JP2024023013A - Micro mixer for flow synthesis device and flow synthesis device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a micro mixer for a flow synthesis device where confluence of a gas phase and a liquid phase can be performed at a prescribed quantitative ratio without flowing back of the liquid phase to a gas phase supply flow channel side even a pressure difference between the supplied gas phase and the liquid phase occurs when the confluence of the gas phase and the liquid phase is performed and a gas-liquid reaction is continuously performed for flow synthesis.

SOLUTION: In a micro mixer for a flow synthesis device having a hexagonal selector valve, a gas phase supply flow channel, a liquid phase supply flow channel, a discharge flow channel, a synthesis flow channel and a sample loop,: a first flow channel where the gas phase or liquid phase supply flow channel, the sample loop and the discharge flow channel are communicated and at the same time, the liquid phase or gas phase supply flow channel and the synthesis flow channel are communicated and a second flow channel where the gas phase or liquid phase supply flow channel, the sample loop and the discharge flow channel are communicated and at the same time, the liquid phase or gas phase supply flow channel, the sample loop and the synthesis flow channel are communicated are alternately changed by the hexagonal selector valve; and the liquid phase and the gas phase can be alternately flowed out to the synthesis flow channel.

SELECTED DRAWING: Figure 1

COPYRIGHT: (C)2024,JPO&INPIT

Description

The present invention relates to a micromixer for a flow synthesizer and a flow synthesizer having the micromixer for a flow synthesizer.

A flow synthesis device with a micromixer uses a microchannel with a microscopic cross section to enable precise temperature control based on the size of the specific surface area, as well as precise mixing control based on molecular diffusion between stable laminar flow interfaces. The reaction time can be controlled by precisely controlling the residence time in the microchannel. Therefore, these properties are used in chemical synthesis and the creation of new substances.

In such a flow synthesis device, a plurality of fluids are continuously introduced into a mixing channel of microchannels in a micromixer and mixed. As mentioned above, mixing in a micromixer utilizes molecular diffusion, but it is not always easy to introduce fluids into a microchannel and mix multiple fluids uniformly by molecular diffusion.

As an improvement measure for this, for example, in Patent Document 1, in order to form the fluid to be mixed in a thin and uniform multi-layer in the mixing part, or to reduce the flow velocity while maintaining a thin layer, a mixing channel and a connection thereto are proposed. The fluid mixer has a plurality of inflow paths, and mixes the fluids by introducing at least two types of fluids from the plurality of inflow paths into the mixing flow path, the mixing flow path having a flow direction. It has been proposed that a plurality of flow path connecting portions are provided by connecting the plurality of inflow paths at predetermined intervals, and that adjacent flow path connecting portions are piped so that different types of fluids are introduced. has been done.

In addition to the above-mentioned point regarding uniform mixing by molecular diffusion, Patent Document 2 also describes how to achieve an ideal molecular weight distribution when performing polymer synthesis by radical polymerization reaction using such a flow synthesizer. The required functions include (i) uniform temperature control, (ii) high viscosity liquid delivery of the polymer product, and (iii) gas-liquid mixing/separation. As a configuration for realizing the function (iii), it is described that a special elastic tube that allows gas to pass through but not liquid is provided in a predetermined pressure chamber, and that the reaction is carried out within the elastic tube. .

International Publication No. 2006/030952 JP2009-274030A

Incidentally, starting materials used when examining various chemical syntheses and the creation of new substances using a flow synthesis apparatus having a micromixer include various starting materials such as gas phase and liquid phase. In general, it is necessary to apply a large pressure to introduce and mix these phases into the mixing channel of the microchannel. The characteristics of the starting materials vary, and the introduction pressure should be selected according to their characteristics. However, when introducing the starting materials into the mixing flow path, it is necessary to minimize the pressure difference between the introduced phases and balance the pressures. Control pressure etc. When the starting materials are in gas phase or liquid phase, it tends to be easier to introduce them into the mixing channel by controlling the introduction pressure, but when the starting materials are in liquid phase and gas phase, their characteristics differ greatly. Differently, it is difficult to balance the pressure.

