JP2024040814A - thin tablet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a thin tablet with high strength.

SOLUTION: A thin tablet 10 comprises a body 20, and a rib 30 that rises from the body 20 to increase strength of the body 20.

SELECTED DRAWING: Figure 1

COPYRIGHT: (C)2024,JPO&INPIT

Description

The present disclosure relates to thin tablets.

Thin tablets are known that are configured to disintegrate within a short period of time in the oral cavity so that the user can easily take them. Patent Document 1 discloses an example of a thin tablet. This thin tablet includes a main body and a protrusion provided on the surface of the main body. For example, when this thin tablet falls onto a flat surface, a gap is formed between the main body and the surface on which the tablet fell due to the projections. Therefore, the user can easily pick up the thin tablet by inserting a finger into the gap.

Japanese Patent Application Publication No. 2020-19750

Thin tablets are thinner than regular tablets, and therefore may break when being transported or held by a user. There is still room for improvement in the strength of the above thin tablets.

The present disclosure aims to provide a thin tablet with high strength.

A thin tablet according to a first aspect of the present disclosure includes a main body and a rib rising from the main body so as to increase the strength of the main body.

A thin tablet according to a second aspect of the present disclosure is the thin tablet according to the first aspect, in which the rib includes a shape along the outer edge of the main body.

A thin tablet according to a third aspect of the present disclosure is the thin tablet according to the first aspect or the second aspect, wherein the rib includes a first portion extending in a first direction in a plan view of the main body; and a second portion extending in a second direction intersecting the direction.

A thin tablet according to a fourth aspect of the present disclosure is a thin tablet according to any one of the first to third aspects, wherein the rib includes a portion rising from an outer edge of the main body.

A thin tablet according to a fifth aspect of the present disclosure is a thin tablet according to any one of the first to fourth aspects, wherein the rib includes a portion rising from inside the outer edge of the main body.

A thin tablet according to a sixth aspect of the present disclosure is a thin tablet according to any one of the first to fifth aspects, in which the main body and the rib are integrally molded.

A thin tablet according to a seventh aspect of the present disclosure is a thin tablet according to any one of the first to sixth aspects, wherein the ratio of the height of the rib to the thickness of the main body is 6% or more. It is.

A thin tablet according to an eighth aspect of the present disclosure is a thin tablet according to any one of the first to seventh aspects, wherein the ratio of the height of the rib to the width of the rib is 10% or more. be.

A thin tablet according to a ninth aspect of the present disclosure is a thin tablet according to any one of the first to eighth aspects, wherein the rib is located at a first position on the outer edge of the main body and at the first position. and a second position different from the first position.

A thin tablet according to a tenth aspect of the present disclosure is a thin tablet according to any one of the first to ninth aspects, wherein the main body has a first surface and a thin tablet in the thickness direction of the main body. The rib includes a second surface opposite to the first surface, and the rib includes a first rib rising from the first surface and a second rib rising from the second surface.

According to the thin tablet according to the present disclosure, strength is high.

FIG. 1 is a perspective view of a thin tablet according to an embodiment. FIG. 2 is a plan view of the thin tablet of FIG. 1. FIG. 2 is a bottom view of the thin tablet of FIG. 1. 3 is a sectional view taken along line D4-D4 in FIG. 2. FIG. The top view of the thin tablet of the 1st modification of embodiment. The top view of the thin tablet of the 2nd modification of embodiment. The top view of the thin tablet of the 3rd modification of embodiment. The top view of the thin tablet of the 4th modification of embodiment. FIG. 7 is a plan view of a thin tablet according to a fifth modification of the embodiment. FIG. 3 is a plan view of thin tablets of Examples 1 to 3. A graph showing the results of the first test. FIG. 3 is a plan view of the thin tablet of Example 4. FIG. 3 is a plan view of the thin tablet of Example 5. Graph showing the results of the second test. Graph showing the results of the third test. FIG. 7 is a plan view of the thin tablet of Example 9. FIG. 3 is a plan view of the thin tablet of Example 10. Graph showing the results of the 4th test. FIG. 3 is a plan view of the thin tablet of Example 11. Graph showing the results of the 5th test.

Hereinafter, a thin tablet according to an embodiment of the present disclosure will be described with reference to the drawings. In addition, the same reference numerals are attached to the same or corresponding parts in the drawings, and the description thereof will not be repeated. In the numerical ranges described in stages in this embodiment, the upper limit or lower limit described in a certain numerical range may be replaced with the upper limit or lower limit of another numerical range described in stages. Further, the upper limit value and the upper limit value, the upper limit value and the lower limit value, or the lower limit value and the lower limit value, which are described separately, may be combined to form a numerical range.

