JP2023079836A - Needle hub and syringe using the same - Google Patents

Abstract

To provide a needle hub with a small dead space, configured to fit with various syringes.SOLUTION: A needle hub 103 includes a frustoconical recess part 117 to be mated with a male luer slip type connector in conformity with ISO 80369-7: 2016 and is equipped with a needle 113 provided in a front side of the recess part, where the depth L of the recess part is 7.384 mm or more and 7.496 mm or less, the inside diameter D of an opening is 4.316 mm or more and 4.376 mm or less, and the inside diameter is narrowed from the opening with an inclination of 6% with respect to the depth.SELECTED DRAWING: Figure 2

Description

TECHNICAL FIELD The present invention relates to a needle hub for puncturing an object and a syringe using the same.

Traditionally, needle hubs and syringes have been made according to ISO standards. By doing so, there is an advantage that the interchangeability of the products is improved and that any syringe assembly can be injected in the same way. Currently, one ISO standard for needle hub and syringe connectors is specified in ISO 80369-7:2016. ISO80369-7:2016 defines luer slip connectors and luer lock connectors.

However, syringes conforming to conventional standards have a large dead space where the liquid remains. Eliminating dead space in syringes to reduce the loss of expensive medicaments is of great benefit.

To eliminate dead space between the needle hub and syringe barrel defined in ISO80369-7:2016, for example, US Pat. a needle hub body having a syringe connector for receiving a syringe barrel attachment at a first end of the needle hub body; The needle hub assembly further includes a needle receiver on a side second end, the needle hub assembly further including a needle extending from the needle receiver, and the syringe connector at least at its distal end to the syringe of the syringe barrel. and an inlet region of the receiving aperture having a cross-sectional dimension (D) of approximately 4.270 mm to 4.315 mm, the inlet region The inner perimeter wall of the receiving opening extending between the perimeter and the top perimeter tapers 6% from the inlet region toward the top surface, and the length (A) of the opening measured along the longitudinal axis is between 3 mm and 7 mm. one end of the needle is received within the needle receiver and does not protrude into the opening, the syringe comprising a syringe barrel, the syringe barrel being the proximal end and the distal end of the syringe extending longitudinally between and including a mounting portion for mounting the needle hub assembly, the syringe further comprising a plunger slidably received within the syringe barrel, the plunger having a sealing a sealing element disposed at the distal end of the plunger and configured to be assembled within at least the mounting portion, the material of the needle hub body of the needle hub assembly being a syringe barrel of the syringe and at least a higher hardness than the material of the syringe barrel mounting portion.

Patent No. 6864475

However, if the coupling force between the injection needle hub body and the syringe is not optimized, the syringe may be overwhelmed by the injection pressure of the liquid medicine and the injection needle hub body and the syringe may be disassembled during injection. In particular, when a highly viscous chemical solution is used, there is a great possibility of this happening. Here, high viscosity assumes that the viscosity is higher than that of water. A luer lock type connector may be used to strengthen the connection between the needle hub and the syringe so that they do not disassemble, but this complicates the structure and increases the cost. In order to reduce the cost, it is better to adopt a luer slip type.

Therefore, the present invention provides a needle hub capable of reducing dead space and increasing coupling force to be fitted with a male luer slip type connector specified in ISO80369-7:2016, and various needle hubs specified in ISO80369-7:2016. To construct a syringe equipped with a male luer slip type connector and a syringe with a small dead space. In addition, we provide a needle hub that mates with a male luer lock type connector specified in ISO80369-7:2016, which also mates with a male luer lock type connector specified in ISO80369-7:2016, and provides wide compatibility. intended to have.

It also aims to provide a syringe comprising a needle hub and a syringe having a male luer slip connector as defined in ISO 80369-7:2016 to reduce cost, reduce dead space and increase coupling force. and A further object is to provide a syringe comprising a needle hub and a syringe having a male luer lock connector as specified in ISO80369-7:2016.

The needle hub of the present invention comprises:
A needle hub having a truncated cone-shaped recess that fits with a male luer slip type connector specified in ISO80369-7:2016, and having a needle mounted in front of the recess,
The recess has a depth L of 7.384 mm or more and 7.496 mm or less, an inner diameter D of the opening of 4.316 mm or more and 4.376 mm or less, and the inner diameter of the recess is inclined from the opening by 6% with respect to the depth. It is the needle hub that narrows.

