JP2022553540A - 操作された制御性ｔ細胞 - Google Patents

操作された制御性ｔ細胞 Download PDF

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JP2022553540A
JP2022553540A JP2022523913A JP2022523913A JP2022553540A JP 2022553540 A JP2022553540 A JP 2022553540A JP 2022523913 A JP2022523913 A JP 2022523913A JP 2022523913 A JP2022523913 A JP 2022523913A JP 2022553540 A JP2022553540 A JP 2022553540A
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Prior art keywords
tcr
cells
seq
tregs
foxp3
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JP2022523913A
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Japanese (ja)
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JP2022553540A5 (enExample
Inventor
ハンス シュタウス，
シャリン トーマス，
オリビエ プレハム，
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UCL Business Ltd
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UCL Business Ltd
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Priority claimed from GB201915341A external-priority patent/GB201915341D0/en
Priority claimed from GB201915344A external-priority patent/GB201915344D0/en
Priority claimed from GB201915347A external-priority patent/GB201915347D0/en
Priority claimed from GB201915357A external-priority patent/GB201915357D0/en
Priority claimed from GB201915360A external-priority patent/GB201915360D0/en
Priority claimed from GB201915354A external-priority patent/GB201915354D0/en
Priority claimed from GB201915362A external-priority patent/GB201915362D0/en
Priority claimed from GB201915348A external-priority patent/GB201915348D0/en
Priority claimed from GB201915351A external-priority patent/GB201915351D0/en
Priority claimed from GB201915366A external-priority patent/GB201915366D0/en
Application filed by UCL Business Ltd filed Critical UCL Business Ltd
Publication of JP2022553540A publication Critical patent/JP2022553540A/ja
Publication of JP2022553540A5 publication Critical patent/JP2022553540A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
JP2022523913A 2019-10-23 2020-10-22 操作された制御性ｔ細胞 Pending JP2022553540A (ja)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
GB1915344.4 2019-10-23
GB1915357.6 2019-10-23
GB1915348.5 2019-10-23
GB201915357A GB201915357D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB1915366.7 2019-10-23
GB201915360A GB201915360D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB201915354A GB201915354D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB1915362.6 2019-10-23
GB201915341A GB201915341D0 (en) 2019-10-23 2019-10-23 Engineered regulatory T cell
GB1915360.0 2019-10-23
GB201915347A GB201915347D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB1915341.0 2019-10-23
GB1915354.3 2019-10-23
GB1915351.9 2019-10-23
GB201915362A GB201915362D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB201915366A GB201915366D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB201915351A GB201915351D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB201915348A GB201915348D0 (en) 2019-10-23 2019-10-23 Engineered regulatory t cell
GB1915347.7 2019-10-23
GB201915344A GB201915344D0 (en) 2019-10-23 2019-10-23 Engineered regulatory T cell
PCT/GB2020/052659 WO2021079122A1 (en) 2019-10-23 2020-10-22 Engineered regulatory t cell

Publications (2)

Publication Number Publication Date
JP2022553540A true JP2022553540A (ja) 2022-12-23
JP2022553540A5 JP2022553540A5 (enExample) 2023-10-19

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JP2022523913A Pending JP2022553540A (ja) 2019-10-23 2020-10-22 操作された制御性ｔ細胞

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US (1) US12643932B2 (enExample)
EP (1) EP4048294A1 (enExample)
JP (1) JP2022553540A (enExample)
CN (1) CN114641564B (enExample)
AU (1) AU2020370033A1 (enExample)
CA (1) CA3154606A1 (enExample)
WO (1) WO2021079122A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201915359D0 (en) 2019-10-23 2019-12-04 Ucl Business Ltd Engineered regulatory t cell
WO2023050063A1 (zh) * 2021-09-28 2023-04-06 溧阳瑅赛生物医药有限公司 一种识别hla-a*02:01/e629-38的tcr及其应用
CN120091826A (zh) * 2022-08-12 2025-06-03 阿巴塔治疗股份有限公司 多发性硬化症的细胞疗法
EP4573114A4 (en) * 2022-08-19 2026-07-29 Memorial Sloan Kettering Cancer Center T-LYMPHOCYTE RECEPTORS TARGETTING RAS MUTATIONS AND ASSOCIATED USES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160194605A1 (en) * 2013-05-10 2016-07-07 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Design and use of specific regulatory t-cells to induce immune tolerance
JP2018506287A (ja) * 2015-02-16 2018-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｈｅｒ２／Ｎｅｕ （ＥＲＢＢ２）受容体タンパク質に由来する３６９〜３７７位エピトープに特異的な完全ヒトＴ細胞受容体

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FR2825261B1 (fr) 2001-06-01 2003-09-12 Maco Pharma Sa Ligne de prelevement du sang placentaire comprenant une poche de rincage
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
EP2050814A1 (en) 2007-10-17 2009-04-22 Txcell Compositions for treating multiple sclerosis
GB0917094D0 (en) * 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
RU2523058C2 (ru) 2012-06-29 2014-07-20 Общество с ограниченной ответственностью "Регенекс" Способ терапии ремиттирующего рассеянного склероза
US9693977B2 (en) 2013-03-15 2017-07-04 President And Fellows Of Harvard College Method of increasing the quantity of colonic T regulatory cells via G-coupled protein receptor 43
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
US20190358258A1 (en) 2015-10-09 2019-11-28 Robert J. Deans Methods for enhancing proliferation of t regulatory cells
US12227756B2 (en) 2018-04-18 2025-02-18 Ucl Business Ltd Engineered regulatory T cell
GB201915359D0 (en) 2019-10-23 2019-12-04 Ucl Business Ltd Engineered regulatory t cell

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160194605A1 (en) * 2013-05-10 2016-07-07 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Design and use of specific regulatory t-cells to induce immune tolerance
JP2018506287A (ja) * 2015-02-16 2018-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｈｅｒ２／Ｎｅｕ （ＥＲＢＢ２）受容体タンパク質に由来する３６９〜３７７位エピトープに特異的な完全ヒトＴ細胞受容体

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Title
KATO ZENICHIRO ET AL.: ""The autoimmune TCR-Ob.2F3 can bind to MBP85-99/HLA-DR2 having an unconventional mode as in TCR-Ob.", MOLECULAR IMMUNOLOGY, vol. Vol. 48, No. 1-3, JPN6024039363, November 2010 (2010-11-01), pages 314 - 320, ISSN: 0005561525 *
KIM YONG CHAN ET AL.: ""Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition o", JOURNAL OF AUTOIMMUNITY, vol. 92, JPN6024039362, August 2018 (2018-08-01), pages 77 - 86, ISSN: 0005426782 *
STEPHENS LEIGH A. ET AL.: ""Curing CNS autoimmune disease with myelin‐reactive Foxp3+ Treg"", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 39, no. 4, JPN6024039361, April 2009 (2009-04-01), pages 1108 - 1117, XP055595690, ISSN: 0005426783, DOI: 10.1002/eji.200839073 *
WRIGHT GRAHAM P. ET AL.: ""Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 45, JPN6023006519, 10 November 2009 (2009-11-10), pages 19078 - 19083, XP055330489, ISSN: 0005561526, DOI: 10.1073/pnas.0907396106 *

Also Published As

Publication number Publication date
CN114641564B (zh) 2024-07-19
EP4048294A1 (en) 2022-08-31
US12643932B2 (en) 2026-06-02
AU2020370033A1 (en) 2022-06-02
CA3154606A1 (en) 2021-04-29
CN114641564A (zh) 2022-06-17
US20220364057A1 (en) 2022-11-17
WO2021079122A1 (en) 2021-04-29

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