JP2024053291A - Inspection module, biological sample analysis system having the same and inspection method of biological sample analysis device - Google Patents

Abstract

To provide an inspection module which can easily detect the occurrence of an abnormality in a measurement device which executes various measurements of a biological sample.SOLUTION: An inspection module 10 for executing an inspection of a measurement circuit included in a cell cultivation analysis device 30 with application of the voltage in a state of being set in the cell cultivation analysis device 30, comprises a substrate 11, an electrode part 14 and a resistance part 15. The substrate 11 includes a first surface 11a and a second surface 11b on the opposite side to the first surface 11a. The electrode part 14 is provided in the substrate 11, is brought into contact with a contact probe 32a provided in the cell cultivation analysis device 30 and is applied with the prescribed voltage. The resistance part 15 is provided in the substrate 11, is electrically connected to the electrode part 14 and has a resistance value that generates a current value within a prescribed range when being applied with the prescribed voltage from the contact probe 32a in the normal state.SELECTED DRAWING: Figure 6

Description

The present invention relates to an inspection module for inspecting a biological sample analyzer, a biological sample analysis system including the same, and a method for inspecting a biological sample analyzer.

2. Description of the Related Art In recent years, measuring devices for measuring biological samples have come into widespread use in fields such as cell culture.
For example, Patent Document 1 discloses an electrochemical biosensor test strip capable of selectively quantitatively analyzing, for example, blood glucose, cholesterol, etc. in blood, and an electrochemical biosensor measuring instrument using this test strip.

JP 2003-528312 A

However, the above-mentioned conventional electrochemical biosensor test strips have the following problems.
That is, the electrochemical biosensor test strip disclosed in the above publication is equipped with a recognition electrode that indicates which substance the immobilized reagent is for quantitatively analyzing, and various blood components such as blood glucose, cholesterol, GOT, GPT, etc. can be quantitatively analyzed using a single measuring device. However, with this test strip, even if there is an abnormality in the measuring circuit of the measuring device, such as a poor connection, a broken wire, or a broken IC, the user may continue to use the test strip without noticing it, and there is a risk that no measurement result or an erroneous measurement result will be obtained.

The objective of the present invention is to provide an inspection module that can easily detect the occurrence of an abnormality in a measurement device that performs various measurements of biological samples, a biological sample analyzer equipped with the same, and an inspection method for the biological sample analyzer.

The inspection module according to the first invention is an inspection module that inspects a measurement circuit included in a biological sample analyzer by applying a voltage to the inspection module when the inspection module is set in the biological sample analyzer, and includes a substrate, an electrode section, and a resistance section. The substrate has a first surface and a second surface opposite to the first surface. The electrode section is provided on the substrate and abuts against a voltage application section provided on the biological sample analyzer, and a predetermined voltage is applied from the voltage application section. The resistance section is provided on the substrate and is electrically connected to the electrode section, and has a resistance value that generates a current value in a predetermined range when a predetermined voltage is applied from the voltage application section in a normal state.

Here, an inspection module having an electrode section and a resistor section provided on a substrate is used to perform inspection of the measurement circuit of a biological sample analyzer, which is normally performed with a sensor attached that measures the biological sample.
Here, the resistance portion is a resistor having a resistance value that generates a predetermined current value when a predetermined voltage is applied to the electrode portion, and by measuring the current value flowing through the resistance portion, it is possible to check for poor electrical connection in the measurement circuit of the biological sample analyzer, for malfunctions in the measurement circuit, etc.

This makes it easier to handle than inspections using sensors that measure biological samples, since there is no need to prepare liquids such as culture media as with electrochemical sensors. Also, there is no variation in measurement accuracy due to individual differences, as with sensors, and highly accurate inspections can be performed. Furthermore, compared to inspections using sensors, for example, there is no need to ensure enzyme reaction time during measurement, so the response speed can be significantly improved and inspections can be performed efficiently.
As a result, occurrence of an abnormality in a measuring device that performs various measurements on biological samples can be easily detected.