The present invention provides a needle hub with reduced dead space and strong coupling with the syringe. Therefore, it is possible to provide a needle hub that can be coupled with a variety of syringes with little dead space. Also, the needle hub of the present invention can be used to inject expensive and highly viscous medical solutions.

Also, the needle hub of the present invention is
comprising threads on the outer surface of the needle hub;
The recess and the thread of the needle hub is a needle hub that can mate with a male luer lock connector as specified in ISO 80369-7:2016.

According to the present invention, it is possible to obtain a luer lock type needle hub compatible with the luer slip type.

Further, the syringe of the present invention is
the needle hub;
a syringe having a male luer slip connector as specified in ISO80369-7:2016;
A plunger with a gasket at the tip and a syringe with
the shape of the outer surface of the gasket and the shape of the inner surface of the tip of the syringe match;
The syringe has a residual amount of the drug solution of 2 μL or more and 50 μL or less.

The present invention provides a syringe with reduced cost, reduced dead space, and increased cohesive strength. Therefore, the syringe of the present invention can be used for injecting expensive and highly viscous medical solutions.

In addition, the syringe of the present invention is
the needle hub;
a syringe having a male luer lock connector as specified in ISO80369-7:2016;
a plunger with a gasket at the tip,
the shape of the outer surface of the gasket and the shape of the inner surface of the tip of the syringe match;
The syringe has a residual amount of the drug solution of 2 μL or more and 50 μL or less.

According to the present invention, it is possible to obtain a luer lock type syringe compatible with the luer slip type.

The present invention provides a needle hub capable of reducing dead space and increasing coupling force to mate with a male luer slip type connector specified in ISO80369-7:2016, which is specified in various ISO80369-7:2016. Syringes with male luer slip connectors and low dead space syringes can be constructed. The present invention also provides a needle hub that mates with a male luer slip type connector as defined in ISO 80369-7:2016, which also mates with a male luer lock type connector as defined in ISO 80369-7:2016, Wide compatibility is possible.

The present invention also provides a syringe comprising a syringe having its needle hub and a male luer slip connector as defined in ISO 80369-7:2016 to reduce cost, reduce dead space and increase coupling force. be able to. Further, the present invention provides a syringe comprising a syringe having its needle hub and a male luer lock connector as defined in ISO 80369-7:2016.

It is a figure showing an outline of a syringe concerning an embodiment of the invention. Fig. 3 is a cross-sectional view of a needle hub according to an embodiment of the invention; Fig. 2 shows an overview of a needle hub according to an embodiment of the invention; 1 is a cross-sectional view of a syringe using a needle hub and luer slip connector according to an embodiment of the present invention; FIG. 1 is a cross-sectional view of a syringe using a needle hub and luer lock connector according to an embodiment of the present invention; FIG.

Various embodiments for carrying out the present invention will be described below with reference to the drawings. The needle hub and syringe described below are for embodying the technical idea of the present disclosure, and unless there is a specific description, the present disclosure is not limited to the following. For ease of explanation or understanding of the main points, different drawings are shown with the same reference numerals for convenience. In particular, similar actions and effects due to similar configurations will not be referred to successively for each embodiment or example. The sizes and positional relationships of members shown in each drawing may be exaggerated for clarity of explanation.

(Explanation of syringe according to embodiment of the present invention)
FIG. 1 is a diagram showing an overview of a syringe according to an embodiment of the invention. A syringe according to an embodiment of the present invention will be described with reference to FIG.

In FIG. 1, the arrow direction 109 in which the needle of the syringe is located is the front end, the front end side, the front end direction, the front end portion, the front direction, etc., and the arrow direction 111 in which the plunger is inserted into the syringe is the rear end, the rear end side, the rear end direction, Rear end, back.

As shown in FIG. 1, a syringe 101 using a luer slip connector has a needle hub 103 with a needle 113 (shown later) at the front end, a syringe 105 for storing a drug solution to be injected, and attached to the syringe 105, It is composed of a plunger 107 for pushing the drug solution of the syringe 105 . The syringe 101 shown in FIG. 1 has a needle hub 103 fitted to the front end of a syringe 105 and connected by a luer slip connector that is frictionally connected. In the case of a luer slip type connector, this frictional force must not be defeated by the injection pressure of the chemical solution.