The present inventor attempted to supply a gas phase and a liquid phase to the general T-shaped micro mixer and mix the two, but the pressure difference was large, and the liquid phase was placed on the supply path side of the gas phase. It was confirmed that the water could not be mixed by backflowing.

The above-mentioned Patent Documents 1 and 2 list gas, liquid, etc. as applicable fluids. However, in the invention described in Patent Document 1, complicated microchannels are formed in order to form the fluid to be mixed into a thin and uniform multilayer and achieve mixing by efficient molecular diffusion. . It is thought that quite high pressure is required to introduce a liquid phase into such a complicated microchannel. Therefore, in order to mix a liquid phase and a gas phase into such a fluid mixer, it is necessary to introduce the gas phase at a higher pressure, which is considered to be extremely difficult in practice. Further, in the invention described in Patent Document 2, as mentioned above, it is described that a specific elastic tube is used to move gas inside and outside the elastic tube, but in order to introduce gas into the elastic tube, , it is thought that a considerable amount of pressure would be required, and it would be difficult to realize this. Patent Document 2 specifically describes moving gas generated by reaction or the like in the liquid phase inside the elastic tube outside the elastic tube, but does not provide a specific example of moving gas outside the elastic tube into the elastic tube. is not mentioned.

Therefore, an object of the present invention is to perform flow synthesis in which a gas phase and a liquid phase are brought together using a micromixer to continuously perform a gas-liquid reaction, even if there is a pressure difference between the supplied gas phase and the liquid phase. , a micro mixer for a flow synthesizer capable of merging a gas phase and a liquid phase at a predetermined ratio without the liquid phase flowing back into the gas phase supply channel side, and a micro mixer for the flow synthesizer. It is an object of the present invention to provide a flow synthesis device having a mixer and capable of performing flow synthesis by a desired gas-liquid reaction.

The present inventor conducted extensive studies to solve the above-mentioned problems. As a result, when performing flow synthesis in which a gas phase and a liquid phase are combined using a micromixer to continuously perform a gas-liquid reaction, the gas phase and liquid phase that are continuously supplied from each supply channel are By continuously and alternately flowing the liquid phase into the synthesis flow path, the liquid phase is prevented from flowing back into the gas phase supply flow path, and the gas-liquid reaction between the gas phase and the liquid phase is continuously performed at the desired ratio. I found out that it is possible to do this. The gist of the present invention is as follows.

The first aspect of the present invention is a micromixer for a flow synthesizer that continuously merges a gas phase and a liquid phase, and the micromixer for a flow synthesizer includes a six-way switching valve, a gas phase supply channel, The hexagonal switching valve has a liquid phase supply channel, a discharge channel, a synthesis channel, and a sample loop, and the hexagonal switching valve has a gas phase supply port connected to the gas phase supply channel, and a gas phase supply port connected to the gas phase supply channel; A liquid phase supply port connected to the phase supply flow path, a discharge port connected to the discharge flow path, a synthesis outlet connected to the synthesis flow path, and two sample loop openings connected to both ends of the sample loop. The hexagonal switching valve has a six-way switching valve in which the gas phase or liquid phase supply channel, the sample loop, and the discharge channel communicate with each other, and at the same time, the liquid phase or gas phase supply channel and the synthesis channel communicate with each other. A second flow path in which the first flow path communicates with the gas phase or liquid phase supply flow path and the discharge flow path, and at the same time, the liquid phase or gas phase supply flow path communicates with the sample loop and the synthesis flow path. By alternately switching between the first flow path and the second flow path and causing at least the gas phase or liquid phase that has flowed into the sample loop to flow out into the synthesis flow path, the liquid phase and the liquid phase can be switched. The present invention relates to a micromixer for a flow synthesizer, which allows gas phases to flow out alternately into a synthesis channel.