The inspection module of the second invention is the inspection module of the first invention, wherein the electrode portion is arranged on a first surface of the substrate and the resistance portion is arranged on a second surface of the substrate.
This makes it possible to easily clean the first surface on which the electrode portion is provided by arranging the resistance portion, which creates unevenness when placed on the substrate, on the second surface opposite the electrode portion.

An inspection module according to a third aspect of the present invention is the inspection module according to the first or second aspect of the present invention, wherein three resistor portions are provided.
This allows inspection to be carried out under conditions almost identical to those when measurements are taken using a sensor.

The inspection module of the fourth invention is an inspection module of the first or second invention, in which a plurality of sets of electrode parts and resistance parts are arranged on the substrate, with one set of electrode part and resistance part prepared for one measurement object.
This makes it possible to use a single inspection module to inspect a biological sample analyzer that uses multiple sensors to perform measurements simultaneously.

The biological sample analysis system of the fifth invention comprises an inspection module of the first or second invention, a voltage application section that applies a predetermined voltage while in contact with an electrode section of the inspection module, a measuring device that measures the current flowing through the resistor section of the inspection module, and a control device that determines whether or not the measurement results of the measuring device are normal depending on whether they are within a predetermined range.
This makes it possible to construct a system that can easily detect the occurrence of an abnormality in a measurement device that performs various measurements on biological samples.

The biological sample analysis system of the sixth invention is the biological sample analysis system of the fifth invention, in which the control device determines that there is a poor connection or an abnormality in the measurement circuit when the measurement result of the measurement device is outside a predetermined range.
This makes it possible to detect whether a connection is unnecessary or whether there is an abnormality in the measurement circuit depending on whether the value of the current flowing through the resistance portion is within a predetermined range.

The inspection module of the seventh invention is a method for inspecting a biological sample analyzer using the inspection module of the first or second invention, and includes the steps of setting the inspection module in the biological sample analyzer, applying a predetermined voltage to the electrode portion of the inspection module, measuring the current flowing through the resistor portion of the inspection module, and determining whether the measurement circuit included in the biological sample analyzer is normal or not depending on whether the value of the current is within a predetermined range.

This makes it easier to handle than inspections using sensors that measure biological samples, since there is no need to prepare liquids such as culture media as with electrochemical sensors. Also, there is no variation in measurement accuracy due to individual differences, as with sensors, and highly accurate inspections can be performed. Furthermore, compared to inspections using sensors, for example, there is no need to ensure enzyme reaction time during measurement, so the response speed can be significantly improved and inspections can be performed efficiently.
As a result, occurrence of an abnormality in a measuring device that performs various measurements on biological samples can be easily detected.

The inspection module of the present invention makes it easy to detect the occurrence of abnormalities in a measurement device that performs various measurements of biological samples.

1 is a perspective view showing a state in which an inspection module according to an embodiment of the present invention is set on an adapter; 2A, 2B, and 2C are a top view, a back view, and a side view showing the configuration of the inspection module in FIG. 1 . FIG. 2 is an assembly diagram of the inspection module of FIG. 1 . FIG. 2 is a plan view showing the configuration of a culture vessel provided at the lower part of the adapter in FIG. 1 . 2 is a perspective view showing a state in which a configuration including the inspection module of FIG. 1 is loaded into a cell culture analyzer. 6 is a cross-sectional view showing the connection relationship between an inspection module set in the cell culture analyzer of FIG. 5 and a contact probe of the cell culture analyzer. 2 is a perspective view showing a state in which a sensor module is set on an adapter in place of the inspection module of FIG. 1; 8 is a perspective view showing a state in which a configuration including the sensor module of FIG. 7 is loaded into a cell culture analyzer. 6 is a cross-sectional view showing the connection relationship between a sensor module set in the cell culture analyzer of FIG. 5 and a contact probe of the cell culture analyzer. FIG. 2 is an electrical circuit diagram of the cell culture analyzer in which the inspection module of FIG. 1 is installed. 11 is a circuit diagram showing in detail the internal configuration of an AFE included in the electric circuit diagram of FIG. 10 . 4 is a flowchart showing the process flow of a method for inspecting a cell culture analyzer using the inspection module of FIG. 1 .

