JP2023182295A - Method for determining sanitation treatment spot - Google Patents

Abstract

To provide a method for determining a sanitation treatment for easily and reliably determining a spot and a condition to effectively implement a sanitation treatment such as cleaning, sterilizing, virucidal, and disinfection.SOLUTION: A method for determining sanitation treatment includes: detecting a polymer compound derived from human body contained in feces in an environment; and determining a spot for sanitation treatment based on the detection result.SELECTED DRAWING: None

Description

The present invention provides a method for determining a sanitary treatment location, a method for determining sanitary treatment conditions, a method for determining a sanitary treatment method, an estimation method, a sanitary treatment kit, a method for displaying contamination status at a candidate site for sanitary treatment, and a method for displaying a sanitary treatment location. Regarding.

The living environment that surrounds us includes a variety of equipment, facilities, devices, etc., and various treatments are performed taking into consideration their respective uses. For example, in commercial facilities, accommodation facilities, etc., processes such as cleaning and sterilization are performed to maintain sanitary conditions. At that time, it has been proposed to determine the degree of contamination, etc., and to determine processing conditions, etc., depending on the degree of contamination, etc.

Patent Document 1 discloses a cleaning method that includes a predetermined detection method for detecting a test substance such as a virus, and a cleaning step for removing the test substance from a target space according to the detection result of the detection method. It is disclosed (claim 19).

Patent Document 2 discloses a method for evaluating the sanitary state of a living environment, which includes a step of detecting the presence or absence of Methylobacterium bacteria in the living environment.

Patent Document 3 describes an installation process in which a specific toilet stain detection sheet or a specific toilet stain detection sheet laminate is placed at multiple locations in an area to be cleaned of a toilet, and stains at the multiple locations based on the discolored state of the installed sheet. Disclosed is a method for determining when to clean a toilet, and a method for determining a cleaning range for a toilet, which comprises a determination step for determining the degree of soiling, and a timing determination step for determining the time to clean the toilet based on the determined degree of dirt. There is.

Japanese Patent Application Publication No. 2015-206671 Japanese Patent Application Publication No. 2012-5455 Japanese Patent Application Publication No. 2013-36189

In the environment, when performing treatments such as cleaning, bleaching, deodorizing, virucidal, and sterilization, chemicals are often used depending on the treatment, but in various facilities, especially commercial facilities, accommodation facilities, and manufacturing facilities. In large facilities, it is inefficient to apply drugs to all areas. In other words, in such large-scale facilities, if it is possible to efficiently determine where and when to perform cleaning and other treatments, labor and costs can be significantly reduced. In particular, since it is important to prevent infection by viruses and bacteria in facilities used by an unspecified number of people, an effective method for performing treatment reliably and efficiently is desired.

The present invention provides a method for determining sanitary treatments that can easily and reliably determine locations and conditions under which sanitary treatments such as cleaning, disinfection, virucidal, and sterilization can be effectively implemented.

The present invention relates to a method for determining a sanitary treatment area, which detects a human body-derived polymer compound (hereinafter referred to as an indicator polymer) contained in feces in the environment, and determines a sanitary treatment area based on the detection result. .

The present invention also relates to a method for determining sanitary treatment conditions, which detects an indicator polymer in the environment and determines sanitary treatment conditions based on the detection results.

The present invention also relates to a method for determining a sanitary treatment method, which detects an indicator polymer in the environment and determines the location to be sanitary treated and the conditions for the sanitary treatment based on the detection results.

The present invention also relates to an estimation method for detecting an indicator polymer in the environment and estimating a location where harmful viruses and/or harmful bacteria are likely to exist based on the detection results.

The present invention also relates to an estimation method that detects indicator polymers in the environment, estimates locations where harmful viruses and/or harmful bacteria are likely to exist, and estimates infection routes based on the detection results. .

The present invention also provides a sanitary treatment kit that includes a means for detecting an indicator polymer in the environment, and a drug used for treating a sanitary treatment area determined based on the detection result of the indicator polymer obtained by the means. Regarding.

The present invention also provides a method for displaying contamination status at a candidate location for sanitary treatment, comprising:
(a) a step of identifying one or more locations in the environment, the step including the following steps (i) to (iii);
(i) generating position data that can identify the installation location of the entity in order to identify the one or more locations within the defined area;
(ii) recording location data of the one or more locations within the environment; and (iii) assigning locations and locations of entities that are linked to location data of the one or more locations within the environment. the step of separating and recording;
(b) recording the detection results of human body-derived polymer compounds contained in feces detected from one or more locations in the environment;
(c) recording the generated detection results according to the separated positions and parts of the real objects recorded in (iii) of (a); a step of displaying the location data along with the location data;
The present invention relates to a method for displaying contamination status at a candidate location for sanitary treatment.

Further, the present invention relates to a method for displaying a sanitary treatment location, in which a sanitary treatment location is determined based on the contamination status of the sanitary treatment candidate location displayed by the display method of the present invention, and is displayed as a sanitary treatment location.

