JP2023521144A - aerosol generation - Google Patents

Abstract

The present invention relates to consumables used in inhalable medium generating assemblies. The invention also relates to aerosol-generating assemblies including consumables, methods of generating inhalable media, uses of vapors and/or aerosols, and kits. [Selection diagram] Fig. 1

Description

The present invention relates to, but is not limited to, consumables used in inhalable medium generating assemblies. The invention also relates to aerosol-generating assemblies including consumables, methods of generating inhalable media, uses of vapors and/or aerosols, and kits.

background

Smoking articles such as cigarettes and cigars burn tobacco during use to produce tobacco smoke. Alternatives to these types of articles release compounds to form inhalable media without combustion.

Examples of such products are heated devices, including e-cigarette/non-combustion heated hybrid devices, also known as e-cigarette hybrid devices. These hybrid devices contain liquids that are vaporized by heating to produce inhalable vapors and/or aerosols. The liquid may contain a flavoring agent and/or an aerosol-forming substance such as glycerol and optionally nicotine. Vapors and/or aerosols pass through a matrix within the device and entrap one or more components of the matrix to produce an inhalation medium. The substrate material may be, for example, tobacco, which may or may not contain nicotine, other non-tobacco products, or combinations, such as compounded mixtures.

overview

According to a first aspect of the present invention, consumables for use in an inhalable medium generating assembly, comprising an acid-containing liquid having a pH of 2 or more and less than 7 and solid nicotine having a pH of 7 or more. A consumable is provided, comprising a containing material.

In some embodiments, the pH of the acid-containing liquid is 4-5 or 4.3-4.8.

In some embodiments, the difference between the pH of the solid nicotine-containing material and the pH of the acid-containing liquid is 3-5.5.

According to a second aspect of the present invention, a consumable for use in an inhalable medium generating assembly, comprising a liquid comprising an acid with a pKa greater than 0.5 and a solid nicotine-containing material having a pH greater than or equal to 7 A consumable is provided comprising:

In some embodiments, the pKa of the acid is greater than 3 or between 3.7 and 4.3.

In some embodiments, the solid nicotine-containing material has a pH of 8-9.5 or 8.5-9.

In some embodiments, the vapor pressure of the acid at 25°C is between 0.1 Pa and 2.5 kPa.

In some embodiments, the acid-containing liquid comprises 0.001-5% by weight acid.

In some embodiments, the solid nicotine-containing material comprises tobacco material. In some embodiments, the tobacco is cut rags or tobacco granules.

In some embodiments, the consumable comprises a carrier material impregnated with an acid-containing liquid. In some embodiments, the carrier material is a wicking material.

In some embodiments, the consumable is a cartridge and the acid-containing liquid is present in a first chamber and the solid nicotine-containing material is present in a second chamber.

In some embodiments, the consumable is a rod comprising a first section containing an acid-containing liquid and a second section containing a solid nicotine-containing material.

In some embodiments, the rod further comprises a cooling section, optionally in the form of a tube.

In some embodiments, the rod further comprises a filter section optionally comprising cellulose acetate filter material.

According to a third aspect of the invention, an aerosol-generating assembly comprising a consumable according to the first or second aspect, wherein the inhalable medium is formed by heating at least a portion of the consumable and solid An assembly configured to form one or more nicotine salts by reacting free nicotine from a nicotine-containing material with an acid is provided.

In some embodiments, the assembly is configured to heat an acid-containing liquid to form an acid-containing vapor and/or aerosol, and contact a solid nicotine-containing material with the acid-containing vapor/aerosol. to incorporate one or more components of solid nicotine-containing material into the inhalable medium. In some embodiments, the assembly is configured such that the solid nicotine-containing material is heated only by vapor/aerosol.

In some embodiments, the assembly is configured to heat the solid nicotine-containing material to form a nicotine-containing vapor and/or aerosol, and the acid-containing liquid and liberated nicotine from the solid nicotine-containing material. is contacted with a vapor/aerosol containing acid such that the acid and free nicotine react to form one or more nicotine salts.

In some embodiments, the solid nicotine-containing material is heated by a vapor or aerosol formed by heating an aerosolizable liquid other than an acid-containing liquid.

According to a fourth aspect of the invention, a method of producing an inhalable medium using an aerosol-generating assembly comprising a consumable according to the first or second aspect, wherein at least a portion of the consumable is heated. forming an inhalable medium comprising one or more components of a solid nicotine-containing material comprising free nicotine, and reacting the free nicotine with an acid to form one or more nicotine salts. provided.

According to a fifth aspect of the present invention, the use of acidic vapors and/or aerosols to extract nicotine from solid nicotine-containing materials having a pH greater than 7, wherein the nicotine extraction rate is nicotine salt in solids Uses are provided that exceed the formation rate, thereby increasing the nicotine content in the vapor and/or aerosol compared to using a neutral vapor and/or aerosol.

According to a sixth aspect of the present invention, (i) a liquid pod containing a liquid containing an acid and having a pH greater than or equal to 2 and less than 7; and (ii) a solid nicotine-containing material having a pH greater than or equal to 7. wherein the liquid pod and the nicotine containing pod are configured for use in an assembly for use in producing an inhalable medium, the assembly, in use, producing vapor and/or Kits are provided configured to produce an inhalable vehicle by contacting an aerosolizable liquid in the form of an aerosol with a solid nicotine-containing material to incorporate one or more components thereof. .

To the extent compatible, features described in connection with one aspect of the invention are expressly disclosed in combination with any and all other aspects. For example, features described in connection with assemblies, cartridges, nicotine-containing pods, liquid pods or kits are expressly included in combination with each of the other features of the assemblies, cartridges, nicotine-containing pods, liquid pods and kits. disclosed. In particular, the solid nicotine-containing materials and aerosolizable liquid features described herein are expressly disclosed in combination with the assembly, cartridge, nicotine-containing pod, liquid pod and kit embodiments of the present invention. be done. Similarly, features described in connection with the apparatus are expressly disclosed in combination with the method and use aspects of the invention, and vice versa.

Features and further advantages of the present invention will become apparent from the following description of preferred embodiments of the invention, given by way of example only, with reference to the accompanying drawings.

Examples of inhalable medium generating assemblies and cartridges according to the invention are described below with reference to the accompanying drawings.

1 shows a schematic longitudinal cross-sectional view of an example of an inhalable medium generating assembly; FIG. Fig. 3 shows a schematic longitudinal cross-section of another example of an inhalable medium generating assembly; Fig. 3 shows a schematic longitudinal cross-section of another example of an inhalable medium generating assembly; 1 shows a schematic longitudinal section of an example of a cartridge with a liquid chamber and an integral solid material chamber; FIG. 1 shows a schematic longitudinal section of an example of a cartridge with a liquid chamber and a removable solid material chamber; FIG. Figure 3 shows nicotine delivery from assemblies according to embodiments of the invention and comparative assemblies. FIG. 4 shows a schematic diagram of an example of a consumable rod according to embodiments of the present invention;

detailed description

In some embodiments, the present invention relates to improving the flavor of inhalable aerosols and increasing the nicotine content within inhalable aerosols. The present invention provides a consumable that is heated within an aerosol generating assembly used in a hybrid device when nicotine is pH treated to raise its pH.

Most generally, the consumables described herein comprise an acid-containing liquid having a pH of 2 or greater and less than 7, and a solid nicotine-containing material having a pH of 7 or greater. Within the consumable, the liquid containing acid and the solid nicotine-containing material are kept separate from each other. The acid adjusts the pH of the nicotine during use of the consumable in the aerosol generating assembly. In some embodiments, a vapor and a vapor passing through a solid nicotine-containing material such that the acid-containing liquid is heated to produce an inhalable medium comprising one or more components, such as nicotine, derived from the solid. /or form an aerosol. In other embodiments, a vapor and/or aerosol is formed containing one or more components of the solid nicotine-containing material, and the vapor and/or aerosol is contacted with a liquid comprising an acid.

In some embodiments, the assemblies described herein volatilize an aerosolizable liquid to produce an inhalable vehicle comprising one or more components such as nicotine derived from a solid, A vapor and/or aerosol is formed that passes through the solid nicotine-containing material.

In some embodiments, base-treated nicotine may be included in solid nicotine-containing materials. Nicotine reacts with a base, the reaction deprotonating nicotine, increasing the volatility of nicotine, and releasing it from its bound state to form the deprotonated base form of nicotine (hereinafter "deprotonated nicotine or simply "free nicotine"). As a result, base-treated nicotine becomes more volatile when heated. However, in the present invention it has been found that inhalable aerosols containing free nicotine (sometimes referred to herein as "inhalable vehicles") have a less desirable flavor than those containing nicotine salts. .

In some embodiments, the inhalable aerosol produced from the consumable has improved sensory qualities such as flavor. In some embodiments, the inhalable aerosol may have a higher nicotine delivery rate when the nicotine source is base treated to increase the pH compared to other inhalable aerosols. Nicotine extraction from the nicotine source may be facilitated.

The inventors have determined that the inclusion of an acid-containing liquid produces a better tasting inhalable aerosol. In some embodiments, the acid in the vapor/aerosol produced by heating the acid-containing liquid reacts with liberated nicotine from the solid nicotine-containing material to form a better tasting salt form. provide nicotine. That is, the acid and free nicotine undergo acid-base salt formation to produce the nicotine salt in the vapor/aerosol.