An inspection module 10 according to one embodiment of the present invention and a cell culture analysis system (biological sample analysis system) 1 equipped with the same will be described below with reference to Figs. 1 to 12.
In this embodiment, more detailed explanation than necessary may be omitted. For example, detailed explanation of already well-known matters or duplicate explanation of substantially the same configuration may be omitted. This is to avoid the following explanation from becoming unnecessarily redundant and to facilitate understanding by those skilled in the art.

Furthermore, the applicant provides the accompanying drawings and the following description so that those skilled in the art can fully understand the present invention, and they are not intended to limit the subject matter described in the claims.
The cell culture analysis system (biological sample analysis system) 1 of this embodiment comprises an inspection module 10, a contact probe (voltage application section) 32a that applies a predetermined voltage while in contact with the electrode section 14 of the inspection module 10, a CPU (measurement device) 34 that measures the current flowing through the resistance section 15 of the inspection module 10, and a PC (control device) 37 that determines whether or not the measurement results of the CPU 34 are normal depending on whether they are within a predetermined range (see Figure 11).

The inspection module 10 according to this embodiment is included in the cell culture analysis system 1, and is set in the cell culture analysis device (biological sample analysis device) 30 (see FIG. 5) and a voltage is applied to inspect the measurement circuit included in the cell culture analysis device 30. As shown in FIG. 1, the inspection module 10 is loaded into the cell culture analysis device 30 (see FIG. 5) described below in a state where it is set on the upper surface of the main body 20a of the adapter 20 in place of the sensor board 50 (see FIG. 7, etc.) that measures the concentration of glucose, etc., contained in the culture medium X. As shown in FIGS. 2(a) to 2(c) and 3, the inspection module 10 includes a board 11, a screw 12, a leg 13, an electrode portion 14, a resistor portion 15, and a plate member 16.

As shown in Figures 2(a) to 2(c), the substrate 11 is a substantially rectangular plate-like member, and has a first surface 11a that comes into contact with the upper surface when set on the main body 20a of the adapter 20 shown in Figure 1, and a second surface 11b opposite the first surface 11a.
As shown in FIG. 2A, the first surface 11a has a plurality of electrode portions 14 provided on the surface.

As shown in Fig. 2(b), the second surface 11b has a plurality of resistor portions 15 provided on the surface thereof. The plurality of resistor portions 15 arranged on the second surface 11b protrude from the surface of the second surface 11b as shown in Fig. 2(c).
3, the screws 12 are inserted into through holes provided at the four corners of the substantially rectangular substrate 11 and screwed into screw holes provided at the four corners of a plate member 16, which will be described later. In this way, the substrate 11 is fixed to the plate member 16.

The legs 13 are provided so as to protrude downward from each of the four corners of a substantially rectangular plate member 16 described later. As shown in FIG. 1 , the legs 13 are inserted into positioning holes 20c provided at the four corners of the main body 20a of the adapter 20, thereby positioning the inspection module 10 with respect to each well 25a of the culture vessel 25.
A contact probe (voltage application unit) 32a of the cell culture analyzer 30 described later comes into contact with the electrode unit 14 to apply a predetermined voltage, thereby detecting the presence or absence of a poor connection or malfunction in the measurement circuit of the cell culture analyzer 30. Four electrode units 14 form one set (see FIG. 5 ), and each set corresponds to one well 25a (see FIG. 4 ) included in the culture vessel 25 described later. In this embodiment, 24 sets (4×24=96) of electrode units 14 are provided on the first surface 11a of the substrate 11 for the 24 wells 25a.

The resistor portion 15 is electrically connected to the electrode portion 14, and when a predetermined voltage is applied to the electrode portion 14, if the measurement circuit of the cell culture analyzer 30 is normal, the resistor portion 15 has a resistance value that allows a current to flow within a predetermined range. As shown in FIG. 2(b), three resistor portions 15 form one set, and each set corresponds to one well 25a (see FIG. 4) included in the culture vessel 25 described below. In this embodiment, 24 sets (3 x 24 = 72 resistor portions) of resistor portions 15 are provided on the second surface 11b of the substrate 11 for the 24 wells 25a.

