JP2023100816A5 - - Google Patents

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JP2023100816A5
JP2023100816A5 JP2023075951A JP2023075951A JP2023100816A5 JP 2023100816 A5 JP2023100816 A5 JP 2023100816A5 JP 2023075951 A JP2023075951 A JP 2023075951A JP 2023075951 A JP2023075951 A JP 2023075951A JP 2023100816 A5 JP2023100816 A5 JP 2023100816A5
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pharmaceutical composition
cancer
composition according
seq
modified oligonucleotides
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JP2023075951A
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JP2023100816A (en
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Priority claimed from JP2020555340A external-priority patent/JP7275164B2/en
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配列表
本出願は、電子形式で配列表と共に出願されている。配列表は、サイズが４２６ｋｂである、２０１９年４月８日に作成されたＢＩＯＬ０３３４ＷＯＳＥＱ＿ＳＴ２５．ｔｘｔのファイル名に対応する。配列表の電子形式及びＢＩＯＬ０３３４ＷＯＳＥＱ＿ＳＴ２５．ｔｘｔと名付けられたファイルにおける情報は、その全体が参照により本明細書に組み込まれる。 SEQUENCE LISTING This application is being filed in electronic form along with a sequence listing. The Sequence Listing is 426 kb in size, BIOL0334WOSEQ_ST25. txt file name. The electronic form of the Sequence Listing and BIOL0334WOSEQ_ST25. txt is hereby incorporated by reference in its entirety.

Claims (17)

以下の化学構造：
（配列番号２５２の核酸塩基配列を有する、配列番号１５９３）
に従う、修飾オリゴヌクレオチド又はその塩。 The following chemical structures:
(SEQ ID NO: 1593, having the nucleobase sequence of SEQ ID NO: 252)
modified oligonucleotides or salts thereof according to ナトリウム塩又はカリウム塩である、請求項１に記載の修飾オリゴヌクレオチド。 2. The modified oligonucleotide of claim 1, which is a sodium salt or a potassium salt. 以下の化学構造：
（配列番号２５２の核酸塩基配列を有する、配列番号１５９３）
に従う、修飾オリゴヌクレオチド。 The following chemical structures:
(SEQ ID NO: 1593, having the nucleobase sequence of SEQ ID NO: 252)
modified oligonucleotides according to. 修飾されたオリゴヌクレオチドの全てのホスホロチオエートヌクレオシド間結合がステレオランダムである、請求項１～３のいずれか１項に記載の修飾オリゴヌクレオチドの集団。 4. The population of modified oligonucleotides of any one of claims 1-3, wherein all phosphorothioate internucleoside linkages of the modified oligonucleotides are stereorandom. 請求項１～３のいずれか１項に記載の修飾オリゴヌクレオチド又は請求項４に記載の集団を含む、医薬組成物。 A pharmaceutical composition comprising the modified oligonucleotide of any one of claims 1-3 or the population of claim 4. 薬学的に許容される希釈剤をさらに含む、請求項５に記載の医薬組成物。 6. The pharmaceutical composition of Claim 5, further comprising a pharmaceutically acceptable diluent. 薬学的に許容される希釈剤が水又はリン酸緩衝食塩水（ＰＢＳ）である、請求項６に記載の医薬組成物。 7. The pharmaceutical composition of claim 6, wherein the pharmaceutically acceptable diluent is water or phosphate buffered saline (PBS). 医薬組成物が、修飾されたオリゴヌクレオチド、及び水又はＰＢＳからなる、請求項７に記載の医薬組成物。 8. Pharmaceutical composition according to claim 7, wherein the pharmaceutical composition consists of the modified oligonucleotide and water or PBS. 医薬組成物が、修飾されたオリゴヌクレオチドの集団、及び水又はＰＢＳからなる、請求項７に記載の医薬組成物。 8. The pharmaceutical composition of claim 7, wherein the pharmaceutical composition consists of the population of modified oligonucleotides and water or PBS. ＥＺＨ２に関連する疾患を治療するための、請求項５～９のいずれか１項に記載の医薬組成物であって、該治療が、医薬組成物を個体に投与することを含む、上記組成物。 A pharmaceutical composition according to any one of claims 5-9 for treating a disease associated with EZH2, wherein said treatment comprises administering the pharmaceutical composition to an individual. . ＥＺＨ２に関連する疾患が、がんである、請求項１０に記載の医薬組成物。 11. The pharmaceutical composition according to claim 10, wherein the disease associated with EZH2 is cancer. がんが、血液がん、骨髄腫、多発性骨髄腫（ＭＭ）、Ｂ細胞悪性腫瘍、リンパ腫、Ｂ細胞リンパ腫、ＤＬＢＣＬ、ＧＣ－ＤＬＢＣＬ、Ｔ細胞リンパ腫、又は白血病である、請求項１１に記載の医薬組成物。 12. The cancer of claim 11, wherein the cancer is hematological cancer, myeloma, multiple myeloma (MM), B-cell malignancy, lymphoma, B-cell lymphoma, DLBCL, GC-DLBCL, T-cell lymphoma, or leukemia. pharmaceutical composition of 医薬組成物の投与が、がん細胞増殖、腫瘍増殖、又は転移を阻害又は低減する、請求項１１又は１２に記載の医薬組成物。 13. The pharmaceutical composition of claim 11 or 12, wherein administration of the pharmaceutical composition inhibits or reduces cancer cell proliferation, tumor growth, or metastasis. 個体がヒトである、請求項１０～１３のいずれか１項に記載の医薬組成物。 The pharmaceutical composition according to any one of claims 10-13, wherein the individual is a human. 細胞内のＥＺＨ２の発現を低減するための、請求項５～９のいずれか１項に記載の医薬組成物。 The pharmaceutical composition according to any one of claims 5 to 9, for reducing intracellular EZH2 expression. 細胞が、がん細胞である、請求項１５に記載の医薬組成物。 16. The pharmaceutical composition according to claim 15, wherein the cells are cancer cells. 細胞が、ヒト細胞である、請求項１５又は１６に記載の医薬組成物。 17. The pharmaceutical composition according to claim 15 or 16, wherein the cells are human cells.
JP2023075951A 2018-04-11 2023-05-02 Modulators of ezh2 expression Pending JP2023100816A (en)

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US201862656244P 2018-04-11 2018-04-11
US62/656,244 2018-04-11
JP2020555340A JP7275164B2 (en) 2018-04-11 2019-04-11 Regulators of EZH2 expression

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JP2023100816A5 true JP2023100816A5 (en) 2023-08-23

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US (1) US11365416B2 (en)
EP (1) EP3775204A4 (en)
JP (2) JP7275164B2 (en)
KR (1) KR20200141481A (en)
CN (1) CN112041440A (en)
AU (1) AU2019252667A1 (en)
BR (1) BR112020018698A2 (en)
CA (1) CA3094020A1 (en)
IL (1) IL277847A (en)
MX (1) MX2020010721A (en)
PE (1) PE20201349A1 (en)
SG (1) SG11202008660TA (en)
WO (1) WO2019200172A1 (en)

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AU2019218987A1 (en) 2018-02-12 2020-07-23 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
SG11202008660TA (en) 2018-04-11 2020-10-29 Ionis Pharmaceuticals Inc Modulators of ezh2 expression

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