While the use of acidic aerosols/vapors improves flavor, less volatile nicotine salts are formed in solid nicotine-containing materials after contact with acidic vapors/aerosols, thus contributing to overall nicotine delivery. It was thought that some reduction would be expected to be observed.

Surprisingly, the inventors found that the inclusion of acid in the aerosol/vapor actually increased the overall nicotine delivery during use compared to the neutral aerosol/vapor. Without being limited by theory, it is believed that the affinity between free nicotine and acids in vapors/aerosols can draw or extract nicotine from solid nicotine-containing materials. This extraction is believed to occur at a rate faster than the rate of nicotine salt formation in solids. Thus, higher nicotine content inhalable aerosols with improved taste can be provided. Using an acidic vapor/aerosol can also increase the total amount of nicotine extracted from the solid.

SOLID NICOTINE-CONTAINING MATERIAL In some examples, the present invention provides a consumable used in an aerosol-generating assembly for producing an inhalable medium, comprising a solid nicotine-containing material (herein "nicotine source"). or simply "solids").

The nicotine source has a pH of 7 or higher. In some examples, the nicotine source has a pH of 8-9.5, 8.2-9.3, 8.3-9.2, or 8.4-9.1. Suitably the pH may be between 8.5 and 9, or may be 8.5. This allows the nicotine in the solid nicotine-containing material to be provided in the form of a deprotonated base (as free nicotine), resulting in an increase in the volatility of the nicotine so that it becomes more volatile after heating.

In some examples, the pH of the nicotine source is such that the difference between the pH of the nicotine source and the pH of the aerosolizable liquid is 3-5.5, 3.5-5, 3.7-4.8, preferably is selected to be between 4.1 and 4.2, preferably between 3.6 and 3.8. Without being bound by theory, it is believed that the greater the pH difference, the higher the affinity between the acidic vapor/aerosol and the free nicotine, resulting in an increased extraction rate and increased nicotine delivery in the inhalable vehicle. It is

The nicotine source may have been treated to raise the pH, and the pH is determined according to the CORESTA Protocol for pH Determination of Tobacco, CORESTA Recommended Method No. 69 (CRM-69). An example of a pH treatment method may include adding a base solution to the nicotine source. The base solution, in some examples, is, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate or mixtures thereof, or Aqueous solutions of other GRAS water-soluble bases may also be included.

In some examples, the nicotine source includes tobacco material. In some examples, the nicotine source is tobacco material. It may also provide tobacco flavoring to the inhalable medium.

As used herein, the term "tobacco material" refers to any material containing tobacco or derivatives thereof. The term "tobacco material" can include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco or tobacco substitutes. The tobacco material may comprise one or more of ground tobacco, tobacco fibers, cut tobacco, extruded tobacco, tobacco stems, reconstituted tobacco, lumped tobacco, spheronized tobacco and/or tobacco extract.

The tobacco used in the production of the tobacco material may be any suitable tobacco such as single grades or blends including Virginia and/or Burley and/or Oriental, cut rag or whole leaf. Tobacco may be a "fine powder" or powder of tobacco particles, puffed tobacco, stems, puffed stems, and other processed stem materials such as chopped and rolled stems. The tobacco material may be ground tobacco or reconstituted tobacco material. The reconstituted tobacco material may comprise tobacco fibers and may be formed by co-molding, a Fourdrinier type papermaking technique with post-addition of tobacco extract, or extrusion.

In some examples, the nicotine source may be porous to allow aerosols and/or vapors to pass through the solid nicotine source. This increases the contact area where the nicotine source contacts the aerosol and/or vapor. Therefore, the components of the nicotine source are efficiently incorporated into the aerosol/vapor.

The nicotine source may additionally include flavorants and/or aerosol-forming agents. As used herein, the terms "perfume" and "flavourant" may be used to produce a desired flavor or aroma in products intended for adult consumers where permitted by local regulations. refers to materials that can

In some examples, the nicotine source may be provided in one of two or more portions of the consumables described herein. In some embodiments, the consumable is a cartridge and the nicotine source is provided in one of the two chambers.

In some examples, a nicotine source may be provided in a nicotine containing pod configured for use in an assembly used to produce an inhalable medium as part of the kits described herein.

Acid-Containing Liquid In some embodiments, the present invention provides a consumable for use in an inhalable medium generating assembly that contains an acid-containing liquid (sometimes referred to herein simply as the "liquid"). Provide consumables including;

The acid-containing liquid may include gels and/or liquids in some examples. Preferably, the acid-containing liquid comprises, consists essentially of, or consists of a liquid.

In some embodiments, the acid-containing liquid is heated to form an acidic vapor and/or aerosol. In some embodiments, the acid-containing liquid is heated by the assembly. In other embodiments, the liquid is heated as a result of contact with the heated aerosol or vapor.

The acid-containing liquid may include liquids conventionally used in e-cigarette or hybrid assemblies. In some examples, the acid-containing liquid may contain flavorants and/or aerosol-forming agents, including, but not limited to, propylene glycol and/or glycerol. In some examples, the acid-containing liquid does not contain nicotine.

In some embodiments, the acid-containing liquid is an aerosolizable liquid intended to be heated to form an aerosol and/or vapor upon use in the aerosol-generating assembly. Aerosolizable liquids typically volatilize around 100-300°C, preferably around 150-250°C.

In some embodiments, the liquid comprises an acid such that the liquid can have a pH of 2 or more and 7 or less. In some examples, the pH of the liquid is 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3 , 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, or 4 up to 6.9, 6.8, 6 .7, 6.6, 6.5, 6.4, 6.3, 6.2, 6.1, 6, 5.9, 5.8, 5.7, 5.6, 5.5, 5 .4, 5.3, 5.2, 5.1, 5, 4.9, 4.8, 4.7, 4.6, 4.5, 4.4, 4.3, 4.2, 4 .1 or 4. Without being bound by theory, it is believed that this results in an affinity between free nicotine from the nicotine source and the acid in the vapor/aerosol, which affinity causes the vapor/aerosol to absorb nicotine. It can be derived or extracted from nicotine sources. It is believed that lowering the pH of the aerosolizable liquid may increase the extraction rate due to the higher affinity between free nicotine and the aerosolizable liquid.

The pH of a liquid depends on various properties such as the kPa or concentration of acid and the acidity or basicity of any other components in the liquid.

In some examples, the pH of the liquid is such that the difference between the pH of the nicotine source and the pH of the liquid is 3-5.5, 3.5-5, 3.7-4.8, preferably 4.1. ~4.2, preferably 3.6-3.8. Without being bound by theory, it is believed that the greater the pH difference, the higher the affinity between the acidic vapor/aerosol and the free nicotine, resulting in an increased extraction rate and increased nicotine delivery in the inhalable vehicle. It is

In some instances, properties of the acid-containing liquid, including but not limited to dipole moment, polarity and vapor pressure, increase the affinity of the liquid for free "deprotonated" nicotine in the nicotine source. may be changed or selected to allow For example, a higher dipolar moment, polarity or vapor pressure can increase the affinity of the liquid for free "deprotonated" nicotine in the nicotine source. The addition of acid may change the polar and vapor pressure properties of the liquid containing the acid.

Any acid suitable for protonating the nicotine acid may be used in the liquid. Examples of acids include inorganic acids such as hydrochloric acid, hydrobromic acid or sulfuric acid, saturated and unsaturated fatty acids, saturated and unsaturated alicyclic acids, aromatic acids (including heteroaromatics), poly carboxylic acids, hydroxy acids, alkoxy acids, keto acids, oxo acids, thio acids, amino acids, and each of the foregoing optionally substituted with one or more heteroatoms including, but not limited to, halogens, etc. are mentioned. In some examples the acid is a carboxylic acid, preferably benzoic acid. In some examples the carboxylic acid is a hydroxy acid, preferably lactic acid. In some examples, the acid is selected from the group consisting of benzoic acid, lactic acid and combinations thereof. The acid selected may be one that protonates free nicotine and promotes acid-base salt formation after the aerosol/vapor contacts the nicotine source, thereby providing the nicotine salt. This enhances nicotine extraction from the nicotine source, increases nicotine delivery of the assembly, and improves nicotine flavor in the inhalable medium.

In some examples, the pKa of the selected acid is greater than 0.5, 1, 1.5, 2, 2.5, 3 or 3.5, or preferably from 3.7 to 4.3. is. Without being bound by theory, this promotes acid-base salt formation of free nicotine to improve flavor and nicotine delivery by the inhalable medium, and reduces the pKa when the pH of the nicotine source is the same. A lower or higher acidity increases the affinity between acid-containing liquids and free nicotine, and also enhances nicotine extraction from the nicotine source, increasing nicotine delivery in the inhalable vehicle at the time of use. believed to be able to increase

In some examples, the acid has a pKa greater than 0.5, 1, 1.5, 2, 2.5, 3, or greater than 3.5, or preferably 3.7-4. .3 and a pH of 4-5, 4.1-4.9, 4.2-4.8, preferably 4.3-4.8, preferably 4.37, preferably 4 .8 to provide a liquid. Thus, in some embodiments, this promotes acid-base salt formation of free nicotine to improve flavor in use and increase nicotine delivery by the inhalable vehicle.

