JP2024502235A - Ｍａｇｅ－ｂ２特異的ｔ細胞受容体 - Google Patents

Ｍａｇｅ－ｂ２特異的ｔ細胞受容体 Download PDF

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JP2024502235A
JP2024502235A JP2023537297A JP2023537297A JP2024502235A JP 2024502235 A JP2024502235 A JP 2024502235A JP 2023537297 A JP2023537297 A JP 2023537297A JP 2023537297 A JP2023537297 A JP 2023537297A JP 2024502235 A JP2024502235 A JP 2024502235A
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JP2024502235A5 (enExample
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キム，ソンウン
ジェン，ヤン
バガル，ダナッシュリー・エス
ユエ，リリー
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アムジエン・インコーポレーテツド
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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JP2023537297A 2020-12-22 2021-12-21 Ｍａｇｅ－ｂ２特異的ｔ細胞受容体 Pending JP2024502235A (ja)

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US202063129447P 2020-12-22 2020-12-22
US63/129,447 2020-12-22
PCT/US2021/064504 WO2022140321A2 (en) 2020-12-22 2021-12-21 Mage-b2-specific t-cell receptors

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JP2024502235A true JP2024502235A (ja) 2024-01-18
JP2024502235A5 JP2024502235A5 (enExample) 2024-12-27

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US (1) US20240100162A1 (enExample)
EP (1) EP4267173A2 (enExample)
JP (1) JP2024502235A (enExample)
AU (1) AU2021410689A1 (enExample)
CA (1) CA3205810A1 (enExample)
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Publication number Priority date Publication date Assignee Title
WO2024137652A2 (en) * 2022-12-20 2024-06-27 Abata Therapeutics, Inc. Cell therapies for type 1 diabetes
CN121358777A (zh) * 2023-07-27 2026-01-16 伊玛提克斯生物技术有限公司 抗mageb2的抗原结合蛋白
WO2025021979A1 (en) * 2023-07-27 2025-01-30 Immatics Biotechnologies Gmbh Novel t cell receptors targeting melanoma-associated antigen (mage) b2 and immune therapy using the same
WO2026025031A1 (en) * 2024-07-26 2026-01-29 Modernatx, Inc. Mrna encoding mageb2 tcer molecule

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016055785A1 (en) * 2014-10-08 2016-04-14 Adaptimmune Limited T cell receptors
JP2019516356A (ja) * 2016-04-08 2019-06-20 アダプティミューン・リミテッド Ｔ細胞受容体
WO2020227091A1 (en) * 2019-05-03 2020-11-12 Gigamune, Inc. Engineered cells expressing anti-tumor t cell receptors and methods of use thereof

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
WO2010126766A1 (en) 2009-04-30 2010-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
KR20190059874A (ko) * 2016-04-08 2019-05-31 어댑티뮨 리미티드 T 세포 수용체
CN112912387A (zh) * 2018-08-22 2021-06-04 弗雷德哈钦森癌症研究中心 靶向kras或her2抗原的免疫疗法
JP7626780B2 (ja) 2020-04-15 2025-02-04 アムジエン・インコーポレーテツド 遺伝子改変自己ｔ細胞を製造するためのプロセス

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016055785A1 (en) * 2014-10-08 2016-04-14 Adaptimmune Limited T cell receptors
JP2019516356A (ja) * 2016-04-08 2019-06-20 アダプティミューン・リミテッド Ｔ細胞受容体
WO2020227091A1 (en) * 2019-05-03 2020-11-12 Gigamune, Inc. Engineered cells expressing anti-tumor t cell receptors and methods of use thereof

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MX2023007519A (es) 2023-08-03
WO2022140321A3 (en) 2022-08-11
US20240100162A1 (en) 2024-03-28
WO2022140321A2 (en) 2022-06-30
CA3205810A1 (en) 2022-06-30
AU2021410689A1 (en) 2023-07-06

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