JP2023071320A - Antimicrobial composition - Google Patents

Abstract

To provide an antimicrobial composition that has fast-acting nature and can effectively disinfect microbes.SOLUTION: An antimicrobial composition comprises component (A): propylene carbonate 20-45 mass%, and component (B): at least one component selected from glycol solvents and alcoholic solvents, with the (A)/(B) ratio of 0.6 or more and less than 2.0.SELECTED DRAWING: None

Description

The present invention relates to microbial control compositions.

For the purpose of keeping the living space clean, there has been proposed a microbial control agent using an ultrasonic atomizer that can be easily sprayed into the space while suppressing wetting of the living environment. As a microorganism control agent, for example, one containing a water-soluble solvent having a microorganism control action, water, and an electrolyte has been proposed. However, the microbial control action of the water-soluble solvent is not immediate, and there is a problem that it is difficult to exhibit the effect in a short period of time.

By the way, an agriculturally acceptable stable aqueous formulation containing 3 to 80% by weight of spores, 2 to 90% by weight of a water-miscible solvent (water-soluble solvent) such as propylene carbonate, and water has been proposed. (See Patent Document 1, for example). According to the invention described in Patent Document 1, spore stability is achieved.

Japanese Patent Publication No. 2011-517461

Patent Document 1 only describes propylene carbonate as an example of a water-miscible solvent that does not swell spores. That is, Patent Literature 1 does not include knowledge that propylene carbonate is effective in controlling microorganisms, or knowledge about the concentration of propylene carbonate suitable for controlling microorganisms.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a microbial control agent composition that has an immediate effect and exerts an excellent microbial sterilization effect.

The present invention has the following aspects.
[1] Component (A): 20 to 45% by mass of propylene carbonate,
(B) component: one or more components selected from glycol-based solvents and alcohol-based solvents;
contains
A microbial control agent composition having a (A)/(B) ratio of 0.6 or more and less than 2.0.
[2] The microbial control agent composition according to [1], which further contains component (C): water.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a microbial control agent composition that has an immediate effect and exerts an excellent microbial sterilization effect.

The present invention will be described in detail below.
In the present invention, "microorganism control" means suppressing the action of microorganisms by preventing their growth, preventing their adhesion, or sterilizing them. Effects obtained by microbial control include sterilization, sterilization, antibacterial, antifungal, antifungal, etc. In the present specification, these effects are collectively referred to as "microbial control effect".
In the present invention, the term "water-soluble" means that 1 g or more of the substance dissolves in 100 g of water at 25°C, and the solution is transparent.
In addition, the term "target surface" as used herein means the surface of an object to be treated to which the microbial control agent composition is applied, such as a bathroom, washroom, kitchen, toilet, entrance, living room, closet, closet, shoe box, etc. This includes the inner surface of a space, the surface existing inside an air conditioner, the surface of articles such as window sashes, curtains, shoes, clothes, and sofas.

The microbial control agent composition of the present invention is a composition containing the following components (A) and (B). The microbial control agent composition may contain components (component (C): water, optional components) other than components (A) and (B).

<(A) Component>
Component (A) is a water-soluble solvent and has a microbial control action by itself.
The component (A) alone takes time to exert its effect and cannot obtain a high effect. Component (A) has an immediate effect due to its synergistic action with component (B), and exhibits an excellent microbial control action.
(A) Component is propylene carbonate.

The content of component (A) is preferably 20 to 45% by mass, more preferably 25 to 45% by mass, still more preferably 30 to 45% by mass, and 35 to 45% by mass relative to the total mass of the microbial control agent composition. % is particularly preferred. If the content of the component (A) is within the above numerical range, it has an immediate effect, and it is easy to obtain an excellent microbial control action. On the other hand, when the content of component (A) is less than the above lower limit, the content of component (A) is less than the amount necessary for controlling microorganisms, and the effect of controlling microorganisms is low. Moreover, when the content of component (A) exceeds the above upper limit, the appropriate content balance with component (B) for controlling microorganisms cannot be maintained, and the effect of controlling microorganisms is low.
In addition, the immediate effect in the microbial control agent composition of the present invention means a property capable of exhibiting an effect equivalent to the microbial control effect of a chlorine-based fungicide.

