JP2023007641A - Liquid concentration measuring device and extracorporeal circulation device - Google Patents

Abstract

To provide a blood concentration measuring device and an extracorporeal circulation device capable of reducing a difference in measured value of the blood concentration due to an individual difference such as a dimension and a shape of a blood storage part.SOLUTION: A liquid concentration measuring device 60 comprises: a liquid storage part 80 fitted to a device main body 70; a sensor part 73 which comprises a light emission part 731 for emitting light to the liquid stored in the liquid storage part 80, and a light reception part 732 which receives light which has transmitted through or reflected by the liquid storage part 80 and liquid stored in the liquid storage part 80; a storage part 75 for storing in advance an initial detection value of the liquid storage part 80 in a state in which no liquid is stored; and a correction control part 744 for, when the liquid is not stored in the liquid storage part 80 and the liquid storage part 80 is fitted to the device main body 70, executing correction operation for adjusting light intensity of the light emitted from the light emission part 731 so as to reduce a difference between the detection value by the light reception part 732 and the initial detection value stored in the storage part 75.SELECTED DRAWING: Figure 4

Description

The present invention relates to a liquid concentration measuring device and an extracorporeal circulation device equipped with this liquid concentration measuring device.

Conventionally, during dialysis treatment, the blood circulating in the blood circuit is temporarily stored in a blood storage unit (liquid storage unit), and is temporarily stored in the blood storage unit using a sensor unit (light emitting unit, light receiving unit). A blood concentration measuring device (liquid concentration measuring device) that calculates the blood concentration of blood is known (see, for example, Patent Document 1). The blood concentration measuring device irradiates light from the light emitting part onto the blood once contained in the blood containing part, and the light reflected by the blood or the light transmitted through the blood is received by the light receiving part, and the light is received by the light receiving part. The blood concentration of the blood is calculated by measuring and calculating the change in the intensity of the light.

Japanese Patent Publication No. 2018-531366

Here, if there are variations in the size and shape of the blood container, the intensity of the incident light used when calculating the blood concentration and the actual intensity of the incident light to the blood differ for each blood container used. different. As a result, there is a possibility that the difference in blood concentration measurement values will increase due to individual differences in the size, shape, etc. of the blood container.

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide a liquid concentration measuring apparatus and an extracorporeal circulation apparatus capable of reducing the difference in liquid concentration measurement values due to individual differences in the size and shape of the liquid containing portion.

The present invention provides an apparatus main body, a liquid storage section detachably attached to the apparatus main body and capable of storing liquid, the liquid storage section attached to the apparatus main body, and the liquid stored in the liquid storage section. a sensor unit having a light emitting unit that emits light toward the liquid storage unit and a light receiving unit that receives light transmitted or reflected by the liquid storage unit and the liquid stored in the liquid storage unit; a storage unit for pre-storing an initial detection value, which is a value detected by the light receiving unit at an initial stage of the liquid storage unit in a state where no liquid is stored, and a storage unit for storing in advance an initial detection value, which is a value detected by the light receiving unit at an initial stage in the liquid storage unit when the liquid storage unit is attached to the apparatus main body and the liquid storage unit is loaded with liquid. calibration operation for adjusting the intensity of the light emitted from the light-emitting unit so as to reduce the difference between the value detected by the light-receiving unit and the initial detection value stored in the storage unit when the is not accommodated. and a calibration control unit for performing calibration.

Further, the storage unit stores an accommodation unit mounting determination range that is a range of detection values detected by the light receiving unit when the liquid containing unit is attached to the apparatus main body, and the detection value by the light receiving unit is It is preferable to provide a determination unit that determines that the liquid storage unit is attached to the apparatus main body when the liquid storage unit is within the storage unit attachment determination range.

Further, the storage unit stores a liquid non-storage determination range that is a range of detection values detected by the light receiving unit when the liquid storage unit does not contain the liquid, and the detection value by the light receiving unit It is preferable to provide a determination unit that determines that no liquid is stored in the liquid storage unit when it is within the liquid non-storage determination range.

Further, it is preferable that the calibration control section does not perform the calibration operation when the liquid storage section is not attached to the apparatus main body, or when the liquid storage section contains liquid.

The present invention also relates to an extracorporeal circulation device including a blood circuit and the liquid concentration measuring device arranged in the blood circuit.