In some examples, the liquid has a vapor pressure at 25° C. of 0.05-3 kPa, 0.1-2.5 kPa, 0.1-2 kPa, 0.1-1.5 kPa, 0.1-1 kPa, 0.1-750 Pa, 0.1-500 Pa, 0.1-250 Pa, 0.1-100 Pa, 0.1-90 Pa, 0.1-80 Pa, 0.1-70 Pa, 0.1-60 Pa, 0.1-70 Pa 1-50 Pa, 0.1-40 Pa, 0.1-30 Pa, 0.1-20 Pa, 0.1-11 Pa, preferably 0.1-0.2, preferably 9-11 Pa . Acids become more volatile with increasing vapor pressure at 25°C. Therefore, more acid can be present in the aerosol/vapour, which can further increase the rate of free nicotine extraction from the nicotine source at the time of use.

In some examples, the liquid contains acid in an amount of 0.001 to 5% by weight. In some embodiments, the liquid is at least 0.01%, 0.1%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or at least 1% Contains a small amount of acid. In some embodiments, the liquid is up to 4.5 wt%, 4 wt%, 3.5 wt%, 3 wt%, 2.5 wt%, 2 wt%, 1.5 wt%, 1 wt% , 0.5%, 0.1% or up to 0.01% by weight of acid. Incorporating a higher concentration of acid into a liquid increases the acidity of the liquid and lowers its pH. Without being limited by theory, increasing the acidity of the liquid increases the affinity of the liquid for free nicotine in the nicotine source, resulting in enhanced nicotine extraction and increased nicotine delivery by the inhalable vehicle at the time of use. is thought to be possible.

In some examples, the acid-containing liquid may be provided in one of two or more portions of the consumables described herein. In some examples, the consumable is a cartridge and the acid-containing liquid may be provided in one of the two chambers of the cartridge described herein.

In some examples, the acid-containing liquid may be provided in a liquid pod configured for use in an assembly used to generate an inhalable medium as part of the kits described herein. .

In some instances, the acid may be selected such that the conjugate acid-base salt formed after reaction with free nicotine in the aerosol/vapor is highly volatile (i.e., has a high vapor pressure). . This can further increase the nicotine delivery in the inhalable vehicle.

In some embodiments, the vapor pressure of the conjugate acid-base will be similar to or slightly lower than the acid used. Conjugate acid-base formation is one mechanism for increasing vapor pressure.

Consumables Consumables may include two or more parts. In some embodiments, the liquid and solid nicotine-containing materials, including acid, are provided in different portions of the consumable so that the consumable remains separate prior to use.

A consumable may be a disposable product that is replaced entirely after use. Alternatively, the user can remove the first and/or second chambers from the consumable and replace the used material, or replenish the material into the first and/or second chamber and then replace it with the consumable. It may be configured to return to

During use in the aerosol-generating assembly, at least one portion of the consumable is heated to generate an aerosol and/or vapor. One or more further portions may be heated after contact with the generated aerosol and/or vapor.

In some embodiments, the portion containing the solid nicotine-containing material is located downstream of the portion containing the acid-containing liquid. In other embodiments, the portion containing the acid-containing liquid is located downstream of the portion containing the solid nicotine-containing material.

In some embodiments, the consumable is such as a cartridge with two or more chambers.

In some embodiments, the consumable comprises a first chamber (referred to herein as the "liquid chamber") for containing an acid-containing liquid and a second chamber for containing a solid nicotine-containing material. (referred to herein as the "solid chamber").

In one embodiment, the first and/or second chambers are in the form of pots, pods (which in some embodiments may be, for example, annular), and/or absorbent padding.

In some embodiments, the consumable is a rod comprising two or more portions that may be arranged, for example, along the longitudinal axis of the rod. One portion of the rod may contain a solid nicotine-containing material and another portion may contain an acid-containing liquid. The liquid may be provided on an absorbent carrier material such as an absorbent padding. Alternatively, the acid-containing liquid may be provided in a collapsible capsule. Other parts of the rod may include parts that cool the passing aerosol, such as cooling tubes. Another portion of the rod may include a filter portion containing filter material.

Assemblies In use, assemblies according to some examples of the present invention synthesize one or more components by passing the liquid volatilized by the heater through a solid nicotine source in the form of at least one of a vapor and an aerosol. from a nicotine source to produce an inhalable medium. In some examples, the inhalable medium is expelled from the outlet.

The assembly includes a first chamber (referred to herein as the "liquid chamber") for containing an aerosolizable liquid and a second chamber (referred to herein as a (referred to as a "solid chamber"). The assembly may further include an outlet and a flow path between the chamber and the outlet.

As the vapor/aerosol passes through the nicotine source, it contacts the nicotine source and takes up one or more components thereof. After being incorporated into the vapor/aerosol, one or more components from the nicotine source may undergo reactions with components in the vapor/aerosol. For example, an acid-base salt-forming reaction may occur. Without being bound by theory, it is believed that the acid-base salt-forming reaction in vapors/aerosols occurs at a faster rate than the acid-base salt-forming reaction in solids. The use of acidic vapours/aerosols may result in an increase in the amount of nicotine extracted or drawn from the tobacco compared to vapours/aerosols with a neutral pH.

In some embodiments, the assembly heats the nicotine source during use to facilitate component release of the nicotine source into the inhaled medium. In other embodiments, the assembly heats both the nicotine source and the aerosolizable liquid. Preferably, the assembly is such that the heater directly heats only the aerosolizable liquid and the nicotine source is heated by thermal heat carried over to the vapor/aerosol formed from the aerosolizable liquid (thereby resulting in a later vapor/aerosol). volatilize components of the nicotine source entrained in the aerosol stream). That is, the assembly is configured to directly heat the aerosolizable liquid, but not the solid nicotine-containing material.

In some instances, the present invention provides a cartridge for use in an inhalable medium generating assembly, wherein in the first chamber an aerosolizable liquid comprising an acid corresponding to the liquid described herein above and a solid nicotine-containing material corresponding to the nicotine source described herein above in a second chamber. The cartridge is configured such that, in use, the vapor and/or aerosol produced from the aerosolizable liquid passes through the second chamber containing the nicotine source and picks up one or more components of the nicotine source. be. Suitably, the cartridge may be configured for use in the inhalable medium generating assembly described herein.

In some embodiments, the assembly cools the vaporized material downstream of the heater and upstream of the second chamber containing the nicotine source so that droplets that, in use, pass through the nicotine source in the second chamber. a cooling device or zone configured to form an aerosol of In some embodiments, the cooling device may be configured to act substantially as a heat exchanger to allow heat recovery from vapor and/or aerosol. The recovered heat can be used, for example, to preheat the nicotine source and/or help heat the aerosolizable liquid.

In one embodiment, the assembly is battery operated.

In one embodiment, each heater is an electrical resistance heater.

In one embodiment, the heater is activated by blowing. That is, the assembly includes a puff-sensing device that only heats the aerosolizable liquid upon sensing a puff. This means that vapor/aerosol is formed in the assembly only during puffing.

Kits The present invention also provides kits that include aerosol-generating assemblies according to embodiments of the present invention. The kit comprises (i) a liquid pod containing an aerosolizable liquid according to embodiments described herein and (ii) a nicotine containing pod containing a solid nicotine containing material according to embodiments described herein. including. The features described above with respect to assembly herein are expressly disclosed in combination with the kit aspect of the present invention. Thus, for example, the assembly may include one or more puff activation devices, cooling elements or zones, activation means such as buttons, additional heaters, wetting agent pumps, and the like.

Use of an acidic vapor and/or aerosol to extract nicotine from a solid nicotine-containing material having a working pH greater than 7, wherein the nicotine extraction rate exceeds the nicotine salt formation rate in the solid nicotine-containing material, and A use is also provided in which the nicotine content in the vapor and/or aerosol is increased compared to using a neutral vapor and/or aerosol.

Exemplary Embodiments Examples of consumables including cartridges, liquid pods, nicotine containing pods and rods, and inhalable medium generating assemblies according to some embodiments of the present invention will now be described with reference to the accompanying drawings. do.

Referring to Figure 1, an example of an inhalable medium generating assembly 1 is shown. Broadly, the assembly 1 volatilizes an aerosolizable liquid containing an acid to produce an inhalable medium containing one or more components derived from the nicotine source to produce a vapor and a vapor passing through the nicotine source. /or form an aerosol.

In this regard, firstly, vapor is generally a substance in the gas phase below its critical temperature, meaning that it can be condensed into a liquid by e.g. raising its pressure without lowering its temperature. Please note that Aerosols, on the other hand, are generally colloids of fine solid particles or droplets present in air or another gas. A "colloid" is a substance in which microscopically dispersed insoluble particles are suspended throughout another substance.

Referring again to FIG. 1, the assembly 1 of this example has a generally hollow cylindrical outer housing 2 . Housing 2 has an open end 3 . In this example a tubular mouthpiece 4 is provided at the open end 3 . The mouthpiece 4 in this example is removable from the housing 2 by the user. An O-ring or other seal 5 helps seal the mouthpiece 4 in the housing 2 . At or towards the other end 6 of the housing 2 is a battery 7 that powers the various components of the assembly 1, as further explained below. Battery 7 may be a rechargeable battery or a disposable battery. A controller 8 is also provided on the housing 2 for controlling the operation of the various components of the assembly 1, as explained further below.

