JP2022134216A - Hair restoration promoting composition containing hydrolysis egg shell membrane component and egg white component - Google Patents
Hair restoration promoting composition containing hydrolysis egg shell membrane component and egg white component Download PDFInfo
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- Non-Alcoholic Beverages (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
Description
本発明は、育毛・発毛を促し脱毛を防ぐ、育毛促進のための組成物に関する。 TECHNICAL FIELD The present invention relates to a composition for promoting hair growth, which promotes hair growth and prevents hair loss.
毛髪の質や量には個人差があり、生まれつき、または若いときから、毛髪の本数が少ない、毛髪が細いなどの理由で外見上髪が薄い場合がある。また、加齢とともに、毛髪が細くなったり、早期に抜け易くなったりして、年齢が上がると髪が薄くなる場合がある。さらに、ストレスや薬剤の副作用などの医学的な原因により、頭髪全体又は一部の髪が抜けたり、細くなったり、発毛が低減したりすることもある。 There are individual differences in the quality and amount of hair, and there are cases in which the hair appears thin due to reasons such as a small number of hairs or fine hair from birth or from a young age. In addition, with aging, the hair tends to become thin or fall out at an early stage, and the hair may become thinner with age. In addition, medical causes such as stress and drug side effects may cause hair loss, thinning, or reduced hair growth in whole or in part.
この問題を解するために、育毛および脱毛抑制果を有するペプチドを有効成分とする育毛剤（特許文献１、２）や、血行促進作用、免疫抑制作用などを有する各種の植物エキスを有効成分とするもの等、様々な育毛、発毛促進剤が開発されているが、安定して十分な効果が得られるものは数少なく、また、人によっては発赤、かゆみ、かぶれなどの症状を生じる場合もある。 In order to solve this problem, hair growth agents containing peptides having hair growth and hair loss suppression effects as active ingredients (Patent Documents 1 and 2) and various plant extracts having blood circulation promoting action, immunosuppressive action, etc. are used as active ingredients. A variety of hair growth stimulants have been developed, such as those that promote hair growth, but there are few that have a stable and sufficient effect, and some people may experience symptoms such as redness, itching, and rashes. .
卵殻膜は、鶏卵などの鳥類の卵の卵殻の内側にある膜で、内外２枚からなり、外卵殻膜は卵殻内面に密着し、内卵殻膜は卵白を包んでおり、抗菌性を有し、発生中の胚を感染から保護している。卵殻膜は、Ｉ型、Ｖ型およびＸ型コラーゲン、グルコサミン、デスモシンおよびヒアルロン酸を主成分とした強靭な繊維性のタンパク質等からなる網目状の構造を有し、これらのタンパク質はシスチンを含むものが多く、酸、アルカリ、プロテアーゼに対して比較的安定で、水に不溶性である。皮膚の再生を促進する効果が知られており、化粧品や栄養剤として実用化されている。 The eggshell membrane is a membrane inside the eggshell of avian eggs such as chicken eggs. It consists of two layers, the outer shell membrane and the inner shell membrane. , which protects the developing embryo from infection. The eggshell membrane has a mesh-like structure composed of tough fibrous proteins mainly composed of type I, V and X collagen, glucosamine, desmosine and hyaluronic acid, and these proteins contain cystine. It is relatively stable against acids, alkalis and proteases, and insoluble in water. Known for its ability to promote skin regeneration, it is put to practical use in cosmetics and nutritional supplements.
この不溶性の卵殻膜を水に可溶性にして卵殻膜成分の消化吸収効率を高めるために、タンパク質を酸またはアルカリ水溶液中で加水分解したり、タンパク質分解酵素で加水分解すること（特許文献３）により、可溶性の加水分解卵殻膜成分が製造され、サプリメントや化粧品の原料として使用されている。 In order to make this insoluble eggshell membrane soluble in water and increase the efficiency of digestion and absorption of eggshell membrane components, protein is hydrolyzed in an acid or alkaline aqueous solution or hydrolyzed with a protease (Patent Document 3). , Soluble hydrolyzed eggshell membrane components are produced and used as raw materials for supplements and cosmetics.