According to the present invention, it is possible to provide a liquid concentration measuring device and an extracorporeal circulation device capable of reducing differences in liquid concentration measurement values due to individual differences such as the size and shape of the liquid containing portion.

1 is a diagram showing the overall configuration of a hemodialysis apparatus according to one embodiment of the present invention; FIG. FIG. 11 is a side view showing a state in which a blood chamber is attached to a sensor clip; 1 is a functional block diagram of a hemodialysis device and a blood concentration measurement device; FIG. It is a flow chart showing the operation of the blood concentration measuring device.

An embodiment of a hemodialysis apparatus (extracorporeal circulation apparatus) including a blood concentration measuring apparatus (liquid concentration measuring apparatus) of the present invention will be described below with reference to the drawings. The hemodialysis apparatus of the present invention purifies the blood of patients with renal failure or drug addiction, removes excess water from the blood, and replenishes the blood with water (fluid replacement) as necessary.

First, the overall configuration of the hemodialysis apparatus 1 of this embodiment will be described with reference to FIG. The hemodialysis apparatus 1 includes a dialyzer 10 as a hemodialyzer, a blood circuit 20, a dialysate circuit 30, a console 100, and a controller 50. A part of the blood circuit 20 , a part of the dialysate circuit 30 , the chemical pump 231 , and the controller 50 are arranged in the console 100 .

The dialyzer 10 includes a tubular container body 11 and a dialysis membrane (not shown) housed inside the container body 11 . The interior of the container body 11 is partitioned into a blood-side channel and a dialysate-side channel by a dialysis membrane (both not shown). The container body 11 is formed with a blood inlet 111 and a blood outlet 112 communicating with the blood-side channel, and a dialysate inlet 113 and a dialysate outlet 114 communicating with the dialysate-side channel.

The blood circuit 20 includes an arterial line 21 , a venous line 22 , a drug line 23 and an overflow line 24 . The arterial line 21, the venous line 22, the drug line 23, and the overflow line 24 are all mainly composed of flexible tubes through which liquids can flow.

One end of the arterial line 21 is connected to the artery of the subject (dialysis patient), and the other end is connected to the blood inlet 111 of the dialyzer 10 . An air bubble sensor 211 , a blood pump 212 and a blood concentration measuring device 60 (liquid concentration measuring device) are arranged in the arterial line 21 .
The air bubble sensor 211 detects air bubbles contained in the blood flowing inside the arterial line 21 . Blood pump 212 is arranged downstream of air bubble sensor 211 in arterial line 21 . The blood pump 212 pumps the blood inside the arterial line 21 by squeezing the tube forming the arterial line 21 .

Blood concentration measuring device 60 is arranged between blood pump 212 and dialyzer 10 in arterial line 21 . The blood concentration measuring device 60 includes a sensor clip 70 (apparatus main body) and a blood chamber 80 (liquid container) detachably attached to the sensor clip 70, as shown in FIG. The blood concentration measuring device 60 temporarily stores the blood passing through the arterial line 21 of the blood circuit 20 in the blood chamber 80, and measures the concentrations of blood components in the blood passing through the arterial line 21 of the blood circuit 20 in real time. Thus, the hematocrit value and oxygen saturation can be calculated. The blood concentration measuring device 60 will be detailed later.

As shown in FIG. 1, the venous line 22 has one end connected to the blood outlet 112 of the dialyzer 10 and the other end connected to the vein of the subject (dialysis patient). A venous pressure sensor 221 , a venous chamber 222 , an air bubble sensor 223 , and a venous clamp 224 are arranged on the venous line 22 .

Venous pressure sensor 221 detects the pressure of blood flowing through venous line 22 . The venous chamber 222 is arranged downstream of the venous pressure sensor 221 in the venous line 22 . The vein side chamber 222 stores a predetermined amount (eg, 20 ml) of blood. The air bubble sensor 223 is arranged downstream of the venous chamber 222 in the venous line 22 . The air bubble sensor 223 detects air bubbles contained in the blood flowing through the venous line 22 . The venous clamp 224 is arranged downstream of the air bubble sensor 223 in the venous line 22 . The venous clamp 224 opens and closes the flow path of the venous line 22 .

The drug line 23 supplies drugs required during hemodialysis to the arterial line 21 . One end (proximal end) of the drug line 23 is connected to a drug pump 231 that delivers the drug, and the other end (distal end) is connected between the blood pump 212 and the blood concentration measuring device 60 in the arterial line 21 . be done.

