JP2023174881A - Port member and bag - Google Patents

Abstract

To provide a port member capable of suppressing positional deviation of a plug body even when a needle body is inserted and removed, and bag including the port member.SOLUTION: A port member 10 provided in a bag includes a hollow cylindrical body 12, and a plug body 11 made of an elastic body held in the cylindrical body 12. The plug body 11 allows a needle body for passing contents of the bag to pierce in the thickness direction from an outer surface 11a to an inner surface 11b of the plug body 11. The plug body 11 includes, in the circumferential direction, protruding portions 13 having a length greater than a width thereof, on an outer peripheral surface 16 in contact with an inner surface of the cylindrical body 12, and recessed portions 15 are formed between the protruding portions 13 and an outer surface 11a, and an inner surface 11b. The cylindrical body 12 is so configured that at least the inner surface of the cylindrical body 12 is integrally molded over an area facing the plug body 11, and the inner surface of the cylindrical body 12 is made of a molding in close contact with the outer peripheral surface 16 of the plug body 11 and the protruding portions 13.SELECTED DRAWING: Figure 1

Description

The present invention relates to a port member and a bag equipped with the same.

Bags such as medical infusion containers are provided with a port having a rubber stopper for inserting a needle in order to take out the contents hygienically. Patent Documents 1 and 2 disclose a medical cap having a columnar stopper whose bottom surface is polygonal, flower-shaped, or star-shaped in order to prevent the needle from coming out.

Japanese Patent Application Publication No. 11-4873 Japanese Unexamined Patent Publication No. 11-19177

The material of the stopper is designed so that when the needle is inserted into the stopper, the stopper sticks tightly to the outer circumferential surface of the needle, and when the needle is removed from the stopper, the hole where the needle was inserted closes due to its restoring force. Rubber or thermoplastic elastomer with excellent elasticity is used. However, when the needle is inserted into and removed from the plug, the plug may come into close contact with the needle and the position of the plug may shift relative to the port. If the stopper is displaced due to insertion and removal of the needle, there is a risk that the stopper may become loose and fall off from the port, causing a problem that the contents cannot be retained in the bag.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a port member and a bag equipped with the same that can suppress displacement of the stopper even when the needle is inserted and removed. do.

In order to solve the above problems, the present invention provides a port member provided in a bag, which includes a hollow cylindrical body and a stopper made of an elastic body held in the cylindrical body. The needle body for passing the contents of the bag can be pierced in the thickness direction, and the stopper body is attached to the outer circumferential surface in contact with the inner surface of the cylindrical body in a circumferential direction that is wider than the width. The cylindrical body has a convex portion having a large length, and the cylindrical body is integrally molded over at least a range in which the inner surface of the cylindrical body faces the plug body, and the inner surface of the cylinder body faces the stopper body. There is provided a port member characterized in that it is made of a molded product that is in close contact with the outer peripheral surface and the convex portion.

The plug may have two or more convex portions on the outer circumferential surface at intervals in the thickness direction of the plug.
The convex portion may be continuous in the circumferential direction.
The cylinder may have an outer surface that can be joined to the bag.
The plug may have a recessed portion in the thickness direction of the outer surface thereof.
The present invention also provides a bag having the port member.
The content may be a medical drug.

According to the present invention, since the convex portion of the stopper and the inner surface of the cylindrical body are firmly connected, it is possible to suppress displacement of the stopper even when the needle is inserted and removed.

It is a sectional view showing an example of a port member. It is a perspective view showing an example of a stopper. FIG. 2 is a front view showing an example of a bag having a port member. FIG. 3 is a cross-sectional view showing an example of a port member having a recessed portion on the outer surface of the plug.

Hereinafter, the present invention will be described based on preferred embodiments and with reference to the drawings. FIG. 1 shows an example of a port member. FIG. 2 shows an example of a plug used in a port member. FIG. 3 shows an example of a bag having a port member. These drawings are schematic diagrams, and the shapes, dimensions, scales, details, etc. of each part may differ from the actual figures.