一方、卵白は低脂肪、高タンパク質という理想的な栄養価の食物であり、含まれる卵白タンパク質は、他の植物性、動物性タンパク質に比べて栄養価が高い優れたタンパク質である。卵白ペプチドは、卵白タンパク質を酵素で低分子化したもので、卵白タンパク質のアミノ酸バランスはそのまま保持しながら耐熱性を有する。卵白タンパク質に比べ消化、吸収スピードが高められ、たとえば、コラコーゲンペプチドと卵白ペプチドを含有すると、タンパク質の体内利用が向上すること（特許文献４）が報告されている。 On the other hand, egg white is a low-fat, high-protein food with ideal nutritional value, and the contained egg white protein is an excellent protein with high nutritional value compared to other vegetable and animal proteins. Egg white peptide is an egg white protein that has been enzymatically reduced in molecular weight, and has heat resistance while maintaining the amino acid balance of the egg white protein. It has been reported that digestion and absorption speed are increased as compared with egg white protein, and for example, inclusion of collagen peptide and egg white peptide improves utilization of protein in the body (Patent Document 4).
本発明は、育毛促進効果が高く安全で、飲食品、サプリメント、医薬部外品として利用することのできる経口用または経皮用の育毛促進用組成物を提供することを課題とする。
本発明は、毛髪にハリおよびコシを与え、毛髪自体の成長を促進し健康な毛髪の数を増やすことのできる、優れた育毛、発毛促進効果を発揮する経口用、経皮用の育毛促進用組成物剤を提供することを課題とする。
An object of the present invention is to provide an oral or percutaneous composition for promoting hair growth, which has a high hair growth-promoting effect, is safe, and can be used as food, drink, supplements, and quasi-drugs.
The present invention is an oral or percutaneous hair growth stimulating agent that exhibits excellent hair growth and hair growth promoting effects, which can impart elasticity and elasticity to hair, promote the growth of hair itself, and increase the number of healthy hairs. An object of the present invention is to provide a composition agent for
産卵後２１日間温められることにより、鶏卵からひよこが誕生するが、その間栄養分の補給はない。ひよこは生まれた瞬間に羽毛１００％で誕生するから、鶏卵には発毛に必要な全ての成分が含まれている。そこでは、優良なタンパク質である卵白タンパク質が毛髪の原料となり、シスチンの豊富な卵殻膜がこれらの発毛制御にかかわっており、これら成分を含むことにより育毛がより促進されると考え、その優れた育毛促進機能を確認することで本発明を完成するに至った。 Chicks are born from chicken eggs by being warmed for 21 days after spawning, but no nutrients are supplied during that time. Chicks are born with 100% feathers the moment they are born, so chicken eggs contain all the ingredients necessary for hair growth. There, egg white protein, which is an excellent protein, is used as a raw material for hair, and cystine-rich eggshell membranes are involved in the control of hair growth. The present invention was completed by confirming the hair growth promoting function.
本発明は、以下（１）～（６）の育毛促進用組成物に関するものである。
（１）加水分解卵殻膜成分および卵白成分を含有することを特徴とする、育毛促進用組成物。
（２）前記加水分解卵殻膜成分が、アルカリ加水分解卵殻膜成分および／または酵素加水分解卵殻膜成分である、上記（１）に記載の育毛促進用組成物。
（３）前記卵白成分が、卵白粉末および／または卵白ペプチドである、上記（１）または（２）に記載の育毛促進用組成物。
（４）前記加水分解卵殻膜成分および卵白成分をそれぞれ乾物換算で、１～５０重量％および０．１～５重量％含有する、上記（１）ないし（３）のいずれかに記載の育毛促進用組成物。
（５）卵黄粉末および／または卵黄レシチンを含む、上記（１）ないし（４）のいずれかに記載の育毛促進用組成物。
（６）経口用または経皮用である、上記（１）ないし（５）のいずれかに記載の育毛促進用組成物。
The present invention relates to compositions for promoting hair growth described in (1) to (6) below.
(1) A composition for promoting hair growth, comprising a hydrolyzed eggshell membrane component and an egg white component.
(2) The composition for promoting hair growth according to (1) above, wherein the hydrolyzed eggshell membrane component is an alkaline hydrolyzed eggshell membrane component and/or an enzymatically hydrolyzed eggshell membrane component.
(3) The composition for promoting hair growth according to (1) or (2) above, wherein the egg white component is egg white powder and/or egg white peptide.
(4) Promote hair growth according to any one of (1) to (3) above, containing 1 to 50% by weight and 0.1 to 5% by weight of the hydrolyzed eggshell membrane component and the egg white component, respectively, in terms of dry matter. composition.
(5) The composition for promoting hair growth according to any one of (1) to (4) above, which contains egg yolk powder and/or egg yolk lecithin.
(6) The composition for promoting hair growth according to any one of (1) to (5) above, which is for oral use or percutaneous use.