One end side (proximal side) of the overflow line 24 is connected to the vein side chamber 222 . The overflow line 24 discharges the physiological saline solution, air, etc. flowing through the intravenous line 22 during the priming process. An overflow clamp 241 is arranged in the overflow line 24 . Overflow clamp 241 opens and closes the flow path of overflow line 24 .

According to the blood circuit 20 described above, the blood drawn from the artery of the subject (dialysis patient) flows through the arterial line 21 by the blood pump 212 and is introduced into the blood-side channel of the dialyzer 10 . The blood introduced into the dialyzer 10 is purified by the dialysate flowing through the dialysate circuit 30, which will be described later, through the dialysis membrane. The blood purified by the dialyzer 10 flows through the venous line 22 and is returned to the subject's veins.

In the present embodiment, the dialysate circuit 30 is configured by a so-called closed capacity control type dialysate circuit 30 . The dialysate circuit 30 includes a dialysate chamber 31, a dialysate supply line 32, a dialysate inlet line 33, a dialysate outlet line 34, a drain line 35, a bypass line 36, and water removal/backfiltration. a pump 37;

The dialysate chamber 31 includes a hard container 311 capable of accommodating a certain volume (eg, 300 ml to 500 ml) of dialysate, and a soft diaphragm 312 that partitions the interior of the container 311 . The inside of the dialysate chamber 31 is partitioned by a diaphragm 312 into a sent liquid containing portion 313 and a drained liquid containing portion 314 .

The dialysate supply line 32 is connected to a dialysate supply device (not shown) at its proximal end and to the dialysate chamber 31 at its distal end. The dialysate supply line 32 supplies the dialysate to the liquid supply storage portion 313 of the dialysate chamber 31 .

The dialysate inlet line 33 connects the dialysate chamber 31 and the dialysate inlet port 113 of the dialyzer 10 , and transfers the dialysate contained in the liquid supply/accommodation portion 313 of the dialysate chamber 31 to the dialysate-side channel of the dialyzer 10 . to be introduced.

The dialysate outlet line 34 connects the dialysate outlet 114 of the dialyzer 10 and the dialysate chamber 31 , and guides the dialysate discharged from the dialyzer 10 to the waste liquid container 314 of the dialysate chamber 31 .
The drainage line 35 is connected at its proximal end to the dialysate chamber 31 and discharges the drainage of the dialysate contained in the drainage storage section 314 .

A bypass line 36 connects the dialysate outlet line 34 and the drain line 35 .
A dewatering/backfiltration pump 37 is arranged in the bypass line 36 . The water removal/backfiltration pump 37 sends the dialysate inside the bypass line 36 in a direction (water removal direction) in which it flows to the drain line 35 side and in a direction (backfiltration direction) in which it flows to the dialysate lead-out line 34 side. It consists of a liquid-driven pump.

The control device 50 is configured by an information processing device (computer), and controls the operation of the hemodialysis apparatus 1 by executing a control program. Specifically, the control device 50 controls the operations of various pumps, clamps, and the like arranged in the blood circuit 20 and the dialysate circuit 30, and various processes performed by the hemodialyzer 1 (operation (dialysis) process , washing step, priming step, blood removal step, fluid replacement step, blood return step, etc.).

In addition, based on the hematocrit value and the oxygen saturation calculated from the concentration of the blood components of the blood flowing through the arterial line 21 of the blood circuit 20 measured by the blood concentration measuring device 60, which will be described later, the control device 50 By monitoring the rate of change in circulating blood volume, a sign of a drop in blood pressure is analyzed, and the sign of a drop in blood pressure is reported to the outside, for example, by a display device or the like.

Control device 50 also controls blood concentration measurement device 60 . The control device 50 has a calibration instructing section 51 as shown in FIG. Calibration instruction unit 51 instructs calibration control unit 744 (described later) of blood concentration measurement device 60 to perform a calibration operation of blood concentration measurement device 60 . The calibration instructing unit 51 performs calibration of the blood concentration measuring device 60 at a predetermined timing when the blood chamber 80 of the blood concentration measuring device 60 described later does not contain blood (the blood chamber 80 is empty). 60 is instructed to perform a calibration operation. Examples of the predetermined timing when the blood chamber 80 of the blood concentration measuring device 60 is empty (empty) include the timing when the console 100 is activated and the timing before executing the priming process. be able to.

