JP2024052277A - How the skin is classified - Google Patents
How the skin is classified Download PDFInfo
- Publication number
- JP2024052277A JP2024052277A JP2022158877A JP2022158877A JP2024052277A JP 2024052277 A JP2024052277 A JP 2024052277A JP 2022158877 A JP2022158877 A JP 2022158877A JP 2022158877 A JP2022158877 A JP 2022158877A JP 2024052277 A JP2024052277 A JP 2024052277A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- humidity
- barrier properties
- low
- environmental temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004888 barrier function Effects 0.000 claims abstract description 125
- 230000007613 environmental effect Effects 0.000 claims abstract description 80
- 238000000034 method Methods 0.000 claims description 69
- 230000008591 skin barrier function Effects 0.000 claims description 59
- 239000002537 cosmetic Substances 0.000 claims description 43
- 238000005259 measurement Methods 0.000 claims description 14
- 230000036555 skin type Effects 0.000 claims description 5
- 210000003491 skin Anatomy 0.000 description 133
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 description 20
- 229960001238 methylnicotinate Drugs 0.000 description 10
- 210000000434 stratum corneum Anatomy 0.000 description 10
- 206010015150 Erythema Diseases 0.000 description 8
- 230000001771 impaired effect Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 210000003467 cheek Anatomy 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 230000001333 moisturizer Effects 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- CELKVAQKCIJCLK-UHFFFAOYSA-N [9-(2-carboxyphenyl)-6-(diethylamino)xanthen-3-ylidene]-diethylazanium;octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC([O-])=O.C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O CELKVAQKCIJCLK-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000003287 bathing Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000036572 transepidermal water loss Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- RVYGVBZGSFLJKH-UHFFFAOYSA-N hexyl pyridine-3-carboxylate Chemical compound CCCCCCOC(=O)C1=CC=CN=C1 RVYGVBZGSFLJKH-UHFFFAOYSA-N 0.000 description 1
- 229940051295 hexylnicotinate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005722 itchiness Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 238000012014 optical coherence tomography Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- WPPDXAHGCGPUPK-UHFFFAOYSA-N red 2 Chemical group C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=2C=3C4=CC=C5C6=CC=C7C8=C(C=9C=CC=CC=9)C9=CC=CC=C9C(C=9C=CC=CC=9)=C8C8=CC=C(C6=C87)C(C=35)=CC=2)C4=C1C1=CC=CC=C1 WPPDXAHGCGPUPK-UHFFFAOYSA-N 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Abstract
【課題】皮膚又は唇（以下、単に皮膚と略する）のバリア性が環境温湿度によってどのように変化するかを把握できるようにする。【解決手段】皮膚の環境温湿度を変えて皮膚のバリア性の計測値を取得し、該計測値に基づき、或る環境温湿度でのバリア性の高低と、該環境温湿度と温度又は湿度が異なる環境温湿度でのバリア性の高低の少なくとも二軸で皮膚のバリア性のタイプを分類する。例えば、次の(i)～(iv)の４タイプに分類する。(i)低湿度環境及び高湿度環境でバリア性が低い皮膚、(ii)低湿度環境でバリア性が低く、高湿度環境でバリア性が高い皮膚、(iii)低湿度環境及び高湿度環境でバリア性が高い皮膚、(iv)低湿度環境でバリア性が高く、高湿度環境でバリア性が低い皮膚。【選択図】図２[Problem] To understand how the barrier property of skin or lips (hereinafter simply referred to as skin) changes depending on environmental temperature and humidity. [Solution] The environmental temperature and humidity of the skin are changed to obtain measured values of the barrier property of the skin, and based on the measured values, the type of barrier property of the skin is classified on at least two axes: high and low barrier property at a certain environmental temperature and humidity, and high and low barrier property at an environmental temperature and humidity different in temperature or humidity from the said environmental temperature and humidity. For example, classification into the following four types (i) to (iv): (i) skin with low barrier property in low humidity and high humidity environments, (ii) skin with low barrier property in low humidity environment and high barrier property in high humidity environment, (iii) skin with high barrier property in low humidity and high humidity environments, (iv) skin with high barrier property in low humidity environment and low barrier property in high humidity environment. [Selected Figure] Figure 2
Description
本発明は、環境温湿度によって皮膚のバリア性がどのように変わるかを分類する皮膚のバリア性の分類方法に関する。 The present invention relates to a method for classifying the skin barrier property by classifying how the skin barrier property changes depending on the environmental temperature and humidity.
皮膚のバリア性とは、外的要因が皮膚表面、表層、皮膚内部に及ぼす影響を防御するという皮膚の特性である。マスク、おむつ、ゴム手袋等の着用により皮膚を湿潤状態におくと皮膚のバリア性が影響を受け、トラブルが生じる場合のあることが知られている。この皮膚のバリア性に関し、特許文献１には、皮膚に水分を負荷すると角層厚が増加し、さらには皮膚の微細構造が変化して穴状構造が形成され、皮膚における指標物質の浸透性が高まること、即ち、皮膚のバリア性が低下すること、したがって、被験物質を皮膚に接触させたときの穴状構造の画像に基づき被験物質が皮膚に与えるバリア性への影響を評価できることが記載されている。 Skin barrier properties are the characteristics of the skin that protect the surface, outer layer, and interior of the skin from the effects of external factors. It is known that keeping the skin moist by wearing a mask, diaper, rubber gloves, etc. can affect the barrier properties of the skin, resulting in problems. Regarding the barrier properties of the skin, Patent Document 1 describes that when moisture is applied to the skin, the thickness of the stratum corneum increases, and the microstructure of the skin changes to form a pore structure, increasing the permeability of the indicator substance in the skin, i.e., decreasing the barrier properties of the skin, and therefore that the effect of the test substance on the barrier properties of the skin can be evaluated based on an image of the pore structure when the test substance is brought into contact with the skin.
また、マスクの着用者は、肌荒れ、乾燥、かゆみなどの肌状態の変化を、夏冬を問わず意識し、吹き出物、ニキビ、べたつき等の肌状態の変化を夏に意識することが報告されている（非特許文献１）。 It has also been reported that mask wearers are aware of changes in their skin condition, such as rough skin, dryness, and itchiness, regardless of whether it is summer or winter, and are more aware of changes in their skin condition, such as breakouts, acne, and stickiness, in the summer (Non-Patent Document 1).
一方、生活環境を考慮したスキンケアのアドバイス方法として、気温、湿度等の生活環境と肌荒れのレベルとアドバイス情報とを関連づけたデータベースを使用することが知られている（特許文献２）。 On the other hand, a method for providing skin care advice that takes into account the living environment is known that uses a database that associates the living environment, such as temperature and humidity, the level of skin roughness, and advice information (Patent Document 2).