According to the present invention, there is provided a method for determining sanitary treatment areas, sanitary treatment conditions, or sanitary treatment methods that can easily and reliably determine areas where sanitary treatments such as cleaning, disinfection, virucidal, and sterilization can be effectively performed. be done. Further, the present invention provides a method that can easily and reliably estimate the location and infection route of a harmful virus and/or harmful bacteria (hereinafter referred to as harmful virus and/or harmful bacteria).

Flowchart of processing steps for carrying out the method of displaying contamination status of the present invention

The indicator polymer of the present invention is a human body-derived polymer compound contained in feces. The present invention has found that the degree of detection of indicator polymers attached to the surface of the living environment is correlated with the possibility of contamination by components containing the indicator polymer, and the present invention has found that the degree of detection of indicator polymers attached to the surface of the living environment is correlated with the possibility of contamination by components containing the indicator polymers, and the possibility of contamination is determined by detecting areas where the degree of detection of indicator polymers is high. By determining that the area is highly susceptible to infection, and determining that area as a place to perform sanitary treatment such as cleaning, disinfection, virucidal, and sterilization, it is possible to efficiently prevent and remove contamination caused by viruses and/or bacteria. This is what I found. Furthermore, the present invention has discovered that the possibility of the presence of harmful viruses and/or harmful bacteria and the route of infection can be estimated with high accuracy based on the degree of detection of the indicator polymer. Based on the degree of detection of the indicator polymer selected in the present invention, it is possible to determine the possibility of contamination, decide where to perform sanitary treatment, determine the possibility of the presence of harmful viruses and/or harmful bacteria, and further investigate the route of infection. Estimation has not been done in the past.

The indicator polymer of the present invention may have a molecular weight of, for example, 10,000 or more, further 15,000 or more, and even 20,000 or more. This molecular weight is a weight average molecular weight, and is measured, for example, by a method such as size exclusion chromatography.

Examples of the indicator polymer of the present invention include digestive tracts such as the oral cavity, esophagus, stomach, small intestine, large intestine, and anus, and associated digestive glands (oral glands, liver, pancreas, etc.) and appendages (teeth, tongue, salivary glands, etc.). etc.).
Examples of the indicator polymer of the present invention include proteins, glycoproteins, polysaccharides, and nucleic acids.

Examples of proteins include enzymes.
Examples of enzymes include proteases such as elastase, trypsin, chymotrypsin, pepsin, aminopeptidase, dipeptidase, and carboxypeptidase, and lipases such as phospholipase and triacylglyceride lipase. Examples of other proteins include calprotectin. The molecular weight of the enzyme may be, for example, 10,000 or more, further 15,000 or more, further 20,000 or more, and even 25,000 or more.
Examples of glycoproteins include mucin, cadherin, proteoglycan, and the like. The molecular weight of the glycoprotein may be, for example, 10,000 or more, further 100,000 or more, further 300,000 or more, further 1 million or more, and even 2 million or more.
Examples of polysaccharides include glycogen and the like. The molecular weight of the polysaccharide may be, for example, 10,000 or more, further 100,000 or more, or even 1,000,000 or more.
Nucleic acids include DNA, mRNA, and the like. The molecular weight of the nucleic acid may be, for example, 10,000 or more, further 30,000 or more, and even 50,000 or more.

The indicator polymer is preferably one or more selected from proteins, glycoproteins, nucleic acids, and polysaccharides, more preferably one or more selected from proteins and glycoproteins, even more preferably one or more selected from proteins, and one or more selected from enzymes. One or more selected types are even more preferred. The enzyme is preferably an enzyme selected from proteases and lipases.
The indicator polymer is preferably one or more selected from elastase and mucin, from the viewpoint of high selectivity of feces in the route of excretion from the body and accuracy as an indicator for estimating fecal contamination, with elastase being more preferred. preferable. Elastase is preferably pancreatic elastase.

In the present invention, an indicator polymer is detected in the environment. The environment may be a living environment, a natural environment, etc. The environment, especially the living environment, may include buildings, public transportation. Additionally, buildings and public transportation may each include equipment associated therewith. There are no restrictions on the scale or purpose of the building.

Examples of the building include buildings selected from commercial facilities, accommodation facilities, educational facilities, medical facilities, nursing facilities, business facilities, and eating and drinking facilities, and may be composite facilities of these facilities. Examples of commercial facilities include shopping centers, supermarkets, cinema complexes, and amusement parks. Examples of accommodation facilities include hotels, inns, and private lodging facilities. Examples of educational facilities include various schools and cultural centers. Examples of medical facilities include hospitals. Examples of nursing facilities include care houses for the elderly. Examples of business facilities include office buildings and factories. Examples of eating facilities include restaurants, coffee shops, and fast food restaurants.

Examples of public transportation include public transportation selected from railway vehicles, road vehicles, ships, and aircraft. Examples of railway vehicles include electric trains and diesel cars. Examples of road vehicles include buses. Examples of ships include passenger ships. Examples of the aircraft include passenger planes.