In the embodiment of the micromixer for a flow synthesizer, the sample loop opening has a first opening and a second opening, and the gas phase supply port, the first opening of the sample loop opening, and the synthesis flow The outlet, the liquid phase supply port, the second opening of the sample loop opening, and the discharge port may be provided in the six-way switching valve in this order clockwise or counterclockwise.

The second aspect of the present invention relates to a flow synthesizer having the micromixer for a flow synthesizer.

In the embodiment of the flow synthesis apparatus, a pressure adjustment device may not be provided on the downstream side of the synthesis flow path.

Note that each channel constituting the aforementioned micromixer and a flow synthesis device having the micromixer is a microchannel, and a microchannel refers to a channel with a cross-sectional width or inner diameter of 1.0 mm or less. shall be.

According to the present invention, when performing flow synthesis in which a gas phase and a liquid phase are brought together by a micromixer to continuously perform a gas-liquid reaction, even if there is a pressure difference between the supplied gas phase and the liquid phase, the liquid A micro mixer for a flow synthesizer that can combine a gas phase and a liquid phase at a predetermined ratio without causing the phase to flow back into the supply channel side of the gas phase, and a micro mixer for the flow synthesizer. Accordingly, it is possible to provide a flow synthesis apparatus capable of performing flow synthesis by a desired gas-liquid reaction.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an explanatory diagram for explaining an overview of a micromixer for a flow synthesis device and a flow synthesis device including the micromixer according to an embodiment of the present invention, and a flow path configuration thereof. FIG. 2 is an explanatory diagram for explaining a state when a gas phase is caused to flow into a sample loop when the hexagonal switching valve has a flow path configuration of a first flow path in the micromixer according to the embodiment shown in FIG. 1; FIG. 3 is an explanatory diagram for explaining a state immediately after switching the hexagonal switching valve to the second flow path from the state shown in FIG. 2; From the state shown in Figure 3, the liquid phase is caused to flow into the sample loop, the gas phase in the sample loop is pushed out by the liquid phase, and the gas phase is forced out into the synthesis flow path, and the gas phase is discharged from the gas phase supply flow path. It is an explanatory view for explaining the state where it is made to flow out into a channel. 5 is an explanatory diagram for explaining a state immediately after switching the hexagonal switching valve to the first flow path from the state shown in FIG. 4. FIG. From the state shown in Figure 5, the gas phase is introduced into the sample loop, the liquid phase in the sample loop is pushed out by the gas phase, and the liquid phase is forced out into the discharge channel, and the liquid phase is synthesized from the liquid phase supply channel. It is an explanatory view for explaining the state where it is made to flow out to a water channel. 7 is an explanatory diagram for explaining a state immediately after switching the hexagonal switching valve to the second flow path from the state shown in FIG. 6. FIG. This is an image showing a state in which a gas phase and a liquid phase are continuously and alternately flowed into a synthesis channel using the micromixer according to the embodiment in an experimental example.

Hereinafter, embodiments of the present invention will be described based on the drawings, but the present invention is not limited to these examples in any way, and it goes without saying that it can be implemented in various forms without departing from the gist of the present invention. .

FIG. 1 is an explanatory diagram for explaining the channel configuration of a micromixer for a flow synthesizer (hereinafter sometimes referred to as "micromixer") 1 and a flow synthesizer 2 having the same according to an embodiment of the present invention. It is.

As shown in FIG. 1, the micromixer 1 has a hexagonal switching valve 10, a gas phase supply channel 11, a liquid phase supply channel 12, a discharge channel 13, a synthesis channel 14, and a sample loop 15. . Further, the six-way switching valve 10 has ports (1) to (6), where the port (1) is a gas phase supply port connected to the gas phase supply channel 11, and the port (2) is one side of the sample loop 15. The first sample loop opening is connected to the end (first end) 15a, the port (3) is a synthesis outlet that is connected to the synthesis flow path 14, and the port (4) is connected to the liquid phase supply flow path 12. The liquid phase supply port is connected to the liquid phase supply port, the port (5) is a second sample loop opening connected to the other end (second end) 15b of the sample loop 15, and the port (6) is a discharge port connected to the discharge channel 13. handle. In the example shown in FIG. 1, ports (1) to (6) are arranged in that order clockwise on the same circumference. The circumferential spacing between the ports is not particularly limited as long as a first flow path and a second flow path, which will be described later, are formed. In the example shown in FIG. 1, each port is provided by dividing the circumference into six equal parts.