[1. Composition of thin tablet]
FIG. 1 is a perspective view of a thin tablet 10 according to an embodiment. FIG. 2 is a plan view of the thin tablet 10 of FIG. 1. FIG. 3 is a bottom view of the thin tablet 10 of FIG. 1. FIG. 4 is a cross-sectional view taken along line D4-D4 in FIG. While conventional thin tablets are thin so that they disintegrate in the oral cavity in a short time, they can break during transportation, when being held by the user, or when being removed using a dust removal machine. was there. The thin tablet 10 of this embodiment is configured to disintegrate in a short time in the oral cavity and to have high strength.

The thin tablet 10 is, for example, an orally disintegrating tablet. The disintegration time of the thin tablet 10 in water is, for example, about 7 seconds or less, preferably 5 seconds or less, and more preferably 4 seconds or less. The oral disintegration time of the thin tablet 10 is, for example, 6 seconds or less, preferably 5 seconds or less.

The medicinal ingredients contained in the thin tablet 10 are pharmaceutical ingredients and nutritional ingredients in foods and health foods. The medicinal ingredient may be a medicinal ingredient alone, or may be coated or granulated for the purpose of sustained release or bitter taste masking. There are no particular restrictions on the use, type, etc. of the medicinal ingredient contained in the thin tablet 10.

In addition to the medicinal ingredients, the thin tablet 10 contains pharmaceutically acceptable excipients, surfactants, lubricants, acidulants, sweeteners, corrigents, fragrances, coloring agents, stabilizers, etc., as necessary. Other optional ingredients may be included. As these optional ingredients, for example, the corresponding ingredients described in the Pharmaceutical Excipients Dictionary (Yakuji Nipposha) and the Japanese Pharmacopoeia can be used. Further, as long as the desired effect of the present embodiment is achieved, there is no particular restriction on the blending ratio of each component, and a person skilled in the art can appropriately determine the blending ratio.

The material of the thin tablet 10 is a mixture obtained by mixing a disintegrating particle composition, a medicinal ingredient (or a pharmaceutical composition containing the medicinal ingredient), and other optional ingredients mentioned above. The disintegrating particle composition contains, for example, acid carboxymethyl cellulose as a disintegrant component. Various optional components known to those skilled in the art may be added and mixed as appropriate to the disintegrating particle composition, for example, for the purpose of adjusting various properties such as disintegration force, binding force, and feeling of taking the tablet. . Examples of such ingredients include flow agents, sweeteners, flavoring agents, coloring agents, and the like.

The amount of each component in the disintegrating particle composition depends on the type of each component, the type and use of the medicinal ingredient for which the disintegrating particle composition is used, the use of the orally disintegrating tablet as the final product, etc. The operator can decide as appropriate.

In addition to being an orally disintegrating tablet, or instead of being an orally disintegrating tablet, the thin tablet 10 may be an easy-to-take solid preparation. Easy-to-dose generally means that the properties and characteristics of a solid preparation, etc., are that it is easy to drink, in other words, it is easy to swallow. For example, the thin tablet 10 may contain a gelling agent that exhibits slipperiness when exposed to water.

The thin tablet 10 has a main body 20 and ribs 30 rising from the main body 20 to increase the strength of the main body 20. The thin tablet 10 can be manufactured by compressing the tablet using a tableting machine, for example, at a compression force of about 2 to 20 kN, preferably about 5 to 20 kN. Since the thin tablet 10 of this embodiment has the ribs 30, the strength of the main body 20 is increased. Moreover, since the thin tablet 10 has the ribs 30, it has a larger surface area than a conventional thin tablet of the same volume. Therefore, the thin tablet 10 disintegrates in the oral cavity in a short time. The main body 20 and the ribs 30 may be integrally molded, or may be molded separately and joined together. In this embodiment, the main body 20 and the ribs 30 are integrally molded.

The shape of the main body 20 in plan view can be arbitrarily selected. The shape of the main body 20 in plan view is, for example, a circle, an ellipse, a triangle, or a polygon larger than a quadrangle. It is preferable that the main body 20 has no corners so as not to cause strong stimulation in the oral cavity of the user. In this embodiment, the shape of the main body 20 in plan view is a circle.

The width LA of the main body 20 in plan view can be arbitrarily selected. The width LA is preferably determined based on the strength of the thin tablet 10 and the ease with which a user can take it. The minimum value of the width LA is 12 mm. When the width LA is 12 mm or more, the main body 20 is thin and easily disintegrates in the oral cavity, so that the user can easily take the drug. The maximum value of the width LA is 20 mm or less. When the width LA is 20 mm or less, the main body 20 does not become too thin, and therefore the main body 20 is difficult to break. A preferable range of the width LA is 12 mm or more and 20 mm or less. In this embodiment, the width LA is 14 mm. The width LA may be constant or may vary depending on the region of the main body 20. If the width LA of the main body 20 differs depending on the region, for example, the maximum width may be defined as the width LA of the main body 20. Note that in this embodiment, the width LA is the diameter of the main body 20.

