JP2022125528A - Liquid medicine application device for manufacturing percutaneous absorption type preparation - Google Patents

Abstract

To provide a liquid medicine application device for manufacturing percutaneous absorption type preparations, which makes it easy to prevent contamination in replacing a medicine to be used and is capable of manufacturing small amounts and various types of percutaneous absorption type preparations with excellent production efficiency.SOLUTION: A liquid medicine application device for manufacturing percutaneous absorption type preparations comprises: an application table 1 on which an application object body W is mounted; a liquid discharge head 2 for liquid medicine application; a liquid discharge head 3 for adhesive compound application; a drive mechanism 4 for configuring the application table 1 and the liquid discharge head 2 for liquid medicine application and/or the liquid discharge head 3 for adhesive compound application to be relatively movable in a plane; and controllers 5, 6 for performing drive control on the liquid discharge head 2 for liquid medicine application, the liquid discharge head 3 for adhesive compound application, and the drive mechanism 4. For the liquid discharge head 2 for liquid medicine application, a liquid discharge head 2 having at least a liquid contact part configured in a disposable specification is used.SELECTED DRAWING: Figure 1

Description

TECHNICAL FIELD The present invention relates to a liquid drug applicator for manufacturing a transdermal drug preparation.

Transdermal absorption type preparations (plasters, tapes), which have become widely used in recent years, consist of a support, an adhesive layer containing or carrying an active ingredient, and a liner, which are laminated in this order. things are common.
This percutaneous absorption type preparation is prepared by mixing an active ingredient in an adhesive and coating it on a support, or by forming an adhesive base layer on a support or a liner and containing the active ingredient in the adhesive base layer. Alternatively, it is produced by supporting it (see, for example, Patent Documents 1 and 2).

JP-A-8-295624 Japanese Patent No. 4913738 WO2020/114953

By the way, since the conventional production equipment for transdermal absorption type preparations is designed to continuously produce a large amount of transdermal absorption type preparations, it is necessary to batch-produce a large variety of transdermal absorption type preparations in small quantities. In particular, there is a problem that it is troublesome to prevent contamination when switching chemicals to be used, resulting in a decrease in production efficiency.

In view of the above-mentioned problems of conventional production equipment for transdermal therapeutic preparations, the present invention provides a transdermal therapeutic preparation that can easily prevent contamination when switching drugs to be used, has high production efficiency, and can produce a large variety of transdermal therapeutic preparations in small quantities. It is an object of the present invention to provide a liquid drug applicator for manufacturing a transdermal drug that can manufacture a

In order to achieve the above object, the liquid drug applicator for manufacturing a transdermal drug preparation of the present invention comprises:
a coating table on which the object to be coated is placed;
a liquid ejection head for applying liquid medicine;
a driving mechanism configured to relatively move the application table and the liquid ejection head for applying the liquid medicine in a plane;
A liquid drug applicator for manufacturing a transdermal drug formulation comprising a liquid ejection head for applying a liquid drug and a controller for driving and controlling a drive mechanism,
The liquid ejection head for applying the liquid medicine is characterized in that at least the liquid contacting portion of the liquid ejection head is configured to be disposable.

In this case, a detection device may be provided for detecting the application amount of the liquid ejected from the liquid ejection head for applying the liquid medicine.

Also, a liquid ejection head for applying an adhesive,
a driving mechanism configured to relatively move the coating table and the liquid ejection head for coating the adhesive within a plane;
A liquid ejection head for applying adhesive and a controller for driving and controlling a drive mechanism can be provided.

According to the liquid drug applicator for producing a transdermal drug preparation of the present invention, the liquid drug applicator is provided with a liquid drug applicator in which at least the liquid-contacting portion of the liquid jet head is configured to be disposable. It is easy to prevent contamination when switching the drug to be used, and it is possible to manufacture a large variety of transdermal preparations in small quantities with high production efficiency.

Further, by providing a detection device for detecting the application amount of the liquid ejected from the liquid ejection head for applying the liquid medicine, it is possible to accurately grasp the application amount of the liquid, that is, the application amount of the medicine.