In the example shown in FIG. 1, the six-way switching valve 1 is configured to be able to switch between the next first flow path and second flow path. The first flow path includes a flow path a where ports (1) and (2) communicate with each other, a flow path b where ports (3) and (4) communicate with each other, and a flow path c where ports (5) and (6) communicate with each other. The gas phase supply channel 11, the sample loop 15, and the discharge channel 13 communicate with each other, and at the same time, the liquid phase supply channel 12 and the synthesis channel 14 communicate with each other. (See Figures 1, 2, 5, 6). The second flow path includes a flow path d in which ports (1) and (6) communicate, a flow path e in which ports (2) and (3) communicate, and a flow path f in which ports (4) and (5) communicate. is formed, and the gas phase supply channel 11 and the discharge channel 13 communicate with each other, and at the same time, the liquid phase supply channel 12, the sample loop 15, and the synthesis channel 14 communicate with each other ( (See Figures 3, 4, 7).

The six-way switching valve 1 is configured, for example, by a rotary valve including a stator provided with ports (1) to (6) and a rotor provided with three flow grooves for forming flow paths a to f. can do. By rotating the rotor, the first flow path and the second flow path can be switched.

In the example shown in FIG. 1, the sample loop 15 replaces a part of the liquid phase that is continuously sent to the synthesis channel 14 with a gas phase, and alternately supplies the gas phase and the liquid phase to the synthesis channel 14. It has the function of temporarily storing the gas phase when it flows out. That is, the mixing ratio of the gas phase and the liquid phase can be adjusted by adjusting the amount stored in the sample loop 15. Therefore, the length of the sample loop 15, etc. can be determined in consideration of the conditions of the synthesis reaction between the gas phase and the liquid phase.

In the example shown in FIG. 1, the flow synthesis device 2 includes the aforementioned micromixer 1; a check valve 16 provided in this order on the upstream side of the gas phase supply channel 11; a mass flow controller 17 that controls the flow rate of the gas phase; A gas phase cylinder 18 that stores the gas phase; a check valve 19, a pump 20, and a liquid phase container 21 that stores the liquid phase, which are provided in this order on the upstream side of the liquid phase supply flow path 12; downstream of the discharge flow path 13; It has a waste tank 22 provided on the side; a reaction tank 23 provided in order on the downstream side of the synthesis channel 14; and a recovery container 24 for storing the product.

In the example shown in FIG. 1, there is only one gas phase cylinder 18 and one liquid phase container 21, but a plurality of them can be provided as necessary. Note that gas phases and liquid phases can be mixed using a general micro mixer. The configuration of the reaction tank 23 can be selected depending on the synthesis reaction. Examples include a catalyst column filled with a solid catalyst, a reaction tube having a spiral shape, and the like. Examples of the solid catalyst packed in the catalyst column include palladium on carbon (Pd/C). The reaction tank 23 can be provided with a heating device or the like, if necessary.

The flow synthesis device 2 shown in FIG. 1 may include a control section that controls the operations of the six-way switching valve 10, the pump 20, the check valves 16 and 19, and the mass flow controller 17.

The operations of the micro mixer 1 and flow synthesizer 2 shown in FIG. 1 will be explained based on FIGS. 2 to 7. Note that FIG. 1 shows the stopped state before operation, and in FIGS. 2 to 7, the flow of the gas phase in the channel is shown by a solid line, and the flow of the liquid phase is shown by a broken line. Additionally, arrows indicate the flow direction.