As shown in FIG. 3, the port member 10 of this embodiment is provided in a bag 20 and can be used to take out the contents (not shown) of the bag 20 to the outside. The contents of the bag 20 include injections such as infusions, physiological saline, medical solutions, and water for injections such as distilled water. It is preferable that the solution be sterilized and have its component composition, osmotic pressure, pH, etc. adjusted in advance so that the contents of the bag 20 can be administered directly into the human body, such as through a vein.

As shown in FIG. 1, the port member 10 includes a hollow cylindrical body 12 and a plug body 11 made of an elastic body held within the cylindrical body 12. Examples of the elastic body include high elastic resins containing at least one of thermoplastic elastomers, gel-like resins, rubbers, and the like. Examples of the thermoplastic elastomer include one or more of olefin elastomers, styrene elastomers, polyamide elastomers, polyurethane elastomers, polyester elastomers, polyvinyl chloride elastomers, and the like. Examples of the gel resin include one or more of acrylic gel resin, silicone gel resin, polyurethane gel resin, polyvinyl chloride gel resin, and polyolefin gel resin. Examples of the rubber include one or more of acrylic rubber, isoprene rubber, chloroprene rubber, styrene rubber, butadiene rubber, butyl rubber, and the like.

The plug 11 has appropriate viscosity, elasticity, etc. so that a needle (not shown) for passing the contents of the bag 20 can be pierced in the thickness direction of the plug 11. It has physical properties. The needle body has a hollow tubular shape to allow the contents to pass through, and has a sharp needle tip at the tip. Examples of the material of the needle include metals such as stainless steel, aluminum, and titanium, and plastics such as polycarbonate (PC) and polyglycolic acid (PGA). The plug 11 may be any needle suitable for the use of the contents of the bag 20 as long as it can be pierced therein. When the needle is inserted into the plug 11, the needle penetrates the plug 11 from the outer surface 11a to the inner surface 11b. The inner surface 11b of the stopper 11 is a liquid contact surface that can come into contact with the content liquid.

As shown in FIGS. 1 and 2, the plug 11 has a convex portion 13 in the circumferential direction of the plug 11 on an outer peripheral surface 16 that is in contact with the inner surface 12a of the cylinder 12. The convex portion 13 has a width in the thickness direction of the plug 11, a length in the circumferential direction of the plug 11, and a height in the radial direction of the plug 11. The convex portion 13 has a length larger than its width. The convex portion 13 may be continuous in the circumferential direction of the plug body 11, and may extend, for example, over 1/4 of the circumference, over half the circumference, or over the entire circumference. The shape of the cross section of the convex portion 13 intersecting the length direction is not particularly limited, and examples thereof include rectangular, trapezoidal, triangular, semicircular, and the like. In this embodiment, the outer circumferential surface 16 of the plug 11 has two or more convex portions 13 spaced apart from each other in the thickness direction of the plug 11 . A concave portion 14 is formed between adjacent convex portions 13, and a concave portion 15 is formed between convex portion 13 and outer surface 11a or inner surface 11b. The number of convex portions 13 is not limited, and may be one or three or more. In the example shown in FIG. 2, the convex portion 13 and the concave portions 14, 15 are formed over the entire circumference of the outer circumferential surface 16.

The cylinder 12 is a molded product that is integrally molded over at least the area where the inner surface 12a of the cylinder 12 faces the plug 11, and the inner surface 12a of the cylinder 12 is in close contact with the outer circumferential surface 16 of the plug 11. That is, the inner surface 12a of the cylinder 12 is in close contact with the outer circumferential surface 16 of the plug body 11 so as to follow the unevenness formed by the convex portion 13 and the concave portions 14 and 15, and is continuously formed from the same molding material. has been done. As a result, the adhesion between the plug body 11 and the cylinder body 12 is improved compared to the case where a columnar plug body is held by a cylindrical body or the case where the cylinder body is held by combining two or more members. This improves the resistance to insertion and withdrawal (penetration and withdrawal) of the needle body.