2(a) to 2(c) is placed on the upper surface of the plate member 16, which is a plate-like member fixed with four screws 12, and the above-mentioned legs 13 are provided at the four corners. As shown in FIG. 3, the plate member 16 has a main body 16a and a plurality of grooves 16b.
The main body portion 16a is a substantially rectangular plate-like member, and has a plurality of grooves 16b formed in positions facing a plurality of resistor portions 15 arranged to protrude from the surface of the second face 11b of the substrate 11.

The groove portion 16b is a recess formed approximately parallel to the longitudinal direction of the approximately rectangular main body portion 16a, and the resistor portion 15 is disposed in the groove portion 16b when the substrate 11 and the plate member 16 are superimposed on each other.
As a result, the protrusion of the resistor portion 15 can be absorbed by the groove portion 16 b of the plate member 16 .
The culture vessel 25 is configured to include a total of 24 wells 25a in four vertical rows and six horizontal rows, as shown in Fig. 4. The culture vessel 25 is disposed between the adaptor 20 and the base member 23, as shown in Fig. 1.

The cell culture analyzer 30 that is inspected using the inspection module 10 of this embodiment has a housing section 30a and a drawer section 31, as shown in FIG.
The drawer 31 advances and retreats relative to the housing 30a, whereby the inspection module 10 set on the adapter 20 shown in FIG. 1 is loaded into the internal space S1 of the housing 30a.
The inspection module 10 loaded into the internal space S1 of the housing portion 30a of the cell culture analysis device 30 can check for any malfunctions in the measurement circuit of the cell culture analysis device 30 by applying a predetermined inspection voltage while the contact probe 32a of the cell culture analysis device 30 is abutted against each electrode portion 14.

Here, in this embodiment, in addition to the contact probe 32a that is brought into contact with a set of four electrode portions 14 provided for inspection purposes, two contact probes 32b are provided for detecting the set of inspection modules 10 or sensor boards 50.
The contact probe 32b is provided at a position corresponding to the two detection electrodes 14a shown in Fig. 2(a). As shown in Fig. 6, the contact probe 32b can detect whether the inspection module 10 or the sensor board 50 is loaded in the housing 30a of the cell culture analyzer 30 by applying a voltage to one of the two probes while in contact with the detection electrode 14a.

In the state shown in FIG. 6, since the inspection module 10 is set and the measurement circuit of the cell culture analyzer 30 is inspected, it is not necessary for the culture medium X to be placed in the well 25a of the culture vessel 25.
As a result, compared to the case where the measurement circuit of the cell culture analyzer 30 is inspected with the sensor substrate 50 for measurement set as shown in Fig. 7, there is no need to prepare the culture medium X, and handling during inspection is easier. Also, compared to the case where the sensor substrate 50 is used, there is no variation in measurement accuracy due to individual differences in the sensor 51, and inspection can be performed with high accuracy. Furthermore, compared to the case where the sensor 51 is used, for example, there is no need to ensure the reaction time of the enzyme during measurement, so the response speed can be significantly improved and inspection can be performed efficiently.

As a result, the occurrence of an abnormality in the measurement circuit of the cell culture analyzer 30 can be easily detected.
Then, when inspection is performed using the inspection module 10 and it is determined that there is no abnormality in the measurement circuit of the cell culture analysis device 30, the sensor board 50 is set on the adapter 20 as shown in Figure 7, with culture medium X placed in each well 25a of the culture container 25.

As shown in FIG. 7, the sensor substrate 50 includes 24 sensors 51 arranged at positions corresponding to the 24 wells 25a of the culture vessel 25 in the main body 50a.
As shown in Fig. 7, the sensor 51 has measurement electrodes (electrodes 53a, 53b, 53c, and 53d) protruding downward from the lower surface side of the main body 50a. The sensor 51 is held by the sensor substrate 50 with the substrate 52 bent into a substantially L-shape (see Fig. 9).

