JP2023523706A - アルツハイマー病を治療するためのｒｈｏキナーゼ阻害剤の使用方法 - Google Patents
アルツハイマー病を治療するためのｒｈｏキナーゼ阻害剤の使用方法 Download PDFInfo
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- 238000004448 titration Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 238000011823 triple-transgenic mouse model Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 238000009424 underpinning Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000025102 vascular smooth muscle contraction Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 229950003000 verubecestat Drugs 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063014272P | 2020-04-23 | 2020-04-23 | |
| US63/014,272 | 2020-04-23 | ||
| PCT/US2021/012588 WO2021216139A1 (fr) | 2020-04-23 | 2021-01-08 | Méthodes d'utilisation d'inhibiteurs de la rho kinase pour traiter la maladie d'alzheimer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023523706A true JP2023523706A (ja) | 2023-06-07 |
| JPWO2021216139A5 JPWO2021216139A5 (fr) | 2024-01-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022563366A Pending JP2023523706A (ja) | 2020-04-23 | 2021-01-08 | アルツハイマー病を治療するためのｒｈｏキナーゼ阻害剤の使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20230190765A1 (fr) |
| EP (1) | EP4138842A4 (fr) |
| JP (1) | JP2023523706A (fr) |
| CN (1) | CN115996728A (fr) |
| CA (1) | CA3175183A1 (fr) |
| MX (1) | MX2022012957A (fr) |
| WO (1) | WO2021216139A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115916187A (zh) * | 2020-03-25 | 2023-04-04 | 乌尔塞制药公司 | 治疗蛋白病相关的游荡的方法 |
| WO2023097151A1 (fr) | 2021-11-29 | 2023-06-01 | Woolsey Pharmaceuticals, Inc. | Procédés de traitement d'agitation et d'autres symptômes comportementaux associés à la démence |
| CN115998736B (zh) * | 2023-03-28 | 2023-06-23 | 中国人民解放军军事科学院军事医学研究院 | Y-27632在特异性抑制幻觉作用中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117896A1 (fr) * | 2004-06-03 | 2005-12-15 | Schering Aktiengesellschaft | Formulations contenant du fasudil, une matrice et une enveloppe |
| WO2006094072A2 (fr) * | 2005-03-01 | 2006-09-08 | Functional Neuroscience Inc. | Methode de traitement de troubles cognitifs au moyen d'une neuromodulation |
| CA2659289A1 (fr) * | 2006-08-10 | 2008-02-14 | Translational Genomics Research Institute | Composes pour ameliorer l'apprentissage et la memoire |
| KR20110014183A (ko) * | 2008-05-12 | 2011-02-10 | 엠네스틱스, 인코포레이티드 | 학습 및 기억을 개선시키기 위한 화합물 |
| WO2013135596A1 (fr) * | 2012-03-12 | 2013-09-19 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Inhibiteurs de kinase rho s'utilisant dans le traitement de la sclérose latérale amyotrophique |
| CN115103672A (zh) * | 2020-01-09 | 2022-09-23 | 悟而喜制药公司 | 治疗与皮质性痴呆相关的游荡的方法 |
| CN115916187A (zh) * | 2020-03-25 | 2023-04-04 | 乌尔塞制药公司 | 治疗蛋白病相关的游荡的方法 |
| MX2023004523A (es) * | 2020-10-22 | 2023-05-08 | Woolsey Pharmaceuticals Inc | Metodos de tratamiento de tauopatias de 4 repeticiones. |
-
2021
- 2021-01-08 CA CA3175183A patent/CA3175183A1/fr active Pending
- 2021-01-08 JP JP2022563366A patent/JP2023523706A/ja active Pending
- 2021-01-08 CN CN202180043725.7A patent/CN115996728A/zh active Pending
- 2021-01-08 US US17/996,812 patent/US20230190765A1/en active Pending
- 2021-01-08 EP EP21793029.6A patent/EP4138842A4/fr active Pending
- 2021-01-08 MX MX2022012957A patent/MX2022012957A/es unknown
- 2021-01-08 WO PCT/US2021/012588 patent/WO2021216139A1/fr unknown
-
2023
- 2023-02-28 US US18/175,605 patent/US11771704B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4138842A1 (fr) | 2023-03-01 |
| WO2021216139A1 (fr) | 2021-10-28 |
| CN115996728A (zh) | 2023-04-21 |
| US20230190765A1 (en) | 2023-06-22 |
| US20230302011A1 (en) | 2023-09-28 |
| CA3175183A1 (fr) | 2021-10-28 |
| US11771704B1 (en) | 2023-10-03 |
| EP4138842A4 (fr) | 2024-04-24 |
| MX2022012957A (es) | 2022-11-09 |
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