JP2023504733A - 抗ｃｌｅｃ－１ａ抗体及びその抗原結合性断片 - Google Patents

抗ｃｌｅｃ－１ａ抗体及びその抗原結合性断片 Download PDF

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Publication number
JP2023504733A
JP2023504733A JP2022533579A JP2022533579A JP2023504733A JP 2023504733 A JP2023504733 A JP 2023504733A JP 2022533579 A JP2022533579 A JP 2022533579A JP 2022533579 A JP2022533579 A JP 2022533579A JP 2023504733 A JP2023504733 A JP 2023504733A
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Japan
Prior art keywords
seq
antibody
clec
chain variable
variable domain
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JP2022533579A
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Japanese (ja)
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JP2023504733A5 (enExample
Inventor
エリゼ・シフォロー
ニコラ・ポワリエ
アリアヌ・ドゥセル
ヴィルジニー・テプニエ
カロリーヌ・マリー
ヴァネッサ・ゴーティエ
サブリナ・パンガム
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Nantes Université
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Universite de Nantes
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Publication of JP2023504733A publication Critical patent/JP2023504733A/ja
Publication of JP2023504733A5 publication Critical patent/JP2023504733A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022533579A 2019-12-05 2020-12-04 抗ｃｌｅｃ－１ａ抗体及びその抗原結合性断片 Pending JP2023504733A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19306583.6 2019-12-05
EP19306583 2019-12-05
PCT/EP2020/084770 WO2021110990A1 (en) 2019-12-05 2020-12-04 Anti-clec-1a antibodies and antigen-binding fragment thereof

Publications (2)

Publication Number Publication Date
JP2023504733A true JP2023504733A (ja) 2023-02-06
JP2023504733A5 JP2023504733A5 (enExample) 2023-12-13

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JP2022533579A Pending JP2023504733A (ja) 2019-12-05 2020-12-04 抗ｃｌｅｃ－１ａ抗体及びその抗原結合性断片

Country Status (6)

Country Link
US (1) US20230331852A1 (enExample)
EP (1) EP4069372A1 (enExample)
JP (1) JP2023504733A (enExample)
CN (1) CN115151309A (enExample)
CA (1) CA3159155A1 (enExample)
WO (1) WO2021110990A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL309107A (en) * 2021-06-08 2024-02-01 Ose Immunotherapeutics Humanized antibodies against CLEC-1A, antigen-binding fragments thereof and their mimetics
CN118510534A (zh) * 2021-11-09 2024-08-16 Ose免疫疗法 Clec-1配体的识别及其用途
JP2025525884A (ja) * 2022-08-01 2025-08-07 オーエスイー・イミュノセラピューティクス ヘテロ二量体Ｆｃ－ＣＬＥＣ－１融合分子及びその使用
WO2025032213A1 (en) * 2023-08-10 2025-02-13 Ose Immunotherapeutics Identification of hla-dra as a ligand of clec-1 and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018073440A1 (en) * 2016-10-21 2018-04-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for promoting t cells response

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
EP3426278B1 (en) * 2016-03-07 2024-01-03 Vib Vzw Cd20 binding single domain antibodies
WO2018049474A1 (en) * 2016-09-16 2018-03-22 Bionomics Limited Antibody and checkpoint inhibitor combination therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018073440A1 (en) * 2016-10-21 2018-04-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for promoting t cells response

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOPEZ ROBLES MD. ET AL.: "Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th1", BLOOD ADVANCES, vol. 1, no. 9, JPN6024051723, 2017, pages 557 - 568, ISSN: 0005781112 *

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Publication number Publication date
CA3159155A1 (en) 2021-06-10
EP4069372A1 (en) 2022-10-12
CN115151309A (zh) 2022-10-04
WO2021110990A1 (en) 2021-06-10
US20230331852A1 (en) 2023-10-19

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