In the present invention, the environment includes an article, and detection of an indicator polymer on the surface of the article can be performed. The articles may include, for example, articles selected from buildings, building fixtures, public transport, and public transport fixtures. According to the present invention, for example, an indicator polymer can be detected on the surface of an article placed indoors. The article may be a fixed article or an unfixed article. The material of the article is also not limited. Examples of articles include furniture, electrical appliances, plumbing items, building materials, fittings, clothing, bedding, etc. More specifically, examples include tables, chairs, sinks, toilet seats, doorknobs, water faucets, switches, Examples include items selected from remote control devices (such as remote controllers for various devices), computer input devices (such as keyboards and mice), wallpaper, cloth ceilings, curtains, and carpets. In addition, examples of goods include elevator switches installed in buildings, escalator handrails installed in buildings, ticket vending machines for public transportation, suspension straps for vehicles, and goods such as shopping baskets and carts frequently used in commercial facilities. can be mentioned. The present invention allows detection of indicator polymers on the surfaces of these articles.

The environment targeted by the present invention may be a toilet, and specifically may be an article placed in a toilet. Items placed in the toilet include, for example, the doorknob and door of the toilet, the light switch, the faucet button, the inside of the toilet (back, sides, edges, etc.), the toilet seat (top, back), toilet seat cover, faucet. Lever, remote controller buttons, remote controller body, door knob for private room door, key for private room door, inside surface of private room door, toilet paper (including stock), toilet paper holder, sink, mirror, towel, hand towel Paper, hand towel holders, automatic dryers, floors, walls, ceilings, light fixtures, light fixture switches, floor sheets, toilet slippers, air freshener containers, ventilation fan switches, ventilation fans, ventilation windows, ventilation window Examples include opening/closing levers, air purifier switches, air purifier internal filters, air purifier bodies, Braille boards for visually impaired people, handrails for the elderly, and containers for hand cleaners and disinfectants.

In the present invention, the environment may be an area targeted for sanitary treatment (hereinafter also referred to as target area). Hereinafter, the term "target area" may mean the environment. The target area may be selected from, for example, buildings such as the above-mentioned commercial facilities, accommodation facilities, and business facilities, public transportation facilities, and the like. Select a location from these target regions to detect the indicator polymer. The location where the indicator polymer is detected can be selected as appropriate in consideration of the purpose, scale, etc. of the target area. In the present invention, it is possible to define a region in the environment that is a target of sanitary treatment, and to detect an indicator polymer in the target region.

In the present invention, indicator polymers can be detected at different locations in a target region, and a location where a relatively large number of indicator polymers are detected among the detected locations can be set as a location where sanitary treatment is performed.

In the present invention, the indicator polymer is detected in the target area, and the conditions for sanitary treatment, such as the type of treatment, the type and amount of chemicals used for treatment, and the number of times the treatment is performed, are determined based on the detection results. . Conditions that are normally used by those skilled in the art for each process can be employed as they are or with modifications.

It is assumed that a location where a large amount of the indicator polymer is detected is a location where the indicator polymer or a component containing the indicator polymer, such as feces, is likely to adhere in various forms. It is assumed that such a location is likely to be contaminated by, for example, feces or viruses and/or bacteria incorporated into the feces, even after cleaning. This may be taken into consideration when determining the locations and conditions for sanitary treatment based on the detection results of the indicator polymer. In the present invention, it is possible to determine the possibility of contamination by viruses and/or bacteria based on the detection results of the indicator polymer, and to determine where to perform sanitary treatment based on the determination results.

In the present invention, the indicator polymer is detected at different locations in the target region, and the sanitary treatment conditions can be determined from the detection frequency of the indicator polymer and the detected amount of the indicator polymer.

In the present invention, when detecting the indicator polymer at different locations in the target area, for example, at least 1 location per 1 m ² , at least 2 locations, at least 3 locations, at most 16 locations, and at most 9 locations, Furthermore, measurements can be performed at a plurality of locations selected at a rate of 6 or less.

In the present invention, the indicator polymer can be detected by a method using an antigen-antibody reaction and/or an enzyme reaction. Detection of the indicator polymer in the target region may be performed, for example, directly on the surface of the article, or on a sample taken from the surface of the article. In the present invention, it is preferable that the indicator polymer be detected by a method that utilizes an antigen-antibody reaction. In the present invention, it is preferable to use a method that utilizes an antigen-antibody reaction that can specifically detect an indicator polymer such as elastase. Examples of methods using antigen-antibody reactions include immunochromatography, enzyme immunoassay (EIA, ELISA), immunoprecipitation, and immunoblotting. Commercially available products that measure the indicator polymer weight using antigen-antibody reactions may be used.

In the present invention, the sanitary process may include a process to improve the sanitary condition of the target area, a process to maintain the sanitary condition of the target area, and the like.
Generally, the hygiene of a living environment is improved and/or maintained by keeping it clean. In the present invention, for example, the sanitary treatment may include one or more types of treatment selected from purification, bacterial adhesion prevention treatment, and virus adhesion prevention treatment. More specifically, the sanitary treatment may include, for example, one or more treatments selected from cleaning, bleaching, disinfection, sterilization, sterilization, antibacterial, virucidal, antiviral, and virus removal. Each treatment can be performed by a known method.

