JP2024001854A - Mew method of measuring skin sag amount - Google Patents
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Abstract
Description
本発明は、例えば、ヒト等の皮膚たるみ量の測定方法、などに関する。 The present invention relates to, for example, a method for measuring the amount of skin sagging in humans.
皮膚のたるみは、多くの人の関心の高い肌の老化現象のひとつである。顔面のたるみの原因は、年齢や真皮のコラーゲン量、皮膚の弾力性や皮下脂肪厚など皮膚の物性の増減が起因しているといわれている。例えば、たるみと弾力性、たるみと皮下脂肪との関係は明らかとなっているが、それら皮膚物性の変化が実際の皮膚表面において、それぞれどのような変化をもたらすのかは知られていない。皮膚のたるみを改善する方法として、エステティックやマッサージなどの美容施術、補正下着に代表される物理的方法や、医薬品、化粧品、サプリメントなどによる化学的方法、またこれを組み合わせた方法が試みられている。皮膚のたるみを改善する方法として、エステティックやマッサージなどの美容施術、補正下着に代表される物理的方法や、医薬品、化粧品、サプリメントなどによる化学的方法、またこれを組み合わせた方法が試みられている(特許文献1、非特許文献1)。 Sagging skin is one of the skin aging phenomena that many people are concerned about. The causes of facial sagging are said to be due to age, changes in the physical properties of the skin, such as the amount of collagen in the dermis, skin elasticity, and subcutaneous fat thickness. For example, although the relationships between sagging and elasticity and between sagging and subcutaneous fat are clear, it is not known what kind of changes these changes in skin physical properties bring about on the actual skin surface. Methods to improve sagging skin include beauty treatments such as aesthetics and massage, physical methods such as corrective underwear, chemical methods using medicines, cosmetics, and supplements, and methods that combine these methods. There is. Methods to improve sagging skin include beauty treatments such as aesthetics and massage, physical methods such as corrective underwear, chemical methods using medicines, cosmetics, and supplements, and methods that combine these methods. (Patent Document 1, Non-Patent Document 1).
本発明が解決しようとする課題は、より簡易にヒト等の被験者の皮膚たるみ量を測定可能な新規な方法を提供すること、などである。 The problem to be solved by the present invention is to provide a novel method that can more easily measure the amount of skin sagging of a human subject.
そこで、本発明の発明者は、鋭意検討を重ねた結果、おもりを用いての重力を活用すること等により、本発明を完成した。 Therefore, as a result of extensive studies, the inventor of the present invention completed the present invention by utilizing gravity using weights.
本発明は、以下の項を含む。
〔項1〕 皮膚のたるみ量を測定する方法であって、
(1)被験者が静的立位姿勢とするステップ、
(2)被験者の皮膚に基準点を設けるステップ、
(3)基準点とは異なる点を測定点とするステップ、
(4)当該基準点を支点として被験者に対しテープ及び当該テープにおもりを付加するステップ、
(5)当該テープの上端を基準点とし、当該テープの下端を測定点とするステップ、
(6)被験者の静的立位姿勢において、少なくとも基準点、測定点を含む状態で、垂直位の皮膚表面を撮像して画像を得るステップ、
(7)ステップ(6)で得られた画像から、測定点の移動量を測定するステップ、
を含む皮膚たるみ量の測定方法。
The present invention includes the following sections.
[Item 1] A method for measuring the amount of skin sagging, comprising:
(1) A step in which the subject assumes a static standing posture;
(2) providing a reference point on the subject's skin;
(3) a step of setting a point different from the reference point as a measurement point;
(4) adding a tape to the subject and a weight to the tape using the reference point as a fulcrum;
(5) using the upper end of the tape as a reference point and the lower end of the tape as a measurement point;
(6) obtaining an image by imaging the vertical skin surface in a static standing posture of the subject, including at least the reference point and the measurement point;
(7) measuring the amount of movement of the measurement point from the image obtained in step (6);
How to measure the amount of skin sagging, including:
香粧品分野などでより簡易にヒト等の皮膚たるみ量を測定可能な新規の方法、などを提供できる。 It is possible to provide a new method that can more easily measure the amount of skin sagging in humans, etc. in the cosmetics field.
