JP2023544548A - 小分子金属キレート剤及び金属酸イオン交換組成物を使用して体液からイオンを除去するプロセス - Google Patents
小分子金属キレート剤及び金属酸イオン交換組成物を使用して体液からイオンを除去するプロセス Download PDFInfo
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Abstract
Description
本出願は、2020年9月30日に出願された、米国特許仮出願番号第63/085834号に対する優先権を主張し、その全体が本明細書に組み込まれている。
本発明は、体液から鉛及びイオンを除去するための体外プロセス又は体内プロセスに関する。血液又はその他の体液を、毒素を選択的に除去することが可能な金属酸イオン交換組成物及び小分子金属キレート剤と直接接触させる。小分子金属キレート剤は、細胞からイオンを除去するのに有効であり、その結果、金属酸イオン交換組成物は、鉛及びその他の金属イオンを吸収し得る。
Ar+ pMs+ 1-xM’t+ xSinOm
AmTiaNb1-aSixOy
式中、Aは、カリウムイオン、ナトリウムイオン、リチウムイオン、ルビジウムイオン、セシウムイオン、カルシウムイオン、マグネシウムイオン、ヒドロニウムイオン又はこれらの混合物からなる群から選択される交換可能な陽イオンであり、「m」は、Aの全金属(全金属=Ti+Nb)に対するモル比であり、0.10~2.00の値を有し、「a」は、Tiである全金属のモル分率であり、0.25~1の値を有し、「1-a」は、Nbである全金属のモル分率であり、0~0.75の値を有し、ここで、a+(1-a)=1であり、「x」は、Siの全金属に対するモル比であり、0.25~1.50の値を有し、「y」は、Oの全金属に対するモル比であり、2.55~7.38の値を有し、100%の相対強度で7Å~8Åのd間隔を有する少なくとも1つのピークを有するX線回折パターンを示す、毒鉄鉱構造、シチナカイト構造、これら2つの構造の連晶、又はこれらの混合物を有するという点を特徴とし、ここで、材料が毒鉄鉱構造を有する場合に、当該回折パターンは、少なくとも表Aに記載のピーク及びd間隔を有する、
Ar+ pMs+ 1-xM’t+ xSinOm
AmTiaNb1-aSixOy
式中、Aは、カリウムイオン、ナトリウムイオン、リチウムイオン、ルビジウムイオン、セシウムイオン、カルシウムイオン、マグネシウムイオン、ヒドロニウムイオン又はこれらの混合物からなる群から選択される交換可能な陽イオンであり、「m」は、Aの全金属(全金属=Ti+Nb)に対するモル比であり、0.10~2.00の値を有し、「a」は、Tiである全金属のモル分率であり、0.25~1の値を有し、「1-a」は、Nbである全金属のモル分率であり、0~0.75の値を有し、ここで、a+(1-a)=1であり、「x」は、Siの全金属に対するモル比であり、0.25~1.50の値を有し、「y」は、Oの全金属に対するモル比であり、2.55~7.38の値を有し、100%の相対強度で7Å~8Åのd間隔を有する少なくとも1つのピークを有するX線回折パターンを示す、毒鉄鉱構造、シチナカイト構造、これら2つの構造の連晶、又はこれらの混合物を有するという点を特徴とし、ここで、材料が毒鉄鉱構造を有する場合に、当該回折パターンは、少なくとも表Aに記載のピーク及びd間隔を有する、
以下を特定の実施形態と併せて説明するが、本明細書は、前述の説明及び添付の特許請求の範囲の範囲を例解するものであり、限定することを意図するものではないことが理解されよう。
AmTiaNb1-aSixOy
式中、Aは、リチウムイオン、カリウムイオン、ナトリウムイオン、ルビジウムイオン、セシウムイオン、カルシウムイオン、マグネシウムイオン、ヒドロニウムイオン又はこれらの混合物からなる群から選択される交換可能な陽イオンであり、「m」は、Aの全金属(全金属=Ti+Nb)に対するモル比であり、0.10~2.0の値を有し、「a」は、Tiである全金属のモル分率であり、0.25~1の値を有し、「1-a」は、Nbである全金属のモル分率であり、0~0.75の値を有し、ここで、a+(1-a)=1であり、「x」は、Siの全金属に対するモル比であり、0.25~1.50の値を有し、「y」は、Oの全金属に対するモル比であり、2.55~7.38の値を有し、100%の相対強度で7Å~8Åのd間隔を有する少なくとも1つのピークを有するX線回折パターンを示す、毒鉄鉱構造、シチナカイト構造、これら2つの構造の連晶、又はこれらの混合物のいずれかを有するという点を特徴とし、材料が毒鉄鉱構造を有する場合に、回折パターンは、少なくとも表Aに記載のピーク及びd間隔を有する
Ar+ pMs+ 1-xM’t+ xSinOm
式中、Aは、アルカリ金属、アルカリ土類金属、ヒドロニウムイオン、アンモニウムイオン、四級アンモニウムイオン、及びこれらの混合物からなる群から選択される交換可能な陽イオンであり、「r」は、Aの加重平均原子価であり、1~2まで変化し、「p」は、全金属(全金属=M+M’)に対するAのモル比であり、1~5まで変化し、「M」は、スカンジウム、イットリウム、ランタン、セリウム、プラセオジム、ネオジム、プロメチウム、サマリウム、ユーロピウム、ガドリニウム、テルビウム、ジスプロシウム、ホルミウム、エルビウム、ツリウム、イッテルビウム、及びルテチウム、並びにこれらの混合物からなる群から選択されるフレームワーク希土類金属であり、「s」は、Mの加重平均原子価であり、3~4まで変化し、「1-x」は、Mである全金属のモル分率であり、M’は、+2、+3、+4、又は+5の原子価を有するフレームワーク金属であり、「t」は、M’の加重平均原子価であり、2~5まで変化し、「x」は、M’である全金属のモル分率であり、0~0.99まで変化し、「n」は、Siの全金属に対するモル比であり、3~10の値を有し、「m」は、Oの全金属に対するモル比であり、