また、本発明は、以下（７）～（９）の飲食品、サプリメント、または医薬部外品に関する。
（７）上記（６）に記載の育毛促進用組成物を含む、飲食品、サプリメント、または医薬部外品。
（８）顆粒剤、錠剤、カプセル剤、液剤、またはドリンク剤である、上記（７）に記載の飲食品またはサプリメント。
（９）皮膚外用剤である、上記（７）に記載の医薬部外品。
In addition, the present invention relates to the following (7) to (9) foods and drinks, supplements, or quasi-drugs.
(7) A food, drink, supplement, or quasi-drug containing the composition for promoting hair growth according to (6) above.
(8) The food, drink or supplement according to (7) above, which is a granule, tablet, capsule, liquid, or drink.
(9) The quasi-drug according to (7) above, which is an external preparation for skin.
卵殻膜成分の育毛促進効果、特に、酵素分解による加水分解卵殻膜成分の育毛促進効果が高いことは、特許文献５にも記載されている。加水分解卵殻膜成分には、シスチン含量が卵殻膜成分の２０倍以上に高められたものもあり、この加水分解卵殻膜成分にさらに、含硫アミノ酸であるシスチンやシステイン含量の高い卵白タンパク質を含む卵白成分を併用することで、毛髪に必要なシスチン含量がより高められる。さらに卵黄粉末や卵黄レシチンなどの卵黄成分を併用すれば、鶏卵の全ての成分とエネルギー源を含むものとなる。
このように、本発明の育毛促進用組成物によれば、加水分解卵殻膜成分と卵白成分とが相乗的に機能することで、育毛促進効果が顕著に向上する。
It is also described in Patent Document 5 that eggshell membrane components are effective in promoting hair growth, and in particular, hydrolyzed eggshell membrane components by enzymatic decomposition are highly effective in promoting hair growth. Some of the hydrolyzed eggshell membrane components have a cystine content increased to 20 times or more that of the eggshell membrane component, and the hydrolyzed eggshell membrane component further contains cystine, which is a sulfur-containing amino acid, and egg white protein with a high cysteine content. By using the egg white component together, the cystine content necessary for hair can be further increased. Furthermore, if an egg yolk component such as egg yolk powder or egg yolk lecithin is used in combination, it will contain all the components of chicken eggs and an energy source.
As described above, according to the composition for promoting hair growth of the present invention, the hydrolyzed eggshell membrane component and the egg white component function synergistically, thereby significantly improving the hair growth promoting effect.
本発明の組成物は、日常的に簡単に摂取できる経口用組成物として、顆粒剤、錠剤、カプセル剤、またはドリンク剤の形態の飲食品、サプリメントとして摂取できる。経口摂取可能であることも、本発明の有利な点の一つであり、また、安全な経皮用組成物として皮膚外用剤としても使用できる。
本発明の経口用または経皮用の育毛促進用組成物は、卵殻膜と卵白という天然物由来の人体や皮膚に対する安全性の高いものを使用しているので、飲食品、サプリメント、または医薬部外品の製造時に多量に配合しても健康に悪影響がなく、また頭皮および頭髪にかぶれ等の症状を引き起こすことがない。刺激性がなく様々な形態で各種育毛、発毛成分と併用できるので、より高い育毛効果を発揮できる。
The composition of the present invention can be ingested as an oral composition that can be easily ingested on a daily basis, as food and drink in the form of granules, tablets, capsules, or drinks, and supplements. One of the advantages of the present invention is that it can be taken orally, and it can also be used as a safe percutaneous composition for external use on the skin.
Since the oral or percutaneous composition for promoting hair growth of the present invention uses eggshell membranes and egg whites, which are derived from natural products and are highly safe for the human body and skin, it can be used in foods, supplements, or pharmaceuticals. Even if it is mixed in a large amount in the production of a non-commercial product, it does not adversely affect health and does not cause symptoms such as rashes on the scalp and hair. Since it is non-irritating and can be used in combination with various hair-restoring ingredients in various forms, a higher hair-restoring effect can be exhibited.
本発明の育毛促進用組成物は、加水分解卵殻膜成分と卵白成分を含むことを特徴とする。
本明細書において「育毛」、「育毛促進」という場合、結果として毛髪の量（本数、太さなど）を増大させる養毛作用や、伸長速度の増大や毛髪の健全化をもたらす作用であり、たとえば、毛髪の成長促進もしくは発毛促進、または脱毛の低減もしくは予防などのいずれか一つ以上の作用を指す。本発明の育毛促進とは、発毛促進、養毛、抗脱毛を含む作用である。
The composition for promoting hair growth of the present invention is characterized by containing a hydrolyzed eggshell membrane component and an egg white component.