It is preferable that the inner surface 12a of the cylindrical body 12 not only cover the periphery of the convex part 13 of the plug body 11, but also come into close contact with the periphery of the concave parts 14 and 15. In particular, the inner surface 12a of the cylindrical body 12 may pinch the convex portion 13 from both sides in the thickness direction, or the inner surface 12a of the cylindrical body 12 may bite into the concave portion 14 between the convex portions 13. Preferably, it is convoluted relative to surface 16. The plug 11 and the cylinder 12 may be joined together by fitting them together after molding, or by insert molding the cylinder 12 by injecting molten resin around the plug 11. and the cylindrical body 12 may be bonded together by welding or the like.

The outer circumferential surface 16 of the plug body 11 has irregularities formed by a convex portion 13 and concave portions 14 and 15, and further has a concave portion 17 in the thickness direction of the outer surface 11a of the plug body 11, as shown in FIG. Good too. In the recess 17, the wall thickness of the portion where the needle passes through the plug 11 is reduced, and the resistance force against elastic deformation of the rubber is relaxed, so that the plug 11 is removed from the cylinder 12 when the needle is inserted or removed. can reduce the removability of

The material constituting at least the inner surface 12a of the cylinder 12 is not particularly limited, but includes polyolefin resins such as polyethylene (PE) resins, polypropylene (PP) resins, and cyclic olefin resins. A component such as an elastomer may be added to the resin constituting the cylinder 12. As long as the inner surface 12a of the cylinder 12 does not face the stopper 11, the cylinder 12 may be constructed by combining two or more members, or the cylinder 12 may have a structure such as an uneven structure on the inner surface 12a or the outer surface 12b. May include. It is preferable that the cylindrical body 12 can be joined to the material constituting the bag 20 at least in the area facing the bag 20. For example, the outer surface 12b of the cylindrical body 12 may be joined to the inner surface of the sheet member 21 that constitutes the bag 20.

FIG. 3 shows an example of a bag 20 having the port member 10 of this embodiment. The bag 20 may be, for example, a soft bag formulation in which an injectable drug is previously diluted and prepared as an intravenous drip infusion and filled into a flexible container made of plastic or the like. The soft bag formulation is useful not only because it is convenient and quick to use, but also because it reduces the risk of breakage and is easier to dispose of than glass bottles or ampoules.

The contents of the bag 20 may be medical drugs such as pharmaceuticals. Examples of medical drugs include aqueous solutions formed by dissolving at least the active ingredients of drugs in water. One or more kinds arbitrarily selected from electrolytes, saccharides, vitamins, proteins, amino acids, etc. may be added to the aqueous solution at any concentration. Note that an aqueous solution in which electrolytes are dissolved is sometimes referred to as an electrolyte solution, and an aqueous solution in which sugars are dissolved is sometimes referred to as a sugar solution. Examples of electrolytes include sodium chloride. Any of these components can be used alone or in combination at any concentration. In this embodiment, a preferred drug solution is, for example, one in which sodium chloride or the like is dissolved in water (for example, distilled water for injection) at an arbitrary concentration. In the case of sodium chloride, the content of these substances is preferably equivalent to that of physiological saline, that is, 0.9% (W/V).

The medicament may also contain a pH adjusting agent. As the pH adjuster, any one that is generally used as a pH adjuster for injections can be used without particular limitation. Furthermore, the liquid properties of the aqueous solution containing the active ingredient, that is, the pH, can be arbitrarily adjusted by using the above-mentioned pH adjuster. Other additives used in the preparation of the drug can be used without any particular limitations as long as they are commonly used as additives for injections. In the present embodiment, other preferable additives include, for example, pharmaceutical excipients as described in "Dictionary of Pharmaceutical Excipients" (edited by Japan Pharmaceutical Excipients Association) published by Yakuji Nipposha in 2000. These additives may be added as salts (for example, monovalent alkali metal salts such as sodium salts and potassium salts) or as hydrates, if desired. These additives are generally mixed in proportions commonly used for injections. In addition, as described in the ``Dictionary of Pharmaceutical Excipients'' (edited by the Japan Pharmaceutical Excipients Association) published by Yakuji Nipposha in 2000, these additives can be used as stabilizers, surfactants, etc., depending on the purpose of use. It can be used as an agent, buffering agent, solubilizer, antioxidant, antifoaming agent, tonicity agent, emulsifier, suspending agent, preservative, soothing agent, solubilizing agent, solubilizing agent, etc. . These additives can be added to the drug in combination of two or more components, if desired.