The blood concentration measuring device 60 will be explained.
The blood concentration measuring device 60 is a device that measures the hematocrit value and oxygen saturation of blood flowing through the arterial line 21 of the blood circuit 20 during hemodialysis. Blood concentration measurement device 60 measures the concentrations of blood components in the blood flowing through arterial line 21, calculates the hematocrit value and oxygen saturation, and monitors the rate of change in circulating blood volume to detect blood pressure drop. You can analyze the signs that will happen.

The blood concentration measuring device 60, as shown in FIG. 2, includes a sensor clip 70 (apparatus main body) and a blood chamber 80 (liquid storage section).

A blood chamber 80 is detachably attached to the sensor clip 70 . The sensor clip 70 includes a first cell holding portion 71 , a second cell holding portion 72 , and a sensor portion 73 having a light emitting portion 731 and a light receiving portion 732 . A light-emitting element is provided in the light-emitting portion 731 . A light receiving element is provided in the light receiving section 732 .

The first cell holding portion 71 and the second cell holding portion 72 are arranged facing each other with a chamber accommodating space S therebetween. The first cell holding part 71 and the second cell holding part 72 sandwich and hold the blood chamber 80 in a state where the blood chamber 80 is arranged in the chamber accommodation space S.

A light-emitting portion 731 of the sensor portion 73 is arranged inside the first cell holding portion 71 . A light receiving portion 732 of the sensor portion 73 is arranged inside the second cell holding portion 72 . The light emitting portion 731 and the light receiving portion 732 are arranged to face each other.

The light emitting section 731 irradiates the blood chamber 80 side with light while the sensor clip 70 sandwiches the blood chamber 80 . The light emitting part 731 emits light toward the blood chamber 80 attached to the sensor clip 70 and the blood contained in the blood chamber 80 . Light of a plurality of wavelengths is emitted from the light emitting unit 731 to the blood chamber 80 and the blood flowing through the blood chamber 80 . The light receiving portion 732 receives light transmitted through the blood chamber 80 and the blood contained in the blood chamber 80 . When the light-receiving unit 732 receives the light transmitted through the blood, the blood concentration measuring device 60 can measure the concentration of blood components based on the difference in transmittance between red blood cells and water in the blood.

The blood chamber 80 constitutes a blood containing cell (liquid containing portion) having a cell containing blood (liquid) therein. The blood chamber 80 has a container main body 81 in which blood is stored, a blood inlet connection portion 82, and a blood outlet connection portion 83 (see FIG. 1).

The container main body 81 is formed in a disk shape having a thickness. A channel through which blood flows is formed inside the container main body 81 . The container body 81 is detachably attached to the sensor clip 70 between the light emitting portion 731 and the light receiving portion 732 of the sensor clip 70 . The container main body 81 is configured to transmit light from the light emitting section 731 .

Blood introduction connecting portion 82 is an introduction portion for introducing blood into blood concentration measuring device 60 . The blood introduction connecting portion 82 is connected to the downstream end of the line connecting the blood pump 212 and the blood concentration measuring device 60 in the arterial line 21 (see FIG. 1).

The blood lead-out connection part 83 is a lead-out part for leading the blood that has flowed through the inside of the blood concentration measuring device 60 toward the dialyzer 10 . The blood lead-out connection part 83 is connected to the upstream end of the line connecting the blood concentration measuring device 60 and the dialyzer 10 in the arterial line 21 .

As shown in FIG. 3, the sensor clip 70 includes a sensor clip side control section 74 (control section) and a sensor clip side storage section 75 (storage section) in addition to the above configuration.
The sensor clip side storage unit 75 stores the initial detection value of the blood unaccommodated state of the blood chamber 80, the blood chamber attachment determination range (accommodation unit attachment determination range), and the blood unaccommodated state determination range of the blood chamber 80 (liquid unaccommodated determination range) and are stored in advance.

The initial detection value of blood chamber 80 in the non-blood-containing state is the initial detection value of blood chamber 80 detected by light-receiving section 732 of sensor section 73 in the non-blood-containing state in which blood is not contained. The initial detection value of the unfilled state of blood in blood chamber 80 is measured at the factory before shipping, for example, using blood chamber 80 as a predetermined standard.

