JP2022042517A - Topical composition for scalp - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a topical composition for the scalp improved in efficiency of delivery to the scalp and to its deep follicle.

SOLUTION: A topical composition for the scalp contains lower alcohol and is accommodated in a container comprising a coating part made of a soft porous material.

SELECTED DRAWING: Figure 1

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to an external composition for the scalp. More specifically, the present invention relates to an external composition for scalp, which is contained in a container having a coating portion made of a soft porous material.

The skin of mammals including humans is composed of epidermis, dermis and subcutaneous tissue, and has a structure in which skin appendages such as hair follicles, sweat glands and sebaceous glands are present.

There are many hair follicles on human skin, but the density and depth of the hair follicles vary greatly depending on the site (Non-Patent Document 1). It is known that the hair follicles of the abdomen, arms and lower thighs, which occupy most of the human skin, tend to have a low hair follicle density of 60 to 80 hair follicles / cm ² and a shallow depth. On the other hand, the hair follicles of the human scalp have a very high hair follicle density of 350 to 500 hair follicles / cm ² and a deep depth. In addition, the hair follicles such as the abdomen have a structure that is slightly inclined with respect to the surface, whereas the hair follicles on the scalp have a relatively straight and long structure from the surface of the skin to the bottom. It has been known.

When the active ingredient such as a drug is administered and applied percutaneously, the route through which the active ingredient penetrates through the skin includes the route through the stratum corneum of the epidermis and the route through the skin appendages such as hair follicles. Are known. Since the stratum corneum occupies most of the surface area of the skin, the application site is wide, but there are problems such as difficulty in permeating large components. On the other hand, although the ratio of skin appendages such as hair follicles to the surface area of the skin is low, there is an advantage that the permeation resistance is often lower than that of the stratum corneum root.

As an external composition applied to the scalp, there are a therapeutic agent and an ameliorating agent for scalp eczema that cause symptoms such as itching in the scalp, a hair nourishing agent, a hair growth agent and the like. It has been pointed out that one of the causes of scalp eczema is the overgrowth of Malassezia fungus in the hair follicles of the scalp. Hair growth agents and hair nourishing agents are formulations that are desired to deliver a sufficient amount of the active ingredient to the blood flow of the hair matrix cells existing in the deep part of the hair follicle and the capillaries of the dermis and the subcutaneous tissue passing under the hair follicle cells. In addition, dryness of the scalp and deterioration of the barrier function worsen the scalp environment and cause dandruff, itchiness, thinning hair, etc., and therefore, it is desired to prevent or improve the scalp at an early stage. Any such external composition is expected to benefit from delivering the active ingredient to the scalp and deep into its hair follicles.

However, when applying the external composition to the scalp, there is a concern that the hair may interfere and it may be difficult to deliver a sufficient amount of the external composition to the scalp and the deep part of the hair follicle. Therefore, in order to avoid hair and apply the external composition to the scalp, a spray-type container that discharges the external composition in the form of a spray should be adopted, and the external composition should be pinpointed to the site where the opening is pressed. It is the mainstream to adopt a discharge type container (so-called narrow mouth container for liquid, see FIG. 4).

Functional Histology, 4th Edition, Translated by Hidetomo Yamada, Igaku-Shoin, July 2001

An object of the present invention is to provide an external composition for scalp with improved delivery efficiency to the scalp and the deep part of the hair follicle.

The present inventors, as a container for accommodating an external composition containing a lower alcohol, press or spread a coating portion made of a soft porous material while pressing the coating portion, and discharge the external composition in a planar manner. It has been found that the efficiency of delivery of the external composition to the deep part of the hair follicle of the scalp is unexpectedly improved by adopting the container of the type. The present invention is based on this novel finding.

