JP2022504760A - 化学療法難治性がんの治療のための新しい併用薬方法 - Google Patents
化学療法難治性がんの治療のための新しい併用薬方法 Download PDFInfo
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Abstract
Description
本発明は、化学療法難治性がんの治療に使用される医薬組成物に関する。
CSCsの成長と生存の阻害剤である。式(I)の化合物は、約0.25 μMの細胞IC50によりStat3経路活性を阻害する。式(I)の化合物は、PCT特許WO2009/036059の、例えば実施例13に従って合成され得る。一部の実施形態では、式(I)の化合物はがんの治療方法に使用される。PCT特許WO2014/169078の、実施例6によれば、式(I)の化合物は、進行がん患者の治療のための臨床試験に入るために選択される。PCT特許WO2009/036101によれば、式(I)の化合物と別の第2の抗がん剤との2剤併用レジメンは、潜在的な相乗抗がん効果を有する。がんの転移や再発の予防、化学療法および/または放射線療法では難治のがんの治療、化学療法または放射線療法に対して本質的に耐薬品性を持つがんの治療においてCSCs経路を阻害するための新しい抗がん戦略の開発の可能性に基づいて、特定のがん患者のための式(I)の化合物に基づく新しい、取替可能な、そしてより効果的な新しい併用薬治療レジメンをさらに開発する緊急の必要性がある。
またはその薬学的に許容される塩もしくは溶媒和物と、低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物と、治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物と、を含む。
またはその薬学的に許容される塩及び溶媒和物から選択される治療的有効量の式(I)の化合物を、それを必要とする被験体に投与することを含む。
またはその薬学的に許容される塩及び溶媒和物から選択される治療的有効量の式(I)の化合物を、それを必要とする被験体に投与することを含む。
またはその薬学的に許容される塩及び溶媒和物から選択される治療的有効量の式(I)の化合物を、それを必要とする被験体に投与することを含む。
またはその薬学的に許容される塩及び溶媒和物から選択される治療的有効量の式(I)の化合物、低用量のゲムシタビン、及び治療的有効量のパクリタキセルを、それを必要とする被験体に投与することを含む。一部の実施形態では、前記被験体は、以前の治療に失敗した膵臓がん患者である。一部の実施形態では、前記被験体は、以前の治療に失敗した転移性膵臓がん患者である。
本明細書で使用される場合、「少なくとも1つの式(I)の化合物」という用語は、式(I)を有する化合物の
プロドラッグ、誘導体、前述のいずれかの薬学的に許容される塩、および前述のいずれかの溶媒和物から選択される化合物を意味する。「式(I)の化合物」という用語は、式(I)を有する化合物
またはその薬学的に許容される塩及び溶媒和物から選択される化合物を意味する。
以下、本発明の様々な特徴をさらに説明するために、実施例を提供する。これらの実施例は本発明を実施するのに有用な方法も説明している。これらの実施例は、保護請求する発明を限定しない。
式(I)の化合物である2-アセチルナフト[2,3-b]フラン-4,9-ジオン、ゲムシタビン、および2-アセチルナフト[2,3-b]フラン-4,9-ジオンとゲムシタビンの組合せの効果を研究した。具体的には、ヒト膵臓腺がん(Panc-1)を有する免疫阻害マウスに、次のような担体、2-アセチルナフト[2,3-b]フラン-4,9-ジオン(100mg/kg、PO、bid)、ゲムシタビン(Gemzar、80mg/kg、IV、q3d)、または2-アセチルナフト[2,3-b]フラン-4,9-ジオンとゲムシタビンの組合せ物を投与した。治療中、腫瘍サイズを定期的に評価した。各点は、5つの腫瘍の平均±SEMを表す。図4に示すように、マウスモデルにおいて、2-アセチルナフト[2,3-b]フラン-4,9-ジオンまたはゲムシタビンは、腫瘍成長の阻害において一定の効果を示したが、当該組合せ物は、腫瘍成長を著しく低減している。
がん異種移植物モデルにおいて、パクリタキセルの併用と非併用時のがん幹細胞マーカーに対する式(I)の化合物である2-アセチルナフト[2,3-b]フラン-4,9-ジオンの効果を検出した。
第II/III相拡張の開放ラベルの国際多中心試験において、式(I)の化合物、2-アセチルナフト[2,3-b]フラン-4,9-ジオンをパクリタキセル及び低用量ゲムシタビンを併用して以前の治療に失敗した進行性膵臓がん患者への作用効果を研究した。
この開示は、特許、特許出願、特許刊行物、ジャーナル、秘書、論文、およびウェブサイトのコンテンツなどの他の文書への参照および引用を行い、これらすべての文書は、全体としてすべての目的のために参照によりここに組み込まれる。この記事で参照によって導入された資料または資料の一部が、本明細書で明確に述べられている定義、声明、またはその他の公開資料と矛盾する場合、引用された資料と本開示との間で矛盾しない内容のみが紹介される。矛盾が生じた場合は、この開示を優先開示として優先して紛争を解決する必要がある。
Claims (16)
- 化学療法難治性膵臓がんの治療における医薬組成物の用途であって、
前記組成物は、治療的有効量の式(I)の化合物、
またはその薬学的に許容される塩もしくは溶媒和物と、
低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物と、
治療的有効量の毎週投与のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物と、を含み、