The housing 2 has a chamber 9 (sometimes referred to herein as the "liquid chamber") that holds or contains an aerosolizable liquid (sometimes simply referred to herein as the "liquid") 10. The liquid 10 corresponds herein to the liquids described above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example. A variety of different configurations can be used for the liquid chamber 9 . In the example of FIG. 1 the liquid chamber 9 is in the form of an annular chamber 9 provided within the housing 2 between the open end 3 and the other end 6 . In this particular example, the housing 2 is divided into two parts, a first part 2a towards the open end 3 and a second part 2b towards the other end 6. FIG. The first and second parts 2a and 2b of the housing 2 may be connected to each other by threads or bayonet fittings or the like. In use, the user can separate the first and second parts 2a and 2b of the housing 2 so that the aerosolizable liquid 10 can be replenished or replaced as needed. Alternatively, the mouthpiece 4 can be removed to make the liquid chamber 9 accessible. However, it will be appreciated that other configurations are possible. For example, the liquid 10 may be supplied in separate annular pot-like liquid chambers that can be removed entirely from the housing 2 . The individual liquid chambers may be disposable so that the user can replace the liquid 10 by inserting a new liquid chamber containing the liquid 10 into the housing 2 . Alternatively, the chamber may be reusable. In such an example, the user may refill or replace the liquid 10 in the liquid chamber removed from the housing 2 and then return the refilled liquid chamber to the housing 2 . It is understood that the housing 2 may not be divided into two parts and may be provided with other configurations to allow contact by the user, for example to allow refilling in situ. would be

The heater 11 is typically provided centrally in the housing 2, ie centrally along the length and width of the housing 2 in this example. In this example the heater 11 is powered by the battery 7 and is therefore electrically connected to the battery 7 . Heater 11 may be an electrical resistance heater including, for example, a Nichrome resistance heater, a ceramic heater, or the like. The heater 11 may be made of a number of different materials, for example a wire, which may be in the form of a coil, a plate (one or more of which may be conductive and one or more of which may be non-conductive). multi-layer plate), mesh (eg, woven or non-woven, as well as multi-layer), thin film heaters, and the like. Other configurations may be used, including non-electrical heating components.

This heater 11 is provided to volatilize the liquid 10 . In the example described, annular wick 12 surrounds heater 11 and is in (thermal) contact with heater 11 . The outermost surface of annular wick 12 contacts liquid 10 contained in liquid chamber 9 . The wick 12 is totally absorbent and serves to draw the liquid 10 out of the liquid chamber 9 by capillary action. The wick 12 is preferably nonwoven and may be a material such as cotton or wool, or a synthetic material including, for example, polyester, nylon, viscose or polypropylene. This will be explained in more detail below, but it should now be noted that in use the liquid 10 drawn into the wick 12 is heated by the heater 11 . The liquid 10 may be volatilized to produce an aerosol of droplets or heated sufficiently to produce a vapor. The aerosol and/or vapor so produced is expelled from the wick 12 and moves toward the mouthpiece 4 as indicated by arrow A upon the action of the user holding the mouthpiece 4 in their mouth. The heater 11 and wick 12 are provided as a single, effectively integrated product, sometimes referred to as an "atomizer", so that the heating and wicking actions are effectively performed by a single unit. good too.

The housing 2 further contains a chamber (sometimes referred to herein as the "solid chamber") 13 that holds or contains a solid nicotine-containing material (referred to herein as the "nicotine source") 14 in the assembly 1. do. The nicotine source 14 corresponds to the nicotine sources described herein above and may be base-treated, eg, having a pH of 8-9.5. In use, the user touches the solid chamber 13 to replace or replenish the nicotine source 14 through the open end 3 of the housing 2 by removing the mouthpiece 4 and/or separating the two parts 2a and 2b of the housing 2. can be done. A variety of different configurations can be used for solid chamber 13 . For example, each solid chamber 13 may be a tube containing nicotine that is completely open at both ends. As another example, solid chambers 13 may each be a tube having one or more end walls with through holes through which vapors and/or aerosols may pass. Solid chamber 13 may remain in situ within housing 2 while the user removes and replaces nicotine source 14 . Alternatively, the solid chamber 13 containing the nicotine source 14 may be a separate product that is wholly inserted into and removed from the housing 2 during use. This type of removable solid chamber 13 may be disposable such that the user replaces the nicotine source 14 by inserting a new solid chamber 13 containing unused nicotine source 14 into the housing 2. good. Alternatively, chamber 13 may be reusable. In such an example, the user may replace the nicotine source 14 within the solid chamber 13 while removed from the housing 2 and then return the refilled chamber 13 to the housing 2 . In yet another example, the solid chamber 13 may be provided inside the housing 2 with a clip or the like to hold the nicotine source 14 in place. In some instances, nicotine source 14 fits easily within solid chamber 13 . Alternatively, chamber 9 containing liquid 10 may itself be configured to support or carry nicotine source 14 . For example, the liquid chamber 9 may have one or more clips, tubes, or the like to receive the nicotine source 14 and hold it in place. Said dual-function liquid chamber 9/solid chamber 13, intended both to contain the liquid 10 and to receive the nicotine source 14, may be in the form of a cartridge or the like and be a disposable product or The nicotine source 14 may be reusable, such that the user replaces or replenishes it as needed. In some instances, the user need only replenish or replace the nicotine source 14 from time to time, provided that sufficient liquid 10 is supplied for multiple uses. When the liquid 10 is consumed, the user disposes of the dual function liquid chamber 9/solid chamber 13 and uses a new one. Likewise, sufficient nicotine source 14 is provided for multiple uses, and the user need only replenish or replace liquid 10 from time to time. When the nicotine source 14 has been consumed, the user disposes of the dual function liquid chamber 9/solid chamber 13 and uses a new one. Specific examples of dual function liquid/solid chambers are discussed in detail below.

A nicotine source 14 is positioned in the housing 2 downstream of where the aerosol and/or vapor is generated from the liquid 10 and upstream of the open end 3 of the housing 2 and the mouthpiece 4 . In this particular example, nicotine source 14 is effectively delivered to the same portion or chamber of housing 2 as wick 12 . The aerosol and/or vapor generated from the liquid 10 is expelled from the wick 12 and travels toward the nicotine source 14, as indicated by arrow A, by the action of the user sucking the mouthpiece 4. As shown in FIG. In certain embodiments, nicotine source 14 is porous such that aerosols and/or vapors pass through nicotine source 14 and then through open end 3 of housing 2 and mouthpiece 4 .

In some embodiments, the nicotine source 14 and/or its chamber 13 are spaced between the nicotine source 14/solid chamber 13 and the interior of the housing 2 such that the entire aerosol and/or vapor flows through the nicotine source 14. is configured such that there are no voids in the

The liquid 10 is preferably a liquid that is volatilizable at moderate temperatures, preferably above 100-300° C., especially around 150-250° C., so as to help reduce the power consumption of the assembly 1 . Suitable materials include materials conventionally used in e-cigarette assemblies including, for example, propylene glycol and glycerol (also known as glycerin). The liquid 10 corresponds herein to the liquids described above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example.

Nicotine source 14 imparts flavor to the aerosol and/or vapor produced from liquid 10 as it passes through nicotine source 14 . As the acidic aerosol and/or vapor passes through and over the nicotine source 14, the hot aerosol and/or vapor causes the organic compounds and other compounds or components to impart organoleptic properties to the nicotine source. The intake from the nicotine source 14 imparts flavor to the aerosol and/or vapor on its way toward the mouthpiece 4 . In particular, liberated “deprotonated” nicotine in nicotine source 14 undergoes acid-base salt formation with acidic vapors and/or aerosols from liquid 10 . In this manner, nicotine can be drawn or extracted from the nicotine source 14 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing the acidic vapor/aerosol through the nicotine source 14 provides the nicotine in a more palatable, salt form.

Assembly 1 provides nicotine for the user. The nicotine may be obtained from nicotine source 14, provided as a coating on nicotine source 14, or the like, or a combination thereof. Similarly, flavoring agents may be added to nicotine source 14 and/or liquid 10 .

In the example illustrated in FIG. 1, the only source of heat needed to heat nicotine source 14 in assembly 1 to produce organic compounds and other compounds or components from nicotine source 14 is from heating liquid 10 . It is the hot aerosol and/or vapor that is produced.

Referring now to Figure 2, another example of an inhalable medium generating assembly is shown. In the following description and in FIG. 2, components and features that are the same or similar to corresponding components and features of the example described with reference to FIG. For brevity, the full description of these components and features is not repeated here. It will be appreciated that the configurations, alternatives, etc., described above with respect to the example of FIG. 1 are also applicable to the example of FIG. Again, in broad terms, assembly 201 of FIG. Vapors and/or aerosols are formed that pass through source 214 .

Assembly 201 in this example has a generally hollow cylindrical outer housing 202 that includes an open end 203 and a tubular mouthpiece 204 . The mouthpiece 204 in this example is removable from the housing 202 by the user, and an O-ring or other seal 205 helps seal the mouthpiece 204 in the housing 202 . A battery 207 that powers the various components of the assembly 201 and a controller 208 are provided at or towards the other end 206 of the housing 202 . The housing 202 in this example is split into two pieces, a first piece 202a facing the open end 203 and a second piece 202b facing the other end 206. As shown in FIG.