First, as shown in FIG. 1, the six-way switching valve 10 is set to the first flow path to prepare a desired gas phase, liquid phase, etc. Then, as shown in FIG. 2, the gas phase and the liquid phase are fed in the state of the first channel. The gas phase is sent from the channel 11 to the channel a, the sample loop 15, the channel c, and the channel 13 while controlling the flow rate by the mass flow controller 17. Optionally, a waste tank 22 may be reached. The waste tank 22 is configured so that the gas phase can be safely discharged to the outside. Further, the structure may be such that the gas phase released to the outside can be recovered and reused. The liquid phase is sent to the flow path 12, flow path b, and flow path 14 while controlling the flow rate by the pump 20. Depending on the case, the reaction tank 23 and collection container 24 may be reached. After the gas phase is stored throughout the sample loop 15 and the liquid phase reaches the flow path 14, the valve 10 is switched to the second flow path as shown in FIG.

FIG. 3 shows the state in the gas phase and liquid phase channels of the micromixer 1 immediately after the valve 10 is switched from the first channel shown in FIG. 2 to the second channel. As shown in FIG. 3, the first flow path constitutes flow path a, flow path b, and flow path c, and the gas phase or liquid phase present in each flow path is transferred to the flow path e in the second flow path. , flow path f, and flow path d. The gas phase in the flow path d is pushed out into the flow path 13 by the gas phase flowing in from the flow path 11, and flows into the waste tank 22 while being sandwiched between the gas phases that were present in the flow path 13. The gas phase flowing into the sample loop 15 is pushed out into the flow path 14 by the gas phase in the flow path e, the liquid phase present in the flow path f, and the liquid phase flowing in from the flow path 12. At this time, since the liquid phase also exists in the flow path 14 on the downstream side of the gas phase, the gas phase flows into the flow path 14 while being sandwiched between the liquid phases. That is, the liquid phase, gas phase, and liquid phase flow out into the channel 14 in this order. Then, as shown in FIG. 4, all of the gas phase in the sample loop 15 is caused to flow into the flow path 14 from the state shown in FIG.

Thereafter, the valve 10 is switched to the first flow path. FIG. 5 shows the state in the gas phase and liquid phase flow paths of the micromixer 1 immediately after the valve 10 is switched from the second flow path shown in FIG. 4 to the first flow path. As shown in FIG. 5, a flow path e, a flow path f, and a flow path d are configured in the second flow path shown in FIG. , it moves to flow path a, flow path b, and flow path c. The liquid phase existing in the flow path b is pushed out by the liquid phase flowing in from the flow path 12, and flows into the flow path 14 while being sandwiched between the liquid phase (which may be a gas phase in some cases) that was present in the flow path 14. do. The liquid phase flowing into the sample loop 15 is pushed out into the flow path 13 by the gas phase flowing from the flow path 11 together with the liquid phase in the flow path a and the gas phase in the flow path c. Then, as shown in FIG. 6, a gas phase is caused to flow into the sample loop 15 and stored throughout it.

Thereafter, the valve 10 is switched to the second flow path. FIG. 7 shows the state in the gas phase and liquid phase flow paths of the micromixer 1 immediately after the valve 10 is switched from the first flow path shown in FIG. 6 to the second flow path. As shown in FIG. 7, a flow path a, a flow path b, and a flow path c are configured in the first flow path shown in FIG. , it moves to flow path e, flow path f, and flow path d. The gas phase in the flow path d is pushed out into the flow path 13 by the gas phase flowing in from the flow path 11, and flows into the waste tank 22 while being sandwiched between the liquid phase that was present in the flow path 13. In this way, a gas phase and a liquid phase can flow into the waste tank 22. The liquid phase that has flowed in may be configured so that it can be discharged to the outside and reused, as in the case of the gas phase described above. The gas phase flowing into the sample loop 15 is pushed out into the flow path 14 by the gas phase in the flow path e, the liquid phase present in the flow path f, and the liquid phase flowing in from the flow path 12. At this time, since the liquid phase also exists in the flow path 14 on the downstream side of the gas phase, the gas phase flows into the flow path 14 while being sandwiched between the liquid phases. That is, the liquid phase, gas phase, and liquid phase flow out into the channel 14 in this order. Then, as shown in FIG. 4, for example, after all of the gas phase present in the sample loop 15 is pushed out to the flow path 14, the valve 10 is switched to the first flow path again as shown in FIG. 5.