しかしながら、例えば、マスクの着用により皮膚や唇が荒れを起こす人と起こさない人とがいることを踏まえると、被験者の皮膚や唇のバリア性が環境温湿度によってどのように変化するかを予想することは難しく、被験者の皮膚のバリア性の改善に有効な化粧料やスキンケア方法を環境温湿度に基づいて画一的にアドバイスすることはできない。 However, for example, given that some people experience rough skin or lips when wearing a mask and others do not, it is difficult to predict how the barrier properties of a subject's skin or lips will change depending on environmental temperature and humidity, and it is not possible to give uniform advice based on environmental temperature and humidity about cosmetics or skin care methods that will be effective in improving the barrier properties of a subject's skin.
そこで、本発明の課題は、当該被験者の皮膚又は唇（以下、単に皮膚と略する）のバリア性が環境温湿度によってどのように変化するかを把握できるようにする新たな皮膚の分類方法を提供し、その分類方法に基づいて当該皮膚の皮膚を分類し、当該皮膚に適した化粧料、スキンケア方法、メイクアップ方法等をアドバイスできるようにすることに関する。 The present invention aims to provide a new method for classifying skin that enables one to understand how the barrier properties of a subject's skin or lips (hereinafter simply referred to as skin) change depending on the environmental temperature and humidity, classify the skin of the subject based on the classification method, and provide advice on cosmetics, skin care methods, makeup methods, etc. that are suitable for the skin.
上述の課題に対し、本発明は、皮膚の環境温湿度を変えて皮膚のバリア性の計測値を取得し、該計測値に基づき、或る環境温湿度でのバリア性の高低と、該環境温湿度と温度又は湿度が異なる環境温湿度でのバリア性の高低の少なくとも二軸で皮膚のバリア性のタイプを分類する皮膚の分類方法を提供する。 In response to the above-mentioned problems, the present invention provides a method for classifying skin barrier properties by changing the environmental temperature and humidity of the skin to obtain measured values of the skin barrier properties, and based on the measured values, classifying the type of skin barrier properties on at least two axes: high and low barrier properties at a certain environmental temperature and humidity, and high and low barrier properties at an environmental temperature and humidity that is different in temperature or humidity from the environmental temperature and humidity.
また、本発明は、上述の分類方法で分類された皮膚のバリア性のタイプと、該タイプの皮膚のバリア性の改善に適した化粧料の情報、メイクアップ方法又はスキンケア方法とが関連づけられて蓄積されているデータベース、及び
該データベースを使用して、皮膚のバリア性のタイプが入力されると、該タイプに関連づけられた化粧料の情報、メイクアップ方法又はスキンケア方法を出力する演算装置を備えた皮膚のバリア性ケアシステムを提供する。
The present invention also provides a skin barrier care system including a database in which types of skin barrier properties classified by the above-mentioned classification method are stored in association with information on cosmetics, makeup methods, or skin care methods suitable for improving the barrier properties of the skin of the type, and a computing device that uses the database to output, when a type of skin barrier property is input, information on cosmetics, makeup methods, or skin care methods associated with the type.
本発明の皮膚の分類方法によれば、或る環境温湿度で皮膚のバリア性の高低と、該環境温湿度と温度又は湿度が異なる環境温湿度での皮膚のバリア性の高低の少なくとも二軸で皮膚のバリア性のタイプを分類するので、被験者の皮膚のバリア性が環境温湿度によってどのように変化するかを適格に把握することができる。 According to the skin classification method of the present invention, the type of skin barrier property is classified on at least two axes: high and low skin barrier property at a certain environmental temperature and humidity, and high and low skin barrier property at an environmental temperature and humidity that is different in temperature or humidity from the environmental temperature and humidity, so that it is possible to accurately grasp how the subject's skin barrier property changes depending on the environmental temperature and humidity.
したがって、本発明の方法で被験者の皮膚を分類しておくと、その分類結果に基づいて当該皮膚に適した化粧料、メイクアップ方法、及びスキンケア方法について、開発したり、化粧料ユーザにアドバイスしたりすることが可能となる。 Therefore, by classifying the subject's skin using the method of the present invention, it is possible to develop cosmetics, makeup methods, and skin care methods suitable for that skin based on the classification results, and to provide advice to cosmetic users.
また、本発明の皮膚のバリア性ケアシステムでは、本発明の分類方法による皮膚のバリア性のタイプと、該タイプの皮膚のバリア性の改善に適した化粧料の情報、メイクアップ方法又はスキンケア方法との対応が蓄積されているので、環境温湿度に対する被験者の皮膚のバリア性を改善する点から、当該被験者に適した化粧料の情報、メイクアップ方法、又はスキンケア方法を容易にアドバイスすることができる。 In addition, the skin barrier care system of the present invention accumulates information on cosmetics, makeup methods, or skin care methods suitable for improving the barrier properties of the skin of each type according to the classification method of the present invention, and therefore can easily provide advice on cosmetics, makeup methods, or skin care methods suitable for the subject in terms of improving the barrier properties of the subject's skin against environmental temperature and humidity.
以下、図面を参照しつつ本発明を詳細に説明する。
（異なる環境温湿度での皮膚のバリア性の計測）
図１は、本発明の分類方法の流れ図である。
本発明では、まず、皮膚の環境温湿度を変え，互いに異なる複数の環境温湿度での皮膚のバリア性の計測値を取得する。
The present invention will now be described in detail with reference to the drawings.
(Measurement of skin barrier properties at different environmental temperatures and humidities)
FIG. 1 is a flow diagram of the classification method of the present invention.
In the present invention, first, the environmental temperature and humidity of the skin are changed, and measurement values of the barrier property of the skin are obtained at a plurality of different environmental temperatures and humidities.
（皮膚）
本発明が分類対象とする皮膚には全身の皮膚と唇が含まれる。即ち、皮膚は、角層を含む表皮、真皮、皮下組織の３層構造を有する身体の外表を覆う組織である。皮膚には額、頬、口元、目元、鼻等の顔、手足、頭皮、耳、首、お尻、胸、お腹、デリケートゾーン、背中、肘、膝、おむつの中や下着と接触する部位等の全身皮膚が含まれる。唇は角層が頬等の皮膚に比して薄く、皮脂腺や汗腺が無いものの、頬等の皮膚と同様に角層と表皮と真皮の積層構造を有する。そこで、本発明では、頬等の皮膚と同様に分類対象とする。
(Skin)
The skin to be classified in the present invention includes the skin of the whole body and the lips. That is, the skin is a tissue covering the outer surface of the body having a three-layer structure of the epidermis including the stratum corneum, the dermis, and the subcutaneous tissue. The skin includes the skin of the whole body such as the face, such as the forehead, cheeks, mouth, eyes, and nose, the hands and feet, the scalp, ears, neck, buttocks, chest, stomach, delicate zones, the back, elbows, knees, and the inside of a diaper or parts that come into contact with underwear. The stratum corneum of the lips is thinner than that of the skin of the cheeks, etc., and does not have sebaceous glands or sweat glands, but has a layered structure of the stratum corneum, epidermis, and dermis like the skin of the cheeks, etc. Therefore, in the present invention, the lips are classified in the same manner as the skin of the cheeks, etc.
