JP2023514455A - 選択的アンドロゲン受容体共有結合性アンタゴニスト（ｓａｒｃａ）およびその使用方法 - Google Patents

選択的アンドロゲン受容体共有結合性アンタゴニスト（ｓａｒｃａ）およびその使用方法 Download PDF

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JP2023514455A
JP2023514455A JP2022550924A JP2022550924A JP2023514455A JP 2023514455 A JP2023514455 A JP 2023514455A JP 2022550924 A JP2022550924 A JP 2022550924A JP 2022550924 A JP2022550924 A JP 2022550924A JP 2023514455 A JP2023514455 A JP 2023514455A
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alkyl
conhr
halide
coor
compound
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JPWO2021173731A5 (es
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ラメシュ ナラヤナン，
タマライ ポンヌサミ，
デュアン ディー． ミラー，
ヤーリー ヒー，
ドン－ジン ホワン，
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ユニバーシティ オブ テネシー リサーチ ファウンデーション
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
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JP2022550924A 2020-02-25 2021-02-24 選択的アンドロゲン受容体共有結合性アンタゴニスト（ｓａｒｃａ）およびその使用方法 Pending JP2023514455A (ja)

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US202062981516P 2020-02-25 2020-02-25
US62/981,516 2020-02-25
PCT/US2021/019490 WO2021173731A1 (en) 2020-02-25 2021-02-24 Selective androgen receptor covalent antagonists (sarcas) and methods of use thereof

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JP2023514455A true JP2023514455A (ja) 2023-04-05
JPWO2021173731A5 JPWO2021173731A5 (es) 2024-02-21

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JP2022550924A Pending JP2023514455A (ja) 2020-02-25 2021-02-24 選択的アンドロゲン受容体共有結合性アンタゴニスト（ｓａｒｃａ）およびその使用方法

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US (1) US20230303496A1 (es)
EP (1) EP4110322A4 (es)
JP (1) JP2023514455A (es)
KR (1) KR20220146532A (es)
CN (1) CN115427028A (es)
AU (1) AU2021227665A1 (es)
CA (1) CA3172890A1 (es)
IL (1) IL295843A (es)
MX (1) MX2022010439A (es)
WO (1) WO2021173731A1 (es)

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EP4219454A1 (en) 2022-01-28 2023-08-02 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Highly efficient process for the preparation of 4-fluoro-1h-pyrazole or salts thereof
WO2023172872A2 (en) * 2022-03-07 2023-09-14 Cardiff Oncology, Inc. Biomarkers for combination therapies

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Publication number Priority date Publication date Assignee Title
CA2502209A1 (en) * 2002-10-15 2004-04-29 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US10865184B2 (en) * 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) * 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) * 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) * 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
CN109310664A (zh) * 2016-06-10 2019-02-05 田纳西大学研究基金会 选择性雄激素受体降解剂(sard)配体和其使用方法
US11230523B2 (en) * 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
WO2019023651A2 (en) * 2017-07-28 2019-01-31 Massachusetts Institute Of Technology MODULATORS OF THE SMALL MOLECULE ANDROGEN RECEPTOR
AU2019271382A1 (en) * 2018-05-16 2020-12-17 Oncternal Therapeutics, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US20210340122A1 (en) * 2018-09-05 2021-11-04 University Of Tennessee Research Foundation Selective androgen receptor degrader (sard) ligands and methods of use thereof
WO2020243373A1 (en) * 2019-05-29 2020-12-03 University Of Tennessee Research Foundation Selective androgen receptor degrader (sard) ligands and methods of use thereof
EP4110327A4 (en) * 2020-02-25 2024-03-13 University of Tennessee Research Foundation SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHOD OF USE THEREOF

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EP4110322A4 (en) 2024-07-24
MX2022010439A (es) 2022-12-07
CN115427028A (zh) 2022-12-02
KR20220146532A (ko) 2022-11-01
WO2021173731A1 (en) 2021-09-02
US20230303496A1 (en) 2023-09-28
CA3172890A1 (en) 2021-09-02
IL295843A (en) 2022-10-01
EP4110322A1 (en) 2023-01-04
AU2021227665A1 (en) 2022-09-22

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