The thickness HA of the main body 20 can be arbitrarily selected. The thickness HA is preferably determined based on the strength of the thin tablet 10 and the ease with which a user can take it. The minimum value of the thickness HA is, for example, 0.5 mm. The minimum value of the thickness HA is preferably 0.8 mm. When the thickness HA is 0.5 mm or more, the main body 20 is difficult to break. The maximum value of the thickness HA is 1.5 mm. The maximum value of the thickness HA is preferably 1.2 mm. When the thickness HA is 1.5 mm or less, the main body 20 is thin and easily disintegrates in the oral cavity, so that the user can easily take it. A preferable range of the thickness HA is 0.5 mm or more and 1.5 mm or less, 0.5 mm or more and 1.2 mm or less, 0.8 mm or more and 1.5 mm or less, or 0.8 mm or more and 1.2 mm or less. In this embodiment, the thickness HA is 0.8 mm. Note that the thickness of the main body 20 may vary depending on the region of the main body 20. When the thickness HA of the main body 20 differs depending on the region, the maximum thickness may be defined as the thickness HA of the main body 20, for example.

The main body 20 has a first surface 21 and a second surface 22 opposite to the first surface 21 in the thickness direction of the main body 20. In this embodiment, the first surface 21 and the second surface 22 are smooth surfaces.

The rib 30 includes a first rib 40 rising from the first surface 21 of the main body 20 and a second rib 50 rising from the second surface 22 of the main body 20. In this embodiment, the first rib 40 and the second rib 50 have substantially the same shape. The shape of the first rib 40 and the shape of the second rib 50 may be different.

The first rib 40 includes an arcuate rib 60A and an inner rib 70A formed inside the arcuate rib 60A. The second rib 50 includes an arcuate rib 60B and an inner rib 70B formed inside the arcuate rib 60B.

The arcuate ribs 60A, 60B are shaped along the outer edges 21A, 22A of the main body 20. The arcuate rib 60A stands up from the outer edge 21A of the first surface 21. The arcuate rib 60B stands up from the outer edge 22A of the second surface 22.

In plan view, the outer edge 61A of the arcuate rib 60A overlaps the outer edge 21A of the first surface 21. In a bottom view, the outer edge 61B of the arcuate rib 60B overlaps the outer edge 22A of the second surface 22. The range in which the arcuate ribs 60A, 60B are formed in the circumferential direction of the main body 20 can be arbitrarily selected. In this embodiment, the arcuate ribs 60A, 60B are formed over the entire circumferential direction of the main body 20. The arcuate ribs 60A, 60B may be formed only in a part of the circumferential direction of the main body 20, or may be formed intermittently in the circumferential direction of the main body 20.

The height LB of the arcuate ribs 60A, 60B from the first surface 21 or the second surface 22 can be arbitrarily selected. From the viewpoint of increasing the strength of the main body 20, the height LB is preferably 0.1 m or more, more preferably 0.3 mm or more, and even more preferably 0.5 mm or more. The minimum value of the ratio RA of the height LB to the thickness HA of the main body 20 is preferably 6% or more. The height LB may be constant or different between the arcuate ribs 60A and 60B. In this embodiment, the height LB is constant.

The width LC of the arcuate ribs 60A, 60B can be arbitrarily selected. From the viewpoint of increasing the strength of the main body 20, the width LC is preferably 1.0 m or more, and more preferably 1.5 mm or more. The ratio RB of the height LB to the width LC is preferably 10% or more. The width LC may be constant or different between the arcuate ribs 60A and 60B. In this embodiment, the width LC is constant.

The inner rib 70A includes a first portion 71A and a second portion 72A. The inner rib 70B includes a first portion 71B and a second portion 72B. The first portions 71A and 71B are linear ribs extending in a first direction in a plan view or bottom view of the main body 20. The second portions 72A and 72B are linear ribs extending in a second direction intersecting the first direction in a plan view or bottom view of the main body 20. The first portions 71A and 71B and the second portions 72A and 72B intersect at the center of the main body 20. The angle at which the first portions 71A and 71B intersect with the second portions 72A and 72B can be selected arbitrarily. In this embodiment, the angle at which the first portions 71A and 71B intersect with the second portions 72A and 72B is 90°. The angle at which the first portions 71A, 71B intersect with the second portions 72A, 72B may be greater than 90° or less than 90°.

The end of the first portion 71A and the end of the second portion 72A are connected to the inner edge 62A of the arcuate rib 60A. The end of the first portion 71B and the end of the second portion 72B are connected to the inner edge 62B of the arcuate rib 60B. The first surface 21 of the main body 20 is exposed in regions 81A to 84A surrounded by the inner edge 62A of the arcuate rib 60A, the edge of the first portion 71A, and the edge of the second portion 72A. The areas of regions 81A to 84A are equal to each other. The second surface 22 of the main body 20 is exposed in regions 81B to 84B surrounded by the inner edge 62B of the arcuate rib 60B, the edge of the first portion 71B, and the edge of the second portion 72B. The areas of regions 81B to 84B are equal to each other.