<(B) Component>
Component (B), like component (A), has a microbial control action by itself.
The component (B) alone takes time to exert its effect, and cannot obtain a high effect.

Component (B) is one or more components selected from glycol-based solvents and alcohol-based solvents.
Examples of glycol-based solvents include ethylene glycol-based solvents such as ethylene glycol, diethylene glycol and triethylene glycol; propylene glycol-based solvents such as propylene glycol, dipropylene glycol, tripropylene glycol and isoprene glycol; ethylene glycol monomethyl ether; and ethylene glycol. Monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monophenyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, diethylene glycol monobenzyl ether, etc. ethylene glycol ethers, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, propylene glycol monobutyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, dipropylene glycol monopropyl ether, Examples include propylene glycol ethers such as propylene glycol monobutyl ether, dialkyl glycol ether solvents such as ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, diethylene glycol methyl ethyl ether, propylene glycol methyl ethyl ether and dipropylene glycol methyl ethyl ether.
Examples of alcohol solvents include methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 3-methoxy-3-methyl-1-butanol and the like.
Among these, propylene glycol, ethylene glycol, and 3-methoxy-3-methyl-1-butanol are used as the component (B) in terms of low odor, availability, and stability of the composition. preferable.
(B) component may be used individually by 1 type, and may be used in combination of 2 or more type.

The content of component (B) is determined from the total mass (100% by mass) of the microbial control agent composition to the blending components other than component (B) (that is, component (A), optionally component (C) and optional component) is the remainder excluding the total content.
From the viewpoint of maintaining good sprayability, the content of component (B) is preferably 18% by mass or more, more preferably 20% by mass or more, and more preferably 25% by mass or more, relative to the total mass of the microbial control agent composition. More preferably, 31.5% by mass or more is particularly preferable.
From the viewpoint of maintaining good microbial control action, the content of component (B) is preferably 55% by mass or less, more preferably 50% by mass or less, relative to the total mass of the microbial control agent composition.

<(A)/(B) mass ratio>
The components (A) and (B) serve as solvents for each other, and by facilitating the contact of the microbial control agent composition with the microorganisms, they have a rapid effect and provide a high microbial control effect. be able to. As the optimum balance, the mass ratio of component (A) to component (B) (hereinafter also referred to as "(A)/(B) ratio") is 0.6 or more and less than 2.0. 64 or more and 1.75 or less are preferable, 0.70 or more and 1.40 or less are more preferable, and 0.70 or more and 1.11 or less are still more preferable. If the (A)/(B) ratio is outside the above numerical range, the microbial control agent composition does not sufficiently come into contact with the microorganisms, resulting in failure to obtain immediate effect and excellent microbial control action.

<(C) Component>
(C) A component is water.
Component (C) makes it easier to control the viscosity of the antimicrobial agent composition to a desired value.

The content of component (C) is preferably 10 to 62% by mass, more preferably 10 to 45% by mass, still more preferably 14.5 to 43% by mass, relative to the total mass of the microbial control agent composition. 5 to 33.5% by weight is particularly preferred. When the content of the component (C) is within the above range, the viscosity of the composition for controlling microorganisms can be easily adjusted to a desired value while maintaining a favorable effect of controlling microorganisms.

<Optional component>
Optional components include deodorants other than components (A) and (B), deodorants, fragrances, and the like.
Examples of deodorants and deodorants include essential oils such as lemongrass, peppermint, eucalyptus, and mint.
The perfume component is not particularly limited, and known perfume components can be used. Known perfume ingredients are described, for example, in "Perfume and Flavor Chemicals", Vol. I and II, Steffen Arctander, Allured Pub. Co. (1994), "Synthetic Perfume Chemistry and Product Knowledge", Genichi Indo, Kagaku Kogyo Nippousha (1996), "Perfme and Flavor Materials of Natural Origin", Steffen Arctander, Allured Pub. Co. (1994), "Encyclopedia of Aroma", edited by Japan Perfume Association, Asakura Shoten (1989), "Perfumery Material Performance V.3.3", Boelens Aroma Chemical Information Service (1996), "Flower Oils and Floral Compou nds In Perfumery" , Danute Lajaujis Anonis, Allured Pub. Co. (1993), and perfume ingredients described in Table 3 of JP-A-2002-173698.