The present invention relates to, for example, the following inventions.
[1] An external composition for the scalp, which contains a lower alcohol and is contained in a container having a coating portion formed of a soft porous material.
[2] The external composition for scalp according to [1], which is used for a hair growth site.
[3] The external composition for scalp according to [1] or [2], wherein the content of the lower alcohol is 5 to 70 w / w% based on the total amount of the external composition.
[4] For prevention, treatment, and / or improvement of at least one symptom selected from the group consisting of eczema, dermatitis, hair loss, thinning hair, dandruff, itching, dryness, and decreased barrier function in the scalp, [1]. The composition for external use for the scalp according to any one of [3].
[5] The composition for external use on the scalp according to any one of [1] to [4], wherein the lower alcohol is ethanol.
[6] The external composition for scalp according to any one of [1] to [5], which is a solubilizing composition.
[7] The external composition for scalp according to any one of [1] to [6], further containing at least one selected from the group consisting of steroids, monoterpenes, and antihistamine components.
[8] The external composition for scalp according to any one of [1] to [7], which further contains a thickener.
[9] A container-containing external composition for scalp, wherein the external composition for scalp containing a lower alcohol is housed in a container having a coating portion formed of a soft porous material.

According to the present invention, as a container for accommodating an external composition containing a lower alcohol, a container having a coating portion formed of a soft porous material is adopted, so that the external composition for the deep part of the hair follicle of the scalp is adopted. The delivery efficiency of goods is improved. Since the container is a type of container in which the applied portion is pressed against the application site or spread while being pressed to discharge the external composition in the container in a planar manner, the external composition is directly applied to the scalp while avoiding hair. It was considered difficult to apply the substance and it was not suitable as a container for containing an external composition for scalp. That is, the effect of the present invention on improving the delivery efficiency of the external composition to the deep part of the hair follicle of the scalp is completely surprising.

It is a perspective view which shows one Embodiment of the container which includes the coating part made from the soft porous material. It is explanatory drawing of the measurement method of the permeation amount using the scalp model with hair follicles. (A) No hair, (b) With hair. It is a graph which shows the result of Test Example 1. FIG. It is a perspective view which shows an example of the narrow mouth container for liquids.

Hereinafter, embodiments for carrying out the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

The external composition for scalp of the present invention contains a lower alcohol. Further, the external composition for scalp of the present invention is contained in a container provided with a coating portion made of a soft porous material.

〔container〕
FIG. 1 is a perspective view showing a container according to an embodiment. The container is called a liquid coating stopper type container or the like provided with a soft porous coating portion. The liquid coating plug-type container 100 provided with the soft porous coating portion shown in FIG. 1 includes a container body 10 for storing the external composition 20 and a cap 30 detachably screwed into the container body 10. The cap 30 has a substantially inverted U-shaped cross section, and a screw is formed on the inner peripheral surface. This screw is screwed with the screw 40 of the container body 10. The container body 10 is formed with a coating portion 50 for discharging the external composition 20. The coating portion 50 may be integrally molded with the container body 10, or may be detachably configured.

The coating portion 50 is formed of a soft porous material. In the present specification, "formed by a soft porous material" means at least a part of a coated portion (preferably about 70% or more, more preferably about 80% or more, still more preferably about 90% or more, and above all. It means that the whole) is composed of a soft porous material. The soft porous material is a porous material having softness suitable for application to the skin and having a large number of pores, regardless of whether the external composition inside the container is discharged to the outside of the container. Just do it. The structure of the soft porous material may be any of a sponge structure, a balloon structure, a honeycomb structure and the like. The pore diameter of the pores is preferably 1 mm or less, more preferably 0.7 mm or less, and further preferably 0.5 mm or less, from the viewpoint that the external composition can be applied more efficiently. It is preferably 0.3 mm or less, and even more preferably 0.3 mm or less. Further, the pore diameter of the pores is preferably 0.01 μm or more, more preferably 0.1 μm or more, and further preferably 1 μm or more.