In the present invention, the sanitary treatment may be a treatment that reduces the disadvantages caused by viruses and/or bacteria. That is, the viruses and/or bacteria targeted by the present invention may be harmful viruses and/or harmful bacteria. Harm includes at least harm to people. The hazardous virus may be a non-enveloped or enveloped virus, in particular a non-enveloped virus. Further, examples of harmful bacteria include Escherichia coli. Treatments that reduce the disadvantages caused by viruses and/or bacteria can be selected in particular from the treatments mentioned above. Disadvantages caused by viruses and/or bacteria are typically infections.

In the present invention, the sanitary treatment may be a treatment using a sanitary treatment agent (hereinafter referred to as a sanitary treatment agent) for at least any one selected from cleaning, sterilization, and virucidal.
The sanitary treatment agent can contain, for example, one or more selected from (a) surfactants, (b) oxidizing bleaches, and (c) disinfectants. The sanitizing agent can contain water. The sanitary treatment agent may be either liquid or solid, but liquid is preferred, and water-containing liquid is more preferred.

(a) The surfactant includes one or more selected from anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants.
(a) Surfactants include, for example, linear alkylbenzene sulfonic acids and their salts, alkyl sulfates and their salts, polyoxyethylene alkyl ether sulfates and their salts, fatty acids and their salts, polyoxyethylene alkyl ethers, alkyl glycosides. , alkylamine oxides, quaternary ammonium salts, and alkylamine ethylene oxide adducts.
The number of carbon atoms in the linear alkyl group of the linear alkylbenzenesulfonic acid may be 8 or more and 20 or less.
The number of carbon atoms in the alkyl group of the alkyl sulfate may be 8 or more and 20 or less.
In the polyoxyethylene alkyl ether sulfuric acid, the average number of added moles of ethylene oxide may be 1 or more and 30 or less, and the number of carbon atoms in the alkyl group may be 8 or more and 20 or less.
The number of carbon atoms in the fatty acid may be 8 or more and 20 or less.
Examples of the salts of anionic surfactants include alkali metal salts such as sodium salts and potassium salts.
In the polyoxyethylene alkyl ether, the average number of added moles of ethylene oxide may be 1 or more and 30 or less, and the number of carbon atoms in the alkyl group may be 8 or more and 20 or less.
The number of carbon atoms in the alkyl group of the alkyl glycoside may be 8 or more and 20 or less.
The alkyl amine oxide may have an alkyl group having 8 or more carbon atoms and 20 or less carbon atoms.
Examples of the quaternary ammonium salt include benzalkonium chloride, benzethonium chloride, and dialkyl chloride (8 to 20 carbon atoms) dimethylammonium.
In the alkylamine ethylene oxide adduct, the number of carbon atoms in the alkyl group may be 8 or more and 20 or less, the average number of added moles of ethylene oxide may be 1 or more and 30 or less, and the amine may be any of primary, secondary, and tertiary. It may be. Examples of the alkylamine ethylene oxide adduct include laurylamine ethylene oxide adduct.
Depending on the type of sanitary treatment, the sanitary treatment agent may contain (a) surfactant, for example, 0.0001% by mass or more, further 0.001% by mass or more, further 0.01% by mass, further 0.1% by mass. It can be contained in an amount of 20% by mass or less, further 10% by mass or less, further 5% by mass or less.

(b) Examples of the oxidizing bleach include hypochlorite, dichloroisocyanurate, hydrogen peroxide, sodium percarbonate, and peracetic acid, with hypochlorite being preferred. Examples of the salt include alkali metal salts such as sodium salt and potassium salt. Although it depends on the type of sanitary treatment, the sanitary treatment agent may contain (b) an oxidizing bleach, for example, 0.0001% by mass or more, further 0.001% by mass or more, further 0.01% by mass, further 0.001% by mass or more. It can be contained in an amount of 1% by mass, further 1% by mass, 10% by mass or less, further 7.5% by mass or less, further 5% by mass or less.

(c) As the bactericidal agent, one or more types selected from bactericidal alcohol and bactericidal organic acid can be mentioned.

Examples of the sterilizing alcohol include one or more selected from ethanol and propanol. Depending on the type of sanitary treatment, the sanitary treatment agent may contain sterilizing alcohol, for example, 0.1% by mass or more, further 1% by mass or more, further 10% by mass, further 40% by mass, and 95% by mass or less. , furthermore, it can be contained in an amount of 90% by mass or less, furthermore, 85% by mass or less.

Examples of bactericidal organic acids include lactic acid or its salts. Examples of the salt include alkali metal salts such as sodium salt and potassium salt. Although it depends on the type of sanitary treatment, the sanitary treatment agent contains sterilizing organic acid, for example, 0.01% by mass or more, further 0.1% by mass or more, further 0.4% by mass, and 7% by mass or less. , furthermore, it can be contained in an amount of 5% by mass or less, furthermore, 3% by mass or less.

(c) The disinfectant may be one or more selected from ethanol, propanol, lactic acid, and salts of lactic acid.

The sanitary treatment agent preferably contains two or more selected from (a) a surfactant, (b) an oxidizing bleach, and (c) a disinfectant.

