JP2023512998A - ドーズダイヤルを通じて回転力が加えられたトーションバネのねじれを一時的に保持させる薬物投入調節装置 - Google Patents
ドーズダイヤルを通じて回転力が加えられたトーションバネのねじれを一時的に保持させる薬物投入調節装置 Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 49
- 229940079593 drug Drugs 0.000 title claims abstract description 49
- 238000002347 injection Methods 0.000 claims abstract description 50
- 239000007924 injection Substances 0.000 claims abstract description 50
- 230000002093 peripheral effect Effects 0.000 claims abstract description 8
- 238000012377 drug delivery Methods 0.000 claims description 11
- 230000008878 coupling Effects 0.000 claims description 7
- 238000010168 coupling process Methods 0.000 claims description 7
- 238000005859 coupling reaction Methods 0.000 claims description 7
- 238000005192 partition Methods 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 description 3
- 229940090047 auto-injector Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
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- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8275—Mechanical
- A61M2205/8281—Mechanical spring operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims (6)
- 中空のハウジング(10)、前記ハウジング(10)の一側上に回転自在に結合されたドーズダイヤル(20)、前記ハウジング(10)の他側上に固着された状態で薬物が内蔵されたカートリッジが収容されると共に、薬物が吐き出される注入ニードルが一側上に結合されるカートリッジホルダー(30)、及び前記ドーズダイヤル(20)内に配される注入ボタン(40)を含む薬物投入調節装置において、
前記ハウジング(10)内に配されたトーションバネ(140)にねじりモーメントを保存して注入しようとする薬物の量を設定させる注入量設定モジュール(100)と、
前記トーションバネ(140)に加えられたねじりモーメントの解除を通じて運動することにより、前記カートリッジホルダー(30)に内蔵されたカートリッジから外部に吐き出させる薬物吐出モジュール(200)と、を含み、
前記注入量設定モジュール(100)は、前記注入ボタン(40)の動作によって、前記ドーズダイヤル(20)にスイッチング可能に結合されるリセットチューブ(110)、前記リセットチューブ(110)の外側上に結合されて同時に回動するラチェットチューブ(120)、前記ラチェットチューブ(120)の外面上に軸方向に沿って摺動自在に回動するスケールドラム(130)、前記ハウジング(10)と前記ラチェットチューブ(120)上に両先端が結合されたトーションバネ(140)及び前記ラチェットチューブ(120)上に回転自在に結合された状態で前記ハウジング(10)の内部に摺動自在に結合するアンカー(170)を含み、
前記アンカー(170)は、内面上に円周方向に沿って突設されたアンカー円周突起(171)、内面上で軸方向に沿って鋸歯状に段付けられるように形成されたチューブ回転防止突起(173)及び外周面上で軸方向に沿って形成されたハウジング係合突起(172、174)を含み、
前記チューブ回転防止突起(173)は、前記ラチェットチューブ(120)を成す回転防止口(124)に結合されるものであって、前記アンカー(170)に回転自在に結合されたラチェットチューブ(120)の一方向回転のみを可能にすることを特徴とする、薬物投入調節装置。 - 前記アンカー(170)は、前記アンカー円周突起(171)を通じて前記ラチェットチューブ(120)上に溝形成されたアンカー係合溝(122)に回転自在に結合された状態を有する一方、
前記ハウジング係合突起(172、174)を通じては、前記ハウジング(10)に形成されたアンカー摺動部(13)上に解除可能に結合することを特徴とする、請求項1に記載の薬物投入調節装置。 - 前記リセットチューブ(110)に結合されたロッドガイド(210)が、前記ピストンロッド(220)の内部上にスクリュー回転結合で結束されることにより、前記ロッドガイド(210)の回転を通じて前記ピストンロッド(220)の下部直線運動を可能にすることにより、ピストンロッド(220)とロッドガイド(210)とのスクリュー方式結合を通じたカートリッジ薬物放出構造を有する、請求項1に記載の薬物投入調節装置。
- 前記トーションバネ(140)は、両端がそれぞれ前記ハウジング(10)に回転不能に結合されるバネベース(150)及びラチェットチューブ(120)上に結合され、
前記ドーズダイヤル(20)を通じた回転時には、