As described above, by alternately and repeatedly switching the first flow path and the second flow path of the valve 10, the liquid phase can be caused to flow from the flow path 12 to the flow path 14 without being affected by the pressure difference. , it becomes possible to repeatedly and continuously cause the gas phase that has flowed into the sample loop 15 to flow between the liquid phases. Furthermore, since the capacity of the sample loop 15 is constant, by controlling the flow rate of the liquid phase, the liquid phase and the gas phase can be alternately flowed out into the flow path 14 so as to achieve a desired ratio. .

In this way, the liquid phase and the gas phase alternately flowed out into the channel 14 so as to have a predetermined quantity ratio can be continuously subjected to a predetermined gas-liquid reaction in the reaction tank 23 adjusted to desired conditions. . In particular, when the reaction tank 23 includes a catalyst column filled with a solid catalyst, it is thought that the gas phase and the liquid phase move between the catalyst particles while being stirred within the catalyst column, so that the gas phase and the liquid phase are efficiently transferred. It is thought that there is a tendency to respond to

The products generated by the gas-liquid reaction in the reaction tank 23 are collected in the collection container 24 together with unreacted substances. The collection container 24 can be configured to be able to discharge the gas phase to the outside.

In this embodiment, the hexagonal switching valve 10 allows the gas phase supply channel 11, the sample loop 15, and the discharge channel 13 to communicate with each other, and at the same time, the liquid phase supply channel 12 and the synthesis channel 14 communicate with each other. The first flow path communicates with the gas phase supply flow path 11 and the discharge flow path 13, and at the same time, the second flow path communicates with the liquid phase supply flow path 12, the sample loop 15, and the synthesis flow path 14. The first flow path and the second flow path are alternately switched so that at least the gas phase flowing into the sample loop 15 flows out into the synthesis flow path 14, thereby converting the liquid phase into the liquid phase. The gas phase is configured to alternately flow out into the synthesis channel 14.

As a modification of this embodiment, for example, the arrangement of the gas phase and the liquid phase can be exchanged. In this case, ports (1) and (4) of the six-way switching valve 10 serve as the liquid phase supply port connected to the liquid phase supply flow path and the gas phase supply port connected to the gas phase supply flow path, respectively. The configuration is the same as the previous embodiment. The six-way switching valve communicates with the liquid phase supply channel (corresponding to the reference numeral 11 in FIGS. 1 to 7), the sample loop 15, and the discharge channel 13, and at the same time communicates with the gas phase supply channel (corresponding to the reference numeral 11 in FIGS. 1 to 7). The first flow path in which the synthesis flow path 14 (which corresponds to the reference numeral 12 in FIGS. 1 to 7) communicates with the liquid phase supply flow path and the discharge flow path 13, and at the same time, the gas phase supply It is configured such that it can be switched to a second flow path in which the sample loop 15 and the synthesis flow path 14 communicate with each other. Further, in the same manner as in the above-described embodiment, the first flow path and the second flow path are alternately switched to allow at least the liquid phase that has flowed into the sample loop 15 to flow out into the synthesis flow path 14. , the liquid phase and the gas phase can be made to flow out alternately into the synthesis channel 14. Note that this modification is applicable when the pressure inside the reaction tank 23 is lower than the pressure inside the gas phase supply channel (corresponding to the reference numeral 12 in FIGS. 1 to 7).

As described above, by having the six-way switching valve 10, the micromixer 1 allows the gas phase and the liquid phase to flow out alternately into the flow path 14 regardless of the pressure difference between the gas phase and the liquid phase. It is possible to merge the phases. Therefore, even if a pressure adjustment device is not provided on the downstream side of the flow path 14, especially on the downstream side of the reaction tank 23, it is possible to supply the gas phase and the liquid phase to the reaction tank 23 at a desired ratio. It is.

