JP2022180029A - pouch - Google Patents

Abstract

To provide a pouch which has such a structure that contents can be taken out without using tweezers and medicine can be applied to the affected area.SOLUTION: There is provided a pouch (1) comprising at least a protective layer (2), a medicine holding layer (3), and a base layer (4) in this order from the top, the protective layer has a tongue-shaped line of weakness (21) made of line of weakness, the medicine holding layer is made of medicine-impregnated nonwoven fabric or the like, is sandwiched between the base layer and the protective layer, and can be isolated from the surroundings to be shielded from the outside air, the base layer has both rigidity that allows a flat surface to be maintained and flexibility that allows adhesion to the shape of the affected area, making the pouch possible to hold the shape in close contact with the medicine-retaining layer. There is easy peel-ability between the protective layer and the base layer, the ratio Z of the area B of the entire medicine-holding layer to the area A of a grip part (23) remaining on the medicine-holding layer after being cut off along the cutting line of the protective layer is 2 or more and 10 or less.SELECTED DRAWING: Figure 1

Description

TECHNICAL FIELD The present invention relates to a pouch for containing medicines to be applied, such as surgical disinfectants, cleaners, cosmetics, alcohol, detergents, etc., and nonwoven fabrics for impregnating the medicines.

For example, in Patent Document 1,
An impregnated sheet made of woven fabric or nonwoven fabric and impregnated with a coating agent;
a base sheet that holds the impregnated sheet on one side and has at least the property of preventing permeation or penetration of the coating agent;
an outer sheet fixed to the surface of the base sheet opposite to the impregnated sheet and forming a space for inserting a user's hand between the base sheet and the base sheet;
A package comprising: a peelable release sheet that covers the impregnated sheet held by the base sheet and has at least the property of preventing permeation or penetration of the coating agent,
The base sheet and the impregnated sheet, the base sheet and the outer sheet, and the base sheet and the release sheet are heat-sealed to each other,
The impregnated sheet is held by the base sheet by sealing the periphery of the impregnated sheet to the base sheet,
The outer sheet and the base sheet are sealed and fixed along their entire peripheries,
A package body is proposed in which a notch is formed in the periphery of both overlapping sheet materials, and one peripheral region of both sheet materials is broken and removed from the notch to form an insertion opening for inserting a user's hand. is doing.

When using this package, the release sheet that covers the impregnated sheet must be removed by inserting tweezers or the like into the notch and pinched to remove the release sheet. prone to problems. In addition, since the operation is complicated, or the impregnated sheet may be touched with a hand, the impregnated sheet may be soiled.

Japanese Patent No. 5995401

Accordingly, it is an object of the present invention to obtain a pouch having a structure that allows a drug to be applied to an affected area by taking it out without using tweezers or the like.

The pouch of the present invention comprises at least a protective layer, a drug-retaining layer, and a base layer in this order from the top,
The protective layer has a tongue-shaped weakened line (parting line) consisting of a weakened line,
The drug holding layer is made of a nonwoven fabric impregnated with a drug, is sandwiched between the base layer and the protective layer, and can be isolated from the surroundings to be shielded from the outside air,
The base layer has both rigidity that allows it to maintain a flat surface and flexibility that allows it to adhere to the surface shape of the affected area.
Having easy peelability between the protective layer and the base layer,
The pouch is characterized in that the ratio Z of the exposed area B of the drug-retaining layer to the gripping area A remaining on the drug-retaining layer after being cut off along the breaking line of the protective layer is 2 or more and 10 or less.

The pouch of the present invention can be opened without using a tool such as tweezers by grasping the pouch with the tongue-shaped uncut protective layer and the base layer without touching the drug holding layer.
Moreover, since the drug-retaining layer can be grasped in a state in which the drug-retaining layer is in close contact with the base layer, the drug-retaining layer itself can maintain a flat surface, and the pouch can stably apply the drug contained therein to the affected area. be.