On the other hand, a luer lock type connector is one in which the male threads on the outer surface of the needle hub 103 are coupled with the female threads of the syringe, as will be illustrated later. Luer lock type connectors are suitable for injecting highly viscous liquid medicines because they are connected not only by the frictional force between the tip of the syringe and the needle hub but also by the fitting of the male and female threads. However, since the structure becomes complicated, the cost may increase.

The syringe 105 has a hollow cylindrical shape and stores a liquid medicine. Syringe 105 has tips (shown later) 135, 147 that mate with the needle hub at its front end and has a through hole in its center. The drug solution that has passed through the through-hole of the fitting portion is allowed to pass through the needle.

Plunger 107 is also called a pusher. The front end of the plunger 107 is fitted with gaskets 133, 145, which are shown later. Gaskets 133 and 145 attached to the front end allow the plunger 107 to function as a piston that pushes the liquid medicine in the syringe 105 to the front end without leakage.

The needle 113 is preferably made of metal. Needle hub 103 is preferably formed of polycarbonate. Syringe 105 is preferably made of a resin such as polypropylene. Also, the plunger 107 is preferably made of a resin such as polypropylene or ABS. Moreover, the gaskets 133 and 145 are preferably made entirely of resin such as silicon or elastomer.

(Explanation of Needle Hub According to Embodiment of the Present Invention)
FIG. 2 is a cross-sectional view of a needle hub according to an embodiment of the invention; FIG. 3 is a diagram showing an overview of a needle hub according to an embodiment of the invention; 2 and 3, a needle hub according to an embodiment of the invention will be described.

As shown in FIG. 2, needle hub 103 according to an embodiment of the present invention has a frustoconical recess 117 that mates with a male luer slip connector as defined in ISO 80369-7:2016. A needle 113 provided on the front side is attached.

The ISO 80369-7:2016 standard is a standard for matching needle hubs and syringes made by different companies, especially for syringes. Although this standard allows for compatibility, the needle hub and syringe must be individually optimized for the desired coupling force.

Needle 113 is inserted into needle housing 115 and fixed with an adhesive. The needle 113 is not completely inserted into the needle housing 115, but a space 125 is formed. The space 125 is a cylindrical space having a diameter that matches the outer diameter of the needle 113 and varies depending on how the needle 113 is inserted. Since this also becomes a dead space for the chemical, it is preferable to make it as small as possible.

Recess 117 has an opening 119 for receiving the connector and a bottom surface 121 for terminating the connector. The distance between the opening 119 and the bottom surface 121, that is, the depth L of the recess is 7.384 mm or more and 7.496 mm or less. Opening 119 and bottom surface 121 form concentric circles about the central longitudinal axis of the syringe. The inner diameter D of the opening 119 is 4.316 mm or more and 4.376 mm or less. The opening of the recess 117 narrows from the opening 119 toward the bottom surface 121 with a slope of 6%. In this manner, the needle hub 103 is strongly mated with an ISO 80369-7:2016 male luer slip connector.

The inner surface of the recess 117 has a smooth curved surface without irregularities. That is, the curved surface as a whole generates friction between the male luer slip connector and the recess 117, rather than reducing the opening with a projection or the like to increase the frictional force. By doing so, the needle hub 103 is also strongly coupled with the male luer slip connector.

A protruding portion 123 is formed substantially at the center position of the bottom surface 121 of the concave portion 117 in plan view. Projection 123 engages the center of the male luer slip connector to locate the central axis. Also, when the shape of needle hub 103 is changed, the dead space may change in the space between needle hub 103 and the luer type connector. Thus, protrusion 123 reduces dead space between the luer slip connector through needle hub 103 .

As shown in FIG. 3, needle hub 103 includes external threads 127 on its outer surface near opening 119 . The threads of this male thread are capable of mating with a male luer lock connector as defined in ISO 80369-7:2016 and female threads 143 (shown later). The engagement between the male thread 127 and the female thread 143 and the engagement of the tip of the luer lock type connector with the concave portion 117 of the needle hub 103 allows the needle hub and the luer lock type connector to be firmly connected. Thus, the needle hub of the present embodiment engages not only the male luer slip connector specified in ISO 80369-7:2016, but also the male luer lock connector specified in ISO 80369-7:2016. and expand compatibility.