Such a micromixer and a flow synthesizer having the same can be applied to various gas-liquid reactions in which a gas phase and a liquid phase are reacted. Examples of such gas-liquid reaction systems include, but are not limited to, catalytic hydrogenation.

(Experiment example)
In the following, the steps shown in FIGS. 2 to 7 will be performed using the micromixer 1 according to the embodiment shown in FIG. An experiment was conducted in which the mixture was alternately discharged into the synthesis channel 14 at different ratios.

The conditions are as follows.
Gas phase: nitrogen, flow rate 10cc/min
Liquid phase: polyethylene glycol 300, flow rate 1.0ml/min
Sample loop 15: length 100mm, inner diameter 1.0mm
Width (inner diameter) of channels 11 to 14: 1.0 mm
Width of channels a(e), b(f), c(d): 0.25mm

As a result, colorless nitrogen gas (gas phase) and pale yellow colored polyethylene glycol (liquid phase) alternately and continuously flowed out into the channel 14, and it was visually confirmed that there was no backflow of the liquid phase into the channel 11. Confirmed by. FIG. 8 shows an image of the fluid flowing out into the synthesis channel 14 at that time. As shown in FIG. 8, boundaries between the gas phase and the liquid phase are observed in the flow path 14 at the positions of the arrows indicated by symbols A to D, and the liquid phase (for example, between AB in FIG. 8) and the gas phase ( 8, for example, between BC, etc.) are continuously and alternately flowing out. Therefore, it can be seen that when the gas phase and the liquid phase are used as substrates for a desired gas-liquid reaction system, it is possible to carry out the desired gas-liquid reaction continuously in the reaction tank on the downstream side of the channel 14.

1 Micro mixer for flow synthesizer; 2 Flow synthesizer; 10 Hexagonal switching valve; 11 Gas phase supply channel; 12 Liquid phase supply channel; 13 Discharge channel; 14 Synthesis channel; 15 Sample loop; 15a one end; 15b other end; 16, 19 check valve; 17 mass flow controller; 18 gas phase cylinder; 20 pump; 21 liquid phase container; 22 waste tank; 23 reaction tank; 24 recovery container; A, B, C, D Boundary between gas and liquid phases.

Claims (4)

A micro mixer for a flow synthesizer that continuously combines a gas phase and a liquid phase,
The micromixer for a flow synthesizer has a six-way switching valve, a gas phase supply channel, a liquid phase supply channel, a discharge channel, a synthesis channel, and a sample loop,
The six-way switching valve has a gas phase supply port connected to the gas phase supply flow path, a liquid phase supply port connected to the liquid phase supply flow path, a discharge port connected to the discharge flow path, and a synthesis flow path. a synthesis outlet connected to the sample loop, and two sample loop openings connected to both ends of the sample loop;
The six-way switching valve has a first channel in which the gas phase or liquid phase supply channel, the sample loop, and the discharge channel communicate with each other, and at the same time, the liquid phase or gas phase supply channel and the synthesis channel communicate with each other. At the same time, the gas phase or liquid phase supply channel and the discharge channel communicate with each other, and at the same time, it is possible to switch to a second channel in which the liquid phase or gas phase supply channel, the sample loop, and the synthesis channel communicate with each other. and
The first flow path and the second flow path are alternately switched to allow at least the gas phase or the liquid phase that has flowed into the sample loop to flow out into the synthesis flow path, thereby converting the liquid phase and the gas phase into the synthesis flow path. A micro mixer for flow synthesizers that allows alternate flow into the flow channels. the sample loop opening has a first opening and a second opening;
The gas phase supply port, the first opening of the sample loop opening, the synthesis outlet, the liquid phase supply port, the second opening of the sample loop opening, and the discharge port are rotated clockwise or counterclockwise in this order. 2. The micromixer for a flow synthesizer according to claim 1, wherein the micromixer is provided around the hexagonal switching valve. A flow synthesis device comprising the micromixer for a flow synthesis device according to claim 1 or 2. 4. The flow synthesis apparatus according to claim 3, wherein a pressure regulating device is not provided on the downstream side of the synthesis flow path.

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