When the above-mentioned pH adjuster and other additives are used in the pharmaceutical composition of the present embodiment, addition and mixing operations in preparing an aqueous solution can be performed according to ordinary pharmaceutical techniques. For example, when preparing an aqueous solution containing only the active ingredient and a pH adjuster, the active ingredient and the pH adjuster may be weighed separately, mixed, and then dissolved in water, or an aqueous solution containing the active ingredient may be prepared. , a weighed amount of pH adjuster may be dissolved. Alternatively, a weighed amount of the active ingredient may be dissolved in an aqueous solution containing a pH adjuster. It is also possible to prepare an aqueous solution containing a pH adjuster and an aqueous solution containing an active ingredient, respectively, and then mix these aqueous solutions so that the concentration of the active ingredient becomes the above concentration. Moreover, it is possible to prepare in the same way even when other additives are included.

The bag 20 of this embodiment uses a sheet member 21 that includes at least a base resin layer and an innermost layer in this order, stacks the innermost layer as the inner surface to seal the periphery, and further includes the port member 10 or its cylindrical body 12, It can be manufactured by forming it into a bag shape. The seal portion 22 at the periphery of the bag body 23 constituted by the sheet member 21 is formed around the entire circumference of the sheet member 21 when two sheet members 21 are joined. When one sheet member 21 is folded to form a fold line on one side of the bag body 23, the seal portion 22 along the fold line may be omitted.
The thickness of the sheet member 21 is not particularly limited, but is preferably 70 to 400 μm, and more preferably 150 to 300 μm from the viewpoint of strength and flexibility required for a container. Furthermore, the width of the seal portion 22 is not particularly limited, but is 2 to 20 mm, preferably 3 to 7 mm.

In the sheet member 21, the innermost layer, which is a sealant layer, has a thickness of 10 to 100 μm, more preferably 20 to 80 μm. If the thickness of the innermost layer is less than 10 μm, the sealing performance may not be sufficient or the welding strength with the port member 10 may not be sufficient. Moreover, when the port member 10 is welded, the innermost layer becomes thinner due to heating and pressurization, which may cause liquid leakage due to pinholes. The thickness of the innermost layer may be greater than 100 μm, but the greater the thickness, the less flexible the container may be. Moreover, it is not preferable in terms of cost.

As a method for laminating the materials constituting the sheet member 21, a method known as a method for manufacturing ordinary containers can be adopted. For example, the layers can be laminated by coextrusion molding such as multilayer inflation molding and multilayer T-die casting, or by a lamination method such as extrusion lamination in which molten resin is directly laminated, or dry lamination using an adhesive. In addition to the innermost layer and base resin layer described above, the sheet member 21 may optionally include an adhesive layer, an intermediate layer, a printed layer, a vapor deposition layer, a coating layer, and the like.

The base resin layer constituting the sheet member 21 is mainly made of PP resin or PE resin. In addition to homopolymers of propylene, PP resins include copolymers obtained by copolymerizing small amounts (preferably 10% by weight or less) of α-olefins such as ethylene and 1-butene, and copolymers such as those disclosed in JP-A No. 2001-226435. It is composed of a copolymer produced by multi-stage polymerization of propylene and α-olefin. Further, compounds of these homopolymers or copolymers and other polyolefins or resins may be used. Among these, to improve the flexibility of the sheet member 21, it is preferable to use a relatively flexible grade with a bending elastic modulus of 400 to 600 MPa, which is commonly used for medical containers. From another point of view, it is preferable that the melt flow rate (230° C., 21.2N) value of the resin constituting the base resin layer is 1 to 4 (g/10 minutes). A specific example of the resin constituting the base resin layer that can be suitably used in this embodiment is "Zelas (registered trademark)" (registered trademark) manufactured by Mitsubishi Chemical Corporation. In particular, it is preferable to use a PP resin having a melting peak temperature of 160 to 170°C.