In the present invention, the sanitary treatment may include contacting the treatment area with a sanitary treatment agent and wiping the treatment area with the flexible liquid-absorbing material in contact with the sanitary treatment agent. In the present invention, the sanitary treatment agent may be brought into contact with the treatment area by at least one of contacting the treatment area with a flexible liquid-absorbing material impregnated with the sanitary treatment agent and spraying the sanitary treatment agent onto the treatment area. This can be done by For example, if the treated area is wiped with a flexible liquid-absorbent material impregnated with a sanitary treatment agent, the treated area can be wiped while the sanitary treatment agent is brought into contact with the treated area. Spraying can be performed using, for example, a trigger type pump. Examples of flexible liquid-absorbing materials include nonwoven fabrics, woven fabrics, and sponges.

The present invention provides a method for determining a sanitary treatment method, which detects an indicator polymer in the environment and determines the location to be sanitary treated and the conditions for the sanitary treatment based on the detection results.
This method of determining a location to perform sanitary treatment may be the method for determining a sanitary treatment location of the present invention.
Further, the method for determining sanitary treatment conditions using this method may be the method for determining sanitary treatment conditions of the present invention.
A sanitary treatment method is determined based on the location to be sanitary treated and the sanitary treatment conditions determined in this way.

In the present invention, detection of the indicator polymer is carried out in order to determine the location and/or sanitary treatment conditions for sanitary treatment. In the present invention, the detection of the indicator polymer may be performed every time a sanitary treatment is performed, but it is not necessary to perform it every time. Furthermore, for example, if a manual is prepared for the type, degree, frequency, etc. of sanitation treatment for each location based on the information on the locations and/or conditions determined by the present invention, from then on, As long as the application does not change significantly, highly hygienic processing can be carried out without necessarily detecting the indicator polymer. In addition, once the area to be sanitary treated and/or the sanitary treatment conditions are determined, the detection of the indicator polymer can be carried out periodically or irregularly to confirm the quality and effectiveness of the determined sanitary treatment method. But it doesn't matter.

Using the determination method of the present invention, it is possible to support sanitary treatment of, for example, the above-mentioned buildings, public transportation periods, and their equipment. In other words, it is possible to provide information on the sanitary treatment method determined by the present invention to the person who carries out the sanitary treatment, thereby allowing the person who carries out the sanitary treatment to reliably and efficiently execute the predetermined sanitary treatment.

As a more specific embodiment of the present invention, the indicator polymer is detected in the target area, the location where the indicator polymer is detected is determined as a location where there is a possibility of contamination with viruses and/or bacteria, and the indicator polymer is detected in the target area. A method for determining a sanitary treatment method includes determining conditions for sanitary treatment to be applied to the determined location based on the detection result. The matters described in each of the determination methods of the present invention described above can be applied to this method as appropriate.
In another more specific embodiment of the present invention, an indicator polymer is detected in a building, for example, indoors and/or outdoors, and the location where the indicator polymer is detected is likely to be contaminated by viruses and/or bacteria. An example of this method is to determine a sanitary treatment method, in which a sanitary treatment method is determined as a place with a certain amount of water, and conditions for sanitary treatment to be applied to the determined place are determined based on the detection result of the indicator polymer. The matters described in each of the determination methods of the present invention described above can be applied to this method as appropriate.

The present invention provides a sanitary treatment method in which at least one of the locations to be sanitary treated and the conditions for the sanitary treatment are determined by the determination method of the present invention, and the sanitary treatment is performed based on the determination.
That is, the sanitary treatment method of the present invention:
(1) Using the determination method of the present invention, determine a location to be subjected to sanitary treatment, and perform sanitary treatment on the determined location;
(2) The conditions for sanitary treatment are determined by the determination method of the present invention, and the sanitary treatment is performed under the determined conditions, or (3) The locations to be sanitary treated and the conditions for sanitary treatment are determined by the determination method of the present invention. Decide and perform sanitary treatment at the determined areas under the determined conditions.
It is a sanitary treatment method.
The matters described in the determination method of the present invention can be appropriately applied to the sanitary treatment method of the present invention. In the sanitary treatment method of the present invention, it is also preferable that the sanitary treatment is carried out using a sanitary treatment agent. The specific examples and preferred examples of the sanitary treatment and sanitary treatment agent described in the determination method of the present invention can also be applied. For example, in the sanitary treatment method of the present invention, the indicator polymer may be at least one selected from proteins, glycoproteins, nucleic acids, and polysaccharides. Furthermore, in the sanitary treatment method of the present invention, the indicator polymer may be at least one selected from elastase and mucin.