The electrodes 53a to 53d are provided at the tip of the substrate 52 of the sensor 51, and various measurements are performed while immersed in the culture medium X placed in each well 25a of the culture vessel 25 described above.
That is, when the sensor substrate 50 is set on the upper surface of the adapter 20 with the electrodes 53a to 53d of the sensor 51 protruding downward as shown in FIG. 7, the four legs 50b of the sensor substrate 50 are inserted into the four positioning holes 20c on the adapter 20 side, thereby positioning the sensor substrate 50 with respect to the culture vessel 25.

At this time, the tip portion of the sensor 51 protruding downward passes through the through hole 20b formed in the main body 20a of the adapter 20 and is immersed in the culture medium X contained in the well 25a of the culture vessel 25 provided below the adapter 20.
The sensor substrate 50 set on the upper surface of the adapter 20 is set with the drawer section 31 of the cell culture analysis device 30 pulled out, as shown in Figure 8, and the drawer section 31 is retracted into the housing section 30a, thereby loading it into the internal space S1 of the housing section 30a of the cell culture analysis device 30.

At this time, as shown in FIG. 8, a set of four electrode pads 54a, 54b, 54c, and 54d are provided on the upper surface of the sensor substrate 50.
The electrode pads 54a to 54d are provided on the upper end side of the substrate 52 in a state of being electrically connected to the electrodes 53a to 53d provided on the lower end side of the substrate 52, and are exposed on the upper surface of the sensor substrate 50. When the sensor substrate 50 is loaded into the cell culture analyzer 30, as shown in Fig. 9, the electrode pads 54a to 54d are brought into contact with the contact probe 32a, and a predetermined voltage for measurement is applied.

This makes it possible to measure the concentrations of various components contained in the culture medium X based on the current values detected at the measurement electrodes (electrodes 53a to 53d) of the sensor 51 when immersed in the culture medium X contained in each well 25a of the culture vessel 25.
Here, in the inspection module 10 of this embodiment, a predetermined voltage is applied via the contact probes 32a as shown in Fig. 10. At this time, the cell culture analyzer 30 applies a voltage to each of the contact probes 32a from 24 AFEs (Analog Front ENDs) 33 provided for each set of four electrode units 14.

The AFE (Analog Front END) 33 is an analog circuit that connects devices such as sensors that detect signals and devices that process digital signals.
Analog signals detected by sensors and the like are often weak and contain a large amount of noise components. For this reason, it is difficult to convert the detected analog signals directly into digital signals by an A/D converter. Therefore, the AFE 33 is provided to adjust the analog signals output from sensors and the like, and includes semiconductor chips such as an operational amplifier 33a, an A/D converter 33b, a D/A converter 33c, and a filter, as shown in FIG.

For ease of explanation, FIG. 11 shows an enlarged view of the configuration of one AFE 33, but it goes without saying that the other 23 AFEs 33 have the same configuration.
Furthermore, the AFE 33 is connected to a CPU (Central Processing Unit) 34, and the CPU (Central Processing Unit) 34 controls the voltages applied from the contact probes 32a and 32b.

The CPU 34 controls the 24 AFEs 33 and executes various processes using various data, programs, etc. stored in an EEPROM (Electrically Erasable Programmable Read-Only Memory) 35 .
The EEPROM (Electrically Erasable Programmable Read-Only Memory) 35 is a type of non-volatile memory in which the recorded contents are not erased even when the power to the cell culture analyzer 30 is turned off, and stores various data, programs, etc.

The CPU 34 transmits the output from the AFE 33 (for example, the current value detected at the electrode portion 14 of the inspection module 10 ) to a PC (Personal Computer) 37 via a USB (Universal Serial Bus) 36 .
The PC 37 determines whether or not there is an abnormality in the measurement circuit of the cell culture analyzer 30 depending on whether or not the current value detected at the electrode portion 14 of the inspection module 10 received via the USB 36 is within a predetermined range.

As shown in FIG. 11, the inspection module 10 includes three resistor portions 15 .
This allows inspection to be performed using the inspection module 10 in a state that is almost the same as when the sensor board 50 is actually set and the culture medium X is measured.

