JP2023543137A - プライミング受容体で操作された免疫細胞 - Google Patents

プライミング受容体で操作された免疫細胞 Download PDF

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JP2023543137A
JP2023543137A JP2023514105A JP2023514105A JP2023543137A JP 2023543137 A JP2023543137 A JP 2023543137A JP 2023514105 A JP2023514105 A JP 2023514105A JP 2023514105 A JP2023514105 A JP 2023514105A JP 2023543137 A JP2023543137 A JP 2023543137A
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dna template
cell
receptor
cells
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アーロン クーパー
ミシェル グエン
アンジー ヤオ
スティーブン サントロ
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アーセナル バイオサイエンシズ インコーポレイテッド
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/42—Cancer antigens
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    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2501/20—Cytokines; Chemokines
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JP2023514105A 2020-08-28 2021-08-27 プライミング受容体で操作された免疫細胞 Withdrawn JP2023543137A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063072080P 2020-08-28 2020-08-28
US63/072,080 2020-08-28
PCT/US2021/048066 WO2022047237A1 (en) 2020-08-28 2021-08-27 Engineered immune cells with priming receptors

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JP2023543137A true JP2023543137A (ja) 2023-10-13
JP2023543137A5 JP2023543137A5 (https=) 2024-09-03
JPWO2022047237A5 JPWO2022047237A5 (https=) 2024-09-03

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US (1) US20230340409A1 (https=)
EP (1) EP4204575A4 (https=)
JP (1) JP2023543137A (https=)
KR (1) KR20230083275A (https=)
CN (1) CN116529364A (https=)
AU (1) AU2021334366A1 (https=)
CA (1) CA3191148A1 (https=)
IL (1) IL300994A (https=)
MX (1) MX2023002455A (https=)
WO (1) WO2022047237A1 (https=)

Families Citing this family (6)

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IL302315A (en) * 2020-10-26 2023-06-01 Arsenal Biosciences Inc Secure port sites
EP4496806A2 (en) * 2022-04-20 2025-01-29 Arsenal Biosciences, Inc. Cells comprising a suppressor of gene expression and/or a synthetic pathway activator and/or an inducible payload
AU2023272589A1 (en) * 2022-05-17 2025-01-09 Arsenal Biosciences, Inc. Systems of engineered receptors targeting psma and ca9
KR20250158048A (ko) 2023-03-03 2025-11-05 아스널 바이오사이언시스, 인크. Psma 및 ca9을 표적으로 하는 시스템
PE20252678A1 (es) * 2023-03-13 2025-11-24 Arsenal Biosciences Inc Activadores de vias sinteticas
CN121674486A (zh) * 2026-02-10 2026-03-17 潍坊吉涛医学科技有限公司 基于慢病毒载体的羊膜细胞永生化建系方法

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WO2018175636A2 (en) * 2017-03-22 2018-09-27 Novartis Ag Compositions and methods for immunooncology
MX2020004541A (es) * 2017-10-30 2021-04-12 Pact Pharma Inc Edicion de genes de celulas primarias.
EP3796894A4 (en) * 2018-04-24 2022-05-04 Ligandal, Inc. METHODS AND COMPOSITIONS FOR GENOMIC EDITING
CN110184301B (zh) * 2018-04-28 2023-02-24 辉大(上海)生物科技有限公司 通过Tild-CRISPR实现高效精确的靶向整合
AU2020355025A1 (en) * 2019-09-23 2022-04-07 Regents Of The University Of Minnesota Genetically-edited immune cells and methods of therapy
IL302315A (en) * 2020-10-26 2023-06-01 Arsenal Biosciences Inc Secure port sites
JP2024512608A (ja) * 2021-03-24 2024-03-19 ジェネンテック， インコーポレイテッド Ｔリンパ球における効率的なｔｃｒ遺伝子編集
CA3227759A1 (en) * 2021-08-11 2023-02-16 Sebastien Levesque Mtor-targeted modification and uses thereof

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AU2021334366A1 (en) 2023-05-11
EP4204575A1 (en) 2023-07-05
IL300994A (en) 2023-04-01
MX2023002455A (es) 2023-05-16
EP4204575A4 (en) 2025-07-09
AU2021334366A9 (en) 2024-06-13
CA3191148A1 (en) 2022-03-03
KR20230083275A (ko) 2023-06-09
US20230340409A1 (en) 2023-10-26
CN116529364A (zh) 2023-08-01
WO2022047237A1 (en) 2022-03-03

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