JP2023505221A - プログラム死リガンド１および／またはプログラム死リガンド２の調節物質 - Google Patents

プログラム死リガンド１および／またはプログラム死リガンド２の調節物質 Download PDF

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Publication number
JP2023505221A
JP2023505221A JP2022533441A JP2022533441A JP2023505221A JP 2023505221 A JP2023505221 A JP 2023505221A JP 2022533441 A JP2022533441 A JP 2022533441A JP 2022533441 A JP2022533441 A JP 2022533441A JP 2023505221 A JP2023505221 A JP 2023505221A
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compound
alkyl
cancer
hydrogen
pdl
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JP2022533441A
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Japanese (ja)
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JP2023505221A5 (enExample
Inventor
マーク ジェイ スト
ビニ マシュー
レベッカ ブーヘイカー
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サウザーン リサーチ インスチチュート
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Publication of JP2023505221A5 publication Critical patent/JP2023505221A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
JP2022533441A 2019-12-04 2020-12-03 プログラム死リガンド１および／またはプログラム死リガンド２の調節物質 Pending JP2023505221A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962943728P 2019-12-04 2019-12-04
US62/943,728 2019-12-04
PCT/US2020/063137 WO2021113528A1 (en) 2019-12-04 2020-12-03 Modulators of programmed death-ligand-1 and/or programmed death-ligand-2

Publications (2)

Publication Number Publication Date
JP2023505221A true JP2023505221A (ja) 2023-02-08
JP2023505221A5 JP2023505221A5 (enExample) 2023-11-29

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ID=76222302

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JP2022533441A Pending JP2023505221A (ja) 2019-12-04 2020-12-03 プログラム死リガンド１および／またはプログラム死リガンド２の調節物質

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Country Link
US (1) US12098216B2 (enExample)
EP (1) EP4069270A4 (enExample)
JP (1) JP2023505221A (enExample)
AU (1) AU2020396100A1 (enExample)
CA (1) CA3159698A1 (enExample)
WO (1) WO2021113528A1 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007007060A2 (en) * 2005-07-07 2007-01-18 Zealand Pharma A/S N- or c- terminally modified small peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144032A0 (en) 1999-01-13 2002-04-21 Genentech Inc Serine protease inhibitors
ES2748434T3 (es) * 2014-01-10 2020-03-16 Univ Cornell Dipéptidos como inhibidores de inmunoproteasomas humanos
US11046729B2 (en) * 2017-10-26 2021-06-29 Southern Research Institute Dipeptide analogs as TGF-beta inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007007060A2 (en) * 2005-07-07 2007-01-18 Zealand Pharma A/S N- or c- terminally modified small peptides

Also Published As

Publication number Publication date
US20230029187A1 (en) 2023-01-26
CA3159698A1 (en) 2021-06-10
WO2021113528A1 (en) 2021-06-10
AU2020396100A1 (en) 2022-06-16
EP4069270A4 (en) 2024-01-03
US12098216B2 (en) 2024-09-24
EP4069270A1 (en) 2022-10-12

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