The present invention provides an estimation method for detecting an indicator polymer in the environment and estimating a location where a harmful virus and/or harmful bacteria are likely to exist based on the detection result.
Furthermore, according to the present invention, indicator polymers are detected in the environment, and based on the detection results, locations where there is a high possibility of the presence of harmful viruses and/or harmful bacteria are estimated, and infection routes are determined. Alternatively, an estimation method for estimating the route of infection by harmful bacteria is provided.
The infection route here may be the infection route to humans. Further, the infection route may be either a route for an infection that has already occurred or a route for an infection that is expected to occur in the future.
Furthermore, even in a new environment, the estimation method used in the present invention can be used to identify locations where harmful viruses and/or harmful bacteria are likely to exist, based on accumulated past data, empirical knowledge or AI. It also includes estimating the route of infection. Alternatively, the indicator polymer may be detected after estimation.
The matters described in each of the determination methods of the present invention described above can be applied to these methods as appropriate. For example, in these methods, the indicator polymer may be at least one selected from proteins, glycoproteins, nucleic acids, and polysaccharides. Further, in these methods, the indicator polymer may be at least one selected from elastase and mucin.
Furthermore, in these methods as well, the harmful virus may be a non-enveloped or enveloped virus, particularly a non-enveloped virus. Furthermore, in these methods as well, the harmful bacteria may be E. coli.

According to the present invention, there is provided a sanitary treatment kit that includes means for detecting an indicator polymer in a target area, and a drug used for treating a sanitary treatment area determined based on the detection result of the indicator polymer obtained by the means. provided. Examples of means for measuring the amount of the indicator polymer include immunochromatography, enzyme immunoassay (EIA method, ELISA method), immunoprecipitation method, immunoblotting, enzyme activity measurement, and the like. Further, examples of the chemicals include cleaning agents, bleaching agents, disinfectants, virucides, antiviral agents, disinfectants, antibacterial agents, and the like. The matters described in each method of the present invention described above can be applied to this kit as appropriate. For example, in this kit, the indicator polymer may be at least one selected from proteins, glycoproteins, nucleic acids, and polysaccharides. Further, in this kit, the indicator polymer may be at least one selected from elastase and mucin.

According to the present invention, there is provided a method for displaying a contamination situation at a candidate location for sanitary treatment, comprising:
(a) a step of identifying one or more locations in the environment, the step including the following steps (i) to (iii);
(i) generating position data that can identify the installation location of the entity in order to identify the one or more locations within the defined area;
(ii) recording location data of the one or more locations within the environment; and (iii) assigning locations and locations of entities that are linked to location data of the one or more locations within the environment. the step of separating and recording;
(b) recording the detection results of human body-derived polymer compounds (hereinafter referred to as indicator polymers) contained in feces detected from one or more locations in the environment;
(c) recording the generated detection results according to the separated positions and parts of the real objects recorded in (iii) of (a); a step of displaying the location data along with the location data;
A method of displaying a contamination situation at a candidate site for sanitary treatment is provided.
The method of displaying the contamination status of the present invention is preferably performed using an information processing device (PC, smartphone, etc.). That is, it is preferable that each data in each step be recorded by an information processing device. FIG. 1 shows an outline of the procedure of the method of displaying the contamination status at candidate locations for sanitary treatment according to the present invention. In FIG. 1, ST stands for step. In FIG. 1, step (a), not shown, is executed by ST(a)-(i), ST(a)-(ii), and ST(a)-(iii).

Step (a) is a step of identifying one or more locations in the environment, and appropriately selects locations in the environment that are candidates for sanitary treatment. For example, as the location, an item inside the room or an item inside the toilet can be selected.
Step (i) [ST(a)-(i) in FIG. 1] is to generate position data that can identify the installation location of the real object in order to identify the one or more locations within the defined area. It is a step. The area may be, for example, a predetermined area within a room. Examples of the real objects include items in a room and items in a toilet. The position data is, for example, data indicating the indoor position of those items.
Step (ii) [ST(a)-(ii) in FIG. 1] is a step of recording position data of the one or more locations in the environment.
Step (iii) [ST(a)-(iii) in FIG. 1] is a step of classifying and recording the real objects linked to the position data of the one or more places in the environment into positions and parts. It is. For example, if there are multiple items with the same attributes in a room, they are separated and information is created and recorded for each item. Specifically, when there are two chairs in a room, they are divided into chairs A and B and their position data is recorded. Furthermore, if each chair has two armrests, position data can be created by subdividing them into armrests A1 and A2. Of course, this processing method can be applied to other entities (such as articles).

Step (b) [ST(b) in FIG. 1] is a step of recording the detection results of the indicator polymer detected from one or more locations in the environment. Detection of the indicator polymer is performed at the position and site of the entity separated in step (iii) of step (a). The detection result can be obtained, for example, by the detection method employed in the sanitary treatment location determination method of the present invention.

Step (c) [ST(c) in Figure 1] records the generated detection results by linking them to the separated locations and parts of the real object recorded in step (iii) of step (a). It is a step. Through this step (c), the detection results for the real object at the predetermined position and the detection results for the predetermined part of the real object at the predetermined position are recorded, and the position and part of the real object are linked with the detection results.

Step (d) [ST(d) in FIG. 1] is a step of displaying the record of step (c) together with the position data of the one or more locations in the environment. The display is performed, for example, on an information display terminal such as an external monitor for a personal computer or a smartphone screen.