（バリア性の計測手法）
バリア性の計測値は、皮膚外部から内部への指標物質の浸透性の評価値として得ることができる。ここで、皮膚外部から内部への浸透性を評価する指標物質としては、色素等の化合物、生体由来の分泌物や排泄物、保湿剤、外用剤、化粧料をあげることができ、具体的には、水若しくは水蒸気、生理食塩水、リン酸緩衝生理食塩水、ニコチン酸メチル、ニコチン酸ヘキシル、乳酸、黄色4号（タートラジン）、赤色215号（ローダミンＢステアレート）、カフェイン、ユビナール、カロテノイド、レチノール、尿、汗、経血、便、擬似尿、擬似経血、擬似便、並びに、皮膚保湿剤、皮膚外用剤、皮膚化粧料若しくは蒸気温熱具に含まれる有効成分や薬効成分などを挙げることができる。
(Method of measuring barrier properties)
The measured value of the barrier property can be obtained as an evaluation value of the permeability of the indicator substance from the outside to the inside of the skin.Here, the indicator substance for evaluating the permeability from the outside to the inside of the skin can be a compound such as a dye, a secretion or excretion derived from a living body, a moisturizer, an external preparation, or a cosmetic, and specifically, can be water or steam, physiological saline, phosphate buffered saline, methyl nicotinate, hexyl nicotinate, lactic acid, Yellow No. 4 (tartrazine), Red No. 215 (rhodamine B stearate), caffeine, ubiquinol, carotenoid, retinol, urine, sweat, menstrual blood, stool, simulated urine, simulated menstrual blood, simulated stool, as well as an active ingredient or medicinal ingredient contained in a skin moisturizer, an external preparation for skin, a skin cosmetic, or a steam heating device.
バリア性の計測手法としては、指標物質の種類に応じて浸透性の評価手法や計測機器を適宜定めることができる。計測値には、計測機器による計測数値や、皮膚の表面性状を目視観察し、スコアリングにより判定した場合の判定値や、刺激後のＶＡＳ（Visual Analogue Scale)等を用いた主観評価値等が含まれる。例えば、ニコチン酸メチル等を指標物質とする場合、皮膚への浸透に伴い皮膚に生じる紅斑のａ* を測色計で計測し、皮膚のバリア性の計測値としてａ* の計測値を使用しても良く、紅斑の程度を複数段階のスコア基準で評価した場合のスコア値を使用してもよい。また、水の浸透状態をコルネオメータで計測し、その計測値を使用してもよい。 As a method for measuring the barrier property, a method for evaluating the permeability and a measuring instrument can be appropriately determined according to the type of the indicator substance. The measured value includes a measured value by a measuring instrument, a judgment value when the surface property of the skin is visually observed and judged by scoring, and a subjective evaluation value using a visual analogue scale (VAS) after stimulation. For example, when methyl nicotinate or the like is used as an indicator substance, the a * of the erythema occurring on the skin due to the penetration into the skin may be measured by a colorimeter, and the measured value of a * may be used as the measured value of the barrier property of the skin, or the score value when the degree of the erythema is evaluated by a multi-level score standard may be used. In addition, the state of penetration of water may be measured by a corneometer, and the measured value may be used.
また、皮膚の正常時と肌荒れ時とでは角層を通して揮散する水分量が異なることから、皮膚のバリア性の計測値として、経表皮水分蒸散量（ＴＥＷＬ）を計測してもよい。角層の肥厚や、角層水分量の低下によりバリア性が低下することから、バリア性の指標となる角層厚や角層水分量をラマン分光法、赤外分光法、光干渉断層撮影法等で計測し、その計測値をバリア性の計測値として使用してもよい。この他、バリア性の指標として、毛細血管の分布、血流、皮膚温、皮脂分泌、発汗量等を計測してもよく、マイクロスコープ画像より鱗屑等の面積を計測してもよく、キメ等の凹凸状態を数値化してもよい。 In addition, since the amount of water volatilized through the stratum corneum differs between normal and rough skin, transepidermal water loss (TEWL) may be measured as a measurement of the barrier property of the skin. Since the barrier property decreases due to thickening of the stratum corneum and a decrease in the water content of the stratum corneum, the thickness and water content of the stratum corneum, which are indicators of barrier property, may be measured by Raman spectroscopy, infrared spectroscopy, optical coherence tomography, etc., and the measured value may be used as a measurement of barrier property. In addition, the distribution of capillaries, blood flow, skin temperature, sebum secretion, sweat amount, etc. may be measured as indicators of barrier property, the area of scales, etc. may be measured from a microscopic image, and the uneven state of the skin texture, etc. may be quantified.
（所定の環境温湿度での保持）
皮膚のバリア性の計測は、皮膚を所定の環境温湿度に所定の保持時間おいた後に行われる。なお、環境温湿度とは皮膚が置かれる環境の温度又は湿度である。環境湿度は、相対湿度、絶対湿度のいずれでもよい。相対湿度を変えた場合の皮膚のバリア性も、絶対湿度を変えた場合のバリア性も本発明は使用することができる。
(Maintaining the specified environmental temperature and humidity)
The barrier property of the skin is measured after the skin is exposed to a predetermined environmental temperature and humidity for a predetermined period of time. The environmental temperature and humidity refers to the temperature or humidity of the environment in which the skin is placed. The environmental humidity may be either relative humidity or absolute humidity. The present invention can use the barrier property of the skin when the relative humidity is changed, as well as when the absolute humidity is changed.
皮膚の環境温湿度を実験的に変えるには、槽内の温度と湿度を制御できる恒温槽、環境可変室、局所の温度と湿度を制御できる器具等の中に皮膚を所定の保持時間おけばよい。この保持時間は、好ましくは３分～６０分、より好ましくは１０分～３０分である。 To experimentally change the environmental temperature and humidity of the skin, the skin may be placed for a specified period of time in a thermostatic bath capable of controlling the temperature and humidity inside the bath, an environmentally variable chamber, or an instrument capable of controlling local temperature and humidity. This holding time is preferably 3 to 60 minutes, and more preferably 10 to 30 minutes.
