JP2022162206A5 - - Google Patents
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- JP2022162206A5 JP2022162206A5 JP2021066901A JP2021066901A JP2022162206A5 JP 2022162206 A5 JP2022162206 A5 JP 2022162206A5 JP 2021066901 A JP2021066901 A JP 2021066901A JP 2021066901 A JP2021066901 A JP 2021066901A JP 2022162206 A5 JP2022162206 A5 JP 2022162206A5
- Authority
- JP
- Japan
- Prior art keywords
- base sequence
- conversion
- converting
- gta
- codons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006243 chemical reaction Methods 0.000 claims 15
- 108020004705 Codon Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108700010070 Codon Usage Proteins 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
Claims (10)
入力された塩基配列を変換する変換部と、
を含み、
変換部は、
入力された塩基配列から翻訳されるポリペプチドを変えることなく、
塩基配列中の５’から３’方向におけるＧＴＡの中の、Ａ、ＴおよびＧいずれかの少なくとも一つを含むコドンを変換し、塩基配列中のＧＴＡを減少させる、
塩基配列変換装置。 an input section for inputting a base sequence encoding a polypeptide;
a conversion unit that converts an input base sequence;
Including,
The conversion section is
Without changing the polypeptide translated from the input nucleotide sequence,
converting codons containing at least one of A, T, and G among GTA in the 5' to 3' direction in the base sequence, thereby reducing GTA in the base sequence;
Base sequence conversion device.
請求項１に記載の塩基配列変換装置。The base sequence conversion apparatus according to claim 1.
請求項１または２に記載の塩基配列変換装置。 The converted codon is the one with the highest codon usage among the codons available for conversion.
The base sequence conversion apparatus according to claim 1 or 2 .
変換工程は、
変換前の塩基配列から翻訳されるポリペプチドを変えることなく、
塩基配列中の５’から３’方向におけるＧＴＡの中の、Ａ、ＴおよびＧいずれかの少なくとも一つを含むコドンを変換し、塩基配列中のＧＴＡを減少させる、
塩基配列変換方法。 A method for converting a base sequence, comprising a conversion step of converting a base sequence encoding a polypeptide,
The conversion process is
Without changing the polypeptide translated from the base sequence before conversion,
converting codons containing at least one of A, T, and G among GTA in the 5' to 3' direction in the base sequence, thereby reducing GTA in the base sequence;
Base sequence conversion method.
請求項４に記載の塩基配列変換方法。The method for converting a base sequence according to claim 4.
請求項４または５に記載の塩基配列変換方法。 The converted codon is the one with the highest codon usage among the codons available for conversion.
The method for converting a base sequence according to claim 4 or 5 .
入力された塩基配列を変換する処理と、
をコンピュータに実行させるプログラムであって、
入力された塩基配列を変換する処理は、
入力された塩基配列から翻訳されるポリペプチドを変えることなく、
塩基配列中の５’から３’方向におけるＧＴＡの中の、Ａ、ＴおよびＧいずれかの少なくとも一つを含むコドンを変換し、塩基配列中のＧＴＡを減少させる、
プログラム。 inputting a nucleotide sequence encoding a polypeptide;
A process of converting the input base sequence;
A program for causing a computer to execute the following:
The process of converting the input base sequence is as follows:
Without changing the polypeptide translated from the input nucleotide sequence,
converting codons containing at least one of A, T, and G among GTA in the 5' to 3' direction in the base sequence, thereby reducing GTA in the base sequence;
program.
請求項８に記載のプログラム。The program according to claim 8.
請求項８または９に記載のプログラム。
The converted codon is the one with the highest codon usage among the codons available for conversion.
10. The program according to claim 8 or 9 .
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021066901A JP2022162206A (en) | 2021-04-12 | 2021-04-12 | Base sequence conversion device, base sequence conversion method, polynucleotide, method for producing polynucleotide, and program |
| PCT/JP2022/006052 WO2022219915A1 (en) | 2021-04-12 | 2022-02-16 | Base sequence converter, base sequence conversion method, polynucleotide, method for producing polynucleotide, and program |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021066901A JP2022162206A (en) | 2021-04-12 | 2021-04-12 | Base sequence conversion device, base sequence conversion method, polynucleotide, method for producing polynucleotide, and program |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022162206A JP2022162206A (en) | 2022-10-24 |
| JP2022162206A5 true JP2022162206A5 (en) | 2024-04-19 |
Family
ID=83639593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021066901A Pending JP2022162206A (en) | 2021-04-12 | 2021-04-12 | Base sequence conversion device, base sequence conversion method, polynucleotide, method for producing polynucleotide, and program |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2022162206A (en) |
| WO (1) | WO2022219915A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10260805A1 (en) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Method and device for optimizing a nucleotide sequence for expression of a protein |
| WO2007102578A1 (en) * | 2006-03-09 | 2007-09-13 | Keio University | Method of designing base sequence |
| US8326547B2 (en) * | 2009-10-07 | 2012-12-04 | Nanjingjinsirui Science & Technology Biology Corp. | Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm |
| WO2013118878A1 (en) * | 2012-02-09 | 2013-08-15 | 独立行政法人理化学研究所 | Cyclic rna and protein production method |
-
2021
- 2021-04-12 JP JP2021066901A patent/JP2022162206A/en active Pending
-
2022
- 2022-02-16 WO PCT/JP2022/006052 patent/WO2022219915A1/en active Application Filing
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