Moreover, as the polyethylene used for the base resin layer of the sheet member 21, low density polyethylene or linear low density polyethylene (linear low density polyethylene) is preferably used. The polyethylene preferably has a density in the range of 0.880 to 0.920 g/cm ³ . The α-olefin has 12 or less carbon atoms, and examples include propylene, butene-1, hexene-1, 4-methylpentene-1, and octene-1. The linear low density polyethylene is preferably one produced using a metallocene catalyst. Linear low-density polyethylene polymerized with a metallocene catalyst has excellent transparency because of its low structural heterogeneity. Further, since the molecular weight distribution is uniform, when the linear low-density polyethylene is heated, the polyethylene has few bleed substances and is less likely to become cloudy.

The polypropylene used for the base resin layer or intermediate layer of the sheet member 21 is manufactured using a Ziegler-Natta catalyst or a metallocene catalyst. Syndiotactic polypropylene produced using a metallocene catalyst is preferred because it has excellent flexibility and transparency. It is desirable that the polypropylene has a melting peak temperature of 110° C. or higher, more preferably 120° C. or higher, and when the polypropylene having the above-mentioned temperature characteristics is used for the intermediate layer, heat resistance is imparted to the bag 20.

The composition of the material constituting the innermost layer of the sheet member 21 includes cyclic olefin resin, polyethylene, polypropylene, polybutene, ethylene/α-olefin copolymer, ethylene/(meth)acrylic acid copolymer, and ethylene/vinyl acetate. Copolymers, polyolefin resins such as ethylene/(meth)acrylic acid ester copolymers, urethane resins, rubber resins, polyester resins, polyester urethane resins, acrylic resins, amide resins, styrene resins, Examples include silane resins. By containing these resins, it is possible to improve the desired performance of a container such as an infusion bag shape, such as the impact resistance of the bag 20 at low temperatures, maintaining transparency immediately after high-pressure steam sterilization, and improving flexibility. Is possible.
The material constituting the innermost layer of the sheet member 21 may contain antioxidants and ultraviolet absorbers to the extent that safety and hygiene are not compromised, in order to improve the appearance of the container, stabilize quality, and provide other required performance. It may contain various additives such as antistatic agents, antistatic agents, lubricants, and antiblocking agents.

After the bag 20 of this embodiment is filled with the chemical solution, it is preferably heat treated at a temperature of 60°C or higher, or subjected to high-pressure steam sterilization at a temperature of higher than 100°C, more preferably at a temperature of 121°C. At this temperature, it is very important to design the molecular structure and determine the glass transition temperature so that molecular motion of the polymer constituting the innermost layer, that is, micro-Brownian motion, does not occur at this temperature. It is necessary to have a glass transition temperature that is at least equal to or higher than the temperature of the heat treatment or high-pressure steam sterilization treatment of the container. If the glass transition temperature is lower than this sterilization temperature, the micro-Brownian motion will occur during heat treatment or high-pressure steam sterilization, and the molecular chains will undergo rotational movement, which will prevent the contained drug components from concentrating in the container used. It becomes impossible to prevent adhesion and diffusion, resulting in a decrease in the content of active ingredients. The optimum glass transition temperature of the polymer to prevent such a phenomenon needs to be at least equal to or higher than the temperature of the heat treatment or high-pressure steam sterilization treatment of the container, and the glass transition temperature of the polymer is 70°C. As mentioned above, it is effective that the temperature is preferably 100°C or higher, more preferably 130°C or higher.

The method of welding the port member 10 to the bag body 23 can be, for example, by overlapping the innermost layers of the sheet member 21, which are sealant layers, and inserting the port member 10 between them and welding them by heat sealing. Although the port member 10 may be welded to the seal portion 22, it is also possible to weld the port member 10 to the sheet member 21 at a location other than the seal portion 22.
The cylindrical body 12 of the port member 10 used in this embodiment has a cylindrical shape, for example, and the proximal end is inserted into the opening of the bag body 23, and the sheets on both sides are bonded or heat-sealed. It is joined to member 21 without any gaps. The dimensions of the cylinder 12 are not limited in the present invention, but for example, the outer diameter excluding the convex portion is about 4 to 20 mm, the wall thickness is about 0.5 to 3 mm, and the length is about 20 to 50 mm. Suitable as a connection part for an infusion set. Moreover, the shape of the port member 10 may be such that the joint portion with the sheet member 21 has a shape such as a boat shape in order to increase the strength of the joint with the bag body 23.