Housing 202 has a chamber (sometimes referred to herein as “liquid chamber”) 209 that holds or contains an aerosolizable liquid (sometimes simply referred to herein as “liquid”) 210 . The liquid 210 corresponds to the liquids described herein above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example. Liquid chamber 209 may be of any of the types described above in connection with the example of FIG. A heater 211 is typically provided centrally (along the length and width) of housing 202 to volatilize liquid 210 . In this example, heater 211 is powered by battery 207 and is therefore electrically connected to battery 207 . The heater 211 may be an electric resistance heater, a ceramic heater, or the like. For example, the heater 211 may be in the form of, for example, a wire, a plate (one or more of which may be conductive and one or more of which may be non-conductive) of different materials. a multi-layer plate consisting of a mesh), a mesh (eg, woven or non-woven, as well as multi-layer), a thin film heater, or the like. Other heating arrangements may be used, including inductive heating arrangements or non-electrical heating arrangements. An annular wick 212 surrounds the heater 211 and is in (thermal) contact with the heater 211 . The outermost surface of annular wick 212 contacts liquid 210 contained in liquid chamber 209 . The liquid 210 may be heated to produce an aerosol of droplets or heated sufficiently to produce a vapor. The aerosol and/or vapor so generated is expelled from the wick 212 and travels toward the mouthpiece 204 as indicated by arrow A upon the action of the user sucking the mouthpiece 204 . Heater 211 and wick 212 may be provided as a single, effectively integrated product such that heating and wicking are effectively performed by a single unit.

Housing 202 further contains a chamber (sometimes referred to herein as a “solid chamber”) 213 that holds or contains nicotine source 214 in assembly 201 . The nicotine source 214 corresponds to the nicotine sources described herein above and may be base-treated and have a pH of, for example, 8-9.5. Solid chamber 213 may be of any of the types described above in connection with the example of FIG. Nicotine source 214 is located in housing 202 downstream of where aerosol and/or vapor is generated from liquid 210 and upstream of open end 203 of housing 202 and mouthpiece 204 . In this particular example, nicotine source 214 is effectively delivered to the same portion or chamber of housing 202 as wick 212 . The aerosol and/or vapor generated from liquid 210 is expelled from wick 212 and travels toward nicotine source 214, as indicated by arrow A, by the user's action on mouthpiece 204. FIG. In certain embodiments, nicotine source 214 is porous such that aerosols and/or vapors pass through nicotine source 214 and then through open end 203 of housing 202 and mouthpiece 204 .

In some embodiments, the nicotine source 214 and/or its chamber 213 are spaced between the nicotine source 214/chamber 213 and the interior of the housing 202 such that the entire aerosol and/or vapor flows through the nicotine source 214. It is constructed so that there are no voids at all. As the aerosol and/or vapor passes through and over the nicotine source 214, the hot aerosol and/or vapor converts organic compounds and other compounds or components into the nicotine source that imparts sensory properties to the nicotine source. Intake from 214 imparts flavor to the aerosol and/or vapor en route to mouthpiece 204 . In particular, liberated “deprotonated” nicotine in nicotine source 214 undergoes acid-base salt formation with acidic vapor and/or aerosol from liquid 210 . In this manner, nicotine can be drawn or extracted from the nicotine source 214 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing the acidic vapor/aerosol through the nicotine source 214 provides the nicotine in a more palatable, salt form.

Liquid chamber 209 containing liquid 210 may itself be configured to support or carry nicotine source 214 . For example, the liquid chamber 209 may have one or more clips, tubes, or the like to receive the nicotine source 214 and hold it in place. The dual-function liquid chamber 209/solid chamber or receptacle 213, intended both to contain the liquid 210 and to receive the nicotine source 214, may be in the form of a cartridge or the like and may be a disposable product or a liquid. 210 and nicotine source 214 may be reusable such that the user replaces or replenishes them as needed. In some instances, the user need only replenish or replace the nicotine source 214 from time to time, provided that sufficient liquid 210 is supplied for multiple uses. When the liquid 210 is consumed, the user disposes of the dual function liquid chamber 209/solid chamber 213 and uses a new one. Similarly, the user would only need to replenish or replace the liquid 210 from time to time provided that he supplied enough nicotine source 214 for multiple uses. When the nicotine source 214 is consumed, the user disposes of the dual function liquid chamber 209/solid chamber 213 and uses a new one.

In the example assembly 201 of FIG. 2, a second heater 215, such as an oven heater, is provided in thermal contact with the nicotine source 214 to preheat the nicotine source 214 throughout use of the assembly 201; or provide additional heat to the nicotine source 214; This facilitates the release of ingredients from nicotine source 214 as vapors and/or aerosols pass through nicotine source 214 in use. The amount of liquid 210 heated may be reduced to achieve the desired heating of nicotine source 214 . The second heater 215 may be, for example, an electrical resistance heater powered by the battery 207, a ceramic heater, or the like. For example, the second heater 215 may be, for example, a wire, which may be in the form of a coil, a plate (one or more of which may be conductive and one or more of which may be non-conductive). multi-layer plates of different materials), mesh (eg, woven or non-woven, as well as multi-layer), thin film heaters, and the like. The second heater 215 may be an induction heater powered by the battery 207, for example. Nicotine source 214 may include materials that are susceptible to induction heating. Other heating arrangements may be used for the second heater 215, including non-electrical heating arrangements.

In the example assembly 201 of FIG. 2, a heater 215 for heating the nicotine source 214 is provided external to the nicotine source 214 and heats the nicotine source 214 by thermal conduction from the exterior of the nicotine source 214 . Heater 215 in this example is generally cylindrical. Heater 215 may actually be an integral element of assembly 201 or may be provided as part of housing 202 . Alternatively, heater 215 may be integral with solid chamber 213 that holds or contains nicotine source 214 . In this alternative, if solid chamber 213 is disposable, heater 215 would be replaced when the user loads assembly 201 with a new solid chamber 213 containing an unused nicotine source. .

Referring now to Figure 3, another example of an inhalable medium generating assembly is shown. In the following description and in FIG. 3, components and features that are the same or similar to corresponding components and features of the example described with reference to FIG. For brevity, the full description of these components and features is not repeated here. It will be appreciated that the arrangements and alternatives, etc., described above with respect to the examples of FIGS. 1 and 2 are also applicable to the example of FIG. Again, broadly, the assembly 301 of FIG. form vapors and/or aerosols.

The assembly 301 of this example also has a generally hollow cylindrical outer housing 302 that includes an open end 303 and a tubular mouthpiece 304 and is removable from the housing 302 by the user. An O-ring or other seal 305 helps seal the mouthpiece 304 in the housing 302 . A battery 307 that powers the various components of the assembly 301 and a controller 308 are provided at or towards the other end 306 of the housing 302 . The housing 302 in this example is also split into two parts, a first part 302a facing the open end 303 and a second part 302b facing the other end 306. As shown in FIG.
Housing 302 has a chamber (sometimes referred to herein as “liquid chamber”) 309 that holds or contains an aerosolizable liquid (sometimes simply referred to herein as “liquid”) 310 . The liquid 310 corresponds to the liquids described herein above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example. Liquid chamber 309 may be of any of the types described above in connection with the examples of FIGS. A heater 311 is generally provided in the center of the housing 302 to heat the liquid 310 . Heater 311 may be of any type described above. In this example, heater 311 is powered by battery 307 and is therefore electrically connected to battery 307 . An annular wick 312 surrounds the heater 311 and is in (thermal) contact with the heater 311 . The outermost surface of annular wick 312 contacts liquid 310 contained in liquid chamber 309 . The liquid 310 may be heated to produce an aerosol of droplets or heated sufficiently to produce a vapor. The aerosol and/or vapor so produced is ejected from the wick 312 and travels toward the mouthpiece 304 as indicated by arrow A upon the action of the user sucking the mouthpiece 304 . Heater 311 and wick 312 may be provided as a single, effectively integrated product such that heating and wicking are effectively performed by a single unit.

Housing 302 further contains a chamber (sometimes referred to herein as a “solid chamber”) 313 that holds or contains nicotine source 314 in assembly 301 . The nicotine source 314 corresponds to the nicotine sources described herein above and may be base-treated and have a pH of, for example, 8-9.5. Solid chamber 313 may be of any of the types described above in connection with the examples of FIGS. (In the example depicted in FIG. 3, solid chamber 313 is in the form of a tube having end walls 316 with through holes 317 through which vapors and/or aerosols may pass, which was mentioned above as an option. nicotine source 314 is positioned in housing 302 downstream of where aerosol and/or vapor is generated from liquid 310 and upstream of open end 303 of housing 302 and mouthpiece 304 . Again in this particular example, nicotine source 314 is effectively delivered to the same portion or chamber of housing 302 as wick 312 . The aerosol and/or vapor generated from the liquid 310 is expelled from the wick 312 and travels toward the nicotine source 314 as indicated by arrow A by the action of the user sucking the mouthpiece 304 . In certain embodiments, nicotine source 314 is porous such that aerosols and/or vapors pass through nicotine source 314 and then through open end 303 of housing 302 and mouthpiece 304 .

In some embodiments, the nicotine source 314 and/or its chamber 313 are spaced between the nicotine source 314/chamber 313 and the interior of the housing 302 such that the entire aerosol and/or vapor flows through the nicotine source 314. It is constructed so that there are no voids at all. As the aerosol and/or vapor passes through and over the nicotine source 314 , the hot aerosol and/or vapor causes the mouthpiece to absorb organic and other compounds or components from the nicotine source 314 . The aerosol and/or vapor on its way to 304 is perfumed. In particular, liberated “deprotonated” nicotine in nicotine source 314 may undergo acid-base salt formation with acidic vapors and/or aerosols from liquid 310 . In this manner, nicotine can be drawn or extracted from the nicotine source 314 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing the acidic vapor/aerosol through the nicotine source 314 may provide nicotine in a more palatable, salt form.