前記ラチェットチューブ(120)に固定された前記トーションバネ(140)の一側は、回動する一方、前記バネベース(150)に固定された前記トーションバネ(140)の他側は、固定された状態を保持することにより、バネのねじれ状態を作る、請求項1に記載の薬物投入調節装置。 - 前記ボタンプレート(160)は、前記ドーズダイヤル(20)内に隔壁を通じて形成された第1ダイヤルチャンバ上で前記ドーズダイヤル(20)の内面に円周方向に沿って形成されたプレート固定段差(24)に固定される、請求項1に記載の薬物投入調節装置。
- 前記注入量設定モジュール(100)は、前記ドーズダイヤル(20)内に固設されるが、ボタンバネ(50)を支持する機能を行うボタンプレート(160)を含み、
前記注入ボタン(40)は、前記ボタンプレート(160)に摺動自在に貫通した状態に結合し、
前記薬物吐出モジュール(200)は、
前記注入ボタン(40)の動作によって、前記注入量設定モジュール(100)上にスイッチング可能に結合されるロッドガイド(210)、
前記ロッドガイド(210)の外側上にスクリュー結合された状態で前記ロッドガイド(210)の回動によって直線運動を実施することにより、カートリッジホルダー(30)に内蔵されたカートリッジの薬物を外部に吐き出させるピストンロッド(220)を含み、
前記注入ボタン(40)は、前記ドーズダイヤル(20)の回転によって同時に回動する一方、前記ボタンプレート(160)を通じて安定したプッシング動作を可能にする、請求項1に記載の薬物投入調節装置。
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KR1020200145239A KR102271959B1 (ko) | 2020-11-03 | 2020-11-03 | 도즈 다이얼을 통해 회전력이 가해진 토션 스프링의 꼬임을 일시적으로 유지하게 하는 약물 투입 조절 장치 |
KR10-2020-0145239 | 2020-11-03 | ||
PCT/KR2021/015683 WO2022098048A1 (ko) | 2020-11-03 | 2021-11-02 | 도즈 다이얼을 통해 회전력이 가해진 토션 스프링의 꼬임을 일시적으로 유지하게 하는 약물 투입 조절 장치 |
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JP2013539697A (ja) * | 2010-10-13 | 2013-10-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 用量設定機構及びそれを使用する方法 |
JP2016514554A (ja) * | 2013-04-05 | 2016-05-23 | ノボ・ノルデイスク・エー/エス | 薬剤送達装置の投与記録装置 |
JP2016530012A (ja) * | 2013-09-03 | 2016-09-29 | サノフイ | 用量設定およびリセット機構を有するペン型薬物注射デバイス |
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US6004297A (en) * | 1998-01-30 | 1999-12-21 | Novo Nordisk A/S | Injection syringe |
EP1645301A1 (en) * | 2004-10-11 | 2006-04-12 | Novo Nordisk A/S | Injection device |
MY148822A (en) * | 2008-05-02 | 2013-06-14 | Sanofi Aventis Deutschland | Medication delivery device |
TW201138882A (en) * | 2010-01-25 | 2011-11-16 | Sanofi Aventis Deutschland | Drive assembly for a drug delivery device and drug delivery device |
JP5732549B2 (ja) * | 2011-02-03 | 2015-06-10 | エス・ホー・エル・グループ・アクチボラゲットShl Group Ab | 薬剤送達装置 |
JP5791780B2 (ja) * | 2011-03-24 | 2015-10-07 | エス・ホー・エル・グループ・アクチボラゲットShl Group Ab | 薬剤送達装置 |
TW201603847A (zh) * | 2014-07-01 | 2016-02-01 | 賽諾菲公司 | 注射裝置及組裝方法 |
KR102271959B1 (ko) * | 2020-11-03 | 2021-07-02 | (주)풍림파마텍 | 도즈 다이얼을 통해 회전력이 가해진 토션 스프링의 꼬임을 일시적으로 유지하게 하는 약물 투입 조절 장치 |
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JP2013539697A (ja) * | 2010-10-13 | 2013-10-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 用量設定機構及びそれを使用する方法 |
JP2016514554A (ja) * | 2013-04-05 | 2016-05-23 | ノボ・ノルデイスク・エー/エス | 薬剤送達装置の投与記録装置 |
JP2016530012A (ja) * | 2013-09-03 | 2016-09-29 | サノフイ | 用量設定およびリセット機構を有するペン型薬物注射デバイス |
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JP7459262B2 (ja) | 2024-04-01 |
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