Also, by providing the liquid ejection head for applying the adhesive, the application of the adhesive can be performed in the same process.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an explanatory diagram showing an embodiment of a liquid drug applicator for manufacturing a transdermal drug preparation of the present invention; FIG. 3 is an explanatory diagram showing an example of applying a liquid drug using the liquid drug applicator for manufacturing the same transdermal drug.

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of a liquid drug applicator for manufacturing a transdermal drug preparation according to the present invention will be described below with reference to the drawings.

FIG. 1 shows an embodiment of a liquid drug applicator for producing transdermal drug preparations according to the present invention.
This liquid drug applicator for manufacturing a transdermal drug formulation comprises an applicator table 1 on which an object W to be applied is placed, a liquid ejection head 2 for applying a liquid drug, and a liquid ejection head 3 for applying an adhesive. , a drive mechanism 4 for relatively moving the application table 1 and the liquid ejection head 2 for applying the liquid medicine and/or the liquid ejection head 3 for applying the adhesive agent in a plane, and the liquid ejection for applying the liquid medicine. Controllers 5 and 6 for driving and controlling the head 2, the liquid ejection head 3 for applying adhesive, and the drive mechanism 4, and a control PC 7 for controlling these are provided.

On the coating table 1, an object to be coated W (a support or liner (including a support or liner having a pressure-sensitive adhesive layer formed on its surface) which constitutes a transdermal preparation; hereinafter the same) is placed. Although it has an independent structure, its form is not particularly limited as long as it has a structure on which the object W to be coated can be placed. can also be adopted.

The liquid ejection head 2 for applying a liquid chemical is for non-contact spraying and coating of the liquid chemical on a predetermined position of the object W placed on the coating table 1, and has the following functions. I am preparing.
・At least the liquid-contacting part of the liquid ejection head, which is in contact with the liquid medicine, must be disposable (no need for cleaning validation).
・Able to handle liquid drugs with a viscosity range of 0.5 to 400 mPa・s ・Able to control the ejection droplet volume in the order of 1 to 100 nl/droplet ・Able to eject particles of up to 100 μm As for the liquid ejection head 2, for example, only the pipe portion which is the wetted portion is replaceable by the user, and the pipe portion deforms from the outside to generate a pressure wave. An unnecessary inkjet head (trade name “PipeJet (registered trademark) head” manufactured by Microjet) (see Patent Document 3 for a specific mechanism) can be used.

The adhesive application liquid ejection head 3 is for spraying and applying an adhesive to a predetermined position of the object W placed on the application table 1 in a non-contact manner, and has the following functions. I am preparing.
・At least the wetted part of the liquid ejection head, which is in contact with the adhesive, is detachable, making it easy to clean and maintain is capable of ejecting a minimum of 0.5 nl/drop ・Equipped with a tappet position calibration mechanism to reduce changes in the amount of coating due to wear of parts. A dispenser head (trade name: “Piezojet (X-JET) head”) that does not require replacement of the head body that includes a piezo element that generates pressure waves by deforming the pipe from the outside. , manufactured by SSI Japan) can be used.
Here, the liquid ejection head 3 is equipped with an air cooling mechanism (not shown) for suppressing a temperature rise during operation, and a compressed air generating source 31 such as a compressor for supplying compressed air to the air cooling mechanism and an air regulator. is provided with a regulator 32 for

In this embodiment, the drive mechanism 4 that relatively moves the application table 1 and the liquid ejection head 2 for applying the liquid medicine and/or the liquid ejection head 3 for applying the adhesive agent in a plane is used for liquid ejection. The head 2 and the liquid ejection head 3 for applying adhesive are fixedly installed, and the application table 1 can be moved within a plane in the X-axis and Y-axis directions via the XY-axis stage 41 and the Zθ-axis stage 42 of the drive mechanism 4. and rotatable around the Z axis.
As a result, the controllers 5 and 6 drive and control the liquid ejection head 2 for applying the liquid medicine, the liquid ejection head 3 for applying the pressure sensitive adhesive, and the drive mechanism 4, so that, for example, as shown in FIG. A liquid medicine and/or an adhesive can be sprayed and applied to a predetermined position of the object W placed on the 1 without contact.