<Inspection method using inspection module 10>
The inspection method for the cell culture analyzer 30 using the inspection module 10 of this embodiment will be described below with reference to the flow chart of FIG.
That is, as shown in FIG. 12, in step S11, the power supply of the cell culture analyzer 30 is turned on.
Next, in step S12, the inspection module 10 is set in the cell culture analyzer 30.
Next, in step S13, the operational amplifier 33a included in each AFE 33 of the cell culture analyzer 30 is turned ON.

Next, in step S14, a predetermined voltage is applied from the operational amplifier 33a of the AFE 33 to the resistor portion 15 of the inspection module 10.
Next, in step S15, a current value detected in a state where a predetermined voltage is applied to the resistor portion 15 is measured. A signal corresponding to the current value is input to the AFE 33 via the contact probe 32a, converted from an analog signal to a digital signal, and then transmitted to the PC 37 via the CPU 34.

Next, in step S16, the PC 37 judges whether the detected current value is within a predetermined range or not. If it is judged to be within the predetermined range, the process proceeds to step S17, and if it is judged not to be within the predetermined range, the process proceeds to step S18.
Next, in step S17, since it was determined in step S16 that the detected current value is within the predetermined range, it is determined that there is no abnormality in the measurement circuit of the cell culture analysis apparatus 30, and this is displayed on the display screen of the PC 37.

On the other hand, in step S18, since it was determined in step S16 that the detected current value is not within the predetermined range, it is determined that there is an abnormality in the measurement circuit of the cell culture analysis device 30, such as a poor electrical connection or an IC abnormality, and this is displayed on the display screen of PC 37.
Next, in step S19, the operational amplifier 33a included in each AFE 37 is turned off.
Next, in step S20, the inspection module 10 is removed from the housing portion 30a of the cell culture analyzer 30.

<Main features>
As shown in Fig. 6 and other figures, the inspection module 10 of this embodiment is a module that inspects a measurement circuit included in a cell culture analyzer 30 by applying a voltage to the module while the module is set in the cell culture analyzer 30, and includes a substrate 11, an electrode section 14, and a resistor section 15. The substrate 11 has a first surface 11a and a second surface 11b opposite to the first surface 11a. The electrode section 14 is provided on the substrate 11, and a predetermined voltage is applied to the electrode section 14 by contacting a contact probe 32a provided on the cell culture analyzer 30. The resistor section 15 is provided on the substrate 11 and electrically connected to the electrode section 14, and has a resistance value that generates a current value in a predetermined range when a predetermined voltage is applied from the contact probe 32a in a normal state.

This eliminates the need to prepare culture medium X, as compared to when inspecting the measurement circuit of the cell culture analyzer 30 using a measurement sensor board 50, thereby reducing the effort required for inspection.
Furthermore, when using the inspection module 10, measurement is performed using the resistance part 15, so compared to inspection using the sensor board 50, there is no variation in measurement accuracy due to individual differences in the sensor 51, and a highly accurate inspection can be performed.

Furthermore, when the inspection module 10 is used, compared to an inspection using the sensor 51, for example, there is no need to ensure enzyme reaction time during measurement, so the response speed can be significantly improved and the inspection can be carried out efficiently.
As a result, the occurrence of an abnormality in the measurement circuit of the cell culture analyzer 30 can be easily detected.

[Other embodiments]
Although one embodiment of the present invention has been described above, the present invention is not limited to the above embodiment, and various modifications are possible without departing from the gist of the invention.
(A)
In the above embodiment, the configuration of the inspection module 10 in which the electrode portion 14 is disposed on the front side of the substrate 11 and the resistor portion 15 is disposed on the back side of the substrate 11 has been described as an example. However, the present invention is not limited to this.
For example, the electrode portion and the resistor portion may be provided on the same surface of the substrate.

(B)
In the above embodiment, an example has been described in which three resistors 15 are arranged for one measurement target (well 25a), but the present invention is not limited to this.
For example, the inspection module may be configured such that two resistor units are provided for one measurement object, or such that four or more resistor units are provided for one measurement object.

(C)
In the above embodiment, an example has been described in which four electrode units 14 are arranged for one measurement target (well 25a), but the present invention is not limited to this.
For example, the inspection module may be configured with three or less electrode units for one measurement object, or may be configured with five or more electrode units.