The height LD of the inner ribs 70A, 70B from the first surface 21 or the second surface 22 can be arbitrarily selected. From the viewpoint of increasing the strength of the main body 20, the height LD is preferably 0.1 m or more, more preferably 0.3 mm or more, and even more preferably 0.5 mm or more. The minimum value of the ratio RB of the height LD to the thickness HA of the main body 20 is preferably 20% or more. The height LD may be constant or different in the inner ribs 70A, 70B. In this embodiment, the height LD is constant.

In this embodiment, the height of the first portions 71A, 71B and the height of the second portions 72A, 72B are equal. The height of the first portions 71A, 71B and the height of the second portions 72A, 72B may be different. The first portions 71A, 71B may have different heights depending on the portion. The second portions 72A, 72B may have different heights depending on the location. When the heights of the inner ribs 70A, 70B differ depending on the region, for example, the maximum height may be defined as the height of the inner ribs 70A, 70B.

The width LE of the inner ribs 70A, 70B can be arbitrarily selected. From the viewpoint of increasing the strength of the main body 20, the width LE is preferably 1.0 m or more, and more preferably 1.5 mm or more. The ratio of the height LD to the width LE is preferably 10% or more.
The width LE may be constant or different in the inner ribs 70A, 70B. In this embodiment, the width LE is constant.

[2. Effects of thin tablets]
According to the thin tablet 10, the following effects can be obtained.

<2-1>
Since the thin tablet 10 has the ribs 30, the main body 20 has high strength. Therefore, even if an external force is applied to the thin tablet 10, for example, when the thin tablet 10 is being transported, held by a user, or removed by a powder remover, Not easy to break.

<2-2>
Since the rib 30 has the arcuate ribs 60A and 60B, the strength of a predetermined range including the outer edge of the main body 20 is increased.

<2-3>
Since the rib 30 has the inner ribs 70A and 70B, the strength of a predetermined range including the center of the main body 20 is increased.

<2-4>
Since the thin tablet 10 has the first rib 40 and the second rib 50, for example, compared to a structure in which the rib 30 is formed only on one of the first surface 21 and the second surface 22 of the main body 20, The main body 20 has high strength.

<2-5>
Since the minimum value of the ratio RA is 20% or more, the strength of the main body 20 is higher.

<2-6>
Since the ratio RB is 10% or more, the strength of the main body 20 is higher.

<2-7>
Since the thin tablet 10 has the ribs 30, it has a larger surface area than a conventional thin tablet of the same volume. Therefore, the thin tablet 10 disintegrates in the oral cavity in a short time.

[3. Modified example]
The above embodiments are illustrative of the forms that thin tablets related to the present disclosure can take, and are not intended to limit the forms. Each aspect disclosed herein can be combined with any other feature disclosed herein. Thin tablets according to the present disclosure may take forms different from those exemplified in the embodiments above. An example thereof is a form in which a part of the structure of the above embodiment is replaced, changed, or omitted, or a form in which a new structure is added to the above embodiment. The present disclosure is not limited by the embodiments described above, but only by the claims. Some examples of modifications of the above embodiment are shown below. Note that the above embodiment and the following modified examples can be combined with each other as long as there is no technical contradiction.

<3-1>
FIG. 5 is a plan view of a thin tablet 100 according to a first modification of the embodiment. The thin tablet 100 differs from the thin tablet 10 in that it has an arcuate rib 160A and does not have inner ribs 70A and 70B, and is similar to the thin tablet 10 in other configurations. Below, the thin tablet 100 of the first modification will be explained, focusing on the parts that are different from the thin tablet 10.

The arcuate rib 160A has a shape along the outer edge 21A of the main body 20. The arcuate rib 160A stands up from the inner side of the outer edge 21A of the first surface 21. In plan view, the outer edge 161A of the arcuate rib 160A is located inside the outer edge 21A of the first surface 21. The range in which the arcuate ribs 160A are formed in the circumferential direction of the main body 20 can be arbitrarily selected. In the first modification, the arcuate rib 160A is formed over the entire circumferential direction of the main body 20. The arcuate rib 160A may be formed only in a part of the circumferential direction of the main body 20, or may be formed intermittently in the circumferential direction of the main body 20.

The distance LX between the outer edge 161A of the arcuate rib 160A and the outer edge 21A of the first surface 21 in the radial direction of the main body 20 can be arbitrarily selected. From the viewpoint of increasing the strength of the main body 20, the distance LX is preferably 1.0 mm or more, more preferably 2.0 mm or more, and even more preferably 3.0 mm or more. In the thin tablet 100, arcuate ribs having the same configuration as the arcuate ribs 160A may be formed on the second surface 22.

