a variants with enhanced efficiency |
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| WO2014089290A1 (en) * | 2012-12-06 | 2014-06-12 | Sigma-Aldrich Co. Llc | Crispr-based genome modification and regulation |
| US9963689B2 (en) * | 2013-12-31 | 2018-05-08 | The Regents Of The University Of California | Cas9 crystals and methods of use thereof |
| AU2018330197B2 (en) * | 2017-09-07 | 2022-09-01 | Intima Bioscience, Inc. | Nuclease systems for genetic engineering |
| WO2020123887A2 (en) * | 2018-12-14 | 2020-06-18 | Pioneer Hi-Bred International, Inc. | Novel crispr-cas systems for genome editing |
| JP2022520428A (ja) * | 2019-02-14 | 2022-03-30 | メタゲノミ アイピー テクノロジーズ，エルエルシー | Ｒｕｖｃドメインを有する酵素 |
| US10982200B2 (en) * | 2019-02-14 | 2021-04-20 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| JP2023533417A (ja) * | 2020-05-08 | 2023-08-03 | メタゲノミ，インコーポレイテッド | Ｒｕｖｃドメインを有する酵素 |
| MX2023002913A (es) * | 2020-09-11 | 2023-06-01 | Metagenomi Inc | Enzimas para edicion de bases. |
| CA3210361A1 (en) * | 2021-03-19 | 2022-09-22 | Brian Thomas | Multiplex editing with cas enzymes |
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| US20230416710A1 (en) | 2023-12-28 |
| AU2022210762A9 (en) | 2024-09-19 |
| GB202215621D0 (en) | 2022-12-07 |
| BR112023014719A2 (pt) | 2023-12-05 |
| CA3205865A1 (en) | 2022-07-28 |
| EP4281554A1 (en) | 2023-11-29 |
| GB2610711A (en) | 2023-03-15 |
| MX2023008629A (es) | 2023-10-25 |
| KR20230134543A (ko) | 2023-09-21 |
| GB2610711B (en) | 2023-08-02 |
| WO2022159758A1 (en) | 2022-07-28 |
| AU2022210762A1 (en) | 2023-08-24 |
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