Specific examples of the soft porous material include a resin foam having an open cell structure. The resin foam may contain a closed cell structure. Specific examples of the resin foam include natural rubber foam; synthetic rubber foam such as polyurethane foam, polystyrene foam, polypropylene foam, and polyethylene foam; and melamine resin foam. As the resin foam, natural rubber foam and synthetic rubber foam are preferable, natural rubber foam and polyurethane foam (for example, soft urethane) are more preferable, and natural rubber foam is preferable because the effect of the present invention is more remarkably exhibited. Rubber foam is more preferred. The coating portion 50 may be formed by using one of these soft porous materials alone, or may be formed by using two or more of them in combination.

Examples of the material forming the container body 10 and the cap 30 include metals such as polyethylene terephthalate (PET), polypropylene (PP), polyethylene (high density polyethylene: HDPE, low density polyethylene: LDPE), polystyrene, glass, and aluminum. Can be mentioned. These may be used alone or in combination of two or more. Further, the container body 10 and the cap 30 may be made of the same material or may be made of different materials.

The shape of the container body 10 is not limited to the shape shown in FIG. 1 as long as it includes a coating portion made of a soft porous material. For example, the coating portion is sideways, downward, slightly upward or downward. It may have a shape bent so as to have an inclined direction. The cap 30 is not limited to the screw fitting structure as long as it is detachable from the container body 10, and may have any fitting structure such as one-touch lock fitting or outer fitting.

〔Composition〕
The external composition for scalp according to this embodiment contains a lower alcohol. As used herein, the lower alcohol means a monohydric alcohol having 1 to 6 carbon atoms.

The lower alcohol is not particularly limited as long as it is physiologically or pharmaceutically acceptable. Specific examples of the lower alcohol include ethanol, propanol, isopropanol, n-butyl alcohol, s-butyl alcohol, t-butyl alcohol, isobutyl alcohol, pentyl alcohol and hexyl alcohol. From the viewpoint of exerting the effect of the present invention more remarkably, the lower alcohol is preferably ethanol, propanol, isopropanol, n-butyl alcohol, s-butyl alcohol, t-butyl alcohol and isobutyl alcohol, and ethanol and isopropanol are preferable. Is more preferable, and ethanol is even more preferable. The lower alcohol may be used alone or in combination of two or more.

The content of the lower alcohol in the external composition for scalp is preferably 5 to 70 w / w% based on the total amount of the external composition, and is preferably 5 to 50 w /, because the effect of the present invention is more remarkable. It is more preferably w%, further preferably 10 to 50 w / w%, and even more preferably 30 to 50 w / w%.

The external composition for scalp according to the present embodiment may further contain an active ingredient or a functional ingredient used in pharmaceutical products, quasi-drugs or cosmetics. Specific examples of the active ingredient or functional ingredient include steroids, moisturizing ingredients, anti-inflammatory ingredients, anti-histamine ingredients, antibacterial ingredients, vitamins, antipruritic ingredients, local anesthetic ingredients, local stimulant ingredients, hair-growth / hair-growth ingredients, and the like. Monoterpen, peptide or its derivative, amino acid or its derivative, cell activation component, anti-aging component, blood circulation promoting component, keratin softening component, whitening component, convergence component, ultraviolet protection component (ultraviolet absorption component, ultraviolet scattering component) Be done. By containing these, it is possible to develop applications according to the active ingredient or the functional ingredient. These active ingredients or functional ingredients may be used alone or in combination of two or more.

The external composition for scalp according to the present embodiment is selected from the group consisting of, for example, eczema, dermatitis, hair loss, thinning hair, dandruff, itch, dryness and deterioration of barrier function in the scalp, depending on the above active ingredient or functional ingredient. It is suitably used for the prevention, treatment and / or amelioration of at least one symptom. Since the external composition for scalp of the present invention improves the efficiency of delivery of the active ingredient or the functional ingredient to the deep part of the hair follicle of the scalp, the desired effect of these ingredients can be fully exerted.

The external composition for scalp according to the present embodiment may further contain at least one selected from the group consisting of steroids, monoterpenes, and antihistamine components. When the external composition for scalp contains a steroid, a monoterpene, or an antihistamine component, the efficiency of delivery to the scalp and the deep part of the hair follicle is further improved. In addition, it is possible to develop applications according to the action of steroids, monoterpenes, or antihistamine components.