The blood chamber attachment determination range is the range of detection values detected by the light receiving section 732 of the sensor section 73 when the blood chamber 80 is attached to the sensor clip 70 . When the determination unit 743 (described later) of the sensor clip-side control unit 74 determines that the detection value by the light receiving unit 732 of the sensor unit 73 is within the blood chamber attachment determination range, the blood chamber 80 is attached to the sensor clip 70. It is determined that The blood chamber attachment determination range is obtained in advance by experiments or the like, for example.

The no-blood-containing state determination range is the range of detection values detected by the light-receiving section 732 of the sensor section 73 when the blood chamber 80 is empty (no blood is contained). When the determination unit 743 (described later) of the sensor clip-side control unit 74 determines that the value detected by the light receiving unit 732 of the sensor unit 73 is within the blood unaccommodated state determination range, blood is not stored in the blood chamber 80. is determined to be empty (empty). The blood unaccommodated state determination range is obtained in advance by experiments or the like, for example.

The sensor clip side control section 74 has a light emission control section 741, a calculation section 742, a determination section 743, and a calibration control section 744, as shown in FIG.

Light emission control section 741 controls the intensity of light emitted from light emitting section 731 .
The calculation unit 742 calculates the intensity of the light received by the light receiving unit 732 as a detection value. Thus, in the blood concentration measuring device 60, the hematocrit value and the oxygen saturation are calculated from the detection values detected by the light receiving section 732 of the sensor section 73 with the blood chamber 80 attached to the sensor clip 70. The calculated hematocrit value and oxygen saturation are sent to the controller 50 of the console 100 .

The determination unit 743 determines that the blood chamber 80 is attached to the sensor clip 70 when the value detected by the light receiving unit 732 of the sensor unit 73 is within the blood chamber attachment determination range. If the value detected by the light-receiving part 732 of the sensor part 73 is within the no-blood state determination range, the determination unit 743 determines that the blood chamber 80 is in an empty state in which blood is not stored.

When the determination unit 743 determines that the blood chamber 80 is attached to the sensor clip 70 and blood is not contained in the blood chamber 80, the calibration control unit 744 detects the value detected by the light receiving unit 732 of the sensor unit 73. calibration that adjusts the intensity of light emitted from the light emitting part 731 of the sensor part 73 so as to reduce the difference between the initial detection value of the blood unfilled state of the blood chamber 80 stored in the sensor clip side storage part 75 perform an action.

More specifically, the calibration control unit 744 detects when the detection value by the light receiving unit 732 of the sensor unit 73 is smaller than the initial detection value of the non-blood storage state of the blood chamber 80 stored in the sensor clip-side storage unit 75. 2, a calibration operation is performed so as to increase the intensity of light emitted from the light emitting portion 731 of the sensor portion 73 . When the detected value by the light receiving portion 732 of the sensor portion 73 is greater than the initial detected value of the blood unfilled state of the blood chamber 80 stored in the sensor clip side storage portion 75, the light emitting portion 731 of the sensor portion 73 emits light. Perform calibration actions to reduce the intensity of the light received.

Calibration control 744 does not perform a calibration operation when blood chamber 80 is not attached to sensor clip 70 or when blood chamber 80 contains blood.

Next, the control of the calibration operation of the hemodialyzer 1 will be described with reference to the flowchart of FIG. In the stage prior to the calibration operation, the initial detection value of the blood unfilled state of the blood chamber 80 is measured, for example, at the time of shipment from the factory, and stored in the sensor clip side storage section 75 .

In step S1 shown in FIG. 4, calibration instructing section 51 of control device 50 of console 100 instructs blood concentration measuring device 60 to perform a calibration operation. Calibration instructing unit 51 instructs calibration control unit 744 of blood concentration measuring device 60 to perform a calibration operation when blood chamber 80 of blood concentration measuring device 60 is in an empty (empty) state. instruct. Examples of the predetermined timing when the blood chamber 80 of the blood concentration measuring device 60 is empty (empty) include the timing when the console 100 is activated and the timing before executing the priming process. be able to.