以下、本発明を実施するための形態について説明する。 EMBODIMENT OF THE INVENTION Hereinafter, the form for implementing this invention is demonstrated.
(基準点)
本発明の基準点は、支点を設定する趣旨である。基準点は、少なくとも1点あればよく、2点以上設けることも可能である。
(Reference point)
The reference point of the present invention is intended to set a fulcrum. At least one reference point is sufficient, and it is also possible to provide two or more reference points.
本発明の基準点は、ホクロ、眉毛等とすることも可能であり、眉上、眉間、鼻根、鼻尖、人中、オトガイ、唇溝、頬、目尻等とすることも可能である。以下実施例では、顔面部の皮膚のたるみ量を測定する例(頬の所定部位を基準点とした例)を示す。 The reference points of the present invention can be moles, eyebrows, etc., and can also be the upper part of the eyebrows, between the eyebrows, the root of the nose, the tip of the nose, the philtrum, the chin, the labial folds, the cheeks, the outer corners of the eyes, etc. In the following example, an example will be shown in which the amount of sagging of the skin on the face is measured (an example where a predetermined part of the cheek is used as a reference point).
(測定点)
本発明の測定点は、1ヶ所、2ヶ所以上、目的に応じて適宜設定できる。例えば、化粧品などの評価において、顔全体に塗布した場合、どの部位に特に効果が高いかを確認したい場合は、任意の部位に複数測定点を設け、各測定点におけるたるみ量の変化を比較する等して評価することができる。本発明では、テープの上端を基準点とし、テープの下端(上端以外の部位、静的立位姿勢において上端と平行ではない部位で下の部位)を測定点とする。
(Measurement point)
The measurement points of the present invention can be set at one location, two or more locations as appropriate depending on the purpose. For example, when evaluating cosmetics, etc., if you want to check which areas are particularly effective when applied to the entire face, set multiple measurement points at any area and compare changes in the amount of sagging at each measurement point. It can be evaluated as follows. In the present invention, the upper end of the tape is used as a reference point, and the lower end of the tape (a region other than the upper end, a lower region that is not parallel to the upper end in a static standing posture) is used as a measurement point.
(テープ)
テープは、皮膚に剥がれないように粘着できるテープであればよい。当該テープは、テープの基材の片面及び/又は両面に粘着剤層を有する。
(tape)
The tape may be any tape that can adhere to the skin without peeling off. The tape has an adhesive layer on one and/or both sides of the base material of the tape.
(おもり)
おもり(重り、錘)を構成する材料は、重力が働くようにすれば、特に限定されるものではないが、具体的には、鋼やSUS等の金属材料や樹脂材料等を用いることができる。おもりの形状も、重力が働くようにすれば、特に限定されるものではない。
(weight)
The material constituting the weight is not particularly limited as long as gravity acts on it, but specifically, metal materials such as steel and SUS, resin materials, etc. can be used. . The shape of the weight is not particularly limited as long as gravity acts on it.
(撮像)
撮像は、例えばデジタルカメラなどの撮像装置で、少なくとも1つの基準点と測定点が含まれるように行う。撮像により画像を取得して、像中に含まれる皮膚表面の形状や面積などの変化を把握する。当該画像は、例えば、静止画、動画、である。
(imaging)
Imaging is performed using an imaging device such as a digital camera, for example, so that at least one reference point and measurement point are included. An image is acquired by imaging, and changes in the shape and area of the skin surface included in the image are ascertained. The image is, for example, a still image or a moving image.
(静的立位姿勢)
静的立位姿勢は、例えば文献(Vol.38 Suppl. No.2 (第46回日本理学療法学術大会 抄録集)、セッションID: OI1-008)に記載の姿勢であるが、ヒト等が体全体で立位している姿勢だけでなく、例えば座位で顔全体が立位している姿勢も含む。
(Static standing posture)
The static standing posture is, for example, the posture described in the literature (Vol. 38 Suppl. No. 2 (46th Japanese Physical Therapy Academic Conference Abstracts), Session ID: OI1-008), but it is This includes not only a posture in which the whole person is standing, but also a posture in which the whole face is in an upright position, for example, while sitting.
(組成物の形態)
本発明の方法を用いる試験で用いられる組成物(皮膚外用のための組成物など)は、アンプル、カプセル、粉末、顆粒、液体、ゲル、気泡、エマルジョン、シート、ミスト、スプレー剤等利用上の適当な形態の1)医薬品類、2)医薬部外品類、3)局所用又は全身用の皮膚外用剤類(例えば、化粧水、乳液、クリーム、軟膏、ローション、オイル、パック等の基礎化粧料、固形石鹸、液体ソープ、ハンドウォッシュ等の洗顔料や皮膚洗浄料、マッサージ用剤、クレンジング用剤、除毛剤、脱毛剤、髭剃り処理料、アフターシェーブローション、プレショーブローション、シェービングクリーム、ファンデーション、口紅、頬紅、アイシャドウ、アイライナー、マスカラ等のメークアップ化粧料、香水類、美爪剤、美爪エナメル、美爪エナメル除去剤、パップ剤、プラスター剤、テープ剤、シート剤、貼付剤、エアゾール剤等)、4)頭皮・頭髪に適用する薬用又は/及び化粧用の製剤類(例えば、シャンプー剤、リンス剤、ヘアートリートメント剤、プレヘアートリートメント剤、パーマネント液、染毛料、整髪料、ヘアートニック剤、育毛・養毛料、パップ剤、プラスター剤、テープ剤、シート剤、エアゾール剤等)、5)浴湯に投じて使用する浴用剤、6)その他、腋臭防止剤や消臭剤、制汗剤、衛生用品、衛生綿類、ウエットティシュ等が挙げられる。
(Form of composition)
Compositions used in tests using the method of the present invention (compositions for external use on the skin, etc.) include ampules, capsules, powders, granules, liquids, gels, bubbles, emulsions, sheets, mist, sprays, etc. Appropriate forms of 1) pharmaceuticals, 2) quasi-drugs, 3) topical or systemic skin preparations (for example, basic cosmetics such as lotions, milky lotions, creams, ointments, lotions, oils, packs, etc.) , facial cleansers and skin cleansers such as bar soaps, liquid soaps, hand washes, massage agents, cleansing agents, hair removers, depilatory agents, shaving agents, aftershave lotions, pre-show lotions, shaving creams, foundations, Makeup cosmetics such as lipstick, blush, eye shadow, eyeliner, mascara, perfumes, nail polish, nail enamel, nail enamel remover, poultices, plasters, tapes, sheets, patches, 4) Medicinal and/or cosmetic preparations applied to the scalp and hair (e.g., shampoos, conditioners, hair treatment agents, pre-hair treatment agents, permanent solutions, hair dyes, hair styling agents, etc.) tonics, hair growth/hair nourishing products, poultices, plasters, tapes, sheets, aerosols, etc.), 5) bath additives used by adding them to bath water, 6) other armpit odor preventers, deodorants, and control agents. Examples include perspiration agents, sanitary products, sanitary cotton, and wet tissues.
次に実施例を挙げ、本発明を更に詳しく説明するが、本発明はこれら実施例に何ら制約されるものではない。なお、以下の実施例において、各種成分の添加量を示す数値の単位%は、質量%を意味する。 EXAMPLES Next, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples in any way. In addition, in the following examples, the unit % of the numerical value showing the addition amount of various components means mass %.
以下、本発明の実施例について、説明する。以下、実施例で挙げる実験で用いた実験材料は次の通りである。 Examples of the present invention will be described below. The experimental materials used in the experiments described in Examples are as follows.
[実施例1]本発明の方法を用いて行うモニター試験で用いるローションの作製
下記モニター試験で用いるローションを次のように作製した。表1に記載のように、カワラヨモギの花の抽出物を1%含有したローション(表1ローション)を作製した。表2に記載のように、プラセボローション(当該抽出物を含有しないローション)を作製した。
[Example 1] Preparation of a lotion used in a monitor test performed using the method of the present invention A lotion used in the monitor test described below was prepared as follows. As shown in Table 1, a lotion containing 1% of mugwort flower extract (Table 1 lotion) was prepared. A placebo lotion (a lotion that does not contain the extract) was prepared as described in Table 2.
(実験1:ヒトでの皮膚モニター試験、皮膚外用剤)
正常なヒト被験者(平均年齢43.6歳の男女13名)の顔の所定部位に、表1記載のローションと、表2記載のプラセボローションとを塗布することにより、2022年1月31日から2022年3月4日の間に試験を行った。表1で示す組成のローションを被験者の顔の半分の所定部位に所定間隔にて塗布し、表2で示すローションを被験者の顔のもう一方の半分の所定部位に所定間隔にて塗布した。この所定間隔は、1日2回ずつ(朝晩)4週間である。所定部位は、「顔全体」である。
(Experiment 1: Human skin monitor test, skin external preparation)
From January 31, 2022, by applying the lotion listed in Table 1 and the placebo lotion listed in Table 2 to designated areas on the face of normal human subjects (13 men and women with an average age of 43.6 years). The test was conducted during March 4, 2022. The lotion having the composition shown in Table 1 was applied at predetermined intervals on one half of the subject's face, and the lotion shown in Table 2 was applied at predetermined intervals on the other half of the subject's face. This predetermined interval is twice a day (morning and evening) for four weeks. The predetermined region is "the entire face."
図1に記載のように皮膚のたるみを測定した。被験者の頬に、中心にドーナツ状に穴の開いた粘着テープ(DermaLabTMCombo(CORTEX TECHNOLOGY)ELASTICITYプローブ用粘着テープ)の下側にホッチキス針(No.11-1M(マックス株式会社))を引掛けた。図1に示すように、粘着テープの貼付位置を、顔面の鼻下から横に引いたラインと目尻から縦に引いたラインの交点と粘着テープのドーナツ円の内側の下部が重なる交点とした。この実験1では、基準点を図1で示すa(当該テープの上端)とし、測定点を図1で示すb(当該テープの下端)とした。 Skin sagging was measured as described in FIG. A stapler (No. 11-1M (Max Corporation)) was pulled under the adhesive tape (DermaLab TM Combo (CORTEX TECHNOLOGY) ELASTICITY probe adhesive tape) with a donut-shaped hole in the center on the subject's cheek. I hung it. As shown in FIG. 1, the adhesive tape was applied at the intersection of a line drawn horizontally from the bottom of the nose on the face and a line drawn vertically from the outer corner of the eye, and the lower part of the inside of the donut circle of the adhesive tape overlapped. In this experiment 1, the reference point was set to a (the upper end of the tape) shown in FIG. 1, and the measurement point was set to b (the lower end of the tape) shown in FIG. 1.
図1記載の分銅は、おもり(5g~20g)である。当該おもりをこの実験1で用いた。この実験1では、分銅とクリップを紐で固定し、クリップ側をホッチキスの針に引掛けた。なお、この実験1では、事前に各被験者に対しおもりを付加し、重力によって頬が1-2mm移動する重さの重りを用いた。 The weight shown in FIG. 1 is a weight (5 g to 20 g). This weight was used in this experiment 1. In this experiment 1, a weight and a clip were fixed with a string, and the clip side was hooked onto a stapler. In Experiment 1, a weight was added to each subject in advance, and the weight was such that the cheek would move 1-2 mm due to gravity.
おもり負荷前と負荷後の顔面の様子をVISIATM Evolution(Canfield Scientific)を用いて左右の顔写真撮影を撮影した。それぞれ試験前と4週間後に撮影を行った。写真加工ソフト(Photoshop)にておもり負荷前と負荷後の撮影した画像を重ね合わせ、画像解析ソフト(Digital Microscope VHX-5000(株式会社キーエンス))にて試験前と4週間後の重り負荷時の粘着テープの移動距離と粘着テープの長さを計測した。実際のおもり負荷時の移動距離は、粘着テープの長さから推定換算値を算出し、比較を行った。当該比較した結果(測定した結果)を表3に示す。表3では、0週の値を1.00として示した。 The appearance of the face before and after weight loading was taken using VISIA ™ Evolution (Canfield Scientific) to take left and right facial photographs. Photographs were taken before and 4 weeks after the test, respectively. Using photo processing software (Photoshop), images taken before and after weight loading were superimposed, and image analysis software (Digital Microscope VHX-5000 (Keyence Corporation)) was used to compare images before and after 4 weeks of weight loading. The distance traveled by the adhesive tape and the length of the adhesive tape were measured. For the actual moving distance when a weight is loaded, an estimated conversion value was calculated from the length of the adhesive tape and compared. Table 3 shows the results of the comparison (measured results). In Table 3, the value at week 0 is shown as 1.00.
表3の*印は、Wilcoxon Rank-Sum Testにおいて、0週の値(表1ローション塗布群)との比較による有意差(p<0.05)、を示す。4週において、表2ローション(プラセボローション)塗布と比べ、表1ローション塗布により、たるみの抑制を確認した。 The * mark in Table 3 indicates a significant difference (p<0.05) in the Wilcoxon Rank-Sum Test compared to the value at week 0 (Table 1 lotion application group). At 4 weeks, it was confirmed that sagging was suppressed by applying Table 1 lotion compared to applying Table 2 lotion (placebo lotion).
なお、4週において、表1ローション塗布群と表2ローション塗布群の値(当該長さ)の比較も行った。この比較の結果は表4に示す。表4の*印は、Wilcoxon Rank-Sum Testにおいて、表2ローション塗布群の値(100.00、とする)との比較による有意差(p<0.05)、を示す。この比較の結果(表4)からも、表2ローション(プラセボローション)塗布と比べ、表1ローション塗布により、たるみの抑制がおきていることを示す。 In addition, at 4 weeks, the values (the length) of the lotion application group in Table 1 and the lotion application group in Table 2 were also compared. The results of this comparison are shown in Table 4. The * mark in Table 4 indicates a significant difference (p<0.05) in the Wilcoxon Rank-Sum Test compared to the value of the lotion application group in Table 2 (assumed to be 100.00). The results of this comparison (Table 4) also indicate that sagging is suppressed by applying the Table 1 lotion compared to applying the Table 2 lotion (placebo lotion).
また、この実験1から、本発明の方法が、皮膚たるみ量を測定できることが示された。 Moreover, this experiment 1 showed that the method of the present invention can measure the amount of skin sagging.
以上、本発明の実施の形態(実施例も含め)について、図面を参照して説明してきたが、本発明の具体的構成は、これに限られるものではなく、本発明の要旨を逸脱しない範囲において、設計変更等があっても、本発明に含まれるものである。 Although the embodiments (including examples) of the present invention have been described above with reference to the drawings, the specific configuration of the present invention is not limited thereto, and is within the scope of the gist of the present invention. Even if there are design changes, etc., they are included in the present invention.
本発明は、香粧品分野などでより簡易にヒト等の皮膚たるみ量を測定可能な新規の方法、などとして利用される。
INDUSTRIAL APPLICATION This invention is utilized as a new method which can more easily measure the amount of skin sagging of humans, etc. in the field of cosmetics and the like.
Claims (1)
(1)被験者が静的立位姿勢とするステップ、
(2)被験者の皮膚に基準点を設けるステップ、
(3)基準点とは異なる点を測定点とするステップ、
(4)当該基準点を支点として被験者に対しテープ及び当該テープにおもりを付加するステップ、
(5)当該テープの上端を基準点とし、当該テープの下端を測定点とするステップ、
(6)被験者の静的立位姿勢において、少なくとも基準点、測定点を含む状態で、垂直位の皮膚表面を撮像して画像を得るステップ、
(7)ステップ(6)で得られた画像から、測定点の移動量を測定するステップ、
を含む皮膚たるみ量の測定方法。 A method for measuring the amount of skin sagging,
(1) A step in which the subject assumes a static standing posture;
(2) providing a reference point on the subject's skin;
(3) a step of setting a point different from the reference point as a measurement point;
(4) adding a tape to the subject and a weight to the tape using the reference point as a fulcrum;
(5) using the upper end of the tape as a reference point and the lower end of the tape as a measurement point;
(6) obtaining an image by imaging the skin surface in a vertical position in a static standing posture of the subject, including at least the reference point and the measurement point;
(7) measuring the amount of movement of the measurement point from the image obtained in step (6);
How to measure the amount of skin sagging, including:
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JP2022099992 | 2022-06-22 |
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