Steroids are steroid hormones having a steroid nucleus, derivatives thereof, and salts thereof, which have anti-inflammatory, immunosuppressive, anti-allergic, and the like. Steroids are also called steroidal anti-inflammatory drugs. Commercially available steroids can also be used.

The derivative of the steroid hormone refers to a product obtained by chemically modifying a part of the functional group of the steroid hormone, a product having a protective group added to a part of the functional group, or the like, and includes an isomer. For example, one or more hydrogen atoms in the steroid nucleus are a hydroxyl group, an amino group, a chloro group, a bromo group, an iodine group, a fluoro group, a trifluoro group, a nitro group, a cyano group, a carboxyl group, and 1 to 1 carbon atoms. 6 alkyl groups, 2 to 6 carbon acetyl groups, 6 to 10 carbon aryl groups, 2 to 6 carbon alkynyl groups, 2 to 6 carbon alkenyl groups, 1 to 6 carbon alkoxyl groups, Those substituted with an alkylamino group having 1 to 6 carbon atoms, those esterified with an organic acid (for example, valeric acid, acetic acid, butyric acid, propionic acid, furancarboxylic acid, etc.), steroids by removing the protective group. Examples thereof include precursors modified to have activity as a system anti-inflammatory agent.

The salt of the steroid hormone and its derivative is not particularly limited as long as it is physiologically or pharmaceutically acceptable. Specific examples thereof include salts with alkali metal salts, alkaline earth metal salts, organic bases and the like, and examples thereof include salts with sodium, potassium, calcium, magnesium, ammonium, diethanolamine, ethylenediamine and the like. Furthermore, ammonia, methylamine, dimethylamine, trimethylamine, dicyclohexylamine, tris (hydroxymethyl) aminomethane, N, N-bis (hydroxyethyl) piperazine, 2-amino-2-methyl-1-propanol, ethanolamine, Salts with amines such as N-methylglucamine and L-glucamine; salts with basic amino acids such as lysine, δ-hydroxylysine and arginine can be mentioned. Also, for example, salts with mineral acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitrate, phosphoric acid; methanesulfonic acid, benzenesulfonic acid, paratoluenesulfonic acid, acetic acid, propionic acid, tartrate acid, fumaric acid, maleic acid. , Salts with organic acids such as malic acid, oxalic acid, succinic acid, valeric acid, citric acid, benzoic acid, mandelic acid, silicic acid, lactic acid, glycolic acid, glucuronic acid, ascorbic acid, nicotinic acid, salicylic acid; asparagine Examples thereof include salts with acidic amino acids such as acids and glutamates. The salt of the steroid hormone and its derivative may be a solvate or a hydrate.

Specific examples of steroids include, for example, prednisolone, hydrocortisone, cortisone, dexamethasone, betamethasone, triamsinolone, triamcinolone acetonide, diflupredonado, mometazone, diflucortron, fluoniside, betamethasone, deprodon, clobetazone, alchrometamethasone, flumethasone and derivatives thereof. , As well as these salts, more specifically clobetazole propionate, halobetazole propionate, diflorazone acetate, betamethasone dipropionate, diflucortron valerate, momemethasone furancarboxylate, betamethasone dipropionate, amcinonide, propion. Dexamethasone acid, diflupredonato, fluoricid, hydrocortisone butyrate propionate, prednisolone valerate acetate (prednisolone valerate acetate), betamethasone dipropionate, prednisolone, becromethasone dipropionate, becromethasone propionate, dexamethasone valerate. , Fluosinolone acetonide, triamcinolone acetonide, hydrocortisone butyrate, hydrocortisone acetate, clobetazone acetate, alcromethasone propionate, dexamethasone, hydrocortisone, betamethasone, dexamethasone acetate, hydrocortisone, cortisone acetate, prednisolone acetate.