In the present specification, the terms "hair growth" and "promotion of hair growth" refer to a hair nourishing action that results in an increase in the amount of hair (number, thickness, etc.), an action that increases the elongation speed, and an action that brings about healthier hair. For example, it refers to any one or more actions such as promoting hair growth or regrowth, or reducing or preventing hair loss. The promotion of hair growth in the present invention is an action including promotion of hair growth, nourishing hair, and anti-hair loss.
本発明で使用される卵殻膜は、陸生の卵生動物すべての卵、特に鳥類の卵の卵殻の内側にある膜であればいずれも使用できる。特に鶏卵の卵殻膜が入手の容易性、コストの点から好ましい。
本発明の加水分解卵殻膜成分は、卵殻膜あるいは卵殻膜含有粉末を、酸水溶液、アルカリ水溶液、アルカリ性有機溶媒溶液、またはタンパク質分解酵素含有液などのタンパク質の分解作用を有する液中で加水分解することによって得られる。本発明で使用される加水分解卵殻膜成分は，いずれの方法によって製造された加水分解卵殻膜成分を用いることができるが、アルカリ加水分解および／または酵素加水分解のものが好ましい。水溶液、エキスとしても使用できるが、取扱性や保存安定性のため、噴霧乾燥、凍結乾燥等の乾燥手段により得られる粉末形態のものが好ましい。
The eggshell membrane used in the present invention may be any membrane that is found inside the eggshell of eggs of all terrestrial oviparous animals, especially avian eggs. In particular, chicken egg shell membranes are preferred from the standpoints of availability and cost.
The hydrolyzed eggshell membrane component of the present invention hydrolyzes eggshell membranes or powder containing eggshell membranes in a liquid having a protein-degrading action, such as an acid aqueous solution, an alkaline aqueous solution, an alkaline organic solvent solution, or a proteolytic enzyme-containing solution. obtained by The hydrolyzed eggshell membrane component used in the present invention can be a hydrolyzed eggshell membrane component produced by any method, but alkali hydrolysis and/or enzymatic hydrolysis are preferred. Although it can be used as an aqueous solution or an extract, it is preferably in the form of a powder obtained by drying means such as spray drying or freeze drying for handling and storage stability.
本発明の卵白成分としては、卵白液、卵白粉末、卵白タンパク質、卵白ペプチド等を用いることができる。卵白に含まれる卵白タンパク質は、低脂肪の高タンパク質であり、含硫アミノ酸であるシスチン、システイン、メチオニンや、分岐鎖アミノ酸の含有量が高い。また、消化～吸収～体内利用において、他の乳タンパク質などの動物性タンパク質および大豆タンパク質などの植物性タンパク質に比べて栄養価に優れている。
卵白ペプチドは、卵白タンパク質を酵素で低分子化したもので、卵白タンパク質のアミノ酸バランスをそのまま保持しながら、卵白タンパク質に比べ消化、吸収スピードが高められている。卵白特有の硫黄臭が低減されている平均分子量が２００～１５００、特に６００～１０００のものが好ましい。
Egg white liquid, egg white powder, egg white protein, egg white peptide and the like can be used as the egg white component of the present invention. Egg white protein contained in egg white is low in fat and high in protein, and has a high content of sulfur-containing amino acids such as cystine, cysteine, and methionine, and branched-chain amino acids. In addition, in terms of digestion, absorption, and utilization within the body, it has a higher nutritional value than other animal proteins such as milk proteins and vegetable proteins such as soybean proteins.
Egg white peptide is a low-molecular-weight egg white protein produced by enzymatic digestion and absorption speed compared to egg white protein while maintaining the amino acid balance of egg white protein. An average molecular weight of 200 to 1,500, particularly 600 to 1,000, which reduces the sulfur smell peculiar to egg white, is preferred.
本発明では卵黄成分である卵黄液、卵黄粉末、卵黄レシチン等を配合することができ、取扱性や保存安定性の観点から、噴霧乾燥、凍結乾燥等の乾燥手段により得られる粉末形態のものが好ましい。
卵白成分、卵黄成分の原料である卵白と卵黄は、陸生の卵生動物すべての卵、特に鳥類の卵のものであればいずれも使用できる。特に鶏卵の卵が入手の容易性、コストの点から好ましい。
In the present invention, egg yolk liquid, egg yolk powder, egg yolk lecithin, etc., which are egg yolk components, can be blended. preferable.