1 is a cross-sectional view showing the structure of an embodiment of a pouch according to the present invention, and a view showing a process of unsealing the pouch and coating the drug holding part thereof. FIG. It is a pouch which concerns on this invention, and is a figure which shows the top view and the process of unsealing it. FIG. 4 is a cross-sectional view showing a process of opening the pouch of the present invention and applying it to an affected area.

Hereinafter, embodiments of the pouch of the present invention will be described with reference to the drawings.
FIG. 1-1 is a vertical cross-sectional view showing an embodiment of a pouch 1 according to the present invention.
The pouch 1 of the present invention is composed of a protective layer 2, a drug holding layer 3 and a base layer 4 in order from the top.

The protective layer 2 used in the present invention is formed of an easily peelable film that envelops the drug holding layer 3 and can be fused to the base layer 4 .
Therefore, as the protective layer, it is preferable to use a film in which a resin layer that can be fused to the base layer 4 and easily peeled off is laminated on the substrate layer.
In FIG. 2-1, the protective layer 2 has a tongue-shaped weakening line 21 (separation line) made of a weakening line. It has become.

The drug holding layer 3 is formed of a nonwoven fabric or the like that contains a drug and can be applied.
A material with sufficient thickness and density is used in order to be able to maintain the state of being sufficiently impregnated with the drug.
This drug holding layer 3 is welded to the base layer 4 . By welding to the base layer 4, it can be applied without bending alone.
As shown in FIG. 2-1, the outer shape of the protective layer 2 is not smaller than that of the base layer 4, and is not welded to the outside of the peripheral welded portion 22, and is pinched from the base layer. You may have the shape which has the knob part 25 which peels and opens.

The base layer 4 has both rigidity that allows it to maintain a flat surface and flexibility that allows it to adhere to the shape of the surface of the affected area. It is formed from a sheet with
In addition, it also has flexibility that allows close contact with the surface shape of the affected area, adheres closely to the drug-retaining layer, forms a shape that matches the shape of the affected area, and enables the shape to be maintained.

1 and 2 are diagrams showing the process of using the pouch 1 of the present invention.
FIG. 1-1 is a cross-sectional view of an unopened pouch 1, and FIG. 2-1 is its plan view.
A drug holding layer 3 impregnated with a drug is sandwiched between the protective layer 2 and the base layer 4, the peripheral edges of the protective layer 2 and the base layer 4 are welded together, and the inside of the pouch containing the drug holding layer 3 is formed. is sealed.

1-2 is a cross-sectional view showing the unsealing process, FIG. 2-2 is a plan view showing the unsealing process, and FIG. 2-3 is a plan view showing the unsealed state.
Put your finger on the grip part 23 inside the tongue-shaped weakening line 21 (separation line) provided on the protective layer 2 of the pouch 1, put your finger on the base layer 4 on the back side, and remove the pouch 1 only at this part. Grab.
The tongue-shaped line of weakness 21 of the protective layer 2 is broken while the tongue-shaped grip portion 23 is gripped. Along with the breakage, the drug-holding layer 3 under the covering portion 24 is exposed in the process of peeling the covering portion 24 of the protective layer 2 from the peripheral edge welded portion 22 with the base layer 4 with the other hand.

FIG. 3-1 is a cross-sectional view showing the process of unsealing and applying to the affected area.
It is turned upside down so that the side of the drug-holding layer 3 from which the protective layer 2 has been peeled off becomes the surface that touches the affected area, and is applied to the affected area. Since the drug-retaining layer 3 adheres to the base layer 4 and has adhesiveness to adhere to the diseased part, it adheres along the shape of the diseased part and can hold the drug in a coated state.

Any film may be used as the protective layer as long as it can be fused to the base layer and has an easily peelable sealant on the fused side.
Therefore, a single film such as low-density polyethylene may be used, or an ethylene/acrylic acid copolymer, an ethylene/methacrylic acid copolymer, an ethylene/ethyl acrylate copolymer, an ethylene/methyl acrylate copolymer, A single film such as can also be used. moreover,
On the fusible resin film, a metal foil layer, a polyethylene terephthalate film or polyamide film having a metal oxide deposition layer, or an ethylene/ A multilayer film laminated with a saponified vinyl acetate copolymer film, a polyethylene terephthalate film, a polyamide film, a polypropylene film, or the like can also be used.