Chamber 309 containing liquid 310 may itself be configured to support or carry nicotine source 314 . For example, the liquid chamber 309 may have one or more clips, tubes, or the like to receive the nicotine source 314 and hold it in place. The dual function liquid chamber 309/solid chamber or receptacle 313, intended both to contain the liquid 310 and to receive the nicotine source 314, may be in the form of a cartridge or the like and may be a disposable product or a liquid 310 and nicotine source 314 may be reusable such that the user replaces or replenishes them as needed. In some instances, the user may only replenish or replace the nicotine source 314 from time to time, provided that sufficient liquid 310 is supplied for multiple uses. When the liquid 310 is consumed, the user disposes of the dual function liquid chamber 309/solid chamber 313 and uses a new one. Similarly, the user may only need to replenish or replace the liquid 310 from time to time, provided that sufficient nicotine source 314 is supplied for multiple uses. When the nicotine source 314 is consumed, the user disposes of the dual function liquid chamber 309/solid chamber 313 and uses a new one.
Again in the example assembly 301 of FIG. 3, a second heater 318 is provided in thermal contact with the nicotine source 314 to, in use, as vapors and/or aerosols pass through the nicotine source 314, The nicotine source 314 is heated to facilitate the release of ingredients from the nicotine source 314 . The second heater 318 may be, for example, an electrical resistance heater powered by the battery 307, a ceramic heater, or the like. Other heating arrangements may be used for the second heater 318, including non-electrical heating arrangements.

In the example assembly 301 of FIG. 3, a heater 318 for heating the nicotine source 314 is provided inside the nicotine source 314 and heats the nicotine source 314 by thermal conduction from the interior of the nicotine source 314 . Heater 318 in this example is generally in the form of a cylindrical rod positioned along the central longitudinal axis of nicotine source 314 . In other constructions, the heater 318 is a wire, which may be in the form of, for example, a coil, a plate (one or more of which may be conductive and one or more of which may be non-conductive). It may be a multi-layer plate consisting of a plurality of different materials, mesh (eg, woven or non-woven, as well as multi-layer), thin film heaters, and the like. The nicotine source 314 in this example is generally tubular or otherwise has an internal opening for receiving the heater 318 . Heater 318 may actually be an integral element of assembly 301 or may be provided as part of housing 302 . In this example, nicotine source 314 surrounds second heater 318 when nicotine source 314 is loaded into assembly 301 (eg, solid chamber 313 containing nicotine source 314 is loaded into assembly 301 ). Alternatively, heater 318 may be integral with chamber 313 that holds or contains nicotine source 314 . In this alternative, if solid chamber 313 is disposable, heater 318 would be replaced when the user loads assembly 301 with a new solid chamber 313 having an unused nicotine source.

In another example, multiple internal heaters 318 may be provided to provide more efficient heating of the nicotine source 314 . In another example, nicotine source 314 includes one or more external heaters (such as second heater 215 in the example of FIG. 2) and one or more internal heaters (such as second heater 318 in the example of FIG. 3). ) may be heated by both

Referring now to FIG. 4, a liquid chamber 601 containing an acid-containing aerosolizable liquid 602 and a receptacle or chamber (sometimes referred to herein as a "solid chamber") 603 for a nicotine source 604 are provided. A schematic longitudinal cross-sectional view of an example cartridge 600 is shown. The liquid 602 corresponds to the liquids described herein above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example. The nicotine source 604 corresponds to the nicotine sources described herein above and may be base-treated and have a pH of, for example, 8-9.5. In this example, the liquid chamber 601 and the nicotine source chamber 603 are initially formed integrally, or initially formed of two parts that are later assembled in a substantially permanent fashion, such that provided as one integral component. Cartridge 600 is such that liquid 602 is volatilized to produce an aerosol of droplets, or heated sufficiently to produce vapor, at least a portion and preferably all or substantially all of the aerosol and/or vapor being nicotine. It is configured to pass through the source 604 and absorb perfume from the nicotine source 604 . In particular, liberated “deprotonated” nicotine in nicotine source 604 may undergo acid-base salt formation with acidic vapors and/or aerosols from liquid 602 . In this manner, nicotine can be drawn or extracted from the nicotine source 604 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing an acidic vapor/aerosol through the nicotine source 604 may provide nicotine in a more palatable, salt form.

In the example of FIG. 4, liquid chamber 601 is provided generally in the center of cartridge 600 . The liquid chamber 601 in the example described is frusto-conical, but may have different shapes such as conical, cylindrical, and the like. Liquid chamber 601 is surrounded by an outer shell 605 that defines an annular channel 606 that encircles the exterior of the length of liquid chamber 601 and extends from one end of liquid chamber 601 to the other. Outer shell 605 extends beyond first end wall 607 of liquid chamber 601 to define chamber 608 beyond first end wall 607 of liquid chamber 601 . In the described example, chamber 608 and annular channel 606 both contain nicotine source 604 and thus can be considered to collectively provide solid chamber 603 for nicotine source 604 . In another example, nicotine source 604 can be provided only in chamber 608, thus defining a solid chamber 603 for nicotine source 604, and annular channel 606 being empty. Chamber 608 is interrupted by an end wall 609 spaced from end wall 607 of liquid chamber 601 . End wall 609 may be part of outer shell 605 or may be another plastic or rubber cap or the like. In yet another example, annular channel 606 contains nicotine source 604 and no material is present in chamber 608; in fact, chamber 608 may be omitted and channel 606 is substantially Terminate at end wall 609 . Channel 606 and/or chamber 608 may be entirely filled with nicotine source 604 or contain only a portion or mass of nicotine source 604 . End wall 609 is porous and/or has one or more through holes 610 to allow aerosols and/or vapors to exit cartridge 600 and be inhaled by the user. . The liquid chamber 601 and solid chamber 603 may each be formed of rigid, watertight and airtight materials such as metal, suitable plastics.

The example cartridge 600 illustrated in FIG. 4 is provided with a heater 611 and a wick 612 in (thermal) contact with the heater 611 . In this example, heater 611 and wick 612 are provided as a single unit, often referred to as an "atomizer." In this example, when cartridge 600 includes an atomizer, the cartridge is often referred to as a "cartomizer." The orientation of heater 611 is shown schematically, for example heater 611 may be a coil having its longitudinal axis perpendicular to the longitudinal axis of cartridge 600 rather than parallel as shown in FIG. .

Wick 612 contacts liquid 602 . This can be accomplished, for example, by inserting the wick 612 through a through hole (not shown) in the second end wall 613 of the liquid chamber 601 . Alternatively, or additionally, the second end wall 613 may be a porous member (schematically depicted in dashed lines in FIG. 4) that allows liquid to pass from the liquid chamber 601 and a wick. 612 may contact porous second end wall 613 . The second end wall 613 may be in the form of a porous ceramic disc, for example. This type of porous second end wall 613 helps regulate liquid flow to the wick 612 . Wick 612 is generally absorbent and serves to draw liquid 602 from liquid chamber 601 by capillary action. The wick 612 is preferably nonwoven and may be a material such as cotton or wool, or a synthetic material including, for example, polyester, nylon, viscose or polypropylene.

In use, cartridge 600 is connected by the user to the battery section (not shown) of the assembly so that heater 611 can be powered. When the atomizer's heater 611 is energized (for example, it may be energized by a user operating a button throughout the assembly, or by a puff detector throughout the assembly, as is known per se), a wick 612 Liquid 602 drawn from liquid chamber 601 is heated by heater 611 which volatilizes or vaporizes the liquid. When a user sucks on the mouthpiece of the entire assembly, vapor and/or aerosol travels, as indicated by arrow A, into annular channel 606 and chamber 608 surrounding the exterior of the length of liquid chamber 601 . The vapor and/or aerosol absorbs the flavorant from the nicotine source 604 and incorporates one or more components thereof. When vapors and/or aerosols contact nicotine source 604, liberated “deprotonated” nicotine in nicotine source 604 may undergo acid-base salt formation with acidic vapors and/or aerosols from liquid 602. good. In this manner, nicotine can be drawn or extracted from the nicotine source 604 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing an acidic vapor/aerosol through the nicotine source 604 can provide nicotine in a more palatable, salt form. Vapors and/or aerosols may then exit cartridge 600 through end wall 609 as indicated by arrow B. FIG. Optionally, a one-way valve 614 is provided inside the end wall 609 so that vapors and/or aerosols can only exit the cartridge 600 and cannot flow back to the heater 611 or electronics throughout the assembly. good.

Referring now to FIG. 5, a chamber (sometimes referred to herein as the "liquid chamber") 701 containing an aerosolizable liquid (sometimes simply referred to herein as the "liquid") 702 A schematic longitudinal cross-sectional view of another example cartridge 700 having a chamber (sometimes referred to herein as a “solid chamber”) 703 defining a chamber 708 containing a nicotine source 704 and a nicotine source 704 is shown. The liquid 702 corresponds to the liquids described herein above and may have a pH of 4-5 and/or may comprise an acid with a pKa greater than 3, for example. The nicotine source 704 corresponds to the nicotine sources described herein above and may be base-treated and have a pH of, for example, 8-9.5. In the following description and in FIG. 5, components and features that are the same or similar to corresponding components and features of the example described with reference to FIG. For brevity, the full description of these components and features is not repeated here.