<Method for producing microbial control agent composition>
The microbial control agent composition is obtained by mixing components (A) and (B), and optionally optional components.

<Method for using the microbial control agent composition>
The microbial control composition is used, for example, by filling it in an ultrasonic atomizer.
The amount of the microbial control agent composition to be filled into the ultrasonic atomizer and the amount to be sprayed are determined in consideration of the size of the treatment space, the area of the target surface, and the like. The amount of the microbial control composition to be sprayed is preferably such that the treatment amount represented by the following formula is 0.1 to 5 g/m ² .
Treatment amount = (spray amount of component (A)) / (area of target surface sprayed with microbial control agent composition)
The spray amount of component (A) is obtained by multiplying the total mass of the sprayed microbial control agent composition by the content (% by mass) of component (A).

The ultrasonic atomizer is not particularly limited, and conventional ultrasonic atomizers can be used.
The ultrasonic nebulizer includes, for example, a tank containing the microbial control agent composition, a liquid-absorbing wick having a first end inserted into the tank, and multiple , an ultrasonic vibrator attached to the jetting part, and an ultrasonic oscillator for vibrating the ultrasonic vibrator.

<Effect>
The microbial control agent composition of the present invention described above contains the (A) component and the (B) component, and the (A)/(B) ratio is within the above range, so that it has immediate effect and It can exhibit excellent sterilization effect of microorganisms.

The microbial control agent composition of the present invention is used, for example, for treatment of living spaces where it is required to control microorganisms such as bacteria and fungi.
Examples of objects to be treated with the microbial control agent composition of the present invention include bathrooms, entrances, shoeboxes, living rooms, bedrooms, closets, cars, air conditioners, window sashes, curtains, and clothes. Further, the method of using the microbial control agent composition of the present invention includes, for example, spraying with a hand spray, spraying with an electric spray, spraying with an aerosol, ultrasonic spraying, a compressor sprayer, impregnating a sheet made of paper, etc., and wiping it off. method, a method of impregnating with a mop and sweeping up, and the like.

[EXAMPLES] Hereafter, although an Example is shown and this invention is demonstrated in detail, this invention is not limited by the following description.
The raw materials used in this example are as follows.

"Raw materials used"
(A) The compound shown below was used as a component.
(A) component: propylene carbonate (trade name: propylene carbonate (deer special grade), manufactured by Kanto Kagaku Co., Ltd.)

(B) The compound shown below was used as a component.
・ B-1: Propylene glycol (trade name: cosmetic propylene glycol, manufactured by ADEKA Co., Ltd.)
・ B-2: Ethylene glycol (trade name: ethylene glycol (Deer 1st grade), manufactured by Kanto Chemical Co., Ltd.)
・ B-3: 3-methoxy-3-methyl-1-butanol (trade name: Solfit, manufactured by Kuraray Co., Ltd.)

"Ultrasonic Nebulizer"
As the ultrasonic nebulizer, a humidifier manufactured by Jisu Technology Co., Ltd. (trade name "SWEET DONUT") was used. board.
- Absorbent core: made of polyester, diameter 10 mm, length (total length): 205 mm.
・Ultrasonic vibrator: Ring-shaped with an outer diameter of 16 mm.
- Ultrasonic oscillator: frequency of 100 kHz, drive power supply of 5V.
- Amount of spray: 15 g/hour.

"Examples 1 to 15, Comparative Examples 1 to 14"
<Preparation of Microbial Control Agent>
The components (A), (B) and (C) (water) were mixed according to the blending amounts shown in Tables 1 to 3 to prepare a microbial control agent composition.
The sterilization performance of the obtained microbial control agent composition was evaluated by the method described below. These results are shown in Tables 1-3.