For example, in FIG. 1, ST(a)-(i) to ST(d) are repeated as one unit, and ST(a)-(i) to ST(d) are repeated until a predetermined number of times is reached. , it is also possible to end the process after reaching a predetermined number of times.
For example, in FIG. 1, ST(a)-(i) to ST(d) are repeated at predetermined intervals, with ST(a)-(i) to ST(d) being one unit. , it is also possible to end the process after a predetermined time has elapsed.

According to the present invention, there is provided a method for displaying a sanitary treatment place, which determines a sanitary treatment place based on the candidate places for sanitary treatment displayed by the display method of the present invention, and displays the determined sanitary treatment place. The method for displaying sanitary treatment areas of the present invention is preferably performed using an information processing device (PC, smartphone, etc.). In the method for displaying sanitary treatment locations of the present invention, one or more locations in the environment identified in step (a) are sanitized based on data of a plurality of candidate locations for sanitary treatment obtained at different measurement times. Processing locations can be determined.

The method for displaying candidate locations for sanitary treatment and/or the method for displaying sanitary treatment locations of the present invention is incorporated into the method for determining sanitary treatment locations, the method for determining sanitary treatment conditions, the method for determining sanitary treatment methods, and the estimation method of the present invention. It can be carried out in
Note that the results displayed according to the present invention can be output by printing on a paper medium, etc., if necessary. Further, the electronic data of the displayed results can be stored in a suitable storage medium. In addition, the electronic data of the displayed results may be used for secondary purposes using the information communication network (Internet), for example, for creating sanitary treatment implementation plans, providing instructions on sanitary treatment procedures based on the implementation plans, etc. It can be used for services.

Targeting corporate offices, we detected elastase and calprotectin, which are high-molecular compounds derived from the human body, contained in feces. The detection locations were as shown in Table 1. A 25 cm ² area at each test site was swabbed with a clean cotton swab impregnated with a 0.005% Tween 80 (nonionic surfactant) solution. Next, the wiped cotton swab was immersed in 0.5 mL of 0.005% Tween 80 solution and rubbed thoroughly to extract the stain. CLOUD-CLONE CORP. Elastase was detected from the extract using ELISA Kit for Pancreatic Elastase 1 (ELA1) (product number: SEB483Hu) manufactured by Pancreatic Co., Ltd., according to the attached instructions. Calprotectin was also detected from the extract using Hycult Biotech's Calprotectin, Human, ELISA kit (product number: HK379) according to the attached instructions. Samples for elastase and calprotectin extraction were collected in different toilets. From each detected amount, the risk of norovirus contamination was determined using the following criteria. The results are shown in Table 1.
<When the indicator polymer is elastase>
Elastase detection amount 9.55 pg or more: High risk Elastase detection amount less than 9.55 pg: Medium risk Elastase not detected: Low risk <When the indicator polymer is calprotectin>
Detected amount of calprotectin 0.311 pg or more: High risk Calprotectin detected amount less than 0.311 pg: Medium risk Calprotectin not detected: Low risk

For example, it is known that norovirus contains 1 billion viruses in 1 g of feces, and infection can be established with 10 to 100 viruses (https://www.mhlw.go.jp/file/06-Seisakujouhou-11130500- Shokuhinanzenbu/0000105093.pdf; "What is the amount of norovirus in 1 billion (10 ⁹ /g)" from the Ministry of Health, Labor and Welfare website). In other words, it is calculated that infection can be established with 10 to 100 ng of feces. On the other hand, there is information that elastase in stool is on average 955 μg/g (Takeda et al., “Clinical significance of measuring elastase-1 in stool”, Inspection and Technology, Igaku Shoin Co., Ltd., September 2001, Vol. 29, No. 10, pp. 1153-1159), it is calculated that 10 to 100 ng of feces contains an average of 9.55 to 95.5 pg of elastase. Therefore, when the indicator polymer was elastase, the risk judgment criteria were set as described above, and it was determined that areas where the amount of elastase was detected at 9.55 pg or more were areas that required particularly intensive sanitary treatment.

Based on a report that the average concentration of calprotectin in the feces of healthy subjects was 31.1 μg/g (Nakamura et al. (2018) Usefulness of fecal calprotectin by monoclonal antibody testing in adult Japanese with inflammatory bowel diseases: a prospective multicenter study). The calculations were made in the same manner as in the elastase example above, and the risk criteria were set as described above.

According to, for example, Japanese Patent No. 4469762, calprotectin is also detected in the stratum corneum. Therefore, in Table 1, the top surface of the toilet seat, the operation button of the warm water toilet seat, and the door, which are considered to have a lot of skin contact. There is also the possibility that skin-derived calprotectin may have adhered to keys, toilet paper holders, and hand soap pumps. Therefore, in order to more accurately determine the risk of contamination due to components derived from feces, elastase is preferably used as the indicator polymer. In other words, by detecting elastase, we can more accurately detect the possibility of fecal contamination even outside the restroom, such as on the walls of restroom stalls where there is a low possibility of intentional contact, or on alcohol disinfectant pumps installed in offices. Can be judged.