皮膚の環境温湿度は種々の態様で変えることができる。例えば、一定の温度、一定の保持時間で環境湿度を変えても良く、一定の環境湿度、一定の保持時間で環境温度を変えても良い。一定の環境温度、一定の環境湿度において保持時間を変えても良い。また、保持時間内の環境温度または環境湿度を所定の条件で昇降させてもよい。環境温湿度を変えたときの皮膚のバリア性の計測値を取得できればよい。 The environmental temperature and humidity of the skin can be changed in various ways. For example, the environmental humidity may be changed at a constant temperature and for a constant holding time, or the environmental temperature may be changed at a constant environmental humidity and for a constant holding time. The holding time may be changed at a constant environmental temperature and humidity. Furthermore, the environmental temperature or humidity during the holding time may be raised or lowered under specified conditions. It is sufficient to be able to obtain the measured value of the barrier property of the skin when the environmental temperature and humidity are changed.
皮膚の環境温湿度を変える幅は、環境温湿度が変わることによる皮膚のバリア性の変化に個人差がでる範囲とすることが好ましい。言い換えると、任意の人において皮膚のバリア性が損なわれる高湿度状態や高温度状態に皮膚を晒しておくことは好ましくない。したがって、環境温湿度を変えて複数人の皮膚のバリア性の計測値を取得したときに、皮膚のバリア性が有意に低下する高温度又は高湿度と、低温度又は低湿度とに挟まれた温湿度範囲で皮膚のバリア性の計測値を取得することが好ましい。 The range of change in the environmental temperature and humidity of the skin is preferably set to a range in which changes in the barrier properties of the skin due to changes in the environmental temperature and humidity will vary from person to person. In other words, it is not preferable to expose the skin to high humidity or high temperature conditions that will impair the barrier properties of the skin in any individual. Therefore, when the environmental temperature and humidity are changed and measurements of the barrier properties of the skin of multiple individuals are obtained, it is preferable to obtain the measurements of the barrier properties of the skin in a temperature and humidity range between a high temperature or high humidity at which the barrier properties of the skin are significantly reduced, and a low temperature or low humidity.
皮膚の環境温湿度を変える好ましい幅としては、例えば、環境温度１０℃以上４０℃以下において、保持時間を１０分以上とする場合に環境湿度１０％ＲＨ超９０％ＲＨ未満の範囲とすることができる。この温度範囲で環境湿度を１０％ＲＨ未満としたり、９０％ＲＨ以上としたりすると、全ての人において皮膚のバリア性が損なわれるので、個人差を見出すことが難しくなり、皮膚のバリア性のタイプを分類する意義が失われる虞がある。 A preferred range for changing the skin's environmental temperature and humidity can be, for example, an environmental humidity range of more than 10% RH and less than 90% RH when the environmental temperature is between 10°C and 40°C and the holding time is 10 minutes or more. If the environmental humidity is less than 10% RH or greater than 90% RH within this temperature range, the skin barrier properties will be impaired in all individuals, making it difficult to detect individual differences and potentially losing the significance of classifying the types of skin barrier properties.
（環境温湿度によって異なるバリア性の高低に基づく皮膚の分類）
異なる環境温湿度での皮膚のバリア性の計測値を取得した後は、該計測値に基づき、或る環境温湿度でのバリア性の高低の軸と、該環境温湿度とは異なる環境温湿度でのバリア性の高低の軸の少なくとも二軸で皮膚のバリア性のタイプを分類する。より具体的には、例えば図２に示すように、高湿度環境での皮膚のバリア性の高低の軸と、低湿度環境での皮膚のバリア性の高低の軸の二軸で皮膚のバリア性のタイプを分類する。従来、皮膚のバリア性は一般に２０℃、４０％ＲＨの温湿度条件で測定されているのに対し、本発明では、異なる温湿度環境でのバリア性の高低に基づいて皮膚のバリア性のタイプを分類する点が特徴的である。
(Classification of skin based on the level of barrier properties that vary depending on environmental temperature and humidity)
After the measurement values of the skin barrier properties at different environmental temperatures and humidities are obtained, the type of the skin barrier properties is classified based on the measurement values on at least two axes, that is, an axis of high and low barrier properties at a certain environmental temperature and humidity and an axis of high and low barrier properties at an environmental temperature and humidity different from the said environmental temperature and humidity. More specifically, as shown in Fig. 2, for example, the type of the skin barrier properties is classified on two axes, that is, an axis of high and low barrier properties at a high humidity environment and an axis of high and low barrier properties at a low humidity environment. Conventionally, the barrier properties of the skin are generally measured under temperature and humidity conditions of 20°C and 40% RH, whereas the present invention is characterized in that the type of the skin barrier properties is classified based on the high and low barrier properties at different temperature and humidity environments.
なお、高湿度環境における皮膚のバリア性の低下は、過度の水分により角層が膨張し、浸軟となることにより生じ、低湿度環境（即ち、乾燥）における皮膚のバリア性の低下は、乾燥により皮膚の水分が失われ、皮脂膜が薄くなり、角層が剥がれやすくなる等により生じることが知られている。このように、高湿度環境による皮膚のバリア性の低下と低湿度環境による皮膚のバリア性の低下とは、バリア性低下のメカニズムが異なる。そのため、高湿度環境においてバリア性が低下し難い皮膚が、低湿度環境においてもバリア性が低下し難いとはいえず、高湿度環境におけるバリア性の変化と、低湿度環境におけるバリア性の変化には個々人の皮膚の特徴が現れる。そこで、本発明では、例えば一定の環境温度において環境湿度を変えて皮膚のバリア性の計測値を取得する場合に、少なくとも高湿度環境でのバリア性の高低と、低湿度環境でのバリア性の高低の二軸で皮膚のバリア性のタイプを分類する。そして、図２に示すように、高湿度環境における皮膚のバリア性の高低と、低湿度環境における皮膚のバリア性の高低の少なくとも２軸で皮膚のバリア性のタイプを分類する。なお、バリア性の評価軸を、高中低の３段階の評価軸としてもよい。その場合、中湿度環境におけるバリア性の計測値を、高湿度環境におけるバリア性の計測値や、低湿度環境におけるバリア性の計測値の基準として使用することができ、図２と同様に皮膚のバリア性のタイプを分類することができる。 It is known that the decrease in the barrier property of the skin in a high humidity environment occurs when the stratum corneum expands and becomes macerated due to excessive moisture, while the decrease in the barrier property of the skin in a low humidity environment (i.e., dryness) occurs when the skin loses moisture due to dryness, the sebum film becomes thinner, and the stratum corneum becomes more likely to peel off. Thus, the mechanism of the decrease in the barrier property of the skin due to a high humidity environment is different from that of the skin due to a low humidity environment. Therefore, it cannot be said that skin whose barrier property is not easily decreased in a high humidity environment is also not easily decreased in a low humidity environment, and the changes in the barrier property in a high humidity environment and the changes in the barrier property in a low humidity environment show the characteristics of each individual's skin. Therefore, in the present invention, for example, when the measured value of the barrier property of the skin is obtained by changing the environmental humidity at a constant environmental temperature, the type of the barrier property of the skin is classified at least on two axes: high and low barrier property in a high humidity environment and high and low barrier property in a low humidity environment. As shown in Figure 2, the types of skin barrier properties are classified on at least two axes: high and low skin barrier properties in a high humidity environment and high and low skin barrier properties in a low humidity environment. The barrier property evaluation axis may be a three-level evaluation axis of high, medium, and low. In that case, the measured value of the barrier property in a medium humidity environment can be used as the standard for the measured value of the barrier property in a high humidity environment and the measured value of the barrier property in a low humidity environment, and the types of skin barrier properties can be classified in the same way as in Figure 2.