In addition, after the port member 10 accommodates the contents, a sealing body (not shown) is provided to prevent leakage to the outside, prevent dust and bacteria from entering from outside the system, and maintain the quality of the contents. Installed and sealed. As the sealing body, an elastic body made of rubber or elastomer is mainly used. Furthermore, in order to prevent the sealing body from falling off due to the action of an external force, measures are also generally taken to fix the sealing body by attaching a cap or arranging a sealing material as necessary.

As a method for manufacturing the cylindrical body 12 of the port member 10, a method known as a method for manufacturing a normal resin molded product, typified by an injection molding method, can be employed. In order to reduce the interaction of the contents contained in the bag 20, different materials may be blended or arranged in multiple layers. For example, it is preferable that the main component of the cylinder 12 is a crystalline polyolefin resin having no cyclic hydrocarbon skeleton, such as PE or PP. Furthermore, a component such as a styrene elastomer may be added to the cylinder 12 within a range that does not impair the heat resistance to heat treatment. Since the port member 10 of this embodiment can be easily joined to the sheet member 21, the time required for sealing can be shortened, resulting in excellent productivity of the bag 20. That is, it becomes possible to provide the bag 20 of this embodiment at low cost.

The bag 20 of this embodiment is a container that can be sealed and can maintain the sterility of the contents, and is particularly preferably an infusion bag that is generally used for filling and storing injection solutions. In addition, these types of containers are preferably transparent and uncolored in order to visually check and confirm the formation and contamination of foreign substances, especially insoluble foreign substances, but the light resistance of the contents and the design of the container are important. In consideration of convenience and convenience, the container may be colored as long as it does not impair the visibility of the contents.

In the bag 20 of this embodiment, an aqueous solution containing an active ingredient is filled into a bag body 23 to which a cylindrical body 12 is joined, a stopper 11 is attached to the cylindrical body 12 to form a port member 10, and then a cap is provided. It can be manufactured by assembling the parts, or by sealing the parts by welding, tightening an aluminum cap, etc. as necessary. Further, by subjecting the bag 20 to a sterilization operation at any stage of these manufacturing steps, the bag 20 can maintain sterility. Further, if desired, operations such as filtration using a dust filter may be performed before filling these containers. In manufacturing the bag 20 of this embodiment, specific sterilization methods for sterilization include, for example, hot water immersion sterilization, hot water shower sterilization, high pressure steam sterilization (autoclave), and the like.

Although the preferred embodiments of the present invention have been described above, it goes without saying that the present invention is not limited to these embodiments. The various shapes and combinations of the constituent members shown in the above-described embodiments are merely examples, and can be variously changed based on design requirements and the like without departing from the gist of the present invention.

EXAMPLES Hereinafter, the present invention will be specifically explained with reference to examples, but the present invention is not limited to the following examples.

<Molding of port member>
By injection molding, a port member consisting of a cylindrical body with a stopper was molded with dimensions of an outer diameter of 10 (mm), a wall thickness of 1.5 (mm), and a length of 35 (mm). In order to improve the adhesion with the cylinder, concave and convex portions with a width of 1 mm in the thickness direction were formed all around the outer peripheral surface of the plug. Table 1 shows the materials used for the plugs and the shapes of the plugs (presence or absence of recesses on the outer surface). When a recess in the thickness direction was provided on the outer surface of the plug, the depth was 3 (mm) and the diameter was 2 (mm). If no recess is provided on the outer surface, the thickness of the plug is uniform.