As shown in FIG. 1-1, the drug holding portion 3 is a sheet having a size sufficiently smaller than the outline of the peripheral edge of the base layer 4, and is formed of a non-woven fabric or the like that contains a drug and can be applied.
A nonwoven fabric can be used as the material for the drug holding layer 3 .

The nonwoven fabric material may include one or more selected from natural fibers, man-made fibers and mixtures thereof. The raw yarn material may include one or more selected from natural fibers, artificial fibers, and mixtures thereof.

Natural fibers include cotton, kapok cotton, coyer, manila hemp, sisal hemp, flax, ramie, kenaf, abaca, sisal hemp, kapok, ramie, jute, hemp, wool, goat wool, cashmere, camel hair, camel hair, alpaca , wool fiber, domestic silk, wild silk, asbestos, cellulose, and mixtures thereof.

Artificial fibers include polynosic rayon, viscose rayon, cupra rayon, acetate, triacetic acid, polyester fiber, polyurethane fiber, polyethylene fiber, polyvinyl chloride fiber, polyvinylidene fiber, and polytetrafluoroethylene fiber. , polyvinyl alcohol fiber, polyacrylonitrile fiber, polypropylene fiber, polyolefin fiber, polyamide fiber, casein fiber, alginate fiber, cellulose fiber, rubber fiber, nylon, SBR (styrene butadiene rubber), NR (natural rubber) and one or more selected from the group consisting of mixtures thereof. The density of the fibers used for this drug holding layer is preferably 0.01 to 5 g/cm ³ . That is, if it is less than 0.01 g/cm ³ , it cannot be maintained in a sufficiently impregnated state with the drug. If the density is 5 g/cm ³ or more, the density of the fibers used in the retention layer is set to 0.01 to 5 g/cm ³ because there are problems such as insufficient permeation and impregnation of the agent. In particular, it is preferable to set the fiber density to 0.2 to 0.4 g/cm ³ .

A porous sponge can also be used as the drug holding layer. As the sponge, a urethane sponge made of urethane foam, an olefin sponge, a fluorine sponge, an ethylene-vinyl acetate copolymer sponge, a vinyl chloride sponge, a cellulose sponge, or the like can be used.
Since the fiber surface is exposed on the surface, when heated while in contact with the base sheet, the surface of the fiber and the porous surface are embedded in the thermoplastic resin of the base sheet and can be welded.

The film used for the base layer 3 is a barrier film that protects the contained drug from deterioration and has an inner surface that can be welded to the protective layer and the drug holding layer.
For example, a polypropylene-based G-Peel sealant/deposited metal oxide layer/polyethylene terephthalate sheet, or a phthalic anhydride-modified high-density polyethylene/saponified ethylene-vinyl acetate copolymer/phthalic anhydride-modified polyethylene/high-density polyethylene structure. A sheet that is co-extruded with .
That is, on the fusible resin film, a metal foil layer, a polyethylene terephthalate film, a polyamide film, or the like having a metal foil layer, a metal oxide deposition layer, etc., as a layer with high gas barrier properties to prevent volatilization and deterioration of chemicals, Moreover, a multilayer film obtained by laminating a film having high barrier properties such as a saponified ethylene/vinyl acetate copolymer film, a polyethylene terephthalate film, a polyamide film, or the like is preferable.

The configuration of a specific embodiment of the present invention will be described below.
In the first embodiment configuration example 1, a silicon oxide-deposited polyethylene terephthalate film (thickness: 12 μm)/polypropylene-based easy peel sealant (thickness: 30 μm) is used as a protective layer. The drug-retaining layer is a polypropylene non-woven fabric (basis weight: 50 g/m ² ).
The base layer is a polypropylene based easy peel sealant (thickness 30 μm)/silicon oxide deposited polyethylene terephthalate film (thickness 12 μm).