In this example, liquid chamber 701 and solid chamber 703 of cartridge 700 are provided as separate components that are removably connected to each other in use. Liquid chamber 701 and solid chamber 703 may be removably secured to each other, for example by clipping or otherwise, or for example solid chamber 703 may simply ride or frictionally fit onto liquid chamber 701 . may Cartridge 700 is such that liquid 702 is volatilized to produce an aerosol of droplets, or heated sufficiently to produce vapor, at least a portion and preferably all or substantially all of the aerosol and/or vapor being nicotine. It is configured to pass through the source 704 and absorb the flavorant from the nicotine source 704 to take up one or more components thereof. When vapors and/or aerosols contact nicotine source 704, the liberated “deprotonated” nicotine in nicotine source 704 may also undergo acid-base salt formation with acidic vapors and/or aerosols from liquid 702. good. In this manner, nicotine can be drawn or extracted from the nicotine source 704 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing the acidic vapor/aerosol through the nicotine source 704 can provide nicotine in a more palatable, salt form.

In this example, the liquid chamber 701 is surrounded by an outer shell 705 that defines an annular channel 706 that encircles the exterior of the length of the liquid chamber 701 and extends from one end of the liquid chamber 701 to the other. Outer shell 705 extends beyond first end wall 707 of liquid chamber 701 and terminates in end wall 709 . End wall 709 may be another plastic or rubber cap or the like. End wall 709 is porous and/or has one or more through holes 710 to allow aerosols and/or vapors to exit annular channel 706 . End wall 709 is closed so that vapor and/or aerosol can only exit annular channel 706 at the end distal from heater 711 and wick 712 and cannot return to heater 711 or the electronics of the entire assembly. A one-way valve 714 may be provided inside the . Nicotine source chamber 703 is positioned above end wall 709 such that, in use, vapors and/or aerosols exiting through end wall 709 travel to solids chamber 703 . Solids chamber 703 has an exit opening and/or porous end wall 715 to allow aerosols and/or vapors to exit cartridge 700 and be inhaled by the user.

In use, cartridge 700 is connected by the user to the battery section (not shown) of the assembly so that heater 711 can be powered. When the atomizer heater 711 is energized (for example, it may be energized by a user operating a button throughout the assembly, or by a puff detector throughout the assembly, as is known per se), the end wall Liquid 702 drawn from liquid chamber 701 by wick 712 through 713 is heated by heater 711 which volatilizes or vaporizes the liquid. When a user sucks on the mouthpiece of the entire assembly, vapor and/or aerosol travels to an annular channel 706 surrounding the exterior of the liquid chamber 701 the length of the outer shell 705, as indicated by arrow A. Towards end wall 709 . The vapor or aerosol then travels through end wall 709 (via one-way valve 714 , if present) and into solid chamber 703 where it releases perfume from nicotine source 704 contained therein. Absorb and take up one or more components of nicotine source 704 . When vapors and/or aerosols contact nicotine source 704, the liberated “deprotonated” nicotine in nicotine source 704 may also undergo acid-base salt formation with acidic vapors and/or aerosols from liquid 702. good. In this manner, nicotine can be drawn or extracted from the nicotine source 704 by acidic vapors and/or aerosols to increase nicotine delivery in the inhalable medium. Additionally, passing the acidic vapor/aerosol through the nicotine source 704 can provide nicotine in a more palatable, salt form. Vapors and/or aerosols may then exit cartridge 700 through end wall 715 of solids chamber 703 as indicated by arrow B. FIG.

4 and 5 are typically used with so-called modular or "e-go" products in which the cartomizer is mounted to the battery section (not shown) by screw threads or bayonet fittings or the like. Especially suitable for combined use. Cartomizers are typically discarded entirely after use and new replacement cartomizers are used. Alternatively, the user may be able to reuse the cartridge by replenishing the liquid and/or replacing the solid material from time to time as needed.

The examples illustrated in Figures 4 and 5 can readily be configured for use with other types of e-cigarette hybrid devices known per se. For example, there are so-called "fake e-cigarettes" or "cigar-like" assemblies that are generally small and have a form and appearance similar to conventional cigarettes. In such assemblies, the liquid chamber typically contains some padding material, for example cotton, to retain the liquid. The cartridges or cartomizers in such known assemblies are typically entirely disposable, but may be capable of being refilled with liquids and/or replaced with solid materials in instances using embodiments of the present invention. . As another example, they typically have large liquid chambers for holding relatively large amounts of liquid and also provide advanced features that allow the user to control many aspects of the assembly. There are so-called tank assemblies or personal vaporizers that do.

As an alternative to any of the above atomizer arrangements, a liquid atomizer (ie heater and wick) may be provided separate from the liquid and solid chambers. The atomizer may, for example, be provided as part of the battery section of the overall assembly to which the cartridge is removably attached by the user during use.

In any of the examples described above in connection with Figures 4 and 5, a nicotine source heater may be provided to "preheat" the nicotine source. This heater may be provided as part of the cartridge, in the assembly to which the cartridge is attached in use, or as part of the battery section.

Referring now to FIG. 7, an example consumption rod 801 is shown. A rod is formed from several adjacent parts. In an exemplary embodiment, rod 801 comprises a portion 802 containing an acid-containing liquid. In this illustrated embodiment, portion 802 comprises a carrier material impregnated with an acidified aerosolizable liquid. The carrier material can be, for example, cotton, solid absorbents or paper filters. In some embodiments, the carrier material is a wicking material. Adjacent portion 803 includes solid nicotine-containing material. In this example, the material is a tobacco matrix containing cut rags and/or tobacco granules. In use, the portion 802 containing the acid-containing liquid is heated by the aerosol-generating assembly to form an acid vapor and/or aerosol. This is led through portion 803 containing the consumption rod and the nicotine-containing material. The heated aerosol/vapor heats the nicotine-containing material to release one or more components of the nicotine-containing material, including nicotine entrapped in the aerosol/vapor. In some embodiments, portion 80 containing nicotine-containing material is also heated by the assembly. The aerosol/vapor then passes through the rod portion 804, which is the cooling section. In this embodiment, this part is a tube that cools the passing aerosol/vapor. Finally, a mouthpiece 805 is placed after the cooling section, which becomes the filter section. This portion of the consumption rod contains a filter material such as cellulose acetate tow, optionally with suitable additives to enhance filtration or otherwise alter the properties of the aerosol.

In an alternative embodiment, the acid-containing liquid may be provided at the jaw portion 805 rather than the distal portion 802 of the consuming rod. In such embodiments, the acid-containing liquid may be provided, for example, in capsules embedded in the filter material or may be impregnated in the filter material. Free nicotine released by the solid nicotine-containing material reacts with the acid to form one or more nicotine salts as it passes through this section.

Several experiments were conducted to evaluate the effect of using acidic vapors and/or aerosols on nicotine extraction from nicotine sources to enhance nicotine delivery in inhalable vehicles.

The objective in this example was to test whether the use of an acidic aerosolizable liquid leads to nicotine extraction from pH-treated tobacco in a manner that increases nicotine delivery in the inhalable vehicle. For these experiments,
1-C, a control sample with an e-liquid composition consisting of glycerol (17 wt%), propylene glycol (71 wt%) and water (12 wt%);
Three aerosolizable liquids: 1-BA, a sample containing 0.04 wt% benzoic acid and e-liquid; and 1-LA, a sample containing 0.04 wt% lactic acid and e-liquid. was prepared.

The solid nicotine-containing material used was a tobacco blend treated with base to a pH of 8.5. The material was loaded as a pod into a standard test system and the liquid was heated. The power of the heater element was 7.5W. Vapor/aerosol formed from the liquid is then passed through or over the pH-treated tobacco composition, entrapping one or more components of the composition and traveling via an outlet to a sensing device. An inhalable medium was obtained.

During one experiment, the system delivered 60 puffs in three blocks of 20 puffs per pod and measured nicotine delivery after each 20 puffs. Puffing was performed using a 55/3/30 regime (55 ml puffed for 3 seconds every 30 seconds). Measurements were repeated four times for each sample. A summary of the results is shown in the table below.

Referring to FIG. 6, a graph of the experimental results described above is shown demonstrating examples of nicotine delivery from assemblies according to embodiments of the present invention as well as comparative assemblies.

Nicotine delivery increased with acidified liquids for 1-20 puff block measurements on each sample. For the benzoic acid-containing liquid, nicotine delivery increased from 67.2 μg/puff (control, 1-C) to 79 μg/puff (1-BA). For lactate-containing liquids, nicotine delivery increased from 67.2 μg/puff (control, 1-C) to 100 μg/puff (1-LA).

Therefore, the results of these experiments suggest that using acidic vapors/aerosols (such as those formed from liquids containing benzoic acid or lactic acid, respectively, in 1-BA or 1-LA), neutral vapors/aerosols ( It shows an increase in the amount of nicotine delivered to the user compared to the liquid used in 1-C, etc.).

Furthermore, the above results demonstrate that the total amount of nicotine components removed from solid tobacco is increased when using acidic vapors/aerosols. Thus, using acidic vapors/aerosols (1-BA, 1-LA) extracts more nicotine from tobacco than neutral vapors/aerosols (1-C). Thus, in some embodiments, assembly allows for increased nicotine extraction rates as well as increased total nicotine available for extraction from the nicotine source.

As used herein, "aerosol-forming agent" refers to a compound or mixture that facilitates the production of an aerosol. Aerosol-forming agents can facilitate aerosol formation by facilitating the initial evaporation and/or condensation of gas into an inhalable solid and/or liquid aerosol.

