JP2023548005A - 抗トランスサイレチン抗体およびその使用方法 - Google Patents

抗トランスサイレチン抗体およびその使用方法 Download PDF

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Publication number
JP2023548005A
JP2023548005A JP2023521103A JP2023521103A JP2023548005A JP 2023548005 A JP2023548005 A JP 2023548005A JP 2023521103 A JP2023521103 A JP 2023521103A JP 2023521103 A JP2023521103 A JP 2023521103A JP 2023548005 A JP2023548005 A JP 2023548005A
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JP
Japan
Prior art keywords
seq
human subject
administering
antibody
antigen
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JP2023521103A
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English (en)
Japanese (ja)
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JP2023548005A5 (enExample
Inventor
キニー、ジーン
ザゴ、ワグナー
トリプラネニ、ラディカ
バード、フレデリック
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Novo Nordisk AS
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Novo Nordisk AS
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Publication of JP2023548005A publication Critical patent/JP2023548005A/ja
Publication of JP2023548005A5 publication Critical patent/JP2023548005A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2023521103A 2020-10-28 2021-10-28 抗トランスサイレチン抗体およびその使用方法 Pending JP2023548005A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063106853P 2020-10-28 2020-10-28
US202063106855P 2020-10-28 2020-10-28
US63/106,855 2020-10-28
US63/106,853 2020-10-28
US202063122720P 2020-12-08 2020-12-08
US63/122,720 2020-12-08
PCT/US2021/057150 WO2022094152A1 (en) 2020-10-28 2021-10-28 Anti-transthyretin antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2023548005A true JP2023548005A (ja) 2023-11-15
JP2023548005A5 JP2023548005A5 (enExample) 2024-10-31

Family

ID=81384336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023521103A Pending JP2023548005A (ja) 2020-10-28 2021-10-28 抗トランスサイレチン抗体およびその使用方法

Country Status (4)

Country Link
US (1) US20230391859A1 (enExample)
EP (1) EP4237005A4 (enExample)
JP (1) JP2023548005A (enExample)
WO (1) WO2022094152A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120641439A (zh) * 2022-11-15 2025-09-12 神经免疫有限公司 用于治疗或预防甲状腺素转运蛋白介导的淀粉样变性的方法
KR20260026033A (ko) * 2023-06-14 2026-02-25 이뮤트린 리미티드 항-원섬유 항체
TW202525341A (zh) 2023-12-15 2025-07-01 丹麥商諾佛 儂迪克股份有限公司 穩定的液體調配物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019532617A (ja) * 2016-07-02 2019-11-14 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017528449A (ja) * 2014-08-26 2017-09-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション アミロイドーシスのための標的化免疫療法
EP4137138A1 (en) * 2014-08-29 2023-02-22 Alnylam Pharmaceuticals, Inc. Methods of treating transthyretin (ttr) mediated amyloidosis
TWI718122B (zh) * 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
JP6896703B2 (ja) * 2015-07-31 2021-06-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＴＴＲ関連疾患を治療または予防するためのトランスサイレチン（ＴＴＲ）ｉＲＮＡ組成物およびその使用方法
JP7017013B2 (ja) * 2016-07-02 2022-02-08 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
US11382974B2 (en) * 2017-08-01 2022-07-12 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of amyloid deposition diseases
BR112020005287A2 (pt) * 2017-09-29 2020-09-24 Intellia Therapeutics, Inc. composições e métodos para edição de gene ttr e tratar amiloidose attr
AU2018375356A1 (en) * 2017-11-29 2020-05-14 Neotope Neuroscience Limited Lyophilized formulation of a monoclonal antibody against transthyretin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019532617A (ja) * 2016-07-02 2019-11-14 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AKIHIKO HOSOI ET AL.: "Novel Antibody for the Treatment of Transthyretin Amyloidosis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 291, no. 48, JPN6025049633, 2016, pages 25096 - 25105, ISSN: 0005749097 *
JACOB GEORGE ET AL.: "A novel monoclonal antibody targeting aggregated transthyretin facilitates its removal and functiona", EUROPEAN HEART JOURNAL, vol. 41, no. 12, JPN6025049632, 22 December 2019 (2019-12-22), pages 1260 - 1270, ISSN: 0005749098 *

Also Published As

Publication number Publication date
EP4237005A4 (en) 2024-10-09
WO2022094152A1 (en) 2022-05-05
US20230391859A1 (en) 2023-12-07
EP4237005A1 (en) 2023-09-06

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