<Evaluation of sterilization performance>
A test plastic plate (plastic plate inoculated with fungi) was prepared by the following method.
0.5 mL of the microbial control agent composition prepared according to the blending amounts shown in Tables 1 to 3 was dropped onto the bacteria dried and fixed on the plastic plate.
Five minutes after the microbial control agent composition was added dropwise, the bacteria were collected from the plastic plate by the method described below, inoculated by smearing onto a potato dextrose agar medium, and cultured at 25°C for 5 days. Colonies were then counted. .
Bacteria were collected from untreated plastic plates, smeared inoculated onto potato dextrose agar medium, and colonies were counted after culturing at 25° C. for 5 days.

(Method for preparing plastic plate for test)
Cladosporium cladosporioies NBRC6348 cultured on a plate medium of potato dextrose agar (manufactured by Difco) at 25° C. for 5 days was added to a sterilized 0.05% Tween 80 (manufactured by Kanto Kagaku) aqueous solution to prepare a bacterial solution of about 107 CFU/mL. bottom.
Then, 0.5 mL of the bacterial solution was inoculated onto a plastic plate (FRP plate, 50 mm×50 mm), dried and fixed at room temperature (thin film, number of bacteria on plate: about 10 6 CFU).

(Method for collecting bacteria from plastic plate)
10 mL of GPLP medium (manufactured by Nihon Pharmaceutical Co., Ltd.) was placed in a sterilized plastic petri dish, and mold was washed out from the plastic plate with the tip of a sterilized pipette.
The fungus solution recovered from the plastic plate was appropriately diluted with physiological saline to a measurable concentration, smeared on a potato dextrose agar medium, cultured at 25°C for 5 days, and then visually observed. The number of formed colonies was counted. The number of viable bacteria was obtained from the counted number of colonies and the dilution ratio of the bacterial solution, and the obtained value was defined as the "number of bacteria after treatment".
Based on the above results, the sterilization effect was evaluated according to the following evaluation criteria.

(Evaluation criteria)
{Sterilization effect}
The number of bacteria obtained for the plastic plate and the untreated plastic plate to which the microbial control agent composition was dropped was converted to the common logarithm (log), and the value obtained by subtracting the number of bacteria after treatment from the number of untreated bacteria (log (un The number of treated bacteria)-log (the number of bacteria after treatment)) was obtained, and the obtained value was taken as the sterilization activity value. Based on the value, the sterilization effect was determined according to the following criteria.
<criterion>
◎◎◎: Sterilization activity value is 4 or more ◎◎: Sterilization activity value is 3 or more and less than 4 ◎: Sterilization activity value is 2 or more and less than 3 〇: Sterilization activity value is 1 or more and less than 2 △: Sterilization activity Value is 0.5 or more and less than 1 ×: Sterilization activity value is less than 0.5

As is clear from Tables 1 and 2, the microbial control agent composition obtained in each example was excellent in sterilization performance.
On the other hand, as is clear from Table 3, the microbial control agents obtained in Comparative Examples 1 to 4 containing only component (A), component (B) or component (C) were inferior in sterilization performance. Moreover, the microbe control agents obtained in Comparative Examples 5 to 7, which contained the components (A) and (C) but did not contain the component (B), were inferior in sterilization performance. Further, Comparative Examples 8 to 10 containing component (A), component (B) and component (C) (water) and having a (A)/(B) ratio of less than 0.6 or 2.0 or more, The microorganism control agents obtained in Comparative Examples 13 and 14 were inferior in sterilization performance. Furthermore, the microbial control agents obtained in Comparative Examples 11 and 12, in which the content of component (A) was less than 20% by mass or more than 45% by mass, were inferior in sterilization performance.

Claims (2)

(A) component: 20 to 45% by mass of propylene carbonate;
(B) component: one or more components selected from glycol-based solvents and alcohol-based solvents;
contains
A microbial control agent composition having a (A)/(B) ratio of 0.6 or more and less than 2.0. 2. The microbial control agent composition according to claim 1, further comprising (C) component: water.