In general, any suitable aerosol-forming agent or agents may be included in the aerosolizable liquid or nicotine source. Suitable aerosol-forming agents include polyols such as sorbitol, glycerol and glycols such as propylene glycol or triethylene glycol, non-polyols such as monohydric alcohols, high boiling hydrocarbons, acids such as lactic acid, glycerol derivatives, diacetin, triacetin, Esters such as triethylene glycol diacetate, triethyl citrate, or myristic acid including ethyl myristate and isopropyl myristate, and aliphatic carboxylic acid esters such as methyl stearate, dimethyl dodecanedioate and dimethyl tetradecanedioate. are not limited to these.

As used herein, the terms "perfumery" and "flavourant" refer to products that produce a desired flavor, aroma, or other somatosensory sensation in products intended for adult consumers when permitted by local regulations. refers to materials that can be used for Examples of fragrances and flavors include natural flavoring materials, botanicals, botanical extracts, synthetically obtained materials, or combinations thereof (e.g., tobacco, cannabis, licorice, hydrangea, eugenol, magnolia leaves, Chamomile, fenugreek, cloves, maple, matcha, mint, aniseed (aniseed), cinnamon, turmeric, Indian spices, Asian spices, herbs, wintergreen, cherries, berries, redberries, cranberries, peaches, apples, oranges, mangoes. , Clementine, Lemon, Lime, Tropical Fruit, Papaya, Rhubarb, Grape, Durian, Dragon Fruit, Cucumber, Blueberry, Mulberry, Citrus, Drambuie, Bourbon, Scotch, Whiskey, Gin, Tequila, Rum, Spearmint, Peppermint, Lavender, Aloe. , cardamom, celery, cascara, nutmeg, sandalwood, bergamot, geranium, tea tree, nazwar, betel, shisha, pine, honey extract, rose oil, vanilla, lemon oil, orange oil, orange blossom, cherry blossom, cinnamon, chara Wey, cognac, jasmine, ylang ylang, sage, fennel, horseradish, peppers, ginger, coriander, coffee, cannabis, peppermint oil from any species of the genus Mentha, eucalyptus, eucalyptus, cocoa, lemongrass, rooibos, flax, Ginkgo biloba, hazel, hibiscus, bay leaf, mate, orange peel, rose, teas such as green or black tea, thyme, juniper, elderflower, basil, bay leaf, cumin, oregano, paprika, rosemary, saffron, lemon peel, mint, perilla, curcuma, cilantro, myrtle, cassis, valerian, green pepper, mace, damien, marjoram, olive, lemon balm, lemon basil, chives, curvy, verbena, tarragon, limonene, thymol, camphene), flavor enhancer, bitter receptor Body site blockers, sensory receptor site activators or stimulants, sugars and/or sugar substitutes (e.g. sucralose, acesulfame potassium, aspartame, saccharin, cyclamate, lactose, sucrose, glucose, fructose, sorbitol, or mannitol ), and other additives such as charcoal, chlorophyll, minerals, botanicals or breath fresheners. Perfumes and flavors may be imitations, synthetic or natural ingredients or blends thereof. Perfumes and flavors may be in any suitable form, for example liquids such as oils, solids such as powders, or gases.

In some embodiments, flavorants include menthol, spearmint and/or peppermint. In some embodiments, the flavorant comprises cucumber, blueberry, citrus and/or redberry flavoring ingredients. In some embodiments, the perfume comprises eugenol. In some embodiments, the flavoring agent comprises flavoring ingredients extracted from tobacco. In some embodiments, the flavoring agent comprises flavoring ingredients extracted from cannabis.

In some embodiments, the flavorant is usually chemically induced and achieves a perceived somatosensory sensation by stimulation of the fifth cranial nerve (trigeminal nerve) in addition to or instead of the aromatic or gustatory nerves. may include sensory materials for the purpose of, which may include substances that provide heating, cooling, tingling and numbing effects. Suitable thermal effect agents may be vanillyl ethyl ether and the like, and suitable cooling agents may be eucoliptol, WS-3 and the like.

For the avoidance of doubt, when the term "comprises" is used herein in defining the invention or features of the invention, the term "comprises" Embodiments are also disclosed in which the term "consists essentially of" or "consists of" can be used instead of to define the invention or feature.

The above embodiments are to be understood as illustrative examples of the invention. Further embodiments of the invention are envisioned. Any feature described in connection with any one embodiment can be used alone or in combination with other features described in any other embodiment or any other embodiment. can also be used in combination with one or more of the features in any combination of Furthermore, equivalents and modifications not shown above may be employed without departing from the scope of the invention as defined in the appended claims.

The various embodiments described herein are presented only to assist in understanding and teaching the claimed features. These embodiments are presented only as representative samples of embodiments and are not exhaustive and/or exclusive. Any advantages, embodiments, examples, functions, features, structures and/or other aspects described herein should be construed as limitations on the scope of the invention as defined by the claims or on the equivalents of the claims. and that other embodiments may be utilized and modifications may be made without departing from the scope of the claimed invention. The various embodiments of the present invention preferably comprise, consist of, or consist essentially of any suitable combination of the disclosed elements, components, features, parts, steps, means, etc. Conceivable. In addition, it is believed that the present disclosure includes other inventions that are not currently claimed but that may be claimed in the future.

Claims (24)

A consumable for use in an inhalable medium generating assembly, the consumable comprising an acid-containing liquid having a pH greater than or equal to 2 and less than 7 and a solid nicotine-containing material having a pH greater than or equal to 7. The consumable according to claim 1, wherein the pH of said liquid containing acid is between 4 and 5 or between 4.3 and 4.8. The consumable according to claim 1 or 2, wherein the difference between the pH of said solid nicotine-containing material and the pH of said acid-containing liquid is 3.0-5.5. A consumable for use in an inhalable medium generating assembly, the consumable comprising a liquid comprising an acid with a pKa greater than 0.5 and a solid nicotine-containing material having a pH of 7 or greater. 5. The consumable of claim 4, wherein the pKa of said acid is greater than 3 or between 3.7 and 4.3. A consumable according to any preceding claim, wherein the solid nicotine-containing material has a pH of 8-9.5 or 8.5-9. The consumable according to any one of claims 1 to 6, wherein the vapor pressure of said acid at 25°C is between 0.1 Pa and 2.5 kPa. A consumable according to any one of the preceding claims, wherein said liquid comprising acid comprises 0.001 to 5% by weight of acid. A consumable product according to any one of the preceding claims, wherein said solid nicotine-containing material comprises tobacco material. 10. The consumable of claim 9, wherein said tobacco is cut rags or tobacco granules. A consumable according to any one of the preceding claims, comprising a carrier material impregnated with said liquid comprising an acid. 12. The consumable according to claim 11, wherein said carrier material is a wicking material. 13. A cartridge according to any one of the preceding claims, wherein the consumable is a cartridge, wherein the liquid containing acid is contained in a first chamber and the solid nicotine-containing material is contained in a second chamber. consumables. A consumable according to any one of the preceding claims, being a rod comprising a first section containing said liquid containing acid and a second section containing said solid nicotine-containing material. 15. The consumable of claim 14, wherein said rod further comprises a cooling section, optionally in the form of a tube. 16. The consumable of claim 14 or 15, wherein said rod further comprises a filter section optionally comprising cellulose acetate filter material. 17. An aerosol-generating assembly comprising a consumable according to any one of claims 1-16, wherein an inhalable medium is formed by heating at least a portion of said consumable, and from said solid nicotine-containing material. and said acid to form one or more nicotine salts. wherein the liquid containing acid is heated to form a vapor and/or aerosol containing acid, and the solid nicotine-containing material is contacted with the vapor/aerosol containing acid to produce the solid nicotine-containing material. 18. The aerosol-generating assembly of claim 17, wherein one or more components of material are incorporated into the inhalable medium. 19. The aerosol-generating assembly of claim 18, wherein said solid nicotine-containing material is configured to be heated only by said vapor/aerosol. said liquid comprising an acid and said vapor/aerosol comprising free nicotine from said solid nicotine-containing material configured to heat said solid nicotine-containing material to form a vapor and/or aerosol comprising nicotine; 18. The aerosol-generating assembly of claim 17, wherein the acid and free nicotine react to form one or more nicotine salts. 21. The aerosol-generating assembly of claim 20, wherein the solid nicotine-containing material is heated by a vapor or aerosol formed by heating an aerosolizable liquid other than the acid-containing liquid. A method of producing an inhalable medium using an aerosol-generating assembly comprising a consumable according to any one of claims 1-16, wherein at least part of the consumable is heated to produce free nicotine. forming an inhalable medium comprising one or more components of a solid nicotine-containing material comprising said free nicotine reacting with said acid to form one or more nicotine salts. Use of an acidic vapor and/or aerosol to extract nicotine from a solid nicotine-containing material having a pH greater than 7, wherein the nicotine extraction rate exceeds the nicotine salt formation rate in said solid, thereby producing a neutral A use wherein the nicotine content in said vapor and/or aerosol is increased compared to when said vapor and/or aerosol is used. (i) a liquid pod containing a liquid containing an acid and having a pH of 2 or more and less than 7;
(ii) a nicotine-containing pod containing a solid nicotine-containing material having a pH of 7 or higher,
The liquid pod and the nicotine-containing pod are configured for use in an assembly for use in producing an inhalable medium, the assembly, in use, containing the aerosolizable liquid in vapor and/or aerosol form. with said solid nicotine-containing material to incorporate one or more components thereof to produce an inhalable vehicle.

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