Note that, instead of the coating table 1, for example, when a conveyor structure that moves while the object to be coated W is placed thereon is adopted, the liquid ejection head 2 for coating the liquid chemical and/or the adhesive coating It is also possible to movably configure the liquid ejection head 3 for application, or to install a plurality of liquid ejection heads 2 for applying liquid medicine and/or liquid ejection heads 3 for applying adhesive. can.
A device for automatically aligning (placing and moving) the object W to be coated can also be provided.

Various detection devices 8 such as sensors are used to detect the state of the liquid medicine and the adhesive that are sprayed and applied onto the object W to be coated from the liquid ejection head 2 for applying liquid medicine and the liquid ejection head 3 for applying adhesive. monitored and controlled by
As an example of the detection device 8 , specifically, a table observation camera 81 for photographing the coating table 1 from a vertical direction or an oblique direction and a light source 82 for illuminating the coating table 1 are provided.
The image data captured by the table observation camera 81 is used to spray and apply the liquid medicine and the liquid medicine from the liquid discharge head 2 for liquid medicine application and the liquid discharge head 3 for adhesive application to the object W to be coated. The liquid discharge head 2 for applying the liquid medicine and the liquid for applying the adhesive are detected according to the position and state of the object W to be coated placed on the coating table 1. A liquid medicine or an adhesive can be sprayed and applied from the ejection head 3 .
Here, the application amount of the liquid medicine or adhesive is determined by photographing with the table observation camera 81 each time of spraying (each discharge), capturing the photographed image data, for example, into the control PC 7, and determining the amount of the discharged droplets. The amount of coating is calculated by calculating the volume from the size and shape of the coating.
As a result, the application amount of the liquid, that is, the application amount of the liquid medicine or adhesive can be accurately grasped in real time, and the liquid medicine or adhesive can be accurately sprayed or applied.

According to this liquid drug applicator for producing a transdermal drug formulation, at least the liquid-contacting portions of the liquid drug-applying liquid ejection head 2 and the pressure-sensitive adhesive-applying liquid ejection head 3 are configured to be disposable. As a result, it is easy to prevent contamination when switching between chemicals and adhesives to be used, and the application of liquid chemicals and adhesives can be carried out in the same process. can be manufactured.

As described above, the liquid drug applicator for manufacturing a transdermal drug preparation of the present invention has been described based on a plurality of examples, but the present invention is not limited to the configurations described in the above examples. The configuration can be changed as appropriate without departing from the scope of the invention, such as by appropriately combining the configurations described in the embodiments.

The liquid drug applicator for manufacturing transdermal therapeutic preparations of the present invention can easily prevent contamination when switching the drug to be used, and can manufacture a large variety of transdermal therapeutic preparations in small quantities with high production efficiency. It can be suitably used for the production of various transdermal preparations.

1 coating table 2 liquid ejection head (for liquid medicine coating)
3 Liquid ejection head (for applying adhesive)
31 pressure air generation source 32 air adjustment regulator 4 drive mechanism 5 controller (for liquid ejection head)
6 controller (for application table)
7 Control PC
8 detection device 81 table observation camera 82 light source W object to be coated

Claims (3)

a coating table on which the object to be coated is placed;
a liquid ejection head for applying liquid medicine;
a driving mechanism configured to relatively move the application table and the liquid ejection head for applying the liquid medicine in a plane;
A liquid drug applicator for manufacturing a transdermal drug formulation comprising a liquid ejection head for applying a liquid drug and a controller for driving and controlling a drive mechanism,
A liquid drug applicator for producing a transdermal drug preparation, wherein at least a liquid-contacting portion of the liquid ejection head for applying the liquid drug is disposable. 2. The liquid drug applicator for manufacturing a transdermal drug formulation according to claim 1, further comprising a detection device for detecting the amount of liquid applied from the liquid ejection head for liquid drug application. . a liquid ejection head for applying adhesive;
a driving mechanism configured to relatively move the coating table and the liquid ejection head for coating the adhesive within a plane;
3. A liquid drug applicator for producing a transdermal drug preparation according to claim 1, further comprising a liquid ejection head for applying adhesive and a controller for driving and controlling a drive mechanism.

Images