As the steroid, prednisolone valerate acetate, hydrocortisone butyrate, hydrocortisone butyrate propionate, difluprednisolone, and bechrometazone propionate are preferable, and prednisolone valerate acetate is more preferable, because the effect of the present invention is more remarkably exhibited.

The steroid may be used alone or in combination of two or more.

The content of the steroid in the external composition for scalp according to the present embodiment is not particularly limited, and is appropriately set according to the type of steroid, the type and content of other compounding ingredients, the use of the external composition, the formulation form, and the like. To. As for the steroid content, for example, the total steroid content is preferably 0.01 to 2 w / w% based on the total amount of the external composition, from the viewpoint of exerting the effect of the present invention more remarkably. , 0.02 to 1 w / w%, more preferably 0.025 to 0.5 w / w%, and particularly preferably 0.05 to 0.25 w / w%.

The content ratio of steroid to lower alcohol in the external composition for scalp according to the present embodiment is not particularly limited, and the types of lower alcohol and steroid, the types and contents of other compounding ingredients, the uses and formulation forms of the external composition. It is set appropriately according to the above. Regarding the content ratio of the steroid to the lower alcohol, from the viewpoint of further enhancing the effect of the present invention, for example, the steroid is based on 1 part by weight of the total content of the lower alcohol contained in the external composition for scalp according to the present embodiment. The total content of steroids is preferably 0.0001 to 0.05 parts by weight, more preferably 0.0002 to 0.03 parts by weight, and preferably 0.0003 to 0.02 parts by weight. It is more preferably 0.0005 to 0.01 parts by weight, and particularly preferably 0.0005 to 0.01 parts by weight.

When the external composition for scalp according to the present embodiment contains steroids, for example, prevention, treatment, and / of at least one symptom selected from the group consisting of eczema, dermatitis, dandruff, itch, and dryness in the scalp. Alternatively, it is preferably used for improvement.

The monoterpene has a structure consisting of two isoprene units and is a compound known as a refreshing agent or the like. The monoterpene is not particularly limited as long as it is physiologically or pharmaceutically acceptable. Further, the monoterpene may be d-form, l-form or dl-form.

Specific examples of the monoterpene include monoterpenes such as menthol, eugenol, timole, linalool, anator, simene and terpineol, and dicyclics such as camphor, borneol, cineole, pinen, camfen, isobornole and fenchen. Examples include formal monoterpenes and acyclic monoterpenes such as geraniol, nerol, milsen, milsenol, linalool, linalool acetate and lavandulone.

As a monoterpene, since the effect of the present invention is more remarkable, monoterpene such as menthol, eugenol, timole, limonene, anator, simene and terpineol, camphor, borneol, cineole, pinen, camphen, iso Bicyclic monoterpenes such as borneol and fenchen are preferred, menthol, camphor and borneol are more preferred, and menthol is even more preferred.

The monoterpene may be used alone or in combination of two or more.

As the monoterpene, an essential oil containing a monoterpene may be used. Examples of such essential oils include cool mint oil, peppermint oil, peppermint oil, eucalyptus oil, bergamot oil, spare mint oil, rose oil and cypress oil. Essential oils containing menthol and camphor include, for example, cool mint oil, peppermint oil, peppermint oil and camphor oil.

The content of monoterpene in the external composition for scalp according to the present embodiment is not particularly limited, and is appropriately depending on the type of monoterpene, the type and content of other compounding ingredients, the use of the external composition, the formulation form, and the like. Set. Regarding the content of monoterpene, from the viewpoint of exerting the effect of the present invention more remarkably, for example, the total content of monoterpene is 0.01 to 5.0 w / w% based on the total amount of the external composition. It is preferably 0.05 to 4.0 w / w%, more preferably 0.1 to 3.5 w / w%, and 0.5 to 3.5 w / w%. It is even more preferably 1.0 to 3.5 w / w%, and particularly preferably 1.0 to 3.5 w / w%. When the external composition for scalp according to the present embodiment contains an essential oil as a monoterpene, it is preferable to set the monoterpene content in the essential oil within the above range.