Claims (10)
- 体内に、Pb2+、Hg2+及び他の重金属毒素又はそれらの混合物のうちの少なくとも1種を有する個体から、前記毒素を除去するプロセスであって、ある量の小分子重金属キレート剤又はイオノフォアを前記個体に投与して、前記個体の骨及び軟組織内の細胞内で前記毒素を錯体化し、前記小分子重金属キレート剤又は前記イオノフォアと前記毒素とを含む錯体を形成し、前記錯体が前記細胞から前記個体の血流又は胃液に移動し、次に、前記錯体を含有する前記血流又は胃液をイオン交換体と接触させて、前記イオン交換体と前記体液との間のイオン交換によって前記流体から前記毒素を除去し、続いて前記イオン交換体を前記身体から除去することを含む、プロセス。
- 前記小分子重金属キレート剤が、2,3-ジメルカプトプロパノール、2,3-ジメルカプトコハク酸、エチレンジアミン四酢酸、グルタチオン、及びシステインから選択される、請求項1に記載のプロセス。
- 前記イオノフォアが、前記毒素の少なくとも1種を前記細胞の内部から前記血流へと運搬することが可能である、請求項1に記載のプロセス。
- 前記イオノフォアが、モネンシン、ピリチオン、ニゲリシン、イオノマイシン、及びカルシマイシンから選択される、請求項3に記載のプロセス。
- 前記イオノフォアが、前記個体の体重1kgあたり0.01~0.6mgの量で前記個体に投与される、請求項3に記載のプロセス。
- 前記イオン交換体が、
チタンシリケート及びニオビウム-チタンシリケート又はこれらの混合物から選択される結晶性金属酸イオン交換体であって、前記金属酸が、無水系における実験式を有し:
AmTiaNb1-aSixOy
式中、Aが、リチウムイオン、カリウムイオン、ナトリウムイオン、ルビジウムイオン、セシウムイオン、カルシウムイオン、マグネシウムイオン、ヒドロニウムイオン又はこれらの混合物からなる群から選択される交換可能な陽イオンであり、「m」が、Aの全金属(全金属=Ti+Nb)に対するモル比であり、0.10~2.0の値を有し、「a」が、Tiである全金属のモル分率であり、0.25~1の値を有し、「1-a」が、Nbである全金属のモル分率であり、0~0.75の値を有し、ここで、a+(1-a)=1であり、「x」が、Siの全金属に対するモル比であり、0.25~1.50の値を有し、「y」が、Oの全金属に対するモル比であり、2.55~7.38の値を有し、100%の相対強度で7Å~8Åのd間隔を有する少なくとも1つのピークを有するX線回折パターンを示す、毒鉄鉱構造、シチナカイト構造、これら2つの構造の連晶、又はこれらの混合物のいずれかを有するという点を特徴とし、前記材料が前記毒鉄鉱構造を有する場合に、前記回折パターンが、少なくとも表Aに記載の前記ピーク及びd間隔を有する、
- 前記イオン交換体が、無水系における実験式を有する希土類シリケート組成物であり:
Ar+ pMs+ 1-xM’t+ xSinOm
式中、Aが、アルカリ金属、アルカリ土類金属、ヒドロニウムイオン、アンモニウムイオン、四級アンモニウムイオン、及びこれらの混合物からなる群から選択される交換可能な陽イオンであり、「r」がAの加重平均原子価であり、1~2まで変化し、「p」が、全金属(全金属=M+M’)に対するAのモル比であり、1~5まで変化し、「M」が、スカンジウム、イットリウム、ランタン、セリウム、プラセオジム、ネオジム、プロメチウム、サマリウム、ユーロピウム、ガドリニウム、テルビウム、ジスプロシウム、ホルミウム、エルビウム、ツリウム、イッテルビウム、及びルテチウム、並びにこれらの混合物からなる群から選択されるフレームワーク希土類金属であり、「s」が、Mの加重平均原子価であり、3~4まで変化し、「1-x」が、Mである全金属のモル分率であり、M’が、+2、+3、+4、又は+5の原子価を有するフレームワーク金属であり、「t」が、M’の加重平均原子価であり、2~5まで変化し、「x」が、M’である全金属のモル分率であり、0~0.99まで変化し、「n」が、Siの全金属に対するモル比であり、3~10の値を有し、「m」が、Oの全金属に対するモル比であり、
- 前記体液が、全血、血漿、又は血液のその他の構成成分、胃腸液、及び血液、血漿、血液のその他の構成成分又は胃腸液を含有する透析溶液からなる群から選択される、請求項1に記載のプロセス。
- 前記イオン交換体が、膜に組み込まれた中空繊維中に充填される、又は前記イオン交換体が、セルロース誘導体組成物を含むコーティングでコーティングされた粒子上に含まれる、請求項1に記載のプロセス。
- 前記イオン交換体が、経口消化される成形物品に形成され、続いて前記イオン交換体と、哺乳動物の腸内の胃腸液に含有されている前記Pb2+毒素及びHg2+毒素と、の間でイオン交換し、次に、前記毒素を含有する前記イオン交換体を排出する、請求項1に記載のプロセス。
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