Egg white and egg yolk, which are the raw materials of the egg white component and the egg yolk component, can be used as long as they are eggs of all terrestrial oviparous animals, especially bird eggs. In particular, hen's eggs are preferred in terms of availability and cost.
本発明の育毛促進用組成物において、加水分解卵殻膜成分、卵白成分それぞれの含有量は特に限定されるものではない。加水分解卵殻膜成分は乾物換算で１～５０重量％、卵白成分は乾物換算で０．１～５重量％含むことが好ましい。
また、本発明の育毛促進用組成物を経口用として使用する場合、さらに卵殻膜含有粉末を配合することが好ましく、加水分解卵殻膜成分に対して卵殻膜含有粉末を同量以下で含有することが好ましい。
In the composition for promoting hair growth of the present invention, the contents of the hydrolyzed eggshell membrane component and the egg white component are not particularly limited. It is preferable that the hydrolyzed eggshell membrane component is contained in an amount of 1 to 50% by weight in terms of dry matter, and the egg white component is contained in an amount of 0.1 to 5% by weight in terms of dry matter.
In addition, when the composition for promoting hair growth of the present invention is used for oral use, it is preferable to further add eggshell membrane-containing powder, and the eggshell membrane-containing powder should be contained in an amount equal to or less than the hydrolyzed eggshell membrane component. is preferred.
本発明の育毛促進用組成物は、錠剤、散剤、顆粒剤、カプセル剤、液剤、ドリンク剤などの経口用組成物とすることができる。刺激性がないために剤型に特に制限はなく、種々の剤型の経口用組成物を製造するための各種成分および製造法は、サプリメント、医薬品等の製造分野で公知な成分から適宜選択することができる。保存、流通に適し、服用時に変形、崩壊が生じず、経口で簡単に服用できる観点から、錠剤に用いることが好ましい。 The composition for promoting hair growth of the present invention can be made into oral compositions such as tablets, powders, granules, capsules, liquids and drinks. There is no particular restriction on the dosage form because it is non-irritating, and various ingredients and production methods for producing oral compositions of various dosage forms are appropriately selected from ingredients known in the field of production of supplements, pharmaceuticals, etc. be able to. From the viewpoints of being suitable for storage and distribution, not deformed or disintegrating when taken, and easily taken orally, it is preferably used in tablets.
本実施形態の顆粒剤、カプセル剤、または錠剤には、顆粒剤、カプセル剤、または錠剤を形成するための各種の公知の添加剤を添加することができ、賦形剤、結合剤、崩壊剤、滑沢剤、その他の栄養素等を添加することができる。
賦形剤としては、公知の賦形剤が適宜使用できるが、化工澱粉および乳糖の少なくとも１種を、賦形性の観点から卵殻膜成分の重量に対して０．３～３倍用いることが好ましく、１～２．５倍であることがより好ましい。化工澱粉としては、焙焼デキストリンなどのデキストリン、酸化澱粉、低粘性変性澱粉などの１種または２種以上を用いることができる。
Various known additives for forming granules, capsules, or tablets can be added to the granules, capsules, or tablets of the present embodiment, and excipients, binders, disintegrants, , lubricants, other nutrients, etc. can be added.
As the excipient, known excipients can be used as appropriate, but at least one of modified starch and lactose is preferably used in an amount of 0.3 to 3 times the weight of the eggshell membrane component from the viewpoint of excipientability. More preferably, it is 1 to 2.5 times. As the modified starch, one or more of dextrin such as roasted dextrin, oxidized starch, and low-viscosity modified starch can be used.
結合剤としては、公知の結合剤が適宜使用できるが、たとえば、デンプン糊、アラビアゴム糊、ヒドロキシプロピルセルロースなどが挙げられる。
崩壊剤としては、公知の崩壊剤が適宜使用できるが、たとえば、セルロース類などを用いることができる。
滑沢剤としては、公知の滑沢剤が適宜使用できるが、たとえば、ステアリン酸マグネシウム、ショ糖脂肪酸エステル、ワックス類、タルク、ビタミンＣなどが挙げられる。
As the binder, a known binder can be used as appropriate, and examples thereof include starch glue, gum arabic glue, hydroxypropyl cellulose and the like.
As the disintegrant, known disintegrants can be appropriately used, and for example, celluloses can be used.
As the lubricant, known lubricants can be appropriately used, and examples thereof include magnesium stearate, sucrose fatty acid esters, waxes, talc, vitamin C and the like.
