JP2022543555A - ｍｉＲＮＡ－１９３ａに関する新たな処置 - Google Patents

ｍｉＲＮＡ－１９３ａに関する新たな処置 Download PDF

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JP2022543555A
JP2022543555A JP2022505487A JP2022505487A JP2022543555A JP 2022543555 A JP2022543555 A JP 2022543555A JP 2022505487 A JP2022505487 A JP 2022505487A JP 2022505487 A JP2022505487 A JP 2022505487A JP 2022543555 A JP2022543555 A JP 2022543555A
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mirna
cancer
use according
pten
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JP2022543555A5 (https=
Inventor
サナズ イェヒェネジャド，
ブライオニー ジェーン テルフォード，
デン ボシュ， マリオン ティナ ジョリアン ファン
ミール ファルシード アレムデイ，
ガンスト， マテウス マリア デ
ピンクステレン， ローレンス アドリアヌス ヘンドリクス ファン
ルーラント クイリーヌス ジョゼフ シャープフェルト，
ミシェル ジャニコ，
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Interna Technologies BV
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Interna Technologies BV
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Publication of JP2022543555A5 publication Critical patent/JP2022543555A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2022505487A 2019-08-12 2020-03-06 ｍｉＲＮＡ－１９３ａに関する新たな処置 Pending JP2022543555A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19191222 2019-08-12
EP19191222.9 2019-08-12
EP20160235.6 2020-02-28
EP20160235 2020-02-28
PCT/EP2020/055965 WO2021028081A1 (en) 2019-08-12 2020-03-06 New treatments involving mirna-193a

Publications (2)

Publication Number Publication Date
JP2022543555A true JP2022543555A (ja) 2022-10-13
JP2022543555A5 JP2022543555A5 (https=) 2023-03-10

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Country Link
US (1) US20220275368A1 (https=)
EP (1) EP4013869A1 (https=)
JP (1) JP2022543555A (https=)
CN (1) CN114729358A (https=)
AU (1) AU2020327537A1 (https=)
CA (1) CA3148713A1 (https=)
WO (1) WO2021028081A1 (https=)

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EP3976058A4 (en) * 2019-06-03 2023-07-19 Carmel-Haifa University Economic Corporation Ltd. TREATMENT OF HEAD AND NECK CANCER IN HUMAN
AU2020327537A1 (en) * 2019-08-12 2022-03-03 Interna Technologies B.V. New treatments involving miRNA-193a
CN114672558B (zh) * 2021-12-29 2023-08-04 河北医科大学第三医院 肝癌药物仑伐替尼耐药机制的研究方法
CN118678969A (zh) * 2022-02-22 2024-09-20 株式会社食物流变功能研究所 抗癌剂及抗癌剂的筛选方法
US20250333732A1 (en) * 2022-05-23 2025-10-30 Empirico Inc. Treatment of sos2 related diseases and disorders
CN116850289B (zh) * 2022-07-29 2025-10-28 东北大学 Plk4靶向药物在治疗对铂类药物耐药型肿瘤中的应用
CN117144008B (zh) * 2023-08-31 2024-03-08 武汉科技大学 三阴性乳腺癌生物标志物及其应用
WO2025111565A1 (en) * 2023-11-22 2025-05-30 Empirico Inc. Treatment of sos2 related diseases and disorders
WO2025155574A1 (en) * 2024-01-16 2025-07-24 University Of Houston System, Board Of Regents Modulation of akap12 signalosome
CN118671343B (zh) * 2024-06-25 2025-04-29 南昌大学第一附属医院 一种头颈鳞状细胞癌分子标记物及其应用
WO2026013165A1 (en) * 2024-07-10 2026-01-15 Université Libre de Bruxelles Combination of ship2 inhibitor and plk1 inhibitor for use in the treatment of cancer
CN118987030B (zh) * 2024-07-16 2025-05-30 广东医科大学附属医院 干预嗜碱性粒细胞exosc3在制备预防或治疗狼疮性肾炎药物中的应用
CN119015428B (zh) * 2024-10-29 2024-12-20 中国人民解放军总医院第三医学中心 一种敲低tmem91诱导肾癌细胞死亡和肿瘤免疫治疗肾癌的应用
CN120989248B (zh) * 2025-10-23 2025-12-23 山东第二医科大学 一种检测lncRNA标志物表达量的试剂在制备口腔鳞状细胞癌诊断产品或预后判断产品中的应用

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JP2021513508A (ja) * 2018-02-12 2021-05-27 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 抗がんマイクロｒｎａ及びその脂質製剤

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US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
TWI476206B (zh) 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
FR2872704B1 (fr) 2004-07-12 2007-11-02 Laurent Schwartz Pluritherapie contre le cancer
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
AU2007254853B2 (en) 2006-06-02 2011-11-17 Aveo Pharmaceuticals, Inc. Hepatocyte growth factor (HGF) binding proteins
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JP2021513508A (ja) * 2018-02-12 2021-05-27 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 抗がんマイクロｒｎａ及びその脂質製剤

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WO2021028081A1 (en) 2021-02-18
CA3148713A1 (en) 2021-02-18
AU2020327537A1 (en) 2022-03-03
EP4013869A1 (en) 2022-06-22
US20220275368A1 (en) 2022-09-01
CN114729358A (zh) 2022-07-08

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