<3-2>
FIG. 6 is a plan view of a thin tablet 200 according to a second modification of the embodiment. The thin tablet 200 differs from the thin tablet 10 in that it does not have the inner rib 70A, and the other configurations are the same as the thin tablet 10. In the thin tablet 200, the inner rib 70B may be omitted on the second surface 22 of the main body 20.

<3-3>
FIG. 7 is a plan view of a thin tablet 300 according to a third modification of the embodiment. The thin tablet 300 differs from the thin tablet 10 in that it has an inner rib 370A and does not have an arcuate rib 60A, but is otherwise similar to the thin tablet 10. Below, the thin tablet 300 of the third modification will be explained, focusing on the parts that are different from the thin tablet 10.

Inner rib 370A of thin tablet 300 includes a first portion 371A and a second portion 372A. The end of the first portion 371A and the end of the second portion 372A reach the outer edge 21A of the first surface 21. The end of the first portion 371A and the end of the second portion 372A may be located inside the outer edge 21A of the first surface 21. In the third modification, the arcuate rib 60B may be omitted on the second surface 22, and an inner rib having the same configuration as the inner rib 370A may be formed.

<3-4>
FIG. 8 is a plan view of a thin tablet 400 according to a fourth modification of the embodiment. The thin tablet 400 differs from the thin tablet 10 in having a first rib 440 instead of the first rib 40, and is similar to the thin tablet 10 in other configurations. Below, the thin tablet 400 of the fourth modification will be explained, focusing on the parts that are different from the thin tablet 10.

The thin tablet 400 has a first rib 440 rising from the first surface 21. The first rib 440 includes a rib 441 and a rib 442. The rib 441 connects a first position 91 on the outer edge 21A of the first surface 21 and a second position 92 that is different from the first position 91. Rib 441 is linear. The rib 442 connects the third position 93 of the outer edge 21A of the first surface 21 to a fourth position 94 that is different from the third position 93. Rib 442 is linear. In the thin tablet 400, the rib 441 or the rib 442 may be omitted, or in addition to the ribs 441 and 442, it may further have a rib having a similar configuration. Further, in the thin tablet 400, the second rib 50 may be omitted on the second surface 22, and a rib having the same structure as the first rib 440 may be formed. At least one of the ribs 441, 442 may include a curved portion at least in part.

<3-5>
FIG. 9 is a plan view of a thin tablet 500 according to a fifth modification of the embodiment. The thin tablet 500 differs from the thin tablet 10 in that it has a first rib 540 instead of the first rib 40, and is similar to the thin tablet 10 in other configurations. Below, the thin tablet 500 of the fifth modification will be explained, focusing on the parts that are different from the thin tablet 10.

The thin tablet 400 has a first rib 540 rising from the first surface 21. The first rib 541 connects a first position 91X of the outer edge 21A of the first surface 21 and a second position 92X different from the first position 91X. The shape of the first rib 541 is a shape in which a plurality of straight lines 541B are connected so as to have a plurality of corners 541A. In the thin tablet 500, the second rib 50 may be omitted on the second surface 22, and a rib having the same structure as the first rib 540 may be formed.

[4. Simulation of thin tablet]
The inventors of the present application conducted a test to confirm the strength of thin tablets produced by simulation. The tests include a first test, a second test, a third test, and a fourth test. In addition, for convenience of explanation, the same elements as in the embodiment or the modification among the elements constituting the thin tablet of the example or the modification will be described with the same reference numerals as in the embodiment or the modification. There are cases.

<4-1. 1st exam>
The first test was a test regarding the strength of the thin tablets of Examples 1 to 3 and the thin tablet of Comparative Example 1. The thin tablets of Examples 1 to 3 are the first modified thin tablets (see FIG. 5). The first test was conducted using the analytical models of the thin tablets of Examples 1 to 3 and the analytical model of the thin tablet of Comparative Example 1 that were generated by simulation. In the first test, as shown in FIG. 10, the thin tablets of Examples 1 to 3 and the thin tablet of Comparative Example were fixed on the fixing surface 610, and a stress of 0.1 MPa was applied to the working surface 620. The strength of the case was confirmed. The fixed surface 610 includes the outer edge 21A of the first surface 21 of the main body 20 and is a predetermined area along the outer edge 21A. The working surface 620 is an area defined by a circle with a diameter of 1 mm.

The specifications of the thin tablets of Examples 1 to 3 are as follows.
The width LA of the main body 20 is 14 mm.
The thickness HA of the main body 20 is 0.8 mm.
The arc rib 160A is formed on the first surface 21 and the second surface 22.
The height LB of the arc rib 160A is 0.3 mm.
The width LC of the arc rib 160A is 1 mm.
The distance LX of the thin tablet in Example 1 is 1.0 mm.
The distance LX of the thin tablet of Example 2 is 2.0 mm.
The distance LX of the thin tablet of Example 3 is 3.0 mm.