In step S2, the determination unit 743 determines whether or not the blood chamber mounting determination range stored in the sensor clip side storage unit 75 is present, and the value detected by the light receiving unit 732 of the sensor unit 73 indicates that blood is not contained. It is determined whether or not it is within the state determination range. If the value detected by the light receiving portion 732 of the sensor portion 73 is within the blood chamber attachment determination range, the determining portion 743 determines that the blood chamber 80 is attached to the sensor clip 70, and the light receiving portion 732 of the sensor portion 73 determines that the blood chamber 80 is attached. If the detected value is within the no-blood-containing state determination range, it is determined that the blood chamber 80 is in an empty (empty) state in which no blood is contained.

If the determination unit 743 determines that the blood chamber 80 is attached to the sensor clip 70 and that the blood chamber 80 is empty (YES), the process proceeds to step S3. If the determination unit 743 determines that the blood chamber 80 is not attached to the sensor clip 70 or that the blood chamber 80 contains blood (NO), the process proceeds to step S4. move on.

In step S3, the calibration control unit 744 reduces the difference between the detection value by the light receiving unit 732 of the sensor unit 73 and the initial detection value of the non-blood storage state of the blood chamber 80 stored in the sensor clip side storage unit 75. First, a calibration operation is performed to adjust the intensity of light emitted from the light emitting section 731 of the sensor section 73 . As a result, even if there are individual differences in the size and shape of blood chamber 80, the calibration control unit 744 performs the calibration operation so that the measured value of the blood concentration due to individual differences in the size and shape of blood chamber 80 can be corrected. difference can be reduced. After step S3, the process ends.

In step S4, the calibration control unit 744 does not perform the calibration operation, and in step S5, notifies the outside that the calibration operation will not be performed, after which the process ends. Thereby, the calibration control section 744 can prohibit the calibration operation when the calibration operation cannot be performed. Therefore, it is possible to prevent the calibration operation from being performed under an erroneous condition. Examples of notification means include display on a display unit, lighting or blinking of an indicator lamp, and notification from a speaker.

According to the blood concentration measuring device 60 of this embodiment described above, the following effects are obtained.

Blood concentration measuring device 60 comprises blood chamber 80 attached to sensor clip 70 and blood contained in blood chamber 80, blood chamber 80 and blood contained in blood chamber 80. a sensor unit 73 having a light receiving unit 732 that receives light transmitted through the sensor unit 73, a sensor clip side storage unit 75 that stores in advance an initial detection value of the blood unaccepted state of the blood chamber 80 in an unacceptable state of blood, blood When the chamber 80 is attached to the sensor clip 70 and blood is not contained in the blood chamber 80, the detected value by the light receiving unit 732 and the initial state of the blood non-contained state of the blood chamber 80 stored in the sensor clip side storage unit 75 and a calibration control unit 744 that performs a calibration operation for adjusting the intensity of the light emitted from the light emitting unit 731 so as to reduce the difference from the detected value. As a result, even if there are individual differences in the size and shape of blood chamber 80, the calibration control unit 744 performs the calibration operation so that the measured value of the blood concentration due to individual differences in the size and shape of blood chamber 80 can be corrected. can reduce the difference between

In this embodiment, the determination unit 743 can determine that the blood chamber 80 is attached to the sensor clip 70 when the value detected by the light receiving unit 732 is within the storage unit attachment determination range. Accordingly, it can be easily determined that the blood chamber 80 is attached to the sensor clip 70 .

In this embodiment, the determination unit 743 can determine that blood is not contained in the blood chamber 80 when the value detected by the light receiving unit 732 is within the blood non-containing determination range. Accordingly, it can be easily determined that the blood chamber 80 contains no blood.

In this embodiment, the calibration control unit 744 does not perform the calibration operation when the blood chamber 80 is not attached to the sensor clip 70 or when the blood chamber 80 contains blood. Thereby, the calibration control section 744 can prohibit the calibration operation when the calibration operation cannot be executed. Therefore, it is possible to prevent the calibration operation from being performed under an erroneous condition. Also, the calibration control unit 744 can notify the outside when the blood chamber 80 is not attached to the sensor clip 70 or when blood is contained in the blood chamber 80 .

In this embodiment, the hemodialyzer 1 is configured to include a blood circuit 20 and a blood concentration measuring device 60 arranged in the blood circuit 20 . As a result, the hemodialyzer 1 can instruct the execution of the calibration operation of the blood concentration measuring device 60 . Therefore, the user does not have to manually calibrate at any timing, so the burden on the user can be reduced.