また、錠剤には、錠剤の硬度を高くして変形や傷つきを防止し、取扱性を向上させるため、硬度向上剤として卵殻カルシウムを含有することができる。卵殻カルシウムは、鶏卵などの鳥類の卵の殻を粉砕・乾燥した微粉末である。また、錠剤中に含まれる成分の変質や分解を防止し、かつ、錠剤表面の耐傷つき性を向上させるため、コーティング皮膜で覆うことが好ましい。
本実施形態の錠剤の大きさは特に制限されないが、一般には直径が約７～１０ｍｍ程度の円形や楕円形とするのが、取扱性、服用のし易さから好ましい。錠剤の１個の重さは、３５０～６００ｍｇ程度であり、有効成分が好ましくは１０～２４０ｍｇ、より好ましは２０～１５０ｍｇ含まれるようにする。
In addition, the tablet may contain eggshell calcium as a hardness improver in order to increase the hardness of the tablet to prevent deformation and damage and improve handling properties. Eggshell calcium is a fine powder obtained by pulverizing and drying avian egg shells such as chicken eggs. In addition, it is preferable to cover the tablet with a coating film in order to prevent deterioration and decomposition of the components contained in the tablet and to improve the scratch resistance of the tablet surface.
The size of the tablet of the present embodiment is not particularly limited, but generally a circular or oval shape with a diameter of about 7 to 10 mm is preferable from the standpoint of handling and ease of administration. Each tablet weighs about 350-600 mg and preferably contains 10-240 mg, more preferably 20-150 mg of the active ingredient.
本発明の経口用の液剤（水剤、懸濁剤、乳剤、シロップ剤、エリキシル剤等）、ドリンク剤は、有効成分を一般的に用いられる希釈剤（精製水、エタノール又はそれらの混液等）に溶解、懸濁又は乳化して製造される。さらにこの液剤は、乳化剤、懸濁化剤、湿潤剤、甘味剤、芳香剤、保存剤等を含有していてもよい。 The oral liquid preparations (solutions, suspensions, emulsions, syrups, elixirs, etc.) and drinks of the present invention contain the active ingredient in a commonly used diluent (purified water, ethanol, mixture thereof, etc.). It is manufactured by dissolving, suspending or emulsifying in In addition, the liquid formulation may contain emulsifying agents, suspending agents, wetting agents, sweetening agents, flavoring agents, preservatives and the like.
本発明の経皮用組成物としては、たとえば皮膚外用剤が挙げられる。皮膚外用剤は、液剤、クリーム剤、軟膏剤、ゲル剤、エアゾール剤等に適用できる。皮膚外用剤には、水、低級アルコール、溶解補助剤、界面活性剤、乳化安定剤、ゲル化剤、粘着剤、その他通常使用される基剤成分を配合でき、必要に応じて副腎皮質ホルモン、血管拡張剤、保湿剤、殺菌剤、清涼化剤、ビタミン類、香料色素等を適宜量で配合することができる。 Examples of transdermal compositions of the present invention include skin external preparations. External skin preparations can be applied to liquids, creams, ointments, gels, aerosols, and the like. Water, lower alcohols, solubilizers, surfactants, emulsion stabilizers, gelling agents, adhesives, and other commonly used base ingredients can be added to external preparations for skin. Vasodilators, moisturizing agents, bactericides, cooling agents, vitamins, flavoring pigments, etc. can be blended in appropriate amounts.
さらに、本発明の経口用組成物は、菓子類、飲料、健康食品、保存食品、加工食品などの食品添加剤とすることができる。ここで、「飲食品」「サプリメント」「医薬部外品」の対象はヒトに限定されるのもではなく、ペットや家畜のような哺乳動物用の飼料も包含する。また、「飲食品」「サプリメント」の概念には、通常の飲食品の他、経腸栄養食品、栄養機能食品、機能性表示食品、特定保健用食品などが包含される。 Furthermore, the oral composition of the present invention can be used as a food additive for sweets, beverages, health foods, preserved foods, processed foods and the like. Here, the objects of "food and drink", "supplements" and "quasi-drugs" are not limited to humans, but also include feeds for mammals such as pets and livestock. In addition, the concepts of "food and drink" and "supplement" include not only normal food and drink, but also enteral nutrition foods, foods with nutrient function claims, foods with function claims, and foods for specified health uses.
以下に、本発明を実施例に基づいて詳細に説明するが、本発明はこれらの実施例により限定されるものではない。 EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.
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