(Description of Syringe Equipped with Syringe Having Luer Slip Connector Through Needle Hub of this Embodiment)
FIG. 4 is a cross-sectional view of a syringe using a needle hub and luer slip connector according to an embodiment of the present invention; Referring to FIG. 4, a syringe using a needle hub and luer slip connector according to an embodiment of the invention will be described.

As shown in FIG. 4, syringe 101 using needle hub 103 and luer slip connector according to the embodiment of the present invention includes plunger 107, gasket 133 attached to the tip of the plunger, syringe 105, and tip of syringe 105. a needle hub 103 matingly attached to 135;

The male luer slip type connector defined in ISO80369-7:2016 and the needle hub 103 are connected only by the frictional force of the smooth curved surface.

The shape of the outer surface 129 of the gasket 133 preferably matches the shape of the inner surface 131 of the tip 135 of the syringe 105 . In this way, the dead space can only be considered the space 125 between the syringe 105 and the needle hub 103, in the needle, and between the needle hub 103 and the needle.

By doing so, it is possible to provide the syringe 101 with a load dead space. The loaded space refers to the residual amount of the drug solution, that is, the volume of these spaces is 50 μL or less, preferably 20 μL or less, and more preferably 14 μL or less.

(Description of Syringe Equipped with Syringe Having Luer Lock Connector Through Needle Hub of this Embodiment)
FIG. 5 is a cross-sectional view of a syringe using a needle hub and luer lock connector according to an embodiment of the present invention; Referring to FIG. 5, a syringe using a needle hub and luer lock type connector according to an embodiment of the invention will be described.

As shown in FIG. 5, a syringe 136 using a needle hub 103 and a luer lock connector according to the embodiment of the present invention includes a plunger 107, a gasket 145 attached to the tip of the plunger, a syringe 137, and a tip of the syringe 137. a needle hub 103 matingly attached to 147;

The male luer lock type connector defined in ISO80369-7:2016 and the needle hub 103 are tightly coupled by the frictional force of the smooth curved surface and the screw engagement of the female thread 143 and the male thread 127 .

The shape of the outer surface 139 of the gasket 145 preferably matches the shape of the inner surface 141 of the tip 147 of the syringe 137 . In this way, the dead space is only considered the space 125 between the syringe 137 and the needle hub 103, in the needle, and between the needle hub 103 and the needle.

By doing so, it is possible to provide a syringe 136 with a load dead space. Similar to the male luer slip type connector specified in ISO80369-7:2016, the loaded space means the amount of residual chemical solution, that is, the volume of these spaces is 50 μL or less, preferably 20 μL or less, more preferably 14 μL or less. point to

By varying the depth L and the inner diameter D of the opening, a polycarbonate needle hub 103 having a concave portion with an inclination of 6% in the spread of the opening with respect to the depth was produced, and combined with polypropylene syringes of each company. Dead space and separation resistance were compared. Table 1 shows the results.

Table 1 Table of needle hub size, dead space and separation resistance

As the separation resistance, ∘ indicates that the syringe is not separated from the syringe after a separation force of 23 N is maintained in the axial direction for 10 seconds, and the axial force at the time of separation is described in the case of separation. The conventional product has a length L of 6.1 mm or more and 6.2 mm or less and an inner diameter D of the opening of 4.27 mm or more and 4.315 mm or less. It's gone. In the conventional product, it is considered that the fact that the depth L was short and sufficient frictional force was not obtained and the bonding force was weak led to the separation.

On the other hand, Comparative Examples 1 to 4, in which the length of the depth L was increased to 7.380 mm or more and 7.492 mm or less, have a stronger binding force than the conventional product, but cannot achieve a certain separation force with the syringes of each company. has occurred. Comparative Examples 1 to 4 have an opening inner diameter D of 4.552 mm or more and 4.593 mm or less, and correspond to those in which the concave portion is extended toward the rear end side of the conventional product. Therefore, it is considered that the weak bonding force in Comparative Examples 1 to 4 is due to the widening of the diameter of the opening.