In the thin tablet of Comparative Example 1, the arcuate rib 160A is omitted. That is, the thin tablet of Comparative Example 1 consists of only the main body 20. The specifications of the main body 20 of the thin tablet of Comparative Example 1 are the same as those of the thin tablets of Examples 1 to 3.

In the first test, in order to confirm the stress acting near the center of the thin tablet excluding the force point and the point of action, as shown in FIG. The maximum stress acting on the area and the average stress were confirmed. The maximum distance between the virtual line XA and the outer edge 610A of the fixed surface 610 is 3.0 mm. The maximum distance between the virtual line XB and the outer edge 620A of the working surface 620 is 1.5 mm.

FIG. 11 shows the results of the first test. It was confirmed that the thin tablets of Examples 1 to 3 had lower maximum stress and average stress than the thin tablet of Comparative Example 1. Therefore, the thin tablets of Examples 1 to 3 have higher strength than the thin tablet of Comparative Example 1. Further, the maximum stress and average stress that act increase in the order of Example 1, Example 2, and Example 3. In other words, the longer the distance LX, the higher the maximum stress and average stress that act. This was confirmed. Therefore, when forming the arcuate rib 160A on the main body 20, it can be understood that the closer to the outer edge 21A of the first surface 21 the higher the strength.

<4-2. 2nd exam>
The second test was a test regarding the strength of the thin tablets of Examples 4 and 5 and the thin tablet of Comparative Example 1. The thin tablet of Example 4 is the thin tablet 10 of the embodiment (see FIG. 2). The thin tablet of Example 5 is a second modified example of a thin tablet 200 (see FIG. 6). Similar to the first test, the second test was conducted using the analytical models of the thin tablets of Examples 4 and 5 and the analytical model of the thin tablet of Comparative Example 1 that were generated by simulation. In the second test, as shown in FIGS. 12 and 13, the thin tablets of Examples 4 and 5 and the thin tablet of Comparative Example were fixed on the fixing surface 610, and a stress of 0.1 MPa was applied to the working surface 620. The strength when applied was confirmed. The fixed surface 610 includes the outer edge 21A of the first surface 21 of the main body 20 and is a predetermined area along the outer edge 21A. The working surface 620 is an area defined by a circle with a diameter of 1 mm.

The specifications of the thin tablet of Example 4 (see FIG. 12) are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 0.8 mm.
- The arcuate rib 60A and the inner rib 70A are formed on the first surface 21 and the second surface 22.
- The height LB of the arcuate rib 60A is 0.3 mm.
- The width LC of the arcuate rib 60A is 1 mm.
- The height LD of the inner rib 70A is 0.3 mm.
- The width LE of the inner rib 70A is 1 mm.

The specifications of the thin tablet of Example 5 (see FIG. 13) are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 0.8 mm.
- The arcuate rib 60A is formed on the first surface 21 and the second surface 22.
- The height LB of the arcuate rib 60A is 0.3 mm.
- The width LC of the arcuate rib 60A is 1 mm.

In the second test, as in the first test, in order to confirm the stress acting near the center of the thin tablet excluding the force point and the point of action, a virtual The maximum stress and average stress acting on the area between line XA and virtual line XB were confirmed. The maximum distance between the virtual line XA and the outer edge 610A of the fixed surface 610 is 3.0 mm. The maximum distance between the virtual line XB and the outer edge 620A of the working surface 620 is 1.5 mm.

FIG. 14 shows the results of the second test. It was confirmed that the thin tablets of Examples 4 and 5 had lower maximum stress and average stress than the thin tablet of Comparative Example 1. Therefore, the thin tablet of Example 4.5 has higher strength than the thin tablet of Comparative Example 1. Furthermore, it was confirmed that the thin tablet of Example 4 had a lower maximum stress and average stress than the thin tablet of Example 5. Therefore, it can be seen that the strength of the main body 20 can be further increased by forming the inner rib 70A in addition to the arcuate rib 60A.

<4-3. Third exam>
The third test was a test regarding the strength of the thin tablets of Examples 6 to 8 and the thin tablet of Comparative Example 1. The thin tablets of Examples 6 to 8 are the thin tablets 10 of the embodiment (see FIG. 2). Similarly to the first test, the third test was conducted using the analytical models of the thin tablets of Examples 6 to 8 and the analytical model of the thin tablet of Comparative Example 1 generated by simulation. In the third test, as in the case of the second test, as shown in FIG. 12, the thin tablets of Examples 6 to 8 were fixed on the fixed surface 610, and a stress of 0.1 MPa was applied to the working surface 620. We confirmed the strength when The fixed surface 610 includes the outer edge 21A of the first surface 21 of the main body 20 and is a predetermined area along the outer edge 21A. The working surface 620 is an area defined by a circle with a diameter of 1 mm.