(D)
In the above embodiment, an example has been described in which the inspection module 10 is connected to inspect the cell culture analyzer 30 instead of the sensor substrate 50 in which the sensor 51 is immersed in the culture vessel 25 including the 24 wells 25a to perform various measurements. However, the present invention is not limited to this.
For example, the number of sensors included in the sensor board is not limited to 24, and instead of a sensor board in which various measurements are performed using a single sensor, the inspection module of the present invention may be used to perform inspection of the biological sample analysis device.

(E)
In the above embodiment, an example has been described in which the cell culture analyzer 30 is used as the biological sample analyzer to be inspected using the inspection module 10 of the present invention. However, the present invention is not limited to this.

For example, other biological sample analysis devices unrelated to cell culture may also be inspected.

The inspection module of the present invention has the effect of easily detecting the occurrence of abnormalities in a measurement device that performs various measurements of biological samples, and is therefore widely applicable to devices that inspect various biological sample analyzers.

1. Cell culture analysis system (biological sample analysis system)
10 Inspection module 11 Substrate 11a First surface 11b Second surface 12 Screw 13 Leg 14 Electrode portion 14a Detection electrode 15 Resistor portion 16 Plate member 16a Main body portion 16b Groove portion 20 Adapter 20a Main body portion 20b Through hole 20c Positioning hole 23 Base member 25 Culture container 25a Well 30 Cell culture analyzer (biological sample analyzer)
30a: Housing portion 31: Lead-out portion 32a: Contact probe (voltage application portion)
32b Contact probe 33 AFE (Analog Front END)
33a: operational amplifier 33b: A/D converter 33c: D/A converter 34: CPU (Central Processing Unit) (measuring device)
35 EEPROM (Electrically Erasable Programmable Read-Only Memory)
36 USB (Universal Serial Bus)
37 PC (control device)
50 Sensor substrate 50a Body portion 50b Leg portion 51 Sensor 52 Substrate 53a, 53b, 53c, 53d Electrodes 54a, 54b, 54c, 54d Electrode pad S1 Internal space X Culture medium

Claims (7)

An inspection module that inspects a measurement circuit included in a biological sample analyzer by applying a voltage to the inspection module when the inspection module is set in the biological sample analyzer,
a substrate having a first surface and a second surface opposite to the first surface;
an electrode section provided on the substrate, in contact with a voltage application section provided on the biological sample analyzer, to which a predetermined voltage is applied from the voltage application section;
a resistor portion provided on the substrate, electrically connected to the electrode portion, and having a resistance value that generates a current value within a predetermined range when the predetermined voltage is applied from the voltage application portion in a normal state;
An inspection module equipped with the electrode portion is disposed on the first surface of the substrate,
The resistor portion is disposed on the second surface of the substrate.
2. The inspection module of claim 1. The resistor portion is provided in three pieces.
3. An inspection module according to claim 1 or 2. a plurality of pairs of the electrode portion and the resistor portion are arranged on the substrate, with one pair of the electrode portion and the resistor portion being prepared for one measurement target;
3. An inspection module according to claim 1 or 2. An inspection module according to claim 1 or 2;
a voltage application unit that applies a predetermined voltage to the electrode unit of the inspection module while being in contact with the electrode unit;
A measuring device for measuring a current flowing through the resistor of the inspection module;
a control device that judges whether the measurement result of the measuring device is normal or not depending on whether the measurement result is within a predetermined range;
A biological sample analysis system comprising: The control device determines that there is a connection failure or an abnormality in the measurement circuit when the measurement result of the measurement device is outside a predetermined range.
The biological sample analyzing system according to claim 5 . A method for inspecting a biological sample analyzer using the inspection module according to claim 1 or 2, comprising the steps of:
a step of setting the inspection module in the biological sample analyzer;
applying a predetermined voltage to the electrode portion of the inspection module;
measuring a current through the resistor of the test module;
determining whether a measurement circuit included in the biological sample analyzer is normal or not depending on whether the value of the current is within a predetermined range;
An inspection method comprising: