JP2023540184A - Compositions and methods - Google Patents

Abstract

The present invention provides aerosol-generating materials for use in aerosol generation. The aerosol-generating material includes from about 10 to about 50% by weight caffeine, from about 15 to about 60% by weight gelling agent, and from about 10 to about 50% by weight aerosol-forming material; is calculated on a dry weight basis. [Selection diagram] None

Description

The present invention relates to aerosol generation for the delivery of caffeine. The present invention also relates to compositions for oral delivery of caffeine.

background

Smoking articles, such as cigarettes and cigars, burn tobacco and produce tobacco smoke during use. An alternative to these types of articles is to release the compound from the substrate material by heating without combustion, thereby releasing an inhalable aerosol or vapor. These are sometimes referred to as non-combustible smoking articles, aerosol generating assemblies, or non-combustible aerosol delivery systems.

An example of such a product is a heating device that releases a compound by heating, but not burning, a solid aerosolizable material. This solid aerosolizable material may include tobacco material in some examples. The heating volatilizes at least one component of the material, typically forming an inhalable aerosol. These products are sometimes referred to as heat not burn devices, tobacco heating devices, or tobacco heating products (THPs). A variety of different configurations are known for volatilizing at least one component of a solid aerosolizable material.

Another example is an electronic cigarette/tobacco heated product hybrid device, also known as an electronic cigarette hybrid device. These hybrid devices include a liquid source (which may or may not contain nicotine) that is vaporized by heating to produce an inhalable vapor or aerosol. The device further includes a solid aerosolizable material (which may or may not include tobacco material), the components of which are entrained in an inhalable vapor or aerosol to produce an inhalation medium. do.

overview

In a first aspect, an aerosol-generating material for use in aerosol generation is provided. This aerosol-generating material is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material;
, where the weight percent values are calculated on a dry weight basis.

In a second aspect, an aerosol-generating composition comprising the aerosol-generating material of the first aspect is provided.

In a third aspect, a consumable for use in a non-combustible aerosol delivery device is provided. The consumable includes the aerosol-generating composition of the second aspect.

In a fourth aspect, there is provided a non-combustible aerosol delivery system comprising the consumable of the third aspect and a non-combustible aerosol delivery device.

In a fifth aspect, a composition for oral delivery of caffeine is provided. This composition is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
about 10 to about 50% by weight of a humectant;
, where the weight percent values are calculated on a dry weight basis.

In a sixth aspect there is provided a method of forming an aerosol-generating material of the first aspect or a composition as defined in the fifth aspect. This method is
(a) providing a slurry comprising caffeine, a gelling agent, an aerosol-forming material or humectant, a solvent, and any further components of the aerosol-forming material or composition;
(b) forming a layer of slurry;
(c) optionally solidifying the layer of slurry;
(d) drying the slurry to form an aerosol-generating material or composition;
Equipped with

In a seventh aspect, a slurry is provided. This slurry is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material (wherein weight % values are calculated on a dry weight basis);
a solvent;
including.

The aerosol-forming material in the aerosol-generating material used for aerosol generation is the same as the humectant in the composition for oral delivery of caffeine.

Features described herein in connection with one aspect of the invention are expressly disclosed in combination with each other aspect, insofar as they are combinable.

Further aspects of the invention described herein may provide for the use of aerosol-generating materials, aerosol-generating compositions, consumables or non-combustible aerosol delivery systems in the production of inhalable aerosols.

Further features and advantages of the invention will become apparent from the following description, which is given by way of example only and refers to the accompanying drawings, in which: FIG.

FIG. 2 is a cross-sectional view of an example of a consumable item. FIG. 2 is a perspective view of the consumable of FIG. 1; FIG. 2 is a cross-sectional elevational view of an example of a consumable item. FIG. 4 is a perspective view of the consumable of FIG. 3; FIG. 1 is a perspective view of an example of a non-combustion aerosol delivery system. FIG. 1 is a cross-sectional view of an example of a non-combustion aerosol delivery system. FIG. 1 is a perspective view of an example of a non-combustion aerosol delivery system. It is an exploded view of an example of a consumable item. 1 is an example of a consumable product that includes multiple discrete portions of aerosol-generating material.

detailed description

As mentioned above, provided herein are aerosol-generating materials for use in aerosol generation. This aerosol-generating material is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material;
, where the weight percent values are calculated on a dry weight basis.

Also provided are compositions for oral delivery of caffeine. The composition includes an aerosol-generating material, the aerosol-generating material comprising:
about 10 to about 50% by weight caffeine,
It contains about 15 to about 60 weight percent gelling agent and about 10 to about 50 weight percent humectant, where weight percent values are calculated on a dry weight basis.

The aerosol-generating material may form part of the aerosol-generating composition. An aerosol-generating composition is a material capable of producing an aerosol when energized, for example, by heating, irradiation, or any other method.

The aerosol-generating material may be an "amorphous solid." In some embodiments, the aerosol-generating material comprises an aerosol-generating film that is an amorphous solid. In some embodiments, the amorphous solid is a "monolithic solid." Aerosol-generating materials can be non-fibrous or fibrous. For example, the aerosol-generating material may be substantially non-fibrous. In some embodiments, the aerosol-generating material may be a dry gel. The aerosol-generating material may be a solid material capable of retaining some fluid within it, such as a liquid. In some embodiments, the retained fluid may be water (such as water absorbed from the surroundings of the aerosol-generating material) or the retained fluid may be a solvent (such as water absorbed from the surroundings of the aerosol-generating material), (e.g., when the In some embodiments, the solvent may be water.

In some embodiments, the aerosol-generating composition comprises, for example, from about 50%, 60%, or 70% by weight aerosol-generating material to about 90%, 95% by weight, based on the weight of the aerosol-generating composition. %, or 100% by weight of aerosol-generating material. These weight percent values are calculated on a wet weight basis (WWB), ie, including any water or other solvent present in the aerosol-generating composition or material.

In some embodiments, the aerosol-generating composition consists of an aerosol-generating material.

In some embodiments, the aerosol-generating material and/or aerosol-generating composition comprises a gelling agent, a solvent, an aerosol-forming material, caffeine, and optionally a flavoring agent, and/or an optional additional active agent, and/or Optionally consists essentially of or consists of fillers.

In some examples, the aerosol-generating material and/or aerosol-generating composition consists essentially of or consists of a gelling agent, a solvent, an aerosol-forming material, and caffeine.

In some embodiments, the aerosol-generating material and/or aerosol-generating composition comprises a gelling agent, water, an aerosol-forming material, caffeine, and optionally a flavoring agent, and/or an optional additional active agent, and/or Optionally consists essentially of or consists of fillers.

In some examples, the aerosol-generating material and/or aerosol-generating composition consists essentially of or consists of a gelling agent, water, an aerosol-forming material, and caffeine.

In some embodiments, the aerosol-generating material is a hydrogel and contains less than about 20% water by weight calculated on a wet weight basis. In some examples, the hydrogel may include less than about 15%, 12%, or 10% water, calculated on a wet weight basis (WWB). In some examples, the hydrogel may include at least about 1%, 2%, or at least about 5% water (WWB) by weight.

In some embodiments, the aerosol-generating material may contain less than about 20% water, such as less than about 15%, 12%, or 10% by weight, calculated on a wet weight basis (WWB). good. For example, the aerosol-generating material may include about 1-15% water by weight on a wet weight basis (WWB), such as 3-12% water. In some embodiments, the aerosol-generating material may include about 1-5% water by weight on a wet weight basis (WWB).

Caffeine Suitably, the aerosol-generating material contains about 10% to about 50% caffeine, such as about 20%, 25%, or 30% to about 45%, 40%, or May contain 35% by weight caffeine (all calculated on a dry weight basis). For example, the aerosol generating material may contain about 20-50%, about 20-45%, about 20-40%, about 25-40%, about 25-35%, or about 30-35% by weight. May contain caffeine.

Caffeine may be extracted from botanical sources including coffee beans.

We found that caffeine has limited solubility in the solutions used in liquid e-smoking delivery systems, meaning that such systems are unable to deliver high levels of caffeine. I found out that there is. The use of aerosol-generating materials may allow for the incorporation of higher levels of caffeine and therefore the delivery of larger amounts of caffeine to the user.

Gelling Agent Suitably, the aerosol-generating material comprises about 15% to about 60% gelling agent, such as about 20%, 25%, or 30% to about 60%, 50% by weight. , 45%, 40%, or 35% by weight of gelling agent (all calculated on a dry weight basis). For example, the aerosol-generating material may include about 20-50%, 25-45%, or 30-40% gelling agent by weight.

In some embodiments, the aerosol-generating material may include about 30-50% by weight gelling agent.

In some embodiments, the gelling agent includes a hydrocolloid.

In some embodiments, the gelling agent is a polysaccharide gelling agent, such as alginate, pectin, starch or its derivatives, cellulose or its derivatives, pullulan, carrageenan, agar and agarose, gelatin, gums such as xanthan gum, guar gum. and gum acacia, silica or silicone compounds such as PDMS and sodium silicates, clays such as kaolin, and polyvinyl alcohol.

In some embodiments, the gelling agent comprises (or is) one or more polysaccharide gelling agents.

In some embodiments, the polysaccharide gelling agent is selected from alginates, pectins, starches or derivatives thereof, or cellulose or derivatives thereof. In some embodiments, the polysaccharide gelling agent is selected from alginates and cellulose derivatives.

In some embodiments, the gelling agent is a polysaccharide gelling agent, and optionally the polysaccharide gelling agent is selected from alginates and cellulose derivatives.

In some embodiments, the alginate is sodium alginate.

In some embodiments, the polysaccharide gelling agent is a cellulose derivative. While not wishing to be bound by theory, the inventors believe that such gelling agents do not react with calcium ions to form crosslinks.

In some embodiments, the polysaccharide gelling agent is an alginate.

In some instances, the gelling agent is not crosslinked. The absence of crosslinks in the gelling agent facilitates faster delivery of caffeine (as well as any additional actives and/or flavors) from the aerosol-generating material.

Examples of cellulosic gelling agents (sometimes referred to herein as cellulose derivatives) include, but are not limited to, hydroxylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC) , hydroxypropyl methylcellulose (HPMC), methylcellulose, ethylcellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose or derivative thereof is hydroxylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC), methylcellulose, ethylcellulose, cellulose acetate (CA), cellulose acetate butyrate. (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose derivative is CMC.

For example, in some embodiments, the gelling agent is alginate, pectin, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, pullulan, xanthan gum guar gum, carrageenan, agarose, acacia gum, fumed silica, PDMS, sodium silicate, Contains (or is) one or more of kaolin, and polyvinyl alcohol.

In some embodiments, the gelling agent comprises (or is) one or more of hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, guar gum, gum acacia, alginate, and/or pectin.

In some examples, the gelling agent includes (or is) alginate and/or pectin and may be combined with a solidifying or crosslinking agent (such as a calcium source) during formation of the aerosol-generating material. In some examples, the aerosol generating material may include calcium cross-linked alginate and/or calcium cross-linked pectin.

In some embodiments, the gelling agent comprises (or is) an alginate, and optionally the alginate comprises about 15-50%, such as about 25-45% (dry weight) of the aerosol-generating material. present in the aerosol-generating material in an amount (calculated on the standard).

In some embodiments, alginate is the only gelling agent present in the aerosol-generating material.

In other embodiments, the gelling agent comprises alginate and at least one additional gelling agent, such as pectin.

In certain embodiments, the gelling agent is carboxymethylcellulose (CMC) in an amount of about 15-50% by weight, such as about 25-45%, or about 30% by weight. exist. In some embodiments, CMC is the only gelling agent present in the aerosol-generating material.

Aerosol-forming materials Aerosol-forming materials may include one or more components capable of forming an aerosol.

Suitably, the aerosol-generating material comprises from about 10% to about 50% by weight of the aerosol-forming material (calculated on a dry weight basis), such as from about 20% to 50%, or about 10%, 20% by weight. , or from 30% to about 45%, 40%, 35%, 30%, or 25% by weight of the aerosol-forming material. For example, the aerosol-generating material may include about 10-50%, about 20-45%, about 25-40%, or about 30-35% by weight of the aerosol-forming material.

In some embodiments, the aerosol-forming material is glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, suberic acid. It may include one or more of diethyl, triethyl citrate, triacetin, diacetin mixtures, benzyl benzoate, benzylphenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

In some embodiments, the aerosol-forming material may include one or more of erythritol, propylene glycol, glycerol, and triacetin. In some examples, the aerosol-forming material consists essentially of or consists of glycerol, optionally in combination with propylene glycol.

Aerosol-forming materials may act as plasticizers. If the plasticizer content is too high, the aerosol-generating material may absorb water, resulting in a material that does not create a suitable consumption experience when used. If the content of plasticizer is too low, the aerosol-generating material may become brittle and break easily. The plasticizer content specified herein provides aerosol-generating material flexibility that allows a sheet of aerosol-generating material or aerosol-generating composition to be wound onto a bobbin, which can be applied to aerosol-generating articles (consumables). ) is useful in the production of

The aerosol-generating composition may further comprise one or more additional actives and/or fragrances, and optionally one or more other functional materials.

In some embodiments, the aerosol-generating composition may further include one or more other functional materials.

In some embodiments, the aerosol-generating material may further include one or more additional actives and/or fragrances, and optionally one or more other functional materials.

In some embodiments, the aerosol-generating material may further include one or more other functional materials.

Additional Active Materials In certain embodiments, caffeine is the only active material present in the aerosol-generating material. In certain embodiments, caffeine may be the only active material present in the aerosol generating composition. However, the aerosol-generating material and/or aerosol-generating composition may further comprise further active ingredients.

In some examples, the aerosol-generating material, in addition to caffeine, contains about 1%, 5%, 10%, 15%, 20%, or 25% to about 65%, 60% by weight. %, 50%, 45%, 40%, 35%, or 30% (calculated on a dry weight basis) of another active substance.

Further active substances as used herein are bioactive materials, ie materials for achieving or enhancing a physiological response. Further active substances may be selected from, for example, functional foods, nootropic substances and psychoactive substances. Further active substances can be naturally occurring or synthetically obtained. Further active substances may include, for example, nicotine, taurine, thein, vitamins (B6, B12, C, etc.), melatonin, cannabinoids, or components, derivatives or combinations thereof. Further active substances may include one or more components, derivatives or extracts of tobacco, hemp or other botanical materials.

In one embodiment, the active substance is a legally acceptable recreational drug.

In some embodiments, the additional active agent includes nicotine. In some embodiments, the additional active agent includes melatonin or vitamin B12.

As mentioned above, further active substances may include one or more components, derivatives or extracts of hemp, for example one or more cannabinoids or terpenes.

The active substance may be CBD or a derivative thereof.

Cannabinoids are a class of natural or synthetic compounds that act on intracellular cannabinoid receptors (ie, CB1 and CB2) that suppress neurotransmitter release in the brain. Cannabinoids can be found naturally in plants such as hemp (phytocannabinoids), naturally found in animals (endocannabinoids), or artificially produced (synthetic cannabinoids). Good too. Hemp species express at least 85 different phytocannabinoids, divided into subclasses including cannabigerol, cannabichromene, cannabidiol, tetrahydrocannabinol, cannabinol and cannabinodiol, as well as other cannabinoids. Cannabinoids found in hemp include, but are not limited to, cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabinol (CBN). , cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevaline (CBCV), cannabigerovarin (CBGV), Nabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), cannabinolpropyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinolic acid (THCA), and tetrahydrocannabivaric acid (THCV) A) is mentioned.

As described herein, further active substances may include or be derived from one or more botanical materials or components, derivatives or extracts thereof. As used herein, the term "plant material" includes any material derived from plants, including, but not limited to, extracts, leaves, bark, fibers, stems, roots, etc. , including seeds, flowers, fruits, pollen, shells, skins, etc. Alternatively, the material may contain active compounds that occur naturally in plant materials or are obtained synthetically. The material may be in the form of a liquid, gas, solid, powder, dust, crushed particles, granules, pellets, fragments, strips, sheets, etc. Examples of botanical materials are tobacco, eucalyptus, star anise, hemp, cacao, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba extract, hazel, hibiscus. , laurel, licorice, matcha, yerba mate, orange peel, papaya, rose, sage, tea (green tea, black tea, etc.), thyme, clove, cinnamon, coffee, aniseed (aniseed), basil, bay leaf, cardamom, coriander, cumin, nutmeg , oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, wintergreen, perilla, turmeric, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian. , pimento, mace, damian, marjoram, olive, lemon balm, lemon basil, chives, kalvi, verbena, tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab, or Any combination. Mint comes from the following mint varieties: mentha arvensis, grapefruit mint (Mentha c.v.), Egyptian mint (Mentha niliaca), peppermint (Mentha piperita), lime mint (Mentha piperita citrata). c.v.) , chocolate mint (Mentha piperita c.v.), curly mint (Mentha spicata crispa), wild mint (Mentha cordifolia), horse mint (Mentha longifolia), pineapple mint (Mentha suaveolens) variegata), pennyroyal mint (Mentha pulegium), It may be selected from English spearmint (Mentha spicata c.v.) and apple mint (Mentha suaveolens).

In some embodiments, the additional active agent comprises or is derived from one or more botanicals or components, derivatives or extracts thereof, and the botanical is tobacco.

In some embodiments, the additional active agent comprises or is derived from one or more botanicals or components, derivatives or extracts thereof, wherein the botanicals include eucalyptus, star anise, cocoa, and hemp. selected from. In some embodiments, the additional active agent comprises (or is) a botanical material selected from eucalyptus, star anise, cacao, and hemp.

In some embodiments, the additional active agent comprises or is derived from one or more botanical substances or components, derivatives or extracts thereof, and the botanical substances are selected from rooibos and fennel. In some embodiments, the additional active agent comprises (or is) a botanical material selected from rooibos and fennel.

In some embodiments, the aerosol-generating material is substantially free of botanical material. In some embodiments, the aerosol-generating material does not include botanical material.

In some embodiments, the aerosol generating composition is substantially free of botanical material. In some embodiments, the aerosol generating composition is free of botanical material. For example, in some instances, the aerosol-generating material further includes tobacco material and/or nicotine. In some examples, the aerosol-generating material may include 5-60% by weight (calculated on a dry weight basis) tobacco material and/or nicotine.

In some examples, the aerosol-generating material is from about 1%, 5%, 10%, 15%, 20%, or 25% to about 65%, 60%, 50%, by weight, It may contain 45%, 40%, 35%, or 30% (calculated on a dry weight basis) of tobacco material by weight. For example, the aerosol-generating material may include up to about 50% by weight tobacco material. For example, the aerosol-generating material may include about 10-50%, 15-40%, or 20-35% tobacco material by weight. In some examples, the aerosol-generating material ranges from about 1%, 2%, 3%, or 4% to about 20%, 18%, 15%, or 12% (dry weight basis) by weight. may contain nicotine (calculated by ). For example, the aerosol-generating material may include about 1-20%, 2-18%, or 3-12% nicotine by weight.

In some examples, the aerosol-generating material includes an additional active agent, such as tobacco extract. In some examples, the aerosol-generating material may include 5-60% by weight (calculated on a dry weight basis) tobacco extract. In some examples, the aerosol-generating material is about 5%, 10%, 15%, 20%, or 25% to about 60%, 50%, 45%, 40%, by weight, It may contain 35% by weight, or 30% by weight (calculated on a dry weight basis) of tobacco extract. For example, the aerosol-generating material may include about 10-50%, 15-40%, or 20-35% tobacco extract by weight. The tobacco extract contains from about 1%, 1.5%, 2%, or 2.5% to about 6%, 5%, 4.5%, or 4% by weight of the aerosol-generating material. nicotine (calculated on a dry weight basis). In some instances, no nicotine other than that derived from any tobacco extract may be present in the aerosol-generating material.

In some embodiments, the aerosol-generating material does not include tobacco material, but does include nicotine. In some such examples, the aerosol-generating material comprises about 1%, 2%, 3%, or 4% by weight to about 20%, 18%, 15%, or 12% (by weight). nicotine (calculated on a dry weight basis). For example, the aerosol-generating material may include about 1-20%, 2-18%, or 3-12% nicotine by weight.

In some embodiments, the aerosol-generating material and aerosol-generating composition do not include tobacco material (including tobacco extract) or nicotine.

In some embodiments, the aerosol-generating material is substantially free of tobacco. In some embodiments, the aerosol-generating material is tobacco-free.

In some embodiments, the aerosol generating composition is substantially free of tobacco. In some embodiments, the aerosol generating composition is tobacco-free.

In some embodiments, the aerosol-generating material does not include tobacco fibers. In certain embodiments, the aerosol-generating material does not include fibrous material.

In some embodiments, the aerosol generating composition does not include tobacco fibers. In certain embodiments, the aerosol generating composition is free of fibrous material.

Fragrance The aerosol-generating material and/or aerosol-generating composition may optionally include a fragrance. For example, the aerosol-generating material may include up to about 65%, 55%, 50%, or 45% fragrance by weight. In some examples, the aerosol-generating material contains at least about 0.1%, 1%, 10%, 20%, 30%, 35%, or 40% fragrance (all on a dry weight basis). ) may also be included. For example, the aerosol-generating material may include 1-65%, 10-65%, 20-50%, or 30-40% perfume.

As used herein, the terms "fragrance" and "flavoring agent" are used to create a desired taste, aroma, or other somatic sensation in products intended for adult consumers where local regulations permit. Refers to materials that can be used. They may be naturally occurring flavoring materials, botanical materials, extracts of botanical materials, synthetically obtained materials, or combinations thereof (e.g. tobacco, hemp, licorice, hydrangea, eugenol, magnolia leaf, chamomile, Fenugreek, cloves, maple, matcha, menthol, Japanese peppermint, aniseed, cinnamon, turmeric, Indian spice, Asian spice, herbs, wintergreen, cherry, berry, red berry, cranberry, peach, apple, orange, mango , clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus, Drambuie, bourbon, scotch, whiskey, gin, tequila, rum, spearmint, peppermint , lavender, aloe vera, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, khat, naswar, betel, shisha, pine, honey essence, rose oil, vanilla, Obtained from any variety of the genus lemon oil, orange oil, orange blossom, cherry blossom, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, wasabi, green pepper, ginger, coriander, coffee, hemp, mint. mint oil, eucalyptus, star anise, cacao, lemongrass, rooibos, flax, ginkgo, hazel, hibiscus, laurel, yerba mate, orange peel, rose, tea (green tea, black tea, etc.), thyme, juniper, elderflower, basil , bay leaf, cumin, oregano, paprika, rosemary, saffron, lemon peel, mint, perilla, curcuma, cilantro, myrtle, blackcurrant, valerian, pimento, mace, damien, marjoram, olive, lemon balm, lemon basil, chives, calvi, verbena, tarragon, limonene, thymol, camphene), flavor enhancers, bitter receptor site blockers, sensory receptor site activators, or stimulants, sugars and/or sugar substitutes (e.g. sucralose, acesulfame potassium, aspartame, saccharin, cyclamate, lactose, sucrose, glucose, fructose, sorbitol, or mannitol), as well as other additives such as charcoal, chlorophyll, minerals, botanical materials, or breath fresheners. They may be imitation, synthetic, or natural ingredients, or blends thereof. They may be in any suitable form, for example liquid (such as an oil), solid (such as a powder), or gas.

In some embodiments, the flavor includes menthol, spearmint, and/or peppermint.

In some embodiments, the flavor comprises cucumber, blueberry, citrus fruit, and/or red berry flavor ingredients.

In some embodiments, the fragrance includes eugenol.

In some embodiments, the flavor comprises flavor components extracted from tobacco.

In some embodiments, the flavor comprises flavor components extracted from hemp.

In some embodiments, the fragrance is typically chemically induced by stimulating the fifth cranial nerve (trigeminal nerve), in addition to or in place of the olfactory or gustatory nerves, and the perceived somatosensation These may include agents that provide a heating effect, a cooling effect, a tingling effect, a numbing effect. Suitable thermal effect agents may include, but are not limited to, vanillyl ethyl ether, and suitable coolants include, but are not limited to, eucalyptol or It may also be WS-3 (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide).

In certain examples, the flavor comprises, consists essentially of, or consists of coffee.

In some embodiments, the flavoring includes coffee and/or tea, such as green tea or black tea. In some embodiments, the flavor comprises flavor components extracted from coffee and/or tea, such as green or black tea.

In some instances, the aerosol-generating material may further include an emulsifier, which emulsifies the molten fragrance during manufacture. For example, the aerosol-generating material may include from about 5% to about 15% by weight emulsifier (calculated on a dry weight basis), preferably about 10% by weight. The emulsifier may include gum acacia.

In some embodiments, the total content of additional actives and/or fragrances is at least about 0.1%, 1%, 5%, 10%, 20%, 25%, or It may be 30% by weight. In some instances, the total content of additional actives and/or fragrances may be less than about 60%, 50%, or 40% by weight (all calculated on a dry weight basis).

In some examples, the total content of tobacco material, nicotine, and/or flavoring is at least about 0.1%, 1%, 5%, 10%, 20%, 25%, or 30% by weight. It may be %. In some instances, the total content of tobacco material, nicotine, and/or flavoring may be less than about 60%, 50%, or 40% by weight (all calculated on a dry weight basis).

Other Functional Materials The one or more other functional materials may include one or more of pH modifiers, colorants, preservatives, fillers, stabilizers, and/or antioxidants.

In some embodiments, the other functional material includes (or is) a filler.

In some embodiments, the aerosol-generating material comprises less than about 65% filler, such as about 1% to 60%, or 5% to 50%, or 5% to 30%, by weight; Alternatively, it may contain 10% to 20% by weight of filler.

In other embodiments, the aerosol-generating material comprises less than 20%, preferably less than 10%, or less than 5% filler by weight. In some examples, the aerosol-generating material includes less than 1% by weight filler, and in some examples, the aerosol-generating material does not include filler.

If present, the filler may be one or more inorganic filler materials such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulfate, magnesium carbonate, and a suitable inorganic adsorbent (molecular sieve). ) may also be included. The filler may be one or more organic filler materials, such as wood pulp, tobacco pulp, hemp fibers, starch and starch derivatives, such as maltodextrin, chitosan, cellulose and cellulose derivatives, such as ground cellulose, microcrystalline cellulose and nanocrystalline cellulose. May include. In certain examples, the aerosol-generating material does not include calcium carbonate, such as chalk.

As those skilled in the art will appreciate, crystalline cellulose can be formed by depolymerizing cellulose by chemical processes (eg, using acids or enzymes). One example of a method for forming crystalline cellulose includes acid hydrolysis of cellulose using an acid such as HCl. The cellulose produced after this treatment is crystalline (ie, no amorphous regions remain). Suitable methods and conditions for forming crystalline cellulose are well known in the art.

In certain embodiments that include fillers, the fillers are fibrous. For example, the filler may be a fibrous organic filler material such as wood pulp, tobacco pulp, hemp fibers, cellulose or cellulose derivatives. In some embodiments, the fibrous organic filler material is wood pulp, hemp fiber, cellulose or cellulose derivatives. In some embodiments, the fibrous filler is wood pulp. While not wishing to be bound by theory, it is believed that including fibrous fillers in the aerosol-generating material can increase the tensile strength of the material. This may be particularly advantageous in instances where the aerosol-generating material is provided as a sheet, for example when the sheet of aerosol-generating material surrounds a rod of aerosolizable material.

In some embodiments, the aerosol generating article does not include tobacco fibers. In certain embodiments, the aerosol generating article does not include fibrous material.

In some embodiments, the aerosol-generating material is formed as a sheet. In some examples, the sheet of aerosol-generating material may be incorporated into a non-combustible aerosol delivery system or consumable in sheet form. The aerosol-generating material sheet may be incorporated as a flat sheet, as a gathered or pleated sheet, as a corrugated sheet, or as a rolled sheet (ie, in the form of a tube). In some such instances, the aerosol-generating material of these embodiments is provided as a sheet, e.g., an aerosolizable or aerosol-generating material (tobacco, or tobacco and an aerosol-generating material such as those described herein). may be included in the system/consumables as a sheet surrounding the rods (such as combinations of). For example, a sheet of aerosol-generating material may be formed on a wrapper surrounding an aerosolizable material such as tobacco. In other examples, the sheet may be shredded and then incorporated into an assembly, preferably mixed into an aerosolizable material such as shredded rag tobacco.

In some examples, the aerosol-generating material may be in the form of a sheet or layer having a thickness of about 0.015 mm to about 1.0 mm. Suitably, the thickness ranges from about 0.05 mm, 0.1 mm, or 0.15 mm to about 0.5 mm, or 0.3 mm, such as from 0.1 to 3 mm, or from 0.15 to 0.3 mm. It may be. Materials with a thickness of 0.2 mm may be particularly suitable. The aerosol-generating material may comprise two or more layers, and the thicknesses described herein refer to the total thickness of these layers.

If the aerosol generating material is too thick, heating efficiency may be compromised. This has a negative impact on power consumption during use. Conversely, if the aerosol-generating material is too thin, it may be difficult to manufacture and handle. That is, very thin materials are more difficult to cast and are also more fragile, which can impair aerosol formation during use.

The thickness specified herein is the average thickness of the material. In some examples, the thickness of the aerosol-generating material may vary by less than 25%, 20%, 15%, 10%, 5%, or 1%.

In some examples, the aerosol-generating material in sheet form may have a tensile strength of about 200 N/m to about 2000 N/m. In some examples, the aerosol-generating material in sheet form may have a tensile strength of about 200 N/m to about 900 N/m. In some instances, such as instances where the aerosol-generating material does not include a filler, the aerosol-generating material in sheet form is about 200 N/m to about 400 N/m, or about 200 N/m to about 300 N/m, or about 250 N/m. /m. Such tensile strength may be particularly suitable for embodiments in which the aerosol-generating material and/or aerosol-generating composition is formed as a sheet and then shredded and incorporated into a consumable. In some instances, such as instances where the aerosol-generating material includes a filler, the aerosol-generating material has a tensile strength of about 600 N/m to about 900 N/m, or about 700 N/m to about 900 N/m, or about 800 N/m. It may have strength. Such tensile strength is particularly suitable for embodiments in which the aerosol-generating material and/or aerosol-generating composition is included in the consumable/non-combustible aerosol delivery system as a rolled sheet, preferably in the form of a tube. It can be.

The aerosol-generating composition comprising the aerosol-generating material may have any suitable areal density, for example from 30 g/m ² to 120 g/m ² . In some examples, the aerosol-generating composition has a unit area of 80-120 g/m ² , or about 70-110 g/m ² , or especially about 90-110 g/m ² , or suitably about 100 g/m ² (so that the sheet has a density similar to shredded rag tobacco and mixtures of these materials do not separate easily). Such areal densities may be particularly suitable when the aerosol-generating composition is included in an assembly consumable/system in sheet form or as shredded sheets (discussed further below). In some examples, the aerosol-generating composition may have a mass per unit area of about 30-70 g/m ² , 40-60 g/m ² , or 25-60 g/m ² may be used to surround the material that can be made into a material.

The aerosol-generating material used for aerosol generation may be present on or in a support to form a substrate. The support may be or include, for example, paper, card, cardboard, cardboard, recycled materials, plastic materials, ceramic materials, composite materials, glass, metal, or metal alloys. In some embodiments, the support comprises a susceptor. In some embodiments, the susceptor is incorporated within the material. In some alternative embodiments, the susceptor is on one or both sides of the material.

The aerosol-generating composition may include a carrier on which the aerosol-generating material is provided. The carrier serves as a support on which the aerosol-generating material layer is formed and facilitates manufacturing. The carrier can provide tensile strength to the aerosol-generating material layer and facilitate handling.

In some examples, the carrier is formed from a material selected from metal foil, paper, carbon paper, greaseproof paper, ceramic, carbon allotropes (e.g., graphite and graphene), plastic, cardboard, wood, or combinations thereof. Good too. In some examples, the carrier may include or consist of tobacco material (such as a sheet of reconstituted tobacco). In some examples, the carrier may be formed from a material selected from metal foil, paper, cardboard, wood, or combinations thereof. In some examples, the carrier itself is a laminate structure comprising multiple layers of materials selected from the list above. In some instances, the carrier can also function as a perfume carrier. For example, the carrier may be impregnated with flavor or tobacco extract.

In some examples, the carrier may be magnetic. This feature may be used to secure the carrier to a non-combustible aerosol delivery device during use, or may be used to create a specific aerosol-generating material shape. In some examples, the aerosol generating composition may include one or more magnets that can be used to secure the material to the induction heater during use.

In some examples, the carrier may be substantially or completely impermeable to gases and/or aerosols. This prevents the aerosol or gas from passing through the carrier layer, thereby controlling the flow and ensuring that the aerosol or gas is delivered to the user. This can also be utilized to prevent gases/aerosols from forming condensation or other deposits during use, for example on the surfaces of heaters provided within the aerosol generation assembly. In this way, consumption efficiency and hygiene can be improved in some instances.

In some examples, the surface of the carrier that contacts the aerosol-generating material may be porous. For example, in some instances, the carrier includes paper. Porous carriers such as paper have been found to be particularly suitable, with the porous (eg paper) layer abutting the aerosol-generating material layer and forming a strong bond. The aerosol-generating material may be formed by drying a gel, and, without being limited by theory, the gel-forming slurry may be partially impregnated into a porous carrier (e.g., paper). , so that the carrier is believed to be partially bound to the gel when it solidifies. This results in a strong bond between the gel and the carrier (and between the dry gel and the carrier).

In some embodiments, the aerosol-generating material may be laminated to a carrier such as a paper sheet.

In some embodiments, when an aerosol-generating material is formed from a slurry as described herein, a layer of slurry may be formed on a carrier such as a paper sheet.

In addition to this, surface roughness can contribute to the strength of the bond between the aerosol-generating material and the carrier. The inventors have determined that the roughness of the paper (on the surface that abuts the carrier) is preferably in the range of 50 to 1000 Bekk sec, preferably 50 to 150 Bekk sec, preferably 100 Bekk sec. Beck seconds (measured over an air pressure interval of 50.66 to 48.00 kPa). (The Beck smoothness tester is an instrument used to measure the smoothness of paper surfaces. In this tester, air at a specific pressure is forced between a smooth glass surface and a paper sample. The time (in seconds) for a fixed volume of air to penetrate between these surfaces is the "Beck smoothness").

Conversely, the surface of the carrier that does not face the aerosol-generating material may be placed in contact with the heater, and a smoother surface may provide more efficient heat transfer. Accordingly, in some examples, the carrier is arranged to have a rougher side that abuts the aerosol-generating material and a smoother side that does not face the aerosol-generating material.

In one particular example, the carrier may be a paper-backed foil, where the paper layer abuts the aerosol-generating material layer and this abutment provides the properties discussed in the previous paragraphs. It will be done. The foil backing is substantially impervious and provides control of the aerosol flow path. The metal foil backing may also serve to transfer heat to the aerosol-generating material.

In another example, a foil layer of paper-backed foil abuts the aerosol-generating material. The foil is substantially impermeable and prevents moisture provided in the aerosol-generating material from being absorbed into the paper, which could weaken the paper's structural integrity.

In some cases, the carrier is formed from or includes a metal foil, such as aluminum foil. A metal carrier may allow for better transfer of thermal energy to the aerosol-generating material. Additionally or alternatively, the metal foil may function as a susceptor within an induction heating system. In certain embodiments, the carrier comprises a metal foil layer and a support layer (such as cardboard). In these embodiments, the metal foil layer may have a thickness of less than 20 μm, such as from about 1 μm to about 10 μm, preferably about 5 μm.

In some examples, the carrier is about 0.010 mm to about 2.0 mm, preferably about 0.015 mm, 0.02 mm, 0.05 mm, or 0.1 mm to about 1.5 mm, 1.0 mm, or It may have a thickness of up to 0.5 mm.

Consumables In another aspect of the present disclosure, a consumable for use in a non-combustible aerosol delivery device is provided. The consumable includes an aerosol-generating composition, the aerosol-generating composition includes an aerosol-generating material, and the aerosol-generating material comprises:
about 10 to about 50% by weight caffeine,
from about 15 to about 60 weight percent gelling agent, and from about 10 to about 50 weight percent aerosol-forming material, where weight percent values are calculated on a dry weight basis.

In some embodiments, the present disclosure relates to consumables that include an aerosol-generating composition and are configured for use with non-combustible aerosol delivery devices. These consumables may be referred to as articles throughout this disclosure.

The consumable may be used with any suitable non-combustible aerosol delivery device.

A consumable is an article containing or consisting of an aerosol-generating composition that is intended to be consumed, in part or in whole, during use by a user. The consumable may include one or more other components, such as an aerosol-generating composition storage region, an aerosol-generating composition transfer component, an aerosol-generating region, a housing, a wrapper, a mouthpiece, a filter, and/or an aerosol modifier. good. The consumable may also include an aerosol generator, such as a heater that, when used, generates heat to cause the production of an aerosol from the aerosol-generating composition. The heater may, for example, comprise a combustible material, a material heatable by electrical conduction, or a susceptor.

The susceptor is a material that can be heated by the introduction of a varying magnetic field, for example an alternating magnetic field. The susceptor may be an electrically conductive material, in which case its penetration with a varying magnetic field causes inductive heating of the heating material. The heating material may be a magnetic material, in which case its penetration with a varying magnetic field causes magnetic hysteresis heating of the heating material. The susceptor may be both electrically conductive and magnetic, in which case the susceptor can be heated by both heating mechanisms. A device configured to generate a varying magnetic field is referred to herein as a magnetic field generator.

Aerosol modifiers are typically located downstream of the aerosol generation region and are configured to modify the aerosol produced, e.g., by altering the taste, flavor, acidity, or other properties of the aerosol. It is a substance that is The aerosol modifier may be included in an aerosol modifier release component operable to selectively release the aerosol modifier.

The aerosol modifier may be, for example, an additive or an adsorbent. Aerosol modifiers may include, for example, one or more of flavorants, colorants, water, and carbon adsorbents. Aerosol modifiers may be, for example, solids, liquids, or gels. Aerosol modifiers may be in powder, thread, or granule form. The aerosol modifier may be free of filtration materials.

An aerosol generator is a device configured to cause the production of an aerosol from an aerosol-generating composition. In some embodiments, the aerosol generator is a heater configured to subject the aerosol-generating composition to thermal energy to release one or more volatile substances from the aerosol-generating composition to form an aerosol. be. In some embodiments, the aerosol generator is configured to cause the production of an aerosol from the aerosol-generating composition without heating. For example, an aerosol generator may be configured to subject the aerosol-generating composition to one or more of vibration, high pressure, or electrostatic energy.

The aerosol-generating material may include or be in the form of an aerosol-generating film. The aerosol-generating film may be substantially free of vegetable material. In particular, in some embodiments, the aerosol-generating film is substantially tobacco-free.

The aerosol-generating film may have a thickness of about 0.015 mm to about 1 mm. For example, the thickness may range from about 0.05 mm, 0.1 mm, or 0.15 mm to about 0.5 mm, or 0.3 mm.

The aerosol-generating film may be continuous. For example, the film may include or be a continuous sheet of material. The sheet may be in the form of a wrapping paper, the wrapping paper may be gathered to form a gathered sheet, or the wrapping paper may be shredded to form a shredded sheet. . The shredded sheet may include one or more strands or strips of aerosol-generating material.

In one example, a consumable for use in a non-combustible aerosol delivery system is provided. The consumable includes a flat support (eg, a continuous aerosol-generating film) that completely covers the aerosol-generating material. FIG. 8 provides a schematic illustration of such a consumable, which comprises a support layer 4 and an aerosol-generating material layer 2.

Aerosol-generating films may be discontinuous. For example, an aerosol-generating film may include one or more discrete portions or regions of aerosol-generating material, such as dots, stripes or lines, which may be supported by a support. In such embodiments, the support may be flat or non-flat.

In some examples, the discrete portions of aerosol-generating material are substantially circular, cylindrical, or hemispherical. In some examples, there is a grid-shaped distribution of aerosol-generating material that is substantially circular, cylindrical, or hemispherical.

In some examples, a consumable for use in a non-combustible aerosol delivery system is provided. The consumable includes a flat support (including multiple discrete portions of aerosol-generating material) having a discontinuous aerosol-generating film deposited thereon.

Figure 9 shows an example of a consumable (401), which is provided with a discontinuous aerosol-generating film that includes discrete portions (403) of aerosol-generating material.

Non-Combustible Aerosol Delivery System In another aspect of the present disclosure, a non-combustible aerosol delivery system is provided that includes the consumables and non-combustible aerosol delivery devices described herein.

According to the present disclosure, a "non-combustible" aerosol delivery system is one in which the component aerosol-generating composition (or components thereof) of the aerosol delivery system is combusted during use to facilitate delivery of at least one substance to the user. It does not combust or burn.

In some embodiments, the delivery system is a non-combustible aerosol delivery system, such as a powdered non-combustible aerosol delivery system.

In some embodiments, the non-combustion aerosol delivery system is an aerosol-generating composition heating system, also known as a non-combustion heated system. An example of such a system is a tobacco heating system.

In some embodiments, the non-combustion aerosol delivery device is non-combustion heated.

In some embodiments, the non-combustion aerosol delivery system is a hybrid system that generates an aerosol using a combination of aerosol-generating compositions, one or more of which may be heated. In some embodiments, the hybrid system includes an aerosol-generating composition described herein comprising or consisting of an aerosol-generating material and an additional liquid or gel aerosol-generating composition.

In some embodiments, the non-combustible aerosol delivery device is an electronic cigarette hybrid device.

Typically, a non-combustion aerosol delivery system may include a non-combustion aerosol delivery device and a consumable for use with the non-combustion aerosol delivery device.

In some embodiments, a non-combustion aerosol delivery system, eg, a non-combustion aerosol delivery device, may include a power source and a controller. The power source may be, for example, a power source or a heat generating power source. In some embodiments, the heating power source comprises a carbon substrate that may be energized to distribute electrical power in the form of heat to the aerosol generating composition or heat transfer material in close proximity to the heating power source.

In some embodiments, a non-combustion aerosol delivery system, e.g., the non-combustion aerosol delivery device includes a consumable receiving region, an aerosol generator, an aerosol generation region, a housing, a mouthpiece, a filter, and/or an aerosol modifying region. It may also be provided with an agent.

A non-combustion aerosol delivery system or device may include a heater configured to heat, but not combust, the aerosol-generating substrate. The heater may be a thin film electrical resistance heater in some examples. In other examples, the heater may include an induction heater or other heater. In still further examples, the heater may be a combustible heat source or a chemical heat source that undergoes an exothermic reaction to produce heat when used.

In some examples, the heater may heat the aerosolizable material from 120° C. to 350° C. in use without combusting it. In some examples, the heater may heat the aerosolizable material to 140° C. to 250° C. without combusting it during use. In some instances, substantially all of the aerosol-generating material is less than about 4 mm, 3 mm, 2 mm, or 1 mm from the heater when in use. In some instances, the solid is located about 0.017 mm to 2.0 mm, preferably about 0.1 mm to 1.0 mm from the heater. These minimum distances may, in some examples, reflect the thickness of the carrier supporting the aerosol-generating material. In some examples, the surface of the aerosol-generating material may directly abut the heater.

In some examples, a heater may be incorporated into the aerosol generating composition. In some such examples, the heater may be an electrical resistance heater (with exposed contacts for connection to an electrical circuit). In other such examples, the heater may be a susceptor incorporated into the aerosol generating composition that is heated by induction.

The non-combustion aerosol delivery system may further include a cooling element and/or a filter. If a cooling element is present, the cooling element may act or function to cool the gaseous or aerosol component. In some examples, the cooling element may act to cool the gaseous component such that the gaseous component condenses to form an aerosol. The cooling element may also act to move very hot parts of the device away from the user. If a filter is present, the filter may comprise any suitable filter known in the art, such as a cellulose acetate plug.

In some examples, the non-combustion aerosol delivery system may be a non-combustion heated system. That is, a non-combustible aerosol delivery system may include solid materials (but not liquid aerosolizable materials). A non-combustion heating device is disclosed in WO2015/062983A2, which publication is incorporated herein by reference in its entirety.

In some examples, the non-combustible aerosol delivery system may be an electronic cigarette hybrid device. That is, a non-combustion aerosol delivery system may include a solid aerosolizable material and a liquid aerosol-generating material. These separate aerosolizable materials may be heated by separate heaters or by the same heater, and in some instances, the downstream aerosolizable material may be heated by the upstream aerosolizable material. may be heated by hot aerosols generated from An electronic cigarette hybrid device is disclosed in WO2016/135331A1, the entirety of which is incorporated herein by reference.