治療的有効量の式(I)の化合物またはその薬学的に許容される塩もしくは溶媒和物は、約80~960mgの用量で毎日投与され、低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物は、約100~800mg/m2で毎週注入投与され、治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物は、約10~100mg/m2で毎週注入投与される、化学療法難治性膵臓がんの治療における医薬組成物の用途。 - 前記膵臓がんは、通常の化学療法に対して耐薬品性を有している請求項1に記載の用途。
- 以前の治療に失敗した被験体膵臓がんを化学療法レジメンに再感作させる方法における医薬組成物の用途であって、
前記組成物は、治療的有効量の式(I)の化合物、
またはその薬学的に許容される塩もしくは溶媒和物と、
低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物と、
治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物と、を含み、
治療的有効量の式(I)の化合物またはその薬学的に許容される塩もしくは溶媒和物は、約80~960mgの用量で毎日投与され、低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物は、約100~800mg/m2で毎週注入投与され、治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物は、約10~100mg/m2で毎週注入投与される、以前の治療に失敗した被験体膵臓がんを化学療法レジメンに再感作させる方法における医薬組成物の用途。 - 膵臓がん被験体から選択されるがん幹細胞及び不均一がん細胞の生存および/または増殖を同時に阻害、低減および/または減弱する方法における医薬組成物の用途であって、
前記組成物は、
治療的有効量の式(I)の化合物、
またはその薬学的に許容される塩もしくは溶媒和物と、
低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物と、
治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物と、を含み、
治療的有効量の式(I)の化合物またはその薬学的に許容される塩もしくは溶媒和物は、約80~960mgの用量で毎日投与され、低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物は、約100~800mg/m2で毎週注入投与され、治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物は、約10~100mg/m2で毎週注入投与される、膵臓がん被験体から選択されるがん幹細胞及び不均一がん細胞の生存および/または増殖を同時に阻害、低減および/または減弱する方法における医薬組成物の用途。 - 被験体がんを治療するか、または被験体がんの再発または転移を予防する方法における医薬組成物の用途であって、
前記組成物は、
治療的有効量の式(I)の化合物、
またはその薬学的に許容される塩もしくは溶媒和物と、
低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物と、
治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物と、を含み、
治療的有効量の式(I)の化合物またはその薬学的に許容される塩もしくは溶媒和物は、約80~960mgの用量で毎日投与され、低用量のゲムシタビンまたはその薬学的に許容される塩もしくは溶媒和物は、約100~800mg/m2で毎週注入投与され、治療的有効量のパクリタキセルまたはその薬学的に許容される塩もしくは溶媒和物は、約10~100mg/m2で毎週注入投与される、被験体がんを治療するか、または被験体がんの再発または転移を予防する方法における医薬組成物の用途。 - 前記がんは、進行性、転移性、切除不能、難治性、または再発性の化学療法耐薬品性がんである請求項1乃至5のいずれか一項に記載の用途。
- 前記がんは、膵臓がんである請求項1乃至5のいずれか一項に記載の用途。
- 前記被験体は、以前の化学療法後に失敗した膵臓がん患者である請求項1乃至5のいずれか一項に記載の用途。
- 前記被験体は、以前の治療後に進行した転移性膵臓がん患者である請求項1乃至5のいずれか一項に記載の用途。
- 前記式(I)の化合物、低用量のゲムシタビン、及びパクリタキセルは、同時に、別々に、および/または順に患者に投与可能である請求項1乃至9のいずれか一項に記載の用途。
- 前記式(I)の化合物は、約80~480mgの用量で毎日投与される請求項1乃至9のいずれか一項に記載の用途。
- 前記式(I)の化合物は、分割用量で投与される請求項1乃至9のいずれか一項に記載の用途。
- 前記式(I)の化合物は、約240 mgの用量で1日2回投与される請求項1乃至9のいずれか一項に記載の用途。
- ゲムシタビンは、約600mg/m2、約550mg/m2、約500mg/m2、約450mg/m2、約400mg/m2、約300mg/m2、約200mg/m2または約100mg/m2で毎週注入投与される請求項1乃至9のいずれか一項に記載の用途。
- パクリタキセルは、約80 mg/m2、約70 mg/m2、約60 mg/m2、約50 mg/m2、約40 mg/m2、約30 mg/m2、約20 mg/m2、または約10 mg/m2で毎週注入投与される請求項1乃至9のいずれか一項に記載の用途。
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