JP2024504467A - がん療法で使用するための乳酸脱水素酵素活性のポリペプチド阻害剤 - Google Patents

がん療法で使用するための乳酸脱水素酵素活性のポリペプチド阻害剤 Download PDF

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JP2024504467A
JP2024504467A JP2023545955A JP2023545955A JP2024504467A JP 2024504467 A JP2024504467 A JP 2024504467A JP 2023545955 A JP2023545955 A JP 2023545955A JP 2023545955 A JP2023545955 A JP 2023545955A JP 2024504467 A JP2024504467 A JP 2024504467A
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ldh
polypeptide
amino acid
seq
nucleic acid
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JP2023545955A
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Japanese (ja)
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JP2024504467A5 (https=
Inventor
ソンヴォー，ピエール
フレドリック，ラファエル
タボルト，レオポルド
リベレル，マキシム
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ユニヴェルシテ カソリーク デ ルーヴァン
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Publication of JP2024504467A publication Critical patent/JP2024504467A/ja
Publication of JP2024504467A5 publication Critical patent/JP2024504467A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2023545955A 2021-02-01 2022-02-01 がん療法で使用するための乳酸脱水素酵素活性のポリペプチド阻害剤 Pending JP2024504467A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21154636.1 2021-02-01
EP21154636 2021-02-01
PCT/EP2022/052282 WO2022162233A2 (en) 2021-02-01 2022-02-01 Polypeptide inhibitors of lactate dehydrogenase activity for use in cancer therapy

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JP2024504467A true JP2024504467A (ja) 2024-01-31
JP2024504467A5 JP2024504467A5 (https=) 2025-02-13

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ID=74494850

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JP2023545955A Pending JP2024504467A (ja) 2021-02-01 2022-02-01 がん療法で使用するための乳酸脱水素酵素活性のポリペプチド阻害剤

Country Status (6)

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US (1) US20240116987A1 (https=)
EP (1) EP4284920A2 (https=)
JP (1) JP2024504467A (https=)
AU (1) AU2022214391A1 (https=)
CA (1) CA3206455A1 (https=)
WO (1) WO2022162233A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3138822A1 (en) * 2019-05-02 2020-11-05 Universite Catholique De Louvain Lactate dehydrogenase inhibitor polypeptides for use in the treatment of cancer
US12357256B2 (en) * 2023-06-23 2025-07-15 Smart Breast Corporation Computer assisted molecular imaging methods and systems

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130263A1 (en) * 1999-10-29 2005-06-16 Genesis Research And Development Corp. Ltd. Compositions isolated from bovine mammary gland and methods for their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
US6444425B1 (en) * 1999-04-02 2002-09-03 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use
RU2556800C2 (ru) 2010-06-14 2015-07-20 Ф.Хоффманн-Ля Рош Аг Пептиды, проникающие в клетки, и их применения
CA3138822A1 (en) * 2019-05-02 2020-11-05 Universite Catholique De Louvain Lactate dehydrogenase inhibitor polypeptides for use in the treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130263A1 (en) * 1999-10-29 2005-06-16 Genesis Research And Development Corp. Ltd. Compositions isolated from bovine mammary gland and methods for their use

Also Published As

Publication number Publication date
EP4284920A2 (en) 2023-12-06
WO2022162233A2 (en) 2022-08-04
WO2022162233A3 (en) 2022-11-10
AU2022214391A1 (en) 2023-08-10
CA3206455A1 (en) 2022-08-04
US20240116987A1 (en) 2024-04-11
AU2022214391A9 (en) 2024-05-09

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