In Example 2, the protective layer is polyethylene terephthalate film (thickness 12 μm)/aluminum foil (thickness 9 μm)/polypropylene-based easy peel sealant (thickness 30 μm).
The drug-retaining layer is a polypropylene non-woven fabric (basis weight: 50 g/m ² ).
The base layer is a polypropylene-based easy peel sealant (thickness 30 μm)/aluminum foil (thickness 9 μm)/polyethylene terephthalate film (thickness 12 μm).

In Example 3, the protective layer is silicon oxide-deposited polyethylene terephthalate film (thickness: 12 μm)/polyethylene-based easy peel sealant (thickness: 30 μm).
The drug-retaining layer is a polypropylene non-woven fabric (basis weight: 60 g/m ² ).
The base layer is linear low density polyethylene (thickness 30 μm)/silicon oxide deposited polyethylene terephthalate film (thickness 12 μm).

In Example 4, the protective layer is polyethylene terephthalate film (thickness 12 μm)/aluminum foil (thickness 9 μm)/polypropylene-based easy peel sealant (thickness 50 μm).
The drug-retaining layer is a polypropylene non-woven fabric (basis weight: 70 g/m ² ).
The base layer is unstretched polypropylene (thickness 30 μm)/aluminum foil (thickness 9 μm)/polyethylene terephthalate film (thickness 12 μm).
As noted above, pouch configurations are possible. Based on Embodiment Configuration Example 1, Examples and Comparative Examples were created in which the area of the grasping portion formed by the tongue-shaped weakening line was changed, and the amount of the drug transferred to the affected area during application, the feeling of use, etc. We considered the evaluation of

<Example 1>
As for the configuration of the pouch, Embodiment Configuration Example 1 was used.
That is, as a protective layer, a silicon oxide-deposited polyethylene terephthalate film (thickness: 12 μm)/polypropylene-based easy peel sealant (thickness: 30 μm).
The drug-retaining layer is a polypropylene non-woven fabric (basis weight: 50 g/m ² ).
The base layer is a polypropylene based easy peel sealant (thickness 30 μm)/silicon oxide deposited polyethylene terephthalate film (thickness 12 μm).
The drug-retaining layer was made of nonwoven fabric with a width of 65 mm and a length of 90 mm.
The protective layer and the base layer had a width of 75 mm and a length of 100 mm.
The tongue-shaped line of weakness was scanned with a laser processing machine using a carbon dioxide laser with a wavelength of 10.6 μm at an output of 21 watts and a ^speed of 2500 mm/sec. A pouch having a ratio Z of exposed area (B)/grip area (A) of 2 was used.

<Example 2>
The area of the grip portion was 14.625 cm ² , and the ratio Z of the area (B) of the entire drug holding layer/the area (A) of the grip portion was 4.
Others were the same as in Example 1.

<Example 3>
The area of the grip portion was 11.7 cm ² , and the ratio Z of the exposed area (B) of the drug holding layer/the area (A) of the grip portion was 5.
Others were the same as in Example 1.

<Example 4>
The area of the grip portion was set to 7.3125 cm ² , and the ratio Z of the exposed area of the drug holding layer (B)/the area of the grip portion (A) was 8.
Others were the same as in Example 1.

<Example 5>
The area of the grip portion was set to 6.5 cm ² , and the ratio Z of the exposed area of the drug holding layer (B)/the area of the grip portion (A) was 9.
Others were the same as in Example 1.

<Example 6>
The area of the grip portion was set to 5.85 cm ² , and the ratio Z of the exposed area of the drug holding layer (B)/the area of the grip portion (A) was 10.
Others were the same as in Example 1.

<Comparative Example 1>
The area of the grip portion is 58.5 cm ² , half of the entire drug-retaining layer is the grip portion, and the ratio Z of the exposed area of the drug-retaining layer (B)/the area of the grip portion (A) is 1. did.
Others were the same as in Example 1.