On the other hand, in Examples 1 to 3, the depth L is 7.384 mm or more and 7.496 mm or more, which is greater than the conventional product, and the opening inner diameter D is 4.316 mm or more and 4.376 mm or less, which is smaller than the comparative example. . Examples 1 to 3 correspond to those in which the concave portion is extended toward the front end of the conventional product. In Examples 1 to 3, a sufficient binding force was obtained, and the syringes of each company did not separate with a constant separation force.

In addition, in Examples 1 to 3, the dead space was 14 μL or less, and the dead space could be made as small as compared with the comparative example and the conventional product. This indicates that the tip of the syringe reaches the bottom of the needle hub and the space between the needle hub and syringe is small enough.

INDUSTRIAL APPLICABILITY The present invention provides a needle hub capable of reducing dead space and increasing coupling force for mating with a male luer slip type connector defined in ISO80369-7:2016, which is defined in various ISO80369-7:2016. Syringes with male luer slip connectors and low dead space syringes can be constructed. The present invention also provides a needle hub that mates with a male luer slip connector as defined in ISO 80369-7:2016, which also mates with a male luer lock connector as defined in ISO 80369-7:2016, Can be widely compatible.

Also provided by the present invention is a syringe comprising a syringe having its needle hub and a male luer slip connector as specified in ISO 80369-7:2016 to reduce cost, reduce dead space and increase coupling force. be able to. Further in accordance with the present invention there is provided a syringe comprising a syringe having its needle hub and a male luer lock connector as defined in ISO 80369-7:2016.

The needle hub and syringe of the present invention can be used to inject expensive and highly viscous medical fluids.

The description of the above embodiments is illustrative in all respects and is not restrictive. Modifications and modifications are possible for those skilled in the art. The scope of the invention is indicated by the claims rather than the above-described embodiments. Furthermore, the scope of the present invention includes modifications from the embodiments within the scope of claims and equivalents.

The needle hub provided by the present invention allows the construction of various ISO 80369-7:2016 male luer slip connectors and syringes.

101 Syringe Using Luer Slip Connector 103 Needle Hub 105 Syringe 107 Plunger 109 Front End 111 Rear End 113 Needle 115 Needle Housing 117 Recess 119 Opening 121 Bottom 123 Protrusion 125 Space 127 External Thread 129 External Surface 131 Internal Surface 133 Gasket 13 5 Tip 136 Syringe with Luer Lock Connector 137 Syringe 139 Outer Surface 141 Inner Surface 143 Internal Thread 145 Gasket 147 Tip

Claims (7)

A needle hub having a truncated cone-shaped recess that fits with a male luer slip type connector specified in ISO80369-7:2016, and having a needle mounted in front of the recess,
The recess has a depth L of 7.384 mm or more and 7.496 mm or less, an inner diameter D of the opening of 4.316 mm or more and 4.376 mm or less, and the inner diameter of the recess is inclined from the opening by 6% with respect to the depth. Narrowing needle hub. The recess has a smooth curved surface without unevenness,
2. The needle hub of claim 1, wherein the curved surface generally creates friction between the male luer slip connector and the recess. A protrusion is formed at a substantially center position of the bottom surface of the recess in a plan view,
3. The projection engages the center of the male luer slip connector to provide center axis positioning and reduce dead space between the needle hub and the male luer slip connector. Needle hub as described. comprising threads on the outer surface of the needle hub;
4. The needle hub of any one of claims 1-3, wherein the recess and the threads of the needle hub are capable of mating with a male luer lock connector as defined in ISO 80369-7:2016. a needle hub according to any one of claims 1 to 4;
a syringe having a male luer slip connector as specified in ISO80369-7:2016;
A plunger with a gasket at the tip and a syringe with
the shape of the outer surface of the gasket and the shape of the inner surface of the tip of the syringe match;
The syringe, wherein the residual amount of the drug solution in the syringe is 2 μL or more and 50 μL or less. a needle hub according to claim 4;
a syringe having a male luer lock connector as specified in ISO80369-7:2016;
a plunger with a gasket at the tip,
the shape of the outer surface of the gasket and the shape of the inner surface of the tip of the syringe match;
The syringe, wherein the residual amount of the drug solution in the syringe is 2 μL or more and 50 μL or less. the needle hub is formed of polycarbonate,
7. Syringe according to claim 5 or 6, wherein the syringe is formed of polypropylene.

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