The specifications of the thin tablets of Examples 6 to 8 (see FIG. 12) are as follows. The thin tablets of Examples 6 to 8 differ only in the height LB of the arcuate rib 60A and the height LD of the inner rib 70A.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 0.8 mm.
- The width LC of the arcuate rib 60A is 1 mm.
- The width LE of the inner rib 70A is 1 mm.
- The arcuate rib 60A and the inner rib 70A are formed on the first surface 21 and the second surface 22.
- The height LB of the arcuate rib 60A in Example 6 is 0.1 mm.
- The height LD of the inner rib 70A in Example 6 is 0.1 mm.
- The height LB of the circular arc rib 60A in Example 7 is 0.3 mm.
- The height LD of the inner rib 70A in Example 7 is 0.3 mm.
- The height LB of the arcuate rib 60A in Example 7 is 0.5 mm.
- The height LD of the inner rib 70A in Example 7 is 0.5 mm.

In the third test, as in the first test, in order to confirm the stress acting around the center of the thin tablet excluding the force point and the point of action, as shown in FIG. The maximum stress acting on the region between the virtual line XB and the average stress were confirmed. The maximum distance between the virtual line XA and the outer edge 610A of the fixed surface 610 is 3.0 mm. The maximum distance between the virtual line XB and the outer edge 620A of the working surface 620 is 1.5 mm.

FIG. 15 shows the results of the third test. It was confirmed that the thin tablets of Examples 6 to 8 had lower maximum stress and average stress than the thin tablet of Comparative Example 1. Therefore, the thin tablets of Examples 6 to 8 have higher strength than the thin tablet of Comparative Example 1. Furthermore, it was confirmed that the maximum stress and average stress acting on the thin tablet were lower in the order of Examples 8, 7, and 6. Therefore, it can be understood that the higher the height of the ribs 30, the higher the strength of the main body 20.

<4-4. 4th exam>
The fourth test was a test regarding the strength of the thin tablets of Examples 9 and 10 and the thin tablet of Comparative Example 1. The thin tablet of Example 9 is the thin tablet 10 of the embodiment (see FIG. 2). The thin tablet of Example 10 is a third modified example (see FIG. 7). Similarly to the first test, the fourth test was conducted using the analytical models of the thin tablets of Examples 9 and 10 and the analytical model of the thin tablet of Comparative Example 1 generated by simulation. In the fourth test, as shown in FIGS. 16 and 17, the thin tablets of Examples 9 and 10 and the thin tablet of Comparative Example 1 were fixed on the fixing surface 610, and a stress of 0.1 MPa was applied to the working surface 620. We confirmed the strength when applied with The fixed surface 610 includes the outer edge 21A of the first surface 21 of the main body 20 and is a predetermined area along the outer edge 21A. The working surface 620 is an area defined by a circle with a diameter of 1 mm. Note that in the fourth test, the fixing surface 610 was shifted by 45° in the circumferential direction of the main body 20 compared to the second test.

The specifications of the thin tablet of Example 9 (see FIG. 16) are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 0.8 mm.
- The arcuate rib 60A and the inner rib 70A are formed on the first surface 21 and the second surface 22.
- The height LB of the arcuate rib 60A is 0.3 mm.
- The width LC of the arcuate rib 60A is 1 mm.
- The height LD of the inner rib 70A is 0.3 mm.
- The width LE of the inner rib 70A is 1 mm.

The specifications of the thin tablet of Example 10 (see FIG. 17) are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 0.8 mm.
- The inner rib 370A is formed on the first surface 21 and the second surface 22.
- The height LD of the inner rib 370A is 0.3 mm.
- The width LE of the inner rib 370A is 1 mm.

FIG. 18 shows the results of the fourth test. It was confirmed that the thin tablets of Examples 9 and 10 had lower maximum stress and average stress than the thin tablet of Comparative Example 1. Therefore, the thin tablets of Examples 9 and 10 have higher strength than the thin tablet of Comparative Example 1. Furthermore, it was confirmed that the thin tablet of Example 9 had a lower maximum stress and average stress than the thin tablet of Example 10. Therefore, it can be seen that the strength of the main body 20 can be further increased by forming the arcuate ribs 60A in addition to the inner ribs 70A.

[5. 3-point bending fracture strength, underwater disintegration time, and oral disintegration time]

<5-1. Overall overview＞
The inventors of the present invention manufactured the thin tablet of Example 11 and the thin tablet of Comparative Example 2, and conducted a fifth test to measure the physical properties of the thin tablet. The inventors of the present invention manufactured thin tablets of Example 11 and Comparative Example 2 using a hand press tablet machine (HANDTAB-100, Ichihashi Seiki Co., Ltd.). The materials constituting the thin tablet of Example 11 and the thin tablet of Comparative Example 2 are a disintegrating particle composition (GRANFILLER-D, manufactured by Daicel Corporation), and sodium stearyl fumarate (PVUV, manufactured by Rettenmeyer). including. The weight ratio of GRANFILLER-D in the thin tablet of Example 11 and the thin tablet of Comparative Example 2 is 99.8%, and the weight ratio of sodium stearyl fumarate is 0.2%.