図２によれば、皮膚を次の(i)～(iv)の４タイプに分類することができる。
(i)低湿度環境及び高湿度環境でバリア性が低い皮膚
(ii)低湿度環境でバリア性が低く、高湿度環境でバリア性が高い皮膚
(iii)低湿度環境及び高湿度環境でバリア性が高い皮膚
(iv)低湿度環境でバリア性が高く、高湿度環境でバリア性が低い皮膚
According to FIG. 2, the skin can be classified into the following four types: (i) to (iv).
(i) Skin has poor barrier properties in low and high humidity environments
(ii) Skin, which has low barrier properties in low humidity environments and high barrier properties in high humidity environments
(iii) Skin with high barrier properties in low and high humidity environments
(iv) Skin, which has high barrier properties in low humidity environments and low barrier properties in high humidity environments
なお、この２軸による皮膚の分類が上述の(i)～(iv)に限られず、例えば、(i)と(ii)の中間のタイプ、(ii)と(iii)の中間のタイプ、(iii)と(iv)の中間のタイプ、(iv)と(i)の中間のタイプ等の皮膚を考えても良い。 The classification of skin according to these two axes is not limited to the above-mentioned (i) to (iv). For example, skin types intermediate between (i) and (ii), between (ii) and (iii), between (iii) and (iv), between (iv) and (i), etc. may be considered.
図２に示した分類と同様に、本発明においては、一定の環境湿度において環境温度を変えて皮膚のバリア性の計測値を取得し、高温度環境に対するバリア性と、低温度環境に対するバリア性の少なくとも２軸で皮膚のバリア性のタイプを分類してもよい。また、或る環境温湿度に対する皮膚のバリア性の高低と、それと異なる環境温湿度に対する皮膚のバリア性の高低の軸で皮膚のタイプを分類してもよい。 As with the classification shown in FIG. 2, in the present invention, the measured values of the skin barrier property may be obtained by changing the environmental temperature at a constant environmental humidity, and the type of skin barrier property may be classified on at least two axes, that is, the barrier property against a high temperature environment and the barrier property against a low temperature environment. In addition, the skin type may be classified on an axis of high/low skin barrier property against a certain environmental temperature and humidity, and an axis of high/low skin barrier property against a different environmental temperature and humidity.
上述した本発明の皮膚のバリア性の分類方法によれば、化粧料やスキンケア方法のアドバイザーは、皮膚のバリア性のタイプごとに、バリア性が低いと評価された環境温湿度でのバリア性を改善するために有用な化粧料の成分や製品名等の化粧料情報、スキンケア方法等を蓄積しておき、当該被験者の皮膚のバリア性のタイプに応じて最適な化粧料情報、スキンケア方法、メイクアップ方法等を被験者に提供することが可能となる。 According to the above-mentioned method of classifying skin barrier properties of the present invention, a cosmetic and skin care method advisor can accumulate cosmetic information, such as cosmetic ingredients and product names, that are useful for improving barrier properties at environmental temperatures and humidity levels that are evaluated as having low barrier properties for each type of skin barrier property, as well as skin care methods, and provide the subject with optimal cosmetic information, skin care methods, makeup methods, and the like, according to the subject's skin barrier property type.
例えば、上述の(iii)タイプの皮膚に対して、当該被験者が日頃利用している化粧料の適用前にスチーマーを使用することや、入浴時に使用できるスキンケアを推奨する。また、(ii)タイプの皮膚には、保湿剤を一般的な方法で使用することを推奨する。 For example, for the above-mentioned (iii) type skin, we recommend using a steamer before applying the subject's usual cosmetics, or skin care that can be used while bathing. For (ii) type skin, we recommend using a moisturizer in the usual way.
また、化粧料やスキンケア方法のアドバイザーは、上述の皮膚のバリア性の分類方法と既存の乾燥肌、脂性肌などの肌分類方法とを組み合わせて肌の特徴を捉え、当該被験者に適した化粧料、スキンケア方法等を推奨することも出来る。 In addition, cosmetic and skin care method advisors can combine the above-mentioned classification method of skin barrier properties with existing skin classification methods such as dry skin and oily skin to grasp the characteristics of the skin and recommend cosmetics and skin care methods that are suitable for the subject.
なお、環境温湿度が変化する原因としては、季節、地域などの外部環境や、マスク、服、帽子、おむつ等の衣類の着用や、サウナ、入浴、洗顔、スチーマーの使用、スチームシートの使用等の原因行為があるので、スキンケア方法のアドバイスにおいては、皮膚のバリア性のタイプに応じて、皮膚のバリア性を低下させる原因行為の抑制や、皮膚を湿潤状態にする入浴やサウナなどの利用を推奨することが望ましい。 The causes of changes in environmental temperature and humidity include external environmental factors such as the season and region, wearing clothing such as masks, clothes, hats, and diapers, and actions such as saunas, bathing, washing the face, using steamers, and using steam sheets. Therefore, when giving advice on skin care methods, it is desirable to recommend the suppression of actions that weaken the skin's barrier properties and the use of baths and saunas that keep the skin moist, depending on the type of skin barrier properties.
（バリア性ケアシステム）
図３に示すように、本発明のバリア性ケアシステム１は、上述の皮膚の分類方法で分類された皮膚のバリア性のタイプと、各タイプの皮膚のバリア性の改善に適した化粧料の有効成分、製品名等の化粧料情報、メイクアップ方法、スキンケア方法等が関連づけられて蓄積されているデータベース２と、被験者の皮膚のバリア性のタイプが入力されると、該データベースを使用して被験者の皮膚のバリア性のタイプに対応する化粧料情報、メイクアップ方法、又はスキンケア方法を出力する演算装置３を備えている。
(Barrier care system)
As shown in FIG. 3, the barrier care system 1 of the present invention includes a database 2 in which skin barrier types classified by the above-mentioned skin classification method are associated with cosmetic information such as active ingredients and product names of cosmetics suitable for improving the barrier property of each type of skin, as well as makeup methods, skin care methods, etc., and a computing device 3 which, when the skin barrier type of a subject is input, uses the database to output cosmetic information, makeup methods, or skin care methods corresponding to the skin barrier type of the subject.