The content ratio of monoterpene to lower alcohol in the external composition for scalp according to the present embodiment is not particularly limited, and the types of lower alcohol and monoterpene, the types and contents of other compounding components, the uses of the external composition and the use of the external composition It is appropriately set according to the formulation form and the like. Regarding the content ratio of monoterpene to lower alcohol, from the viewpoint of further enhancing the effect of the present invention, for example, with respect to 1 part by weight of the total content of lower alcohol contained in the external composition for scalp according to the present embodiment. The total content of the monoterpene is preferably 0.0001 to 1 part by weight, more preferably 0.0005 to 0.8 part by weight, and preferably 0.001 to 0.7 part by weight. It is even more preferably 0.005 to 0.5 parts by weight, and particularly preferably 0.01 to 0.1 parts by weight. When the external composition for scalp according to the present embodiment contains an essential oil as a monoterpene, it is preferable to set the ratio of the monoterpene content in the essential oil within the above range.

When the external composition for scalp according to the present embodiment contains monoterpenes, for example, prevention, treatment, and / or prevention of at least one symptom selected from the group consisting of eczema, dermatitis, dandruff, and itching in the scalp. It is suitably used for improvement.

The antihistamine component is not particularly limited as long as it is physiologically or pharmaceutically acceptable. Examples of the antihistamine component include diphenhydramine, chlorpheniramine, isotipendyl, ketotifen, bepotastin, dimenhydrinate, cyproheptazine, diphenylpyraline, promethazine, iproheptin, emedastin, clemastine, azelastin, levocabastine, hydroxyzine, and mekitadin. Examples include phenazine, cetirizine, oxatomid, terfenadine, epinastine, astemizole, evastin, and salts of these compounds. The salt of the above compound is not particularly limited as long as it is physiologically or pharmaceutically acceptable, and examples thereof include various salts as exemplified above for salts of steroid hormones and derivatives thereof. The salt of the antihistamine component may be a solvate or a hydrate.

Specific examples of the antihistamine component include ethanolamine-based compounds such as diphenhydramine hydrochloride, diphenhydramine, and dimenhydrinate; propylamine-based compounds such as chlorpheniramine maleate and chlorpheniramine; and phenothiazine-based compounds such as promethazine hydrochloride and isotipendyl hydrochloride. ; Piperazine-based compounds such as hydroxyzine; Piperidine-based compounds such as diphenhydramine hydrochloride; epinastin hydrochloride, loratadine, fexofenadine hydrochloride and the like can be mentioned.

As the antihistamine component, an ethanolamine-based compound, a propylamine-based compound, and a phenothiazine-based compound are preferable because the effect of the present invention is more remarkable, and diphenhydramine hydrochloride, diphenhydramine, chlorpheniramine maleate, chlorpheniramine, etc. Isothipendyl hydrochloride is more preferable, and diphenhydramine hydrochloride and diphenhydramine are even more preferable.

The antihistamine component may be used alone or in combination of two or more.

The content of the antihistamine component in the external composition for scalp according to the present embodiment is not particularly limited, and depends on the type of antihistamine component, the type and content of other compounding components, the use and formulation form of the external composition, and the like. Is set as appropriate. Regarding the content of the antihistamine component, from the viewpoint of exerting the effect of the present invention more remarkably, for example, the total content of the antihistamine component is 0.1 to 5.0 w / w based on the total amount of the external composition. %, More preferably 0.15 to 4.5 w / w%, further preferably 0.2 to 4.0 w / w%, and even more preferably 0.3 to 3.0 w / w. % Is particularly preferable.