<Evaluation of piercing properties>
Test No. Using a port member consisting of a cylinder with a stopper from 1 to 4, a sensory evaluation was conducted on the difference in piercing performance when a plastic needle is penetrated from the outer surface of the stopper in the thickness direction. The results are summarized in Table 1. Evaluate the relative strength of the force applied to penetrate the plug, and rank it in the order of force required for penetration: "x" (difficult to penetrate), "△" (slightly large force but still difficult to penetrate) Possible), “○” (Easy to pierce), and “◎” (Very easy to pierce). Regarding the removability from the cylinder, when the needle penetrates the plug, if the plug does not come off from the cylinder, an "○" is written, and if it comes off, an "×" is written. .

<Evaluation of liquid leakage>
Test No. Using port members consisting of 3 and 4 cylindrical bodies with a stopper, liquid leakage when the needle was inserted into the stopper was evaluated. Put 50 ml of water into a 50 ml plastic bag with this cylindrical body sealed, and after passing the needle of the infusion set vertically through the stopper, hang the plastic bag with the stopper facing down for 24 hours. Afterward, we checked to see if there were any leaks. If there was no liquid leakage, "○" was written, and if there was liquid leakage, "x" was written.

The above evaluation results are shown in Table 1. Concave and convex portions are provided around the entire outer circumference of the stopper, and when it is in close contact with the cylinder, it will not come off when the needle is inserted, and this structure is effective in holding the stopper against the cylinder. It was shown to be effective. Furthermore, when a recess was provided on the outer surface of the plug, the force applied during penetration could be suppressed. Furthermore, regardless of the shape, the contents did not leak out after 24 hours with the needle inserted into the stopper, and it was confirmed that there was no problem in use.

DESCRIPTION OF SYMBOLS 10...Port member, 11...Plug body, 11a...Outer surface of the plug body, 11b...Inner surface of the plug body, 12...Cylinder body, 12a...Inner surface of the cylinder body, 12b...Outer surface of the cylinder body, 13...Convexity of the plug body shaped part, 14, 15... concave part of the stopper, 16... outer peripheral surface of the stopper, 17... concave part, 20... bag, 21... sheet member, 22... seal part, 23... bag main body.

Claims (7)

A port member provided in a bag,
It has a hollow cylindrical body and a stopper made of an elastic body held in the cylindrical body,
The plug can be penetrated by a needle for passing the contents of the bag in the thickness direction from the outer surface to the inner surface of the plug,
The plug body has a convex portion on an outer circumferential surface in contact with the inner surface of the cylindrical body, the length being larger than the width in the circumferential direction,
The plug has two or more convex portions spaced apart from each other in the thickness direction of the plug on the outer circumferential surface, and is separate from a concave portion formed between adjacent convex portions. , a concave portion is formed between the convex portion and the outer surface and the inner surface,
The cylindrical body is a molded product in which at least the inner surface of the cylindrical body is integrally molded over a range that faces the plug, and the inner surface of the cylindrical body is in close contact with the outer circumferential surface and the convex portion of the plug. A port member comprising: A port member provided in a bag,
It has a hollow cylindrical body and a stopper made of an elastic body held in the cylindrical body,
The plug can be penetrated by a needle for passing the contents of the bag in the thickness direction from the outer surface to the inner surface of the plug,
The plug body has a convex portion on an outer circumferential surface in contact with the inner surface of the cylindrical body, the length being larger than the width in the circumferential direction,
The plug body has only one convex portion on the outer peripheral surface, and a concave portion is formed between the convex portion and the outer surface and the inner surface,
The cylindrical body is a molded product in which at least the inner surface of the cylindrical body is integrally molded over a range that faces the plug, and the inner surface of the cylindrical body is in close contact with the outer circumferential surface and the convex portion of the plug. A port member comprising: The port member according to claim 1 or 2, wherein the convex portion is continuous in the circumferential direction. The port member according to any one of claims 1 to 3, wherein the cylindrical body has an outer surface that can be joined to the bag. The port member according to any one of claims 1 to 4, characterized in that the plug has a recessed portion in the thickness direction of the outer surface thereof. A bag provided with the port member according to any one of claims 1 to 5. 7. The bag according to claim 6, wherein the contents are a medical drug.

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