このデータベースに蓄積する化粧料情報には、化粧料の適用部位によって肌用の化粧料、頭皮又は頭髪用化粧料、唇用化粧料が含まれる。また、洗浄料、保湿用化粧料等の基礎化粧料、ＵＶケア化粧料、メイクアップ化粧料等の種々の用途の化粧料が含まれる。 The cosmetic information stored in this database includes cosmetics for the skin, cosmetics for the scalp or hair, and cosmetics for the lips, depending on the area to which the cosmetic is applied. It also includes cosmetics for various purposes, such as basic cosmetics such as cleansing cosmetics and moisturizing cosmetics, UV care cosmetics, and makeup cosmetics.
データベースに蓄積するメイクアップ方法には、皮膚のバリア性のタイプごとに避けた方が良いメイクアップ方法や推奨できるメイクアップ方法が含まれる。例えば、低湿度環境及び高湿度環境の双方でバリア性が低い皮膚に対し、メイクアップベースとして、香料及びアルコールを含有せず、キメのあらさや粉ふきを目立ちにくくし、くすみを自然にカバーできるものや、毛穴や肌トラブル跡の色ムラや凹凸をカバーできるものの使用を推奨すること、化粧方法としては、ファンデーションでカバーしたい部位にファンデーションを少量ずつ重ねる方法を推奨することなどを挙げることできる。また、メイクアップ化粧料を肌に塗布する前に予め肌のバリア性を向上させる製剤を塗布しておくことを推奨してもよい。 The makeup methods stored in the database include makeup methods that should be avoided and makeup methods that can be recommended for each type of skin barrier property. For example, for skin with low barrier property in both low and high humidity environments, it may be recommended to use a makeup base that does not contain fragrances or alcohol, that makes rough texture and powdering less noticeable, that can naturally cover dullness, and that can cover uneven color and unevenness caused by pores and skin troubles, and a makeup method that recommends applying small amounts of foundation on areas that you want to cover with foundation. It may also be recommended to apply a preparation that improves the barrier property of the skin before applying a makeup cosmetic to the skin.
スキンケア方法にはマッサージ方法、加湿方法、基礎化粧料の適用順序等が含まれる。 Skin care methods include massage methods, humidification methods, and the order in which basic cosmetics are applied.
データベース２では、当該皮膚タイプでバリア性が低いとされる低湿度環境または高湿度環境でバリア性を改善する化粧料情報、メイクアップ方法、及びスキンケア方法を蓄積することが好ましく、また、当該皮膚タイプでバリア性が高いとされる低湿度環境または高湿度環境において、バリア性を緩和させて所定の有効成分の浸透を促進させる化粧料情報、メイクアップ方法、及びスキンケア方法を蓄積することも好ましい。 In database 2, it is preferable to store cosmetic information, makeup methods, and skin care methods that improve the barrier properties in low-humidity or high-humidity environments where the barrier properties are considered to be low for the skin type, and it is also preferable to store cosmetic information, makeup methods, and skin care methods that reduce the barrier properties and promote the penetration of a specified active ingredient in low-humidity or high-humidity environments where the barrier properties are considered to be high for the skin type.
したがって、このバリア性ケアシステム１によれば、被験者の皮膚のバリア性のタイプを入力することにより、簡便に当該被験者に適した化粧料情報、メイクアップ方法、スキンケア方法等を得ることができるので、スキンケアのアドバイザーが顧客にスキンケアアドバイスをしたり、化粧料メーカーが化粧料を用いたメイクアップ方法やスキンケア方法を化粧料ユーザに説明したり、環境温湿度変化に対して皮膚のバリア性が低下することを抑制する環境耐性スキンケア製品の開発の方向性を定める際に有用となる。また、化粧料ユーザ等が自己の皮膚のバリア性の改善に適した化粧料情報やスキンケア方法、メイクアップ方法を知る上でも有用となる。 Therefore, this barrier care system 1 allows the subject to easily obtain cosmetic information, makeup methods, skin care methods, etc. suitable for the subject by inputting the barrier type of the subject's skin, which is useful for skin care advisors to give skin care advice to customers, for cosmetic manufacturers to explain makeup and skin care methods using cosmetics to cosmetic users, and for determining the direction of development of environmentally resistant skin care products that suppress the deterioration of skin barrier properties due to changes in environmental temperature and humidity. It is also useful for cosmetic users to know cosmetic information, skin care methods, and makeup methods suitable for improving the barrier properties of their own skin.
以下、本発明を実験例に基づいて具体的に説明する。
（１）実験例１
健常な男女１５名（男性４名、女性１１名）について、恒温槽内に腕を３０分間保持した後の腕の皮膚のバリア性の計測値を得た。この場合、恒温槽は、温度３０℃で一定とし、湿度を３０％ＲＨ、４０％ＲＨ、５０％ＲＨ、６０％ＲＨ、７０％ＲＨ、８０％ＲＨ、又は９０％ＲＨに変化させた。なお、各被験者は、恒温槽内に腕を入れる前に、腕を洗浄し、環境温湿度（２５℃、５０％ＲＨ）の居室で１５分間待機する馴化を行った。
The present invention will now be described in detail with reference to experimental examples.
(1) Experimental Example 1
For 15 healthy men and women (4 men, 11 women), the barrier properties of the arm skin were measured after the arms were kept in a thermostatic chamber for 30 minutes. In this case, the temperature of the thermostatic chamber was kept constant at 30° C., and the humidity was changed to 30%, 40%, 50%, 60%, 70%, 80%, or 90% RH. Before placing the arms in the thermostatic chamber, each subject washed their arms and waited for 15 minutes in a room with an environmental temperature and humidity (25° C., 50% RH) to acclimate them.
腕を恒温槽に入れる前と、恒温槽から出した直後にそれぞれニコチン酸メチル（０．０１％）を含浸させた濾紙を腕に１５秒間接触させ、その２０分後に、腕に生じた紅斑を目視観察し、次の基準でスコアづけすることにより計測値を得た。結果を図４に示す。
スコア：基準
０：赤味なし
０．５：若干赤い
１：濾紙の面積の半分以上赤い
２：濾紙を当てた部分が赤い
３：赤味の有る部分が濾紙の面積より大きい
４：赤味の有る部分が濾紙の面積より大きく、かつ腫れている
Before placing the arm in the thermostatic chamber and immediately after removing it from the thermostatic chamber, filter paper impregnated with methyl nicotinate (0.01%) was placed in contact with the arm for 15 seconds, and 20 minutes later, the erythema on the arm was visually observed and scored according to the following criteria to obtain the measurement value. The results are shown in Figure 4.