The content ratio of the antihistamine component to the lower alcohol in the external composition for scalp according to the present embodiment is not particularly limited, and the types of the lower alcohol and the antihistamine component, the types and contents of other compounding components, and the external composition. It is appropriately set according to the intended use, the form of the formulation, and the like. The content ratio of the antihistamine component to the lower alcohol is, for example, from the viewpoint of further enhancing the effect of the present invention, for example, with respect to 1 part by weight of the total content of the lower alcohol contained in the external composition for scalp according to the present embodiment. The total content of the antihistamine component is preferably 0.001 to 1 part by weight, more preferably 0.002 to 0.9 part by weight, and 0.003 to 0.8 part by weight. It is more preferably 0.004 to 0.6 parts by weight, and particularly preferably 0.004 to 0.6 parts by weight.

When the external composition for scalp according to the present embodiment contains an antihistamine component, for example, prevention, treatment, and / of at least one symptom selected from the group consisting of eczema, dermatitis, dandruff, and itching in the scalp. Alternatively, it is preferably used for improvement.

Specific examples of other active ingredients or functional ingredients that can be contained in the external composition for scalp according to the present embodiment are antipruritic ingredients such as crotamitone; glycyrrhizinic acid and its derivatives and salts thereof (for example, dipotassium glycyrrhizinate). , Monoammonium glycyrrhizinate), glycyrrhetinic acid and its derivatives (eg, stearyl glycyrrhetinate) and their salts, salicylic acid and its derivatives (eg, glycol salicylate, methyl salicylate) and their salts, anti-inflammatory components such as allantin; isopropyl Antibacterial components such as methylphenol, benzalkonium chloride, benzethonium chloride; astringent components such as zinc oxide and caramine; local anesthetic components such as ethyl aminobenzoate, oxypolyethoxydodecane, dibucaine, dibucaine hydrochloride, lidocaine, lidocaine hydrochloride; ammonia Local stimulant components such as water; vitamins such as tocopherol acetate, tocopherol, pantenol, vitamin A oil, retinol palmitate; pyrocton olamine, carrot extract, assembly extract, pantothenyl ethyl ether, D-pantothenyl alcohol, Seaweed extract, minoxydil, finasteride, carpronium chloride, hinokithiol, estradiol benzoate, pyridoxin hydrochloride, potassium pantothenate, resorcin, thixetsuninjin tincture, cashew tincture, arnica tincture, dl-α-tocopherol, 2-L-ascorbin Examples thereof include, but are not limited to, hair-growth and hair-growth components such as acid phosphate diester potassium salt and 6-benzylaminopurine.

In addition to the above components, the external composition for scalp according to the present embodiment contains a base or carrier other than lower alcohols usually used for pharmaceuticals, quasi-drugs or cosmetics, as long as the effects of the present invention are not impaired. May be. In addition, the external composition for scalp according to the present embodiment may contain additives usually used for pharmaceuticals, quasi-drugs or cosmetics as long as the effects of the present invention are not impaired.

When the external composition for scalp according to the present embodiment contains a thickener as an additive, the efficiency of delivering the active ingredient or the functional ingredient to the hair follicles is high even if the external composition is applied to the scalp due to the thickening action. There is concern that it will tend to be suppressed. However, according to the present invention, since the external composition is housed in a container having a coating portion made of a soft porous material and used, the scalp and its hair follicles even if it contains a thickener. The efficiency of delivery of the active or functional ingredient to is enhanced.

Examples of the thickener include cellulosic thickeners such as cellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobicized hydroxypropylmethylcellulose, carboxymethylcellulose and carboxyethylcellulose; polyvinyl alcohol, Vinyl thickeners such as polyvinylpyrrolidone and carboxyvinyl polymers; hyaluronic acid, acetylated hyaluronic acid, oligohyaluronic acid, hydrolyzed hyaluronic acid, chondroitin sulfate, alginic acid, and salts thereof (eg, sodium hyaluronate, acetylhyaluronic acid). Mucopolysaccharide thickeners such as sodium, chondroitin sodium sulfate, sodium alginate); guar gum, cationized guar gum, locust bean gum, carrageenan, xanthan gum, alkyl methacrylate copolymer, polyethylene glycol, bentonite, macrogol, quins Seeds, dextran, gellan gum and the like can be mentioned.

As the thickener, a cellