JP2023548303A - 癌を処置する為の医薬組成物及びその使用方法 - Google Patents

癌を処置する為の医薬組成物及びその使用方法 Download PDF

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Publication number
JP2023548303A
JP2023548303A JP2023526030A JP2023526030A JP2023548303A JP 2023548303 A JP2023548303 A JP 2023548303A JP 2023526030 A JP2023526030 A JP 2023526030A JP 2023526030 A JP2023526030 A JP 2023526030A JP 2023548303 A JP2023548303 A JP 2023548303A
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JP
Japan
Prior art keywords
effective amount
venetoclax
decitabine
cedazuridine
days
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Pending
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JP2023526030A
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English (en)
Japanese (ja)
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JP2023548303A5 (https=
Inventor
ダオ，キム－ヒエン
キール，ハロルド
オガネシアン，アラム
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of JP2023548303A publication Critical patent/JP2023548303A/ja
Publication of JP2023548303A5 publication Critical patent/JP2023548303A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2023526030A 2020-10-29 2021-10-27 癌を処置する為の医薬組成物及びその使用方法 Pending JP2023548303A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063107010P 2020-10-29 2020-10-29
US63/107,010 2020-10-29
PCT/US2021/056809 WO2022093930A1 (en) 2020-10-29 2021-10-27 Pharmaceutical compositions and methods of using the same for treating cancer

Publications (2)

Publication Number Publication Date
JP2023548303A true JP2023548303A (ja) 2023-11-16
JP2023548303A5 JP2023548303A5 (https=) 2024-10-08

Family

ID=81384423

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023526030A Pending JP2023548303A (ja) 2020-10-29 2021-10-27 癌を処置する為の医薬組成物及びその使用方法

Country Status (10)

Country Link
US (1) US20230405037A1 (https=)
EP (1) EP4237094A4 (https=)
JP (1) JP2023548303A (https=)
KR (1) KR20230097034A (https=)
CN (1) CN116018145A (https=)
AU (1) AU2021369508A1 (https=)
CA (1) CA3188316A1 (https=)
MX (1) MX2023003305A (https=)
TW (1) TW202227096A (https=)
WO (1) WO2022093930A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024229073A1 (en) * 2023-05-02 2024-11-07 Otsuka Pharmaceutical Co., Ltd. Response-based dosing for treating cancer with a hypomethylating agent and cedazuridine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200085848A1 (en) * 2018-09-19 2020-03-19 Otsuka Pharmaceutical Co., Ltd. Low dose combination cda substrate drug/cedazuridine with extended administration
WO2020196665A1 (en) * 2019-03-25 2020-10-01 Otsuka Pharmaceutical Co., Ltd. Antitumor composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200085848A1 (en) * 2018-09-19 2020-03-19 Otsuka Pharmaceutical Co., Ltd. Low dose combination cda substrate drug/cedazuridine with extended administration
WO2020196665A1 (en) * 2019-03-25 2020-10-01 Otsuka Pharmaceutical Co., Ltd. Antitumor composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOOD CANCER JOURNAL, vol. 33, no. 12, JPN6025046103, 2019, pages 2795 - 2804, ISSN: 0005728294 *
GUILLERMO GARCIA-MANERO ET AL.: ""Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross ov", BLOOD, vol. Vol.134，Supplement 1, JPN6025011865, 13 November 2019 (2019-11-13), pages 846, ISSN: 0005728293 *
MICHAEL R SAVONA ET AL.: ""An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multi", THE LANCET HAEMATOLOGY, vol. 6, JPN6025011866, April 2019 (2019-04-01), pages 194 - 203, ISSN: 0005775104 *

Also Published As

Publication number Publication date
WO2022093930A1 (en) 2022-05-05
EP4237094A4 (en) 2024-07-10
US20230405037A1 (en) 2023-12-21
EP4237094A1 (en) 2023-09-06
TW202227096A (zh) 2022-07-16
CN116018145A (zh) 2023-04-25
MX2023003305A (es) 2023-04-13
AU2021369508A1 (en) 2023-03-02
KR20230097034A (ko) 2023-06-30
CA3188316A1 (en) 2022-05-05

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