Score: Criteria 0: No redness 0.5: Slightly red 1: More than half of the area of the filter paper is red 2: The area where the filter paper is in contact is red 3: The red area is larger than the area of the filter paper 4: The red area is larger than the area of the filter paper and is swollen
図４から、環境温度が３０℃の場合に環境湿度が３０％ＲＨ～８０％ＲＨでは被験者の紅斑スコアがばらついており、この範囲に皮膚のバリア性の個人差が認められること、また、環境湿度５０％ＲＨあたりの皮膚のバリア性に対し、それより高湿度側でも低湿度側でもスコア値が高いことから、５０％ＲＨより高湿度側でも低湿度側でもそれぞれ皮膚のバリア性が損なわれていることが推察される。 From Figure 4, when the environmental temperature is 30°C and the environmental humidity is between 30% RH and 80% RH, the subjects' erythema scores vary, and individual differences in skin barrier properties are evident within this range. In addition, compared to an environmental humidity of around 50% RH, the score values are high both on the higher and lower humidity sides, suggesting that the skin barrier properties are impaired both on the higher and lower humidity sides of 50% RH.
一方、環境湿度が９０％ＲＨではスコア値が有意に高くなっており、３０℃、９０％ＲＨでは全ての被験者において皮膚のバリア性が大きく損なわれていることがわかる。 On the other hand, the score was significantly higher when the environmental humidity was 90% RH, indicating that the skin barrier function was significantly impaired in all subjects at 30°C and 90% RH.
なお、被験者の腕を上記の同様の環境温湿度に同様の時間おき、ニコチン酸メチルを適用した後に皮膚の紅斑を測色計のａ* （Ｄ６５光源）として計測した場合にも、環境湿度が３０％ＲＨ～８０％ＲＨでは被験者の紅斑スコアがばらつき、９０％ＲＨではスコア値が有意に高く、全ての被験者において皮膚のバリア性が大きく損なわれていることが確認された。 Furthermore, when the subjects' arms were exposed to the same environmental temperature and humidity as above for the same period of time, and methyl nicotinate was applied and then the skin erythema was measured using a colorimeter with a * (D65 light source), the subjects' erythema scores varied when the environmental humidity was between 30% RH and 80% RH, and the score was significantly high at 90% RH, confirming that the skin barrier property was significantly impaired in all subjects.
上述のように５０％ＲＨより高湿度側でも低湿度側でもスコア値が高く、それぞれで皮膚のバリア性が損なわれていると推察されることから、図４に示した結果を、次の(i)～(iv)のタイプに分けた。
(i)タイプ：高湿度（７０％ＲＨ）におけるバリア性が低く（スコア値０．５以上）、低湿度（３０％ＲＨ）におけるバリア性が低い（スコア値０．５以上）タイプ、
(ii)タイプ：高湿度（７０％ＲＨ）におけるバリア性が高く（スコア値０．５未満）、低湿度（３０％ＲＨ）におけるバリア性が低い（スコア値０．５以上）タイプ、
(iii)タイプ：高湿度（７０％ＲＨ）におけるバリア性が高く（スコア値０．５未満）、低湿度（３０％ＲＨ）におけるバリア性が高い（スコア値０．５未満）タイプ、
(iv)タイプ：高湿度（７０％ＲＨ）におけるバリア性が低く（スコア値０．５以上）、低湿度（３０％ＲＨ）におけるバリア性が高い（スコア値０．５未満）タイプ
As described above, the scores were high both on the higher and lower humidity sides of 50% RH, and it is presumed that the barrier properties of the skin were impaired in each case. Therefore, the results shown in Figure 4 were divided into the following types (i) to (iv).
(i) Type: A type having low barrier properties (score value of 0.5 or more) at high humidity (70% RH) and low barrier properties (score value of 0.5 or more) at low humidity (30% RH);
(ii) Type: A type having high barrier properties (score value less than 0.5) at high humidity (70% RH) and low barrier properties (score value 0.5 or more) at low humidity (30% RH);
(iii) Type: A type having high barrier properties at high humidity (70% RH) (score value less than 0.5) and high barrier properties at low humidity (30% RH) (score value less than 0.5);
(iv) Type: A type having low barrier properties (score value of 0.5 or more) at high humidity (70% RH) and high barrier properties (score value of less than 0.5) at low humidity (30% RH)
各タイプの温度３０℃、湿度３０％ＲＨ、５０％ＲＨ、７０％ＲＨ、９０％ＲＨにおけるスコア値の平均と、各タイプの出現率は表１の通りである。 The average score values for each type at a temperature of 30°C and humidity levels of 30%, 50%, 70% and 90% RH, as well as the occurrence rate of each type, are shown in Table 1.
以上の結果を図５に示す。
図５に示すように、温度３０℃、湿度３０～７０％ＲＨの皮膚のバリア性は高湿度に対するバリア性の軸と、低湿度に対するバリア性の軸により４つのタイプに分類できることがわかる。
The results are shown in FIG.
As shown in FIG. 5, the barrier properties of the skin at a temperature of 30° C. and a humidity of 30 to 70% RH can be classified into four types according to the axis of barrier properties against high humidity and the axis of barrier properties against low humidity.
なお、表１から、高湿度におけるバリア性が高い(ii)タイプ、及び(iii)タイプであっても湿度が９０％ＲＨとなるとバリア性が損なわれること、言い換えると３０℃、９０％ＲＨではいずれのタイプの被験者でもバリア性が損なわれることがわかる。 Table 1 also shows that even types (ii) and (iii), which have high barrier properties at high humidity, lose their barrier properties when the humidity reaches 90% RH. In other words, at 30°C and 90% RH, the barrier properties of all types of subjects are lost.
（２）実験例２
上述の（１）実験例１と同様にして、３名の被験者について、恒温槽における環境温湿度を、温度を１０℃又は３０℃に変化させ、湿度を９０％ＲＨで一定とした後、ニコチン酸メチル（０．０１％）を含浸させた濾紙を腕に１５秒間接触させた。濾紙を腕に接触させる前と、接触後２０分において、腕のａ* を測色計で計測し、その差Δａ* （即ち、ニコチン酸メチル作用後のａ* －ニコチン酸メチル作用前のａ* ）を求めた。その結果を図６に示す。
(2) Experimental Example 2
In the same manner as in the above (1) Experimental Example 1, the environmental temperature and humidity in the thermostatic chamber was changed to 10°C or 30°C, and the humidity was kept constant at 90% RH for three subjects, and then filter paper impregnated with methyl nicotinate (0.01%) was placed in contact with the arm for 15 seconds. The a * of the arm was measured with a colorimeter before and 20 minutes after the filter paper was placed in contact with the arm, and the difference Δa * (i.e., a * after the action of methyl nicotinate - a * before the action of methyl nicotinate) was calculated. The results are shown in Figure 6.
図６から、３０℃、９０％ＲＨでは皮膚のバリア性が損なわれるが、同じ湿度で温度を１０℃にした場合には３０℃の場合よりも皮膚のバリア性が損なわれていないことがわかる。したがって、環境温湿度が異なる２軸のバリア性の計測値による皮膚のバリア性の分類は、環境温度を一定とし、環境湿度を変えて行うことが望ましいことがわかる。 Figure 6 shows that the barrier properties of the skin are impaired at 30°C and 90% RH, but when the temperature is increased to 10°C at the same humidity, the barrier properties of the skin are not impaired as much as at 30°C. Therefore, it can be seen that it is desirable to classify the barrier properties of the skin based on the measured values of the barrier properties on two axes with different environmental temperatures and humidity by keeping the environmental temperature constant and varying the environmental humidity.