<Formulation example>
Tables 2 to 4 show formulation examples of sanitary treatment agents that can be used in the sanitary treatment according to the present invention. The sanitary treatment method of the present invention can be carried out using these sanitary treatment agents. However, sanitary treatment agents are not limited to these.
Table 2 shows treatment agents that are mainly used by impregnating sheet materials such as nonwoven fabrics, and can be used to obtain sheet-like sanitary treatment agent products. The sheet-shaped sanitary treatment agent product is suitable for contacting and wiping the treatment area with the sanitary treatment agent.
Table 3 shows treatment agents that are mainly used by spraying, and can be used to obtain spray-type sanitary treatment products. Spray-type sanitary treatment products are suitable for efficiently contacting (spraying) the sanitary treatment agent with the treatment area. After contacting with a sanitary treatment agent using a spray-type sanitary treatment product, the treated area may be wiped with a flexible material such as a nonwoven fabric or a sponge, if necessary.
Table 4 shows processing agents used mainly for the purpose of cleaning and sterilization, and the products can take various forms. For example, it can be used in sheet-like sanitary treatment products and spray-type sanitary treatment products as described above.

The components (partially) used in Tables 2 to 4 are as follows.
・Amphitol 20N:: Kao Corporation, lauryl dimethylamine oxide/Amphitol 20AB:: Kao Corporation, lauric acid amidopropyl betaine/Neoperex GS: Kao Corporation, alkylbenzenesulfonic acid/Emar 20CS: Kao Corporation , polyoxyethylene lauryl ether sodium sulfate/secondary alcohol EO 3 moles: nonionic surfactant with an average of 3 moles of ethylene oxide added to a secondary alcohol (12 to 14 carbon atoms), Softanol 30, Nippon Shokubai Co., Ltd., alkyl glycoside : AG-124, manufactured by Kao Corporation, nonionic surfactant Rheodol TW-L120: manufactured by Kao Corporation, polyoxyethylene sorbitan monolaurate/laurylamine EO adduct (2 moles): ethylene oxide added to laurylamine Nonionic surfactant with an average of 2 moles added Penetol GE-EH: Kao Corporation, 2-ethylhexyl glyceryl ether Sanisol B-50: Kao Corporation, alkylbenzyldimethylammonium chloride BDG: Butyl diglycol ( diethylene glycol monobutyl ether) manufactured by Nippon Nyukazai Co., Ltd., solvent/MFG: propylene glycol monomethyl ether, manufactured by Nippon Nyukazai Co., Ltd., solvent/betaine polymer: Example of JP 2018-199770, manufactured by the method of Production Example 1 Polymer: Carbopol ETD2020 PLYMER: Lubrizol Advanced Materials, carboxyvinyl polymer, preservative: Caisson CG, DuPont

Claims (11)

A method for determining sanitary treatment locations by detecting human-derived polymer compounds (hereinafter referred to as indicator polymers) contained in feces in the environment and determining the locations for sanitary treatment based on the detection results. A method for determining sanitary treatment conditions that detects indicator polymers in the environment and determines sanitary treatment conditions based on the detection results. A method for determining a sanitary treatment method, which detects an indicator polymer in the environment and determines the location to be sanitary treated and the conditions for sanitary treatment based on the detection results. The determination method according to any one of claims 1 to 3, wherein the sanitary treatment is a treatment using a sanitary treatment agent for at least any one selected from cleaning, sterilization, and virucidal. 5. The determination method according to claim 1, wherein the indicator polymer is at least one selected from proteins, glycoproteins, nucleic acids, and polysaccharides. The determination method according to any one of claims 1 to 5, wherein the indicator polymer is at least one selected from elastase and mucin. An estimation method that detects human-derived macromolecular compounds contained in feces in the environment and estimates locations where harmful viruses and/or harmful bacteria are likely to exist based on the detection results. An estimation method that detects human-derived polymer compounds contained in feces in the environment, and based on the detection results, estimates the locations where harmful viruses and/or harmful bacteria are likely to exist, and estimates the infection route. . A means for detecting a human body-derived polymer compound (hereinafter referred to as an indicator polymer) contained in feces in the environment, and a method used to treat sanitary treatment points determined based on the detection results of the indicator polymer obtained by the means. Hygiene treatment kit, including drugs and. A method for displaying contamination status at a candidate location for sanitary treatment, the method comprising:
(a) a step of identifying one or more locations in the environment, the step including the following steps (i) to (iii);
(i) generating position data that can identify the installation location of the entity in order to identify the one or more locations within the defined area;
(ii) recording location data of the one or more locations within the environment; and (iii) assigning locations and locations of entities that are linked to location data of the one or more locations within the environment. the step of separating and recording;
(b) recording the detection results of human body-derived polymer compounds contained in feces detected from one or more locations in the environment;
(c) recording the generated detection results according to the separated positions and parts of the real objects recorded in (iii) of (a); a step of displaying the location data along with the location data;
A method for displaying contamination status at candidate locations for sanitary treatment, comprising: A method for displaying a sanitary treatment location, which determines a sanitary treatment location based on the contamination status of the candidate location for sanitary treatment displayed by the display method according to claim 10, and displays the determined sanitary treatment location.