This consumable item may also be referred to herein as a cartridge. The consumable may be adapted for use in a THP, e-cigarette hybrid device, or another aerosol-generating device. In some examples, the consumable may further include a filter and/or cooling element as previously described. In some examples, the consumable may be surrounded by a packaging material such as paper.

The consumable may further include a vent. These may be provided on the side walls of the article. In some examples, vents may be provided in the filter and/or cooling element. These holes allow cool air to be drawn into the article during use, which can mix with the heated volatile components and thereby cool the aerosol.

Venting promotes the production of visible heating volatiles from the article when it is heated during use. The heated volatile components are visualized by cooling the heated volatile components such that supersaturation of the heated volatile components occurs. The heated volatiles then undergo droplet formation (also known as nucleation) and eventually the size of the aerosol particles of heated volatiles decreases by further condensation of the heated volatiles and from the heated volatiles. Increases due to agglomeration of newly formed droplets.

In some examples, the ratio of cold air to the sum of heated volatiles and cold air (known as the ventilation ratio) is at least 15%. A ventilation ratio of 15% allows heating volatile components to be visualized by the method described above. The visibility of heated volatiles allows the user to identify that volatiles have been produced, enhancing the sensory experience of the smoking experience.

In another example, the ventilation ratio is between 50% and 85% to further cool the heated volatile components. In some examples, the ventilation ratio may be at least 60% or 65%.

1 and 2, a partially cutaway cross-sectional and perspective view of an example article consumable 101 ("article") is shown. Article 101 is adapted for use with a device that has a power source and a heater. Article 101 of this embodiment is particularly suitable for use with device 51 shown in FIGS. 5-7, described below. In use, article 101 can be removably inserted into the device at insertion point 20 of device 51 shown in FIG.

One example article 101 is in the form of a generally cylindrical rod that includes an aerosol-generating composition object 103 and a filter assembly 105 in the form of a rod. The aerosol-generating composition includes an aerosol-generating material described herein. In some embodiments, it may be included in sheet form. In some embodiments, it may be included in the form of shredded sheets. In some embodiments, the aerosol generating compositions described herein may be incorporated in sheet and shredded form.

Filter assembly 105 includes three segments: cooling segment 107 , filter segment 109 , and mouth end segment 111 . Article 101 has a first end 113, also known as a buccal or proximal end, and a second end 115, also known as a distal end. Aerosol-generating composition object 103 is disposed toward distal end 115 of article 101 . In one example, the cooling segment 107 has an aerosol-generating composition between the aerosol-generating composition object 103 and the filter segment 109 such that the cooling segment 107 is in an abutting relationship with the aerosol-generating material 103 and the filter segment 109. It is placed adjacent to the composition object 103. In other examples, there may be separations between the aerosol-generating composition body 103 and the cooling segment 107 and between the aerosol-generating composition body 103 and the filter segment 109. Filter segment 109 is positioned between cooling segment 107 and oral end segment 111 . Mouth end segment 111 is located toward proximal end 113 of article 101 and adjacent filter segment 109 . In one example, filter segment 109 is in abutting relationship with oral end segment 111. In one embodiment, the total length of filter assembly 105 is between 37 mm and 45 mm, and more preferably, the total length of filter assembly 105 is 41 mm.

In one example, the rod of aerosol generating composition 103 has a length of 34 mm to 50 mm, preferably has a length of 38 mm to 46 mm, preferably has a length of 42 mm.

In one example, the overall length of article 101 is between 71 mm and 95 mm, preferably between 79 mm and 87 mm, preferably between 83 mm.

One axial end of the aerosol-generating composition object 103 is visible at the distal end 115 of the article 101. However, in other embodiments, the distal end 115 of the article 101 may include an end member (not shown) that covers one axial end of the aerosol-generating composition object 103.

The aerosol-generating composition object 103 is joined to the filter assembly 105 by an annular tipping paper (not shown), the annular tipping paper being disposed substantially around the filter assembly 105 to encircle the filter assembly 105 and disposing the aerosol-generating composition. It extends partially along the length of object 103. In one example, the chip paper is made from 58 GSM standard chip base paper. In one example, the tipping paper has a length of 42 mm to 50 mm, preferably 46 mm.

In one example, cooling segment 107 is an annular tube positioned around and defining a void within the cooling segment. This void provides a chamber through which the heated volatile components generated from the aerosol-generating composition object 103 flow. Cooling segment 107 is hollow to provide a chamber for aerosol accumulation, but withstands axial compressive forces and bending moments that may occur during manufacture and while article 101 is in use during insertion into device 51 It has sufficient rigidity. In one example, the wall thickness of cooling segment 107 is approximately 0.29 mm.

Cooling segment 107 provides physical displacement between aerosol generating composition 103 and filter segment 109. The physical displacement provided by cooling segment 107 creates a thermal gradient between the longitudinal ends of cooling segment 107 . In one example, the cooling segment 107 provides a temperature difference of at least 40 degrees Celsius between the heated volatile components entering the first end of the cooling segment 107 and the heated volatile components exiting the second end of the cooling segment 107. It is configured as follows. In one example, the cooling segment 107 provides a temperature difference of at least 60 degrees Celsius between the heated volatile components entering the first end of the cooling segment 107 and the heated volatile components exiting the second end of the cooling segment 107. It is configured as follows. This temperature difference between the longitudinal ends of the cooling element 107 protects the temperature-sensitive filter segment 109 from the high temperature of the aerosol-generating composition 103 when the aerosol-generating composition 103 is heated by the device 51. Provided that no physical displacement is provided between the filter segment 109 and the heating elements of the aerosol-generating composition object 103 and device 51, the temperature-sensitive filter segment 109 may be damaged during use and may not be needed. There is a possibility that it will not be able to perform its functions effectively.

In one example, the length of cooling segment 107 is at least 15 mm. In one example, the length of the cooling segment 107 is between 20mm and 30mm, more specifically between 23mm and 27mm, more specifically between 25mm and 27mm, preferably 25mm.

Cooling segment 107 is made of paper, which indicates that cooling segment 107 is constructed from a material that does not produce compounds of concern (e.g., toxic compounds) when adjacent to the heater of device 51 in use. means. In one example, cooling segment 107 is fabricated from a spirally wrapped paper tube that provides a hollow interior chamber but maintains mechanical rigidity. Spiral-wrapped paper tubes can meet the stringent dimensional accuracy requirements of high speed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.

In another example, cooling segment 107 is a recess made from stiff plug wrap or chipping paper. The rigid plug wrap or tip paper is manufactured to have sufficient stiffness to withstand axial compressive forces and bending moments that may occur during manufacture and while the article 101 is in use during insertion into the device 51. .

Filter segment 109 may be formed from any filter material sufficient to remove one or more volatile compounds from heated volatile components from the aerosol generating composition. In one example, filter segment 109 is made from a monoacetate material, such as cellulose acetate. Filter segment 109 provides cooling and irritation reduction of heated volatile components without depleting the amount of heated volatile components to a level that is unsatisfactory to the user.

In some embodiments, a capsule (not shown) may be provided within filter segment 109. This capsule may be located substantially centrally of the filter segment 109, both radially and longitudinally of the filter segment 109. In other examples, the capsule may be off-centered in one or more dimensions. In some instances, a capsule, if present, may contain volatile ingredients such as perfume or aerosol-forming materials.

The density of the cellulose acetate tow material of filter segment 109 controls the pressure drop across filter segment 109 and thus the suction resistance of article 101. Therefore, the selection of the material for filter segment 109 is important in controlling the suction resistance of article 101. Additionally, the filter segments perform a filtration function in article 101.

In one example, filter segment 109 is made of 8Y15 grade filter tow material. This filter tow material provides a filtration effect on the heated volatile material while reducing the size of condensed aerosol droplets resulting from the heated volatile material.

The presence of filter segment 109 provides an insulating effect by further cooling the heated volatile components exiting cooling segment 107. This additional cooling effect reduces the contact temperature of the user's lips against the surface of filter segment 109.

In one example, filter segment 109 has a length of 6 mm to 10 mm, preferably 8 mm.

Oral end segment 111 is an annular tube and is disposed around and defines a void within oral end segment 111 . This void provides a chamber for heated volatile components flowing from filter segment 109. Mouth end segment 111 is hollow to provide a chamber for aerosol accumulation, but not axial compressive forces and bending moments that may occur during manufacture and during use of the article during insertion into device 51. It has sufficient rigidity to withstand. In one example, the wall thickness of the oral end segment 111 is approximately 0.29 mm. In one example, the length of the oral end segment 111 is between 6 mm and 10 mm, preferably 8 mm.

The mouth end segment 111 may be manufactured from a helically wrapped paper tube that provides a hollow interior chamber but maintains significant mechanical rigidity. Spiral-wrapped paper tubes can meet the stringent dimensional accuracy requirements of high speed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.

The mouth end segment 111 serves to prevent liquid condensate that accumulates at the outlet of the filter segment 109 from coming into direct contact with the user.

It is understood that in one example, the oral end segment 111 and the cooling segment 107 may be formed from a single tube, and the filter segment 109 may be disposed within the tube to separate the oral end segment 111 and the cooling segment 107. I want to be

3 and 4, a partially cutaway cross-sectional view and perspective view of an example article 301 are shown. The reference numbers shown in FIGS. 3 and 4 correspond to the reference numbers shown in FIGS. 1 and 2, but the numbers have been increased by 200.

In the example article 301 shown in FIGS. 3 and 4, a ventilation area 317 is provided in the article 301 to allow air to flow from the exterior of the article 301 into the interior of the article 301. In one example, vent area 317 takes the form of one or more vent holes 317 formed through the outer layer of article 301. This vent may be placed in the cooling segment 307 to aid in cooling the article 301. In one example, the ventilation region 317 comprises one or more rows of holes, each row of holes preferably being arranged along the outer periphery of the article 301 in a cross-section substantially perpendicular to the longitudinal axis of the article 301. Ru.

In one example, there are one to four rows of vents to provide ventilation to article 301. Each row of vents may have between 12 and 36 vents 317. The diameter of the ventilation hole 317 can be, for example, 100 to 500 μm. In one example, the axial spacing between rows of vent holes 317 is between 0.25 mm and 0.75 mm, preferably 0.5 mm.

In one example, vents 317 have a uniform size. In another example, vents 317 have different sizes. The vents are created using one or more of any suitable technique, such as laser technology, mechanical drilling of the cooling segment 307, or pre-drilling of the cooling segment 307 before it is formed in the article 301. be able to. Vent holes 317 are positioned to effectively cool article 301.

In one example, the row of vent holes 317 is located at least 11 mm from the proximal end 313 of the article, preferably 17 mm to 20 mm from the proximal end 313 of the article 301. The position of the ventilation hole 317 is determined so that the user does not block the ventilation hole 317 when using the article 301.

By providing a row of vents 17 mm to 20 mm from the proximal end 313 of article 301, vent holes 317 are aligned with device 51 when article 301 is fully inserted into device 51, as seen in FIGS. can be placed outside. By placing the vent on the outside of the device, unheated air can enter the article 301 from outside the device 51 through the vent and help cool the article 301.

The length of cooling segment 307 is such that when article 301 is fully inserted into device 51, cooling segment 307 is partially inserted into device 51. The length of this cooling segment 307 serves the primary function of providing a physical gap between the heating device of the device 51 and the heat-sensitive filter device 309 and when the article 301 is fully inserted into the device 51. provides a second feature that allows the vents 317 to be placed within the cooling segment while also being placed outside the device 51. As can be seen in FIGS. 6 and 7, the majority of the cooling element 307 is located within the device 51. However, cooling element 307 has a portion that extends outside of device 51. Vent holes 317 are arranged in this portion of the cooling element 307 that extends outside the device 51 .

Referring now to FIGS. 5-7 in more detail, the aerosol-generating composition is heated to volatilize at least one component of the aerosol-generating composition, typically configured to form an inhalable aerosol. An example of a device 51 is shown. Device 51 is a heating device that releases the compound by heating but not burning the aerosol-generating composition.

The first end 53 may be referred to herein as the oral or proximal end 53 of the device 51, and the second end 55 may be referred to herein as the distal end 55 of the device 51. It is sometimes called. Device 51 has an on/off button 57 that allows the entire device 51 to be activated/deactivated as desired by the user.

Device 51 includes a housing 59 for locating and protecting various internal components of device 51. In the illustrated example, the housing 59 includes a unitary sleeve 11 surrounding the outer edge of the device 51, which includes a top panel 17 generally forming the "top" of the device 51, and a "bottom" portion of the device 51. It is covered with a bottom panel 19 which generally forms a . In another example, the housing includes, in addition to top panel 17 and bottom panel 19, a front panel, a rear panel, and a pair of opposing side panels.

Top panel 17 and/or bottom panel 19 may be removably secured to unitary sleeve 11 to allow easy access to the interior of device 51 or, for example, when a user It may be "permanently" fixed to the unitary sleeve 11 to prevent access to the interior. In one example, panels 17 and 19 are made of a plastic material (including glass-filled nylon formed by injection molding, etc.) and unitary sleeve 11 is made of aluminum, although other materials and other manufacturing processes may be used. You may.

The top panel 17 of the device 51 has an opening 20 at the oral end 53 of the device 51 through which, in use, a user can insert an article 101, 301 containing an aerosol-generating composition. It can be inserted into and removed from device 51.

Housing 59 has heating device 23, control circuit 25, and power source 27 disposed or secured therein. In this example, heating device 23, control circuit 25, and power source 27 are laterally adjacent (i.e., adjacent when viewed from one end), and control circuit 25 is located generally between heating device 23 and power source 27. However, other arrangements are also possible.

Control circuit 25 may include a controller, such as a microprocessor device, constructed and arranged to control the heating of the aerosol-generating composition within article 101, 301, as discussed further below.

Power source 27 may be, for example, a battery, which may be a rechargeable battery or a non-rechargeable battery. Examples of suitable batteries include, for example, lithium ion batteries, nickel batteries (eg, nickel cadmium batteries), alkaline batteries, and the like. Battery 27 is electrically coupled to heating device 23 and provides power when necessary under the control of control circuitry 25 to heat the aerosol-generating composition within the article (as previously discussed). volatilize the aerosol-generating composition without burning the material).

The advantage of locating the power source 27 laterally in close proximity to the heating device 23 is that a physically larger power source 25 can be used without making the overall device 51 too long. Of course, a physically larger power source 25 will generally have a higher capacity (i.e., the total electrical energy it can provide, often measured in ampere-hours, etc.), and thus will provide better battery life for the device 51. It can be made longer.

In one example, the heating device 23 is generally in the form of a hollow cylindrical tube having a hollow internal heating chamber 29 in which the article 101, 301 containing the aerosol-generating composition is heated during use. inserted for. Various configurations are possible for the heating device 23. For example, heating device 23 may include a single heating element or may be formed from a plurality of heating elements aligned along the longitudinal axis of heating device 23. The or each heating element may be annular or tubular, or may be at least partially annular or at least partially tubular along its outer circumference. In one example, the or each heating element may be a thin film heater. In another example, the or each heating element may be made from a ceramic material. Examples of suitable ceramic materials include alumina and aluminum nitride ceramics, and silicon nitride ceramics, which may be laminated and sintered. Other heating configurations are possible, including, for example, induction heating, infrared heating elements (which heat by emitting infrared radiation), resistive heating elements formed by resistive electrical windings, and the like.

In one particular example, heating device 23 is supported by a stainless steel support tube and includes a polyimide heating element. The heating device 23 is configured such that when the article 101, 301 is inserted into the device 51, substantially the entire body of the aerosol-generating composition 103, 303 of the article 101, 301 is inserted into the heating device 23. dimensions are given.

The or each heating element may independently target selected zones of the aerosol-generating composition, e.g. sequentially (over time as described above) or together (simultaneously) as desired. It may be arranged so that it can be heated.

The heating device 23 in this example is surrounded by insulation 31 along at least part of its length. Insulation 31 helps reduce heat passing from heating device 23 to the exterior of device 51. This generally reduces heat losses and thus helps keep the power requirements of heating device 23 low. Insulation 31 also helps keep the exterior of device 51 cool during operation of heating device 23. In one example, the insulation 31 may be a double-walled sleeve that provides a low pressure area between the two walls of the sleeve. That is, the insulation 31 may be, for example, a "vacuum" tube, ie, a tube that is at least partially evacuated to minimize heat transfer by conduction and/or convection. Other configurations for the insulation 31 are also possible, including the use of insulation materials (e.g., including suitable foam-type materials) in addition to or instead of a double-walled sleeve. For example.

Housing 59 may further include various internal support structures 37 for supporting all internal components, as well as heating device 23.

Device 51 includes a collar 33 extending around opening 20 and projecting from opening 20 into the interior of housing 59 , and a generally tubular chamber 35 disposed between collar 33 and one end of vacuum sleeve 31 . It further includes: Chamber 35 further includes a cooling structure 35f, which in this example includes a plurality of cooling fins 35f spaced apart along the outer surface of chamber 35, each cooling fin extending along the outer surface of chamber 35. arranged so as to surround it. An air gap 36 exists between the hollow chamber 35 and the article 101, 301 when the article 101, 301 is inserted into the device 51 over at least a portion of the length of the hollow chamber 35. The void 36 surrounds the entire circumference of the article 101, 301 over at least a portion of the cooling segment 307.

The collar 33 includes a plurality of ridges 60 arranged around the outer periphery of the opening 20, and these ridges protrude into the opening 20. The ridge 60 occupies a space within the opening 20 such that the open distance of the opening 20 at the location of the ridge 60 is less than the open distance of the opening 20 at the location without the ridge 60 . The ridges 60 are configured to engage an article 101, 301 inserted into the device to help secure it within the device 51. Open spaces (not shown) defined by adjacent pairs of ridges 60 and articles 101, 301 form a ventilation path around the outer surface of articles 101, 301. These vent paths allow hot steam escaping from the articles 101 , 301 to exit the device 51 and allow cooling air to flow into the device 51 around the articles 101 , 301 within the air gap 36 .

In operation, the article 101, 301 is removably inserted into the insertion site 20 of the device 51, as shown in FIGS. 5-7. With particular reference to FIG. 6, in one example, the aerosol-generating composition object 103, 303 (which is located on the distal end 115, 315 side of the article 101, 301) is completely within the heating apparatus 23 of the device 51. be accommodated in. The proximal ends 113, 313 of articles 101, 301 extend from device 51 and function as a mouthpiece assembly for the user.

In operation, heating device 23 heats article 101, 301 to volatilize at least one component of the aerosol-generating composition from aerosol-generating composition body 103, 303.

The primary flow path for heated volatile components from the aerosol-generating composition object 103, 303 is axially through the article 101, 301, through the inner chamber of the cooling segment 107, 307, and through the filter segment 109, 309. through the oral end segments 111, 313 to the user. In one example, the temperature of the heated volatile components produced from the aerosol-generating composition is between 60° C. and 250° C., which may exceed acceptable inhalation temperatures for the user. The heated volatile components are cooled as they travel through the cooling segments 107, 307, and some volatile components condense on the inner surfaces of the cooling segments 107, 307.

In the example article 301 shown in FIGS. 3 and 4, cold air may enter the cooling segment 307 through vents 317 formed in the cooling segment 307. This cold air mixes with the heated volatile components to further cool the heated volatile components.

Manufacturing method In another aspect,
about 10 to about 50% by weight caffeine,
from about 15 to about 60% by weight gelling agent, and from about 10 to about 50% by weight aerosol-forming material (where weight % values are calculated on a dry weight basis)
A method of forming an aerosol-generating material is provided. This method is
(a) providing a slurry comprising caffeine, a gelling agent, an aerosol former, a solvent, and any further components of an aerosol-generating material;
(b) forming a layer of slurry;
(c) optionally solidifying the layer of slurry;
(d) drying the slurry to form an aerosol-generating material;
Equipped with

Another aspect of the invention provides a method of making a consumable or system as previously described. The method includes a method of making an aerosol-generating material and incorporating the aerosol-generating material into a consumable or system. The method includes the steps of: (a) forming a slurry comprising components of an aerosol-generating material or their precursors; (b) forming a layer of the slurry; and (c) optionally solidifying the slurry. (d) drying to form an aerosol-generating material; and (e) incorporating the resulting aerosol-generating material into a consumable or system.

Step (b) of forming a layer of slurry in the above method may include, for example, spraying, casting or extruding the slurry. In some instances, this layer is formed by electrostatic spraying a slurry. In some examples, this layer is formed by casting a slurry.

In some examples, steps (b) and/or (c) and/or (d) may be performed at least partially simultaneously (eg, during electrostatic spraying). In some examples, these steps may be performed sequentially.

In some examples, a solidifying agent or crosslinking agent (such as a calcium source) may be added to the slurry before or during step (b). This is appropriate when gelling occurs relatively slowly (eg with alginate gelling agents), so the slurry may be cast, for example, after the solidifying or crosslinking agent has been added.

In other examples, step (c) of solidifying or crosslinking the slurry may include adding a solidifying or crosslinking agent to the slurry layer. The solidifying or crosslinking agent may, for example, be sprayed onto the slurry or preloaded onto the surface to which the slurry is to be laminated. Step (c) therefore comprises crosslinking, eg crosslinking of the gelling agent.

For example, a solidifying or crosslinking agent containing a calcium source (such as calcium chloride or calcium citrate) may be added to a slurry containing alginate and/or pectin to form a calcium crosslinked alginate/pectin gel. In some instances where gelation occurs quickly (such as when pectin gelling agents are used), calcium should be added after casting (as the slurry is too viscous to cast) .

The total amount of solidifying or crosslinking agents, such as calcium sources, may be from 0.5 to 5% by weight (calculated on dry weight basis). It has been found that adding too little solidifying agent or crosslinking agent may result in a gel that does not stabilize any perfume and may lead to the perfume falling out of the gel. It has also been found that adding too much solidifying agent or crosslinking agent results in a gel that is very sticky and results in poor handling.

Alginates are derivatives of alginic acid and are typically high molecular weight polymers (10-600 kDa). Alginic acid is a copolymer of β-D-mannuronic acid (M) and α-L-guluronic acid (G) units (blocks) linked with (1,4)-glycosidic bonds to form a polysaccharide. When calcium cations are added, the alginate crosslinks to form a gel. Alginates with high G monomer content may form gels more easily upon addition of calcium sources. Thus, in some examples, the gel precursor comprises at least about 40%, 45%, 50%, 55%, 60%, or 70% of the monomer units in the alginate copolymer are α-L-guluronic acid. It may also contain alginate which is an acid (G) unit.