The thin tablet of Example 11 is the thin tablet of the embodiment. The specifications of the thin tablet of Example 11 are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 1.05 mm.
- The arcuate rib 60A and the inner rib 70A are formed on the first surface 21 and the second surface 22.
- The height LB of the arcuate rib 60A is 0.30 mm.
- The width LC of the arcuate rib 60A is 1.5 mm.
- The height LD of the inner rib 70A is 0.30 mm.
- The width LE of the inner rib 70A is 1 mm.
-Weight is 200mg.
-Tablet compression force is 24KN.
- The maximum thickness including the ribs 30 is 1.35 mm.

In the thin tablet of Comparative Example 2, the rib 30 is omitted from the thin tablet of Example 11. That is, the thin tablet of Comparative Example 2 consists of only the main body 20. The specifications of the main body 20 of the thin tablet of Comparative Example 1 are as follows.
- The width LA of the main body 20 is 14 mm.
- The thickness HA of the main body 20 is 1.07 mm.
-Weight is 200mg.
-Tablet compression force is 24KN.

<5-2.3-point bending fracture strength>
As shown in FIG. 19, the arcuate ribs 60A and inner ribs 70A formed on the first surface 21 of the thin tablet of Example 11 were placed on the rails 100A and 100B of the testing machine, and The three-point bending fracture strength was measured by pressing the center of the main body 20 with an indenter 100C. The distance between the rail 100A and the rail 100B, in other words, the distance between the fulcrums is 10 mm. Regarding the thin tablet of Comparative Example 2, the first surface 21 was placed on the rails 100A and 100B of the testing machine in the same manner as in Example 11, and the center of the main body 20 was pressed with the indenter 100C from the second surface 22 side. , 3-point bending fracture strength was measured. Three samples were prepared for each of the thin tablet of Example 11 and the thin tablet of Comparative Example 2, and the average value of three measurements was taken as the measurement result. Note that the portions of the rails 100A, 100B and indenter 100C of the testing machine that come into contact with the thin tablet are curved surfaces. Therefore, the rails 100A, 100B of the testing machine and the indenter 100C are in line contact with the thin tablet.

<5-3. Underwater disintegration time＞
The disintegration time in water was measured using a disintegration tester (NT-400, Toyama Sangyo Co., Ltd.) according to the method described in the Japanese Pharmacopoeia (without an auxiliary board). Three samples were prepared for each of the thin tablet of Example 11 and the thin tablet of Comparative Example 2, and the average value of three measurements was taken as the measurement result.

<5-4. Oral disintegration time＞
One tablet of the thin tablet of Example 11 and the thin tablet of Comparative Example 2 was placed in the mouth and held between the tongue and upper jaw without applying force until the thin tablet completely disintegrated. The time was measured. Six samples were prepared for each of the thin tablet of Example 11 and the thin tablet of Comparative Example 2, and the tests were conducted twice by three adults. The average value of six measurements was taken as the measurement result.

FIG. 20 shows the results of the fifth test. It was confirmed that the thin tablet of Example 11 had a higher three-point bending fracture strength than the thin tablet of Comparative Example 2. Therefore, the thin tablet of Example 11 has higher strength than the thin tablet of Comparative Example 2. It was confirmed that the thin tablet of Example 11 had shorter disintegration time in water and shorter oral disintegration time than the thin tablet of Comparative Example 2.

10, 100, 200, 300, 400, 500: Thin tablet 20: Main body 21: First surface 22: Second surface 30: Rib 71A, 371A: First part 72A, 372A: Second part 21A, 22A: Outer edge 91 , 91X: 1st position 92, 92X: 2nd position

Claims (10)

The main body and
A thin tablet comprising: a rib rising from the main body so as to increase the strength of the main body. The thin tablet according to claim 1, wherein the rib includes a shape along an outer edge of the main body. The rib is
a first portion extending in a first direction in a plan view of the main body;
The thin tablet according to claim 1 or 2, further comprising a second portion extending in a second direction intersecting the first direction. The thin tablet according to claim 1 or 2, wherein the rib includes a portion rising from an outer edge of the main body. The thin tablet according to claim 1 or 2, wherein the rib includes a portion rising from inside the outer edge of the main body. The thin tablet according to claim 1 or 2, wherein the main body and the rib are integrally molded. The thin tablet according to claim 1 or 2, wherein a ratio of the height of the rib to the thickness of the main body is 6% or more. The thin tablet according to claim 1 or 2, wherein the ratio of the height of the rib to the width of the rib is 10% or more. The thin tablet according to claim 1 or 2, wherein the rib includes a portion connecting a first position on the outer edge of the main body and a second position different from the first position. The main body includes a first surface and a second surface opposite to the first surface in the thickness direction of the main body,
The thin tablet according to claim 1 or 2, wherein the ribs include a first rib rising from the first surface and a second rib rising from the second surface.