（３）実験例３
上述の（１）実験例１において(i)タイプと分類された３名の被験者について、恒温槽における環境温湿度を、温度３０℃、湿度９０％ＲＨで一定とし、保持時間を１０又は３０分に変化させた。この保持時間の経過後、ニコチン酸メチル（０．０１％）を含浸させた濾紙を腕に１５秒間接触させた。濾紙を腕に接触させる前と、接触後２０分において、腕のａ* を測色計で計測し、その差Δａ* （即ち、ニコチン酸メチル作用後のａ* －ニコチン酸メチル作用前のａ* ）を求めた。その結果を図７に示す。
(3) Experimental Example 3
For three subjects classified as type (i) in the above (1) Experimental Example 1, the environmental temperature and humidity in the thermostatic chamber were kept constant at 30°C and 90% RH, and the retention time was changed to 10 or 30 minutes. After this retention time had elapsed, filter paper impregnated with methyl nicotinate (0.01%) was contacted with the arm for 15 seconds. The a * of the arm was measured with a colorimeter before and 20 minutes after contact with the filter paper, and the difference Δa * (i.e., a * after the action of methyl nicotinate - a * before the action of methyl nicotinate) was calculated. The results are shown in Figure 7.
図７から、保持時間１０分と３０分では皮膚のバリア性の損なわれ方に違いがないため、３０℃、９０％ＲＨで皮膚のバリア性の変化を調べるための保持時間は１０分あれば十分であることがわかる。 Figure 7 shows that there is no difference in how the skin's barrier properties are impaired between holding times of 10 and 30 minutes, so a holding time of 10 minutes is sufficient to examine changes in the skin's barrier properties at 30°C and 90% RH.
以上の実験例から、皮膚は環境温湿度によってバリア性がどのように変わるかによって複数のタイプに分類できることがわかる。よって、そのタイプごとに、バリア性の改善に対して有効な物質を見出し、その情報を蓄積することが望ましいことがわかる。 The above experimental examples show that skin can be classified into several types based on how its barrier properties change with environmental temperature and humidity. Therefore, it is desirable to find substances that are effective in improving the barrier properties of each type and accumulate information on them.
１ バリア性ケアシステム
２ データベース
３ 演算装置
1. Barrier care system 2. Database 3. Calculation device
Claims (6)
(i)低湿度環境及び高湿度環境でバリア性が低い皮膚
(ii)低湿度環境でバリア性が低く、高湿度環境でバリア性が高い皮膚
(iii)低湿度環境及び高湿度環境でバリア性が高い皮膚
(iv)低湿度環境でバリア性が高く、高湿度環境でバリア性が低い皮膚 The method according to claim 2, wherein the skin barrier properties are classified into at least the following four types (i) to (iv).
(i) Skin has poor barrier properties in low and high humidity environments
(ii) Skin, which has low barrier properties in low humidity environments and high barrier properties in high humidity environments
(iii) Skin with high barrier properties in low and high humidity environments
(iv) Skin, which has high barrier properties in low humidity environments and low barrier properties in high humidity environments
該データベースを使用して、皮膚のバリア性のタイプが入力されると、該タイプに関連づけられた化粧料の情報、メイクアップ方法又はスキンケア方法を出力する演算装置を備えた皮膚のバリア性ケアシステム。 A skin barrier care system comprising: a database in which types of skin barrier properties classified by the skin classification method according to any one of claims 1 to 5 are stored in association with information on cosmetics, makeup methods, or skin care methods suitable for improving the barrier properties of said skin types; and a computing device which uses the database to output information on cosmetics, makeup methods, or skin care methods associated with a type of skin barrier properties when the type of skin barrier properties is input.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022158877A JP2024052277A (en) | 2022-09-30 | 2022-09-30 | How the skin is classified |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022158877A JP2024052277A (en) | 2022-09-30 | 2022-09-30 | How the skin is classified |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2024052277A true JP2024052277A (en) | 2024-04-11 |
Family
ID=90622727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022158877A Pending JP2024052277A (en) | 2022-09-30 | 2022-09-30 | How the skin is classified |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2024052277A (en) |
-
2022
- 2022-09-30 JP JP2022158877A patent/JP2024052277A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tagami | Location‐related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin | |
| Draelos et al. | Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea | |
| De Paepe et al. | Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter® | |
| Millington et al. | Skin | |
| Darlenski et al. | Influence of skin type, race, sex, and anatomic location on epidermal barrier function | |
| Kleesz et al. | Full-body skin mapping for six biophysical parameters: baseline values at 16 anatomical sites in 125 human subjects | |
| Gerhardt et al. | Influence of epidermal hydration on the friction of human skin against textiles | |
| Egawa et al. | Changes in the depth profile of water in the stratum corneum treated with water | |
| Wa et al. | Mapping the human face: biophysical properties | |
| BR112020013544A2 (en) | preparation of mild surfactant and method for it | |
| Mac‐Mary et al. | Assessment of effects of an additional dietary natural mineral water uptake on skin hydration in healthy subjects by dynamic barrier function measurements and clinic scoring | |
| Ohno et al. | Effects of water nanodroplets on skin moisture and viscoelasticity during air‐conditioning | |
| JP6326557B1 (en) | Method for evaluating the effect of the test substance or article on the skin | |
| JP7454076B2 (en) | Evaluation method for stress-relieving bases or cosmetics | |
| JP2024052277A (en) | How the skin is classified | |
| Jung et al. | Influence of polyester spacer fabric, cotton, chloroprene rubber, and silicone on microclimatic and morphologic physiologic skin parameters in vivo | |
| Nishimura et al. | Effect of spraying of fine water particles on facial skin moisture and viscoelasticity in adult women | |
| JP6406819B2 (en) | Judgment method of skin type | |
| JP2003024282A (en) | Method for evaluating skin state | |
| Yu et al. | Comparative Analysis of Skin Condition after Using Cleansing Oil and Cleansing Water for Removing Facial Makeup. | |
| Borzdynski et al. | Emerging technology for enhanced assessment of skin status | |
| Matthews-Brzozowska et al. | Minimally invasive treatments revitalizing facial skin-a case study | |
| JP7281261B2 (en) | Analysis method for sensory irritation of substances | |
| Dashore et al. | Assessment of efficacy of six different moisturizing creams in maintaining the hydration of skin in healthy human volunteers: A randomized controlled study | |
| Gupta et al. | Ethnic Differences in Skin Properties |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20231214 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20231214 |