In some examples, the slurry may be warmed before and during casting. This may be a slow gelation that improves handling and eases the casting process. Additionally, warming the slurry may optionally melt the perfume ingredients (eg, menthol), making it easier to handle.

In some examples, menthol or other optional flavoring may be distributed throughout the slurry in powder form. In some examples, menthol or other flavoring may be molten in the slurry (which is warmed). In such instances, an emulsifier such as gum acacia may be added to disperse the molten menthol into the slurry.

Caffeine may be added to the slurry in powder form.

In some examples, caffeine may be added in the form of a solution. The solvent may optionally be water or ethanol. In some embodiments, the solvent is water.

In some examples, the slurry may be cast onto a bandcast sheet. The sheet may be loaded with a release agent, such as lecithin, which may assist in separating the bandcast and aerosol-generating material.

During step (d), the slurry may be heated to remove at least about 60%, 70%, 80%, 85%, or 90% by weight of the solvent.

The aerosol-generating film is produced by combining caffeine, a gelling agent, an aerosol-forming agent, a solvent, and any additional ingredients to form a slurry, and then heating the slurry to volatilize at least a portion of the solvent to form an aerosol. It may be formed by forming a product film. The slurry may be heated to remove at least about 60%, 70%, 80%, 85%, or 90% by weight of the solvent.

In another embodiment, a slurry is provided. This slurry is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material (wherein weight % values are calculated on a dry weight basis);
a solvent;
including.

In some embodiments, the slurry solvent includes or is one or more of water, ethanol, methanol, dimethyl sulfoxide, acetone, hexane, and toluene.

In certain embodiments, the slurry solvent may include water. In some examples, the slurry solvent may consist essentially of or consist of water.

In some examples, the slurry may include about 50%, 60%, 70%, 80%, or 90% by weight (WWB) solvent.

In some examples, the slurry has a pressure of from about 1 to about 20 Pa·s at 46.5°C, such as from about 10 to about 20 Pa·s at 46.5°C, such as from about 14 to about 16 Pa·s at 46.5°C. It has a viscosity of s.

The discussion herein regarding aerosol generating materials is expressly disclosed in combination with any slurry aspect of the invention.

Compositions for oral delivery of caffeine Compositions for oral delivery of caffeine are also provided. This composition is
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
about 10 to about 50% by weight of a humectant;
, where the weight percent values are calculated on a dry weight basis.

In some embodiments, compositions for oral delivery of caffeine may be provided in the form of chewing tobacco, soluble strips, lozenges, gum, snus, or wet snuff.

In some embodiments, compositions for oral delivery of caffeine include sweeteners, taste modifiers, salts, buffering agents, colorants, oral care additives, preservatives, disintegrants, emulsifiers, preservatives, etc. and one or more additives selected from antioxidants.

The aerosol-forming materials discussed above may be used as humectants in compositions for oral delivery of caffeine. The above disclosure regarding aerosol-generating materials used in aerosol generation (e.g., caffeine, gelling agents, aerosol-forming materials [humectants], other optional ingredients, e.g., additional actives, fragrances, and other functionalities) (relating to flexible materials) apply equally to this aspect of the invention.

For example, humectants include glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, It may include one or more compounds selected from triacetin, diacetin mixtures, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

In some embodiments, the humectant may include one or more of erythritol, propylene glycol, glycerol, and triacetin. In some examples, the humectant comprises, consists essentially of, or consists of glycerol, optionally in combination with propylene glycol.

Suitably, the composition comprises from about 10% to about 50% by weight of a humectant (calculated on a dry weight basis), such as from about 20% to 50%, or from about 10% to 20%, by weight. It may include about 45%, 40%, 35%, 30%, or 25% by weight humectant.

Exemplary Embodiment 1. An aerosol-generating material or slurry as defined in the Summary of the Disclosure comprising about 20-50% by weight caffeine.
2. The aerosol-generating material or slurry of embodiment 1 comprising about 20-45% by weight caffeine.
3. The aerosol-generating material or slurry of embodiment 2 comprising about 20-40% by weight caffeine.
4. The aerosol-generating material or slurry of embodiment 3 comprising about 20-35% by weight caffeine.
5. The aerosol-generating material or slurry of embodiment 1 comprising about 25-45% by weight caffeine.
6. The aerosol-generating material or slurry of embodiment 5, comprising about 25-40% caffeine by weight.
7. The aerosol-generating material or slurry of embodiment 6, comprising about 25-35% by weight caffeine.
7A. The aerosol-generating material or slurry of embodiment 6, comprising about 30-35% by weight caffeine.
8. The aerosol-generating material or slurry of any of embodiments 1-7, comprising about 20-60% by weight gelling agent.
9. The aerosol-generating material or slurry of embodiment 8 comprising about 20-50% by weight gelling agent.
10. The aerosol-generating material or slurry of embodiment 9 comprising about 20-45% by weight gelling agent.
11. The aerosol-generating material or slurry of embodiment 10, comprising about 20-40% by weight gelling agent.
12. The aerosol-generating material or slurry of embodiment 11, comprising about 20-35% by weight gelling agent.
13. The aerosol-generating material or slurry of any of embodiments 1-7, comprising about 25-60% by weight gelling agent.
14. The aerosol-generating material or slurry of embodiment 13, comprising about 25-50% by weight gelling agent.
15. The aerosol-generating material or slurry of embodiment 14, comprising about 25-45% by weight gelling agent.
16. The aerosol-generating material or slurry of embodiment 15, comprising about 25-40% by weight gelling agent.
17. The aerosol-generating material or slurry of embodiment 16, comprising about 25-35% by weight gelling agent.
18. The aerosol-generating material or slurry of any of embodiments 1-7, comprising about 30-60% by weight gelling agent.
19. The aerosol-generating material or slurry of embodiment 18, comprising about 30-50% by weight gelling agent.
20. The aerosol-generating material or slurry of embodiment 19, comprising about 30-45% by weight gelling agent.
21. The aerosol-generating material or slurry of embodiment 20, comprising about 30-40% by weight gelling agent.
22. The aerosol-generating material or slurry of embodiment 21, comprising about 30-35% by weight gelling agent.
23. The aerosol-forming material or slurry of any of the preceding embodiments, comprising about 10-45% by weight aerosol-forming material/humectant.
24. The aerosol-forming material or slurry of embodiment 23, comprising about 10-40% by weight aerosol-forming material/humectant.
25. The aerosol-forming material or slurry of embodiment 24, comprising about 10-35% by weight aerosol-forming material/humectant.
26. The aerosol-generating material or slurry of embodiment 25, comprising about 10-30% by weight aerosol-forming material/humectant.
27. The aerosol-forming material or slurry of embodiment 26, comprising about 10-25% by weight aerosol-forming material/humectant.
28. The aerosol-forming material or slurry of any of embodiments 1-22, comprising about 20-50% by weight aerosol-forming material/humectant.
29. The aerosol-forming material or slurry of embodiment 28, comprising about 20-45% by weight aerosol-forming material/humectant.
30. The aerosol-generating material or slurry of embodiment 29, comprising about 20-40% by weight aerosol-forming material/humectant.
31. The aerosol-generating material or slurry of embodiment 30, comprising about 20-35% by weight aerosol-forming material/humectant.
32. The aerosol-forming material or slurry of embodiment 31, comprising about 20-30% by weight aerosol-forming material/humectant.
33. The aerosol-forming material or slurry of embodiment 32, comprising about 20-25% by weight aerosol-forming material/humectant.
33A. The aerosol-forming material or slurry of any of embodiments 1-22, comprising about 30-40% by weight aerosol-forming material/humectant.
33B. The aerosol-forming material or slurry of any of embodiments 1-22, comprising about 30-35% by weight aerosol-forming material/humectant.
34. The aerosol-forming material or slurry of any of embodiments 1-22, comprising about 30% by weight aerosol-forming material/humectant.
35. Aerosol forming materials/humectants include glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, citric acid. Any of the foregoing embodiments comprising (or being) one or more of triethyl, triacetin, diacetin mixtures, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate. aerosol-generating material or slurry.
36. 36. The aerosol-generating material or slurry of embodiment 35, wherein the aerosol-forming material/humectant comprises (or is) one or more of erythritol, propylene glycol, glycerol, and triacetin.
37. 37. The aerosol-forming material or slurry of embodiment 35 or 36, wherein the aerosol-forming material/humectant comprises (or is) glycerol, optionally in combination with propylene glycol.
38. The aerosol-generating material or slurry of any of the preceding embodiments, wherein the gelling agent comprises a hydrocolloid.
39. The gelling agent is a polysaccharide gelling agent such as alginate, pectin, starch or its derivatives, cellulose or its derivatives, pullulan, carrageenan, agar and agarose, gelatin, gums such as xanthan gum, guar gum and acacia gum, silica or silicone. The aerosol-generating material or slurry of any of the preceding embodiments, comprising (or being) one or more compounds selected from compounds such as PDMS and sodium silicate, clays, such as kaolin, and polyvinyl alcohol.
40. The aerosol-generating material or slurry of any preceding embodiment, wherein the gelling agent comprises one or more polysaccharide gelling agents.
41. The aerosol-generating material or slurry of any preceding embodiment, wherein the gelling agent comprises one or more polysaccharide gelling agents.
42. The aerosol-generating material or slurry of any of embodiments 39-41, wherein the polysaccharide gelling agent is selected from alginates, pectins, starches or derivatives thereof, cellulose or derivatives thereof.
43. 43. The aerosol-generating material or slurry of embodiment 42, wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives.
44. 44. The aerosol-generating material or slurry of embodiment 43, wherein the polysaccharide gelling agent is a cellulose derivative.
45. Cellulose or its derivatives, or cellulose derivatives include hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC), methylcellulose, ethylcellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB) , and cellulose acetate propionate (CAP).
46. 46. The aerosol-generating material or slurry of embodiment 45, wherein the cellulose or derivative thereof, or cellulose derivative is CMC.
47. 47. The aerosol-generating material or slurry of embodiment 46, wherein CMC is the only gelling agent present in the aerosol-generating material.
48. 44. The aerosol-generating material or slurry of embodiment 43, wherein the polysaccharide gelling agent is an alginate.
49. 49. The aerosol-generating material or slurry of embodiment 48, wherein the alginate is the only gelling agent present in the aerosol-generating material.
50. The gelling agent is one of alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, pullulan, xanthan gum, guar gum, carrageenan, agarose, acacia gum, fumed silica, PDMS, sodium silicate, kaolin, and polyvinyl alcohol. 40. The aerosol-generating material or slurry of embodiment 39, comprising (or being) one or more.
51. The aerosol-generating material or slurry of embodiment 39, wherein the gelling agent comprises (or is) one or more of hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, guar gum, gum acacia, alginate, and/or pectin. .
52. The aerosol-generating material or slurry of any of embodiments 39-43, 45, 46 or 48-51, wherein the alginate is sodium alginate.
53. The aerosol-generating material or slurry of any preceding embodiment, wherein the gelling agent is not crosslinked.
54. The aerosol-generating material or slurry of any of the preceding embodiments, further comprising one or more additional actives and/or fragrances, and optionally one or more other functional materials.
55. The aerosol-generating material or slurry of any preceding embodiment, further comprising one or more other functional materials.
56. or the aerosol-generating material of embodiment 54 or 55, wherein the other functional material comprises one or more of a pH modifier, a colorant, a preservative, a binder, a filler, a stabilizer, and/or an antioxidant. slurry.
57. 56. The aerosol-generating material or slurry of embodiment 55, wherein the other functional material includes one or more fillers.
58. 58. The aerosol-generating material or slurry of embodiment 57, wherein the filler is selected from inorganic filler materials, wood pulp, hemp fibers, cellulose and cellulose derivatives.
59. The aerosol-generating material or slurry of any of the preceding embodiments is free of calcium carbonate, such as chalk.
60. 60. The aerosol-generating material or slurry of any of embodiments 1-57 or 59, free of fibrous material.
61. The aerosol-generating material or slurry of any preceding embodiment that is free of tobacco fibers.
62. Any of the foregoing consisting of or consisting essentially of a gelling agent, water, an aerosol-forming material, caffeine, and optionally a flavoring, and/or an optional further active substance, and/or an optional filler. An aerosol-generating material according to an embodiment of the invention.
63. The aerosol-generating material of any preceding embodiment consisting of or consisting essentially of a gelling agent, water, an aerosol-forming material, and caffeine.
64. An aerosol-generating composition comprising an aerosol-generating material according to any of the preceding embodiments.
65. The aerosol-generating composition of embodiment 64, further comprising one or more additional actives and/or fragrances, and optionally one or more other functional materials.
66. The aerosol-generating composition of embodiment 64 or 65, further comprising one or more other functional materials.
67. The aerosol-generating composition of embodiment 65 or 66, wherein the other functional material comprises one or more of a pH modifier, a colorant, a preservative, a binder, a filler, a stabilizer, and/or an antioxidant. .
68. 68. The aerosol-generating composition of embodiment 67, wherein the other functional material includes one or more fillers.
69. 69. The aerosol-generating composition of embodiment 67 or 68, wherein the filler is selected from inorganic filler materials, wood pulp, hemp fibers, cellulose and cellulose derivatives.
70. The aerosol-generating composition of any of embodiments 64-69, which is free of calcium carbonate, such as chalk.
71. The aerosol-generating composition of any of embodiments 64-68 or 70, which is free of fibrous material.
72. The aerosol-generating composition of any of embodiments 64-71, which is free of tobacco fibers.
73. The aerosol-generating composition of any of embodiments 64-72, comprising about 50-100% by weight (in WWB) aerosol-generating material.
74. The aerosol-generating composition of any of embodiments 64-72, comprising about 50-95% by weight (WWB) aerosol-generating material.
75. The aerosol-generating composition of any of embodiments 64-72, comprising about 50-90% by weight (WWB) aerosol-generating material.
76. The aerosol-generating composition of any of embodiments 64-72, comprising about 60-100% by weight (WWB) aerosol-generating material.
77. The aerosol-generating composition of any of embodiments 64-72, comprising about 60-95% by weight (WWB) aerosol-generating material.
78. The aerosol-generating composition of any of embodiments 64-72, comprising about 60-90% by weight (WWB) aerosol-generating material.
79. The aerosol-generating composition of any of embodiments 64-72, comprising about 70-100% by weight (WWB) aerosol-generating material.
80. The aerosol-generating composition of any of embodiments 64-72, comprising about 70-95% by weight (WWB) aerosol-generating material.
81. The aerosol-generating composition of any of embodiments 64-72, comprising about 70-90% by weight (in WWB) aerosol-generating material.
82. The aerosol-generating composition of any of embodiments 64-72, consisting of or consisting essentially of an aerosol-generating material.
83. A consumable for use in a non-combustible aerosol delivery device, the consumable comprising the aerosol generating composition of any of embodiments 64-82.
84. A non-combustion aerosol delivery system comprising the consumable of embodiment 83 and a non-combustion aerosol delivery device.
85. Embodiment 84 The consumable for use in the non-combustion aerosol delivery device of embodiment 83 or the non-combustion aerosol delivery system of embodiment 84, wherein the non-combustion aerosol delivery device is a non-combustion heated device.
86. Embodiment 84 The consumable for use in the non-combustion aerosol delivery device of embodiment 83 or the non-combustion aerosol delivery system of embodiment 84, wherein the non-combustion aerosol delivery device is an electronic cigarette hybrid device.
87. 64. A method of forming an aerosol-generating material as defined in any of embodiments 1-63, comprising:
(a) providing a slurry comprising caffeine, a gelling agent, an aerosol-forming agent, a solvent, and any further components of an aerosol-generating material;
(b) forming a layer of the slurry;
(c) optionally solidifying the layer of slurry;
(d) drying the slurry to form an aerosol-generating material;
A method of providing.
88. The method of embodiment 87, or the slurry of any of embodiments 1-61, wherein the solvent comprises water.
89. The method of embodiment 87, or the slurry of any of embodiments 1-61, wherein the solvent consists essentially of or consists of water.
90. The method of embodiments 87-89, or embodiments 1-61, 88, or 88, wherein the slurry comprises about 50%, 60%, 70%, 80%, or 90% by weight solvent (by WWB). 89 slurry.

The composition of the fifth aspect as defined in the Summary of the Disclosure (ie, the composition for oral delivery of caffeine) may be an aerosol-generating material as defined in any of the previous embodiments.

DEFINITIONS The aerosol-generating compositions described herein include an aerosol-generating material. Aerosol-generating materials can be non-fibrous or fibrous. In some embodiments, the aerosol-generating material may be a dry gel. The aerosol-generating material may have some fluid within it, such as a liquid.

As used herein, the term "tobacco material" refers to any material that includes tobacco or derivatives thereof. The term "tobacco material" may include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco, or tobacco substitutes. The tobacco material may include one or more of ground tobacco, tobacco fiber, shredded tobacco, extruded tobacco, tobacco stalks, reconstituted tobacco, and/or tobacco extract.

The tobacco used to make the tobacco material may be any suitable tobacco, such as single grades or blends, chopped rag or whole leaf, including Virginia and/or Burley and/or Oriental. It may also be "fine powder" or dust of tobacco particles, puffed tobacco, petioles, puffed petioles, and other processed petiole materials (such as rolled chopped petioles). The tobacco material may be ground tobacco or reconstituted tobacco material. The reconstituted tobacco material may include tobacco fibers and may be formed by casting, a fourdrinier-type approach with backside addition of tobacco extract, or extrusion.

All weight percentages (indicated as wt%) described herein are calculated on a dry weight basis (DWB) unless otherwise specified. All weight ratios are also calculated on a dry weight basis. Weights expressed on a dry weight basis refer to the entire extract, slurry or material other than water or other solvents, even if they include components that are liquid by themselves at room temperature and pressure, such as glycerol. good. Conversely, weight percentages expressed on a wet weight basis (WWB) refer to all components including water or other solvents.

For the avoidance of doubt, when the term "comprising" is used herein in defining the invention or a feature of the invention, "consisting essentially of" or "consisting of" should be substituted for "comprising". Embodiments are also disclosed in which inventions and features can be defined using the term "becomes". Reference to a material that "comprises" particular features means that those features are included in, contained in, or retained within the material.

The embodiments described above are to be understood as illustrative of the invention. Any feature described in connection with any one embodiment may be used alone or in combination with other features described, and may also be used in connection with any other embodiment or any other embodiment. It is to be understood that the features may be used in combination with any combination of one or more features of the embodiments. Furthermore, equivalents and modifications not described above may be used without departing from the scope of the invention as defined in the appended claims.

The various embodiments described herein are presented solely to aid in understanding and teaching the claimed features. These embodiments are provided as a representative sample of embodiments only and are not exhaustive and/or exclusive. The advantages, embodiments, examples, features, features, structures and/or other aspects described herein are limitations on the scope of the invention as defined by the claims or equivalents of the claims. It is understood that there are no limitations to the invention, and that other embodiments may be utilized and changes may be made without departing from the scope of the claimed invention. Various embodiments of the invention suitably include or include suitable combinations of elements, components, features, parts, steps, means, etc. of the disclosure other than those specifically described herein. It may consist of or consist essentially of. Additionally, this disclosure may include other inventions that are not currently claimed but may be claimed in the future.

Claims (20)

An aerosol-generating material used for aerosol generation, the aerosol-generating material comprising:
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material, with weight percentage values calculated on a dry weight basis. The aerosol-generating material of claim 1, comprising about 20 to about 40% by weight caffeine, such as about 30 to about 35% by weight caffeine. 3. An aerosol-generating material according to claim 1 or 2, comprising from about 20 to about 40% by weight aerosol-forming material, such as from about 30 to about 35% by weight aerosol-forming material. 4. The aerosol-generating material of any one of claims 1-3, comprising from about 30 to about 50% by weight gelling agent. The gelling agent may be a polysaccharide gelling agent such as alginate, pectin, starch or its derivatives, cellulose or its derivatives, pullulan, carrageenan, agar and agarose; gelatin; gums such as xanthan gum, guar gum and acacia gum; silica or According to any one of claims 1 to 4, comprising or being one or more compounds selected from silicone compounds, such as PDMS and sodium silicate; clays, such as kaolin; and polyvinyl alcohol. aerosol-generating materials. 6. The aerosol-generating material of claim 5, wherein the gelling agent comprises or is one or more polysaccharide gelling agents. Aerosol-generating material according to claim 5 or 6, wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives. The cellulose derivatives include hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC), methylcellulose, ethylcellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate protein. Aerosol-generating material according to any one of claims 5 to 7, selected from pionates (CAP). Aerosol-generating material according to any one of claims 1 to 8, wherein the gelling agent is not crosslinked. Aerosol-generating material according to any one of claims 1 to 4, wherein the gelling agent is a cellulose derivative such as CMC. The aerosol forming material is glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso-erythritol, ethyl vanillate, ethyl laurate, diethyl suberate, triethyl citrate, Any of claims 1 to 10, comprising (or being) one or more of triacetin, diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate. The aerosol-generating material according to paragraph 1. Aerosol-generating material according to any one of the preceding claims, wherein the aerosol-forming material comprises or is glycerol, optionally in combination with propylene glycol. An aerosol-generating composition comprising an aerosol-generating material according to any one of claims 1 to 12. 14. The aerosol-generating composition of claim 13, comprising about 50-100% by weight (WWB) of said aerosol-generating material. A consumable article for use in a non-combustible aerosol delivery device, the consumable article comprising an aerosol-generating composition according to claim 13 or 14. A non-combustion aerosol delivery system comprising the consumable of claim 15 and a non-combustion aerosol delivery device. A composition for oral delivery of caffeine, the composition comprising:
about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
about 10 to about 50% by weight of a humectant;
% by weight are calculated on a dry weight basis. 18. A method of forming an aerosol-generating material according to any one of claims 1 to 12, or a composition for oral delivery according to claim 17, comprising:
(a) providing a slurry comprising the caffeine, the gelling agent, the aerosol-forming material or humectant, a solvent, and any further components of the aerosol-forming material or composition;
(b) forming a layer of the slurry;
(c) optionally solidifying the layer of the slurry;
(d) drying the slurry to form the aerosol-generating material or composition;
A method of providing. about 10 to about 50% by weight of caffeine;
about 15 to about 60% by weight gelling agent;
from about 10 to about 50% by weight of an aerosol-forming material or humectant (wherein weight % values are calculated on a dry weight basis);
a solvent;
including slurry. 20. The method of claim 18, or the slurry of claim 19, wherein the solvent comprises water.

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