<Comparative Example 2>
The area of the grip portion was set to 5.318 cm ² , and the ratio Z of the exposed area of the drug holding layer (B)/the area of the grip portion (A) was 11.
Others were the same as in Example 1.

<Comparative Example 3>
The weak line of the grip part was made into a pouch without processing.
Others were the same as in Example 1.

<Comparative Example 4>
The grip portion is configured without the drug-retaining layer, and the area of the grip portion is 11.7 cm ² , and the ratio Z of the exposed area (B) of the drug-retaining layer/the area (A) of the grip portion is 5. was made into a pouch.
Others were the same as in Example 1.

<Evaluation method>
Before the protective layer was fused, 40 pouches were prepared by impregnating the drug holding layer with 20 g of the drug.
<Assumed coating amount measurement>
A pouch whose weight was measured by peeling off the protective layer was attached to a non-woven fabric with a length of 100 mm, a width of 150 mm, and a thickness of 3 mm. was measured. This measurement was performed on 10 pouches, and ◯ was given when the estimated coating amount was 50% or more and less than 80% of the impregnated drug, and ⊚ was given when 80% or more.
<Usage feeling>
30 panelists applied the above pouch to the affected area and judged whether the feeling of use was good or bad.

<Pouch evaluation test results>
<Estimated transition ratio>
The pouch of Comparative Example 1 in which the area of the grip portion was half the area of the drug-holding layer had a very small amount of estimated application to the affected area, and was NG. Other configurations had transfer ratios of 50 percent or greater. Pouches with an area ratio (B/A) of 5 or more were able to transfer an estimated coating amount of 80% or more.
<Usage feeling>
In the example, the feeling of use was good. In Comparative Example 2, the area of the grip portion was small, making it difficult to grip, and the application portion was large, so that the pouch easily adhered to the periphery of the drug. Comparative Example 3 required tweezers for application because there was no grip portion. In Comparative Example 4, there was no drug-retaining layer in the grip portion, and there was a problem that the drug-retaining layer portion bent and could not be applied stably.

From the above results, the ratio of the exposed area (B) of the drug-retaining layer to the area (A) of the grip portion is 2 times or more, preferably 5 or more and 10 or less.
In addition, it was found that the grip portion is effective, and it is particularly important for the feeling of use that the portion to be gripped contains a drug-retaining layer.
The above results are shown in Table 1.

The pouch of the present invention is as described above. After opening at the tongue-shaped weakening line, the pouch is grasped by the tongue-shaped uncut protective layer and the base layer without using tools such as tweezers. The package can be opened without touching the drug holding layer.
Moreover, since the drug-retaining layer can be gripped while in close contact with the base layer, the drug-retaining layer itself does not break or curl excessively, and the surface can be maintained. The pouch of the present invention has many merits, such as being able to be stably applied to the affected area.

1 Pouch 2 Protective layer 21 Vulnerable line (tongue shape)
22 . Drug-retaining layer 4: base layer A: gripping area (gripping area remaining on the drug-retaining layer)
B: Exposed area (exposed area of the drug-retaining layer)
Z ratio (ratio of exposed area B/grip area A)

Claims (1)

A pouch comprising at least a protective layer, a drug-retaining layer, and a base layer in this order from the top,
The protective layer has a tongue-shaped weakened line (parting line) consisting of a weakened line,
The drug-retaining layer is made of a drug-impregnated nonwoven fabric or the like, is sandwiched between the base layer and the protective layer, and can be isolated from the surroundings to be shielded from the outside air,
The base layer has both rigidity that allows it to maintain a flat surface and flexibility that allows it to adhere to the surface shape of the affected area.
Having easy peelability between the protective layer and the base layer,
A pouch characterized in that a ratio Z of an exposed area B of the drug-holding layer to a grasping area A remaining on the drug-holding layer after being cut off along a breaking line of the protective layer is 2 or more and 10 or less.

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