Although preferred embodiments of the blood concentration measuring apparatus 60 and the hemodialysis apparatus 1 of the present invention have been described above, the present invention is not limited to the above-described embodiments, and can be modified as appropriate.

For example, in the above-described embodiment, the blood containing portion detachably attached to the sensor clip 70 is configured by the blood chamber 80 having cells for containing blood inside, but the present invention is not limited to this. The blood containing portion may be composed of a tube through which blood flows.

Further, in the above embodiment, the sensor clip side control section 74 is provided in the blood concentration measuring device 60, but it is not limited to this. The function of the sensor clip side control section 74 may be provided in the control device 50 of the console 100 .

Further, in the above-described embodiment, the light-receiving portion 732 of the sensor portion 73 is configured to detect light transmitted through blood, but the present invention is not limited to this. The light-receiving portion 732 of the sensor portion 73 may be configured to detect the light reflected by the blood.

Also. In the above embodiment, the calibration operation of the blood concentration measuring device 60 is configured to be executed by a calibration instruction from the calibration instruction section 51 of the control device 50 of the console 100, but it is not limited to this. The calibration operation of blood concentration measuring device 60 may be performed by directly operating blood concentration measuring device 60 .

Further, in the above-described embodiment, the configuration for determining whether the blood chamber 80 is attached to the sensor clip 70 is to determine whether or not the detection value by the light receiving section 732 of the sensor section 73 is within the storage section attachment determination range. However, it is not limited to this. The configuration for determining that the blood chamber 80 is attached to the sensor clip 70 detects, for example, whether there is mechanical, electrical, or magnetic contact when the blood chamber 80 is attached to the sensor clip 70. It may be realized by

Further, in the above-described embodiment, the case where blood is stored in the liquid storage section has been described, but the present invention is not limited to this, and may be applied to the case where dialysate is stored in the liquid storage section.

Further, in the above-described embodiment, in the sensor section 73, the light emitting section 731 is provided in the first cell holding section 71 and the light receiving section 732 is provided in the second cell holding section 72, but the present invention is not limited to this. Conversely, the light emitting portion 731 may be provided in the second cell holding portion 72 and the light receiving portion 732 may be provided in the first cell holding portion 71 .

1 Hemodialysis device (extracorporeal circulation device)
20 blood circuit 60 blood concentration measuring device (liquid concentration measuring device)
70 sensor clip (device body)
73 sensor unit 74 sensor clip side control unit (control unit)
75 sensor clip side storage unit (storage unit)
80 blood chamber (liquid containing part)
731 light emitting unit 732 light receiving unit 743 determination unit 744 calibration control unit

Claims (5)

a device body;
a liquid storage unit configured to be detachable from the device main body and capable of storing liquid;
a light emitting unit that emits light toward the liquid containing portion attached to the device main body and the liquid contained in the liquid containing portion; a sensor unit having a light receiving unit that receives reflected light;
a storage unit that stores in advance an initial detection value, which is a value detected by the light receiving unit at an initial stage of the liquid storage unit in a non-liquid storage state in which liquid is not stored;
reducing the difference between the detection value by the light receiving unit and the initial detection value stored in the storage unit when the liquid storage unit is attached to the apparatus main body and the liquid storage unit does not contain liquid; and a calibration control section that performs a calibration operation to adjust the intensity of the light emitted from the light emitting section as follows. The storage unit stores a storage unit attachment determination range, which is a range of detection values detected by the light receiving unit when the liquid storage unit is attached to the device main body,
2. The liquid concentration measuring apparatus according to claim 1, further comprising a determination unit that determines that the liquid storage unit is attached to the device main body when the value detected by the light receiving unit is within the storage unit attachment determination range. The storage unit stores a liquid non-accommodation determination range that is a range of detection values detected by the light receiving unit when no liquid is contained in the liquid container,
3. The liquid concentration measuring apparatus according to claim 1, further comprising a determination unit that determines that no liquid is stored in the liquid storage unit when the value detected by the light receiving unit is within the liquid non-storage determination range. The calibration control unit according to any one of claims 1 to 3, wherein the calibration control unit does not perform the calibration operation when the liquid storage unit is not attached to the device main body or when the liquid storage unit contains liquid. A liquid concentration measuring device according to any one of the above. blood circuit,
and the liquid concentration measuring device according to any one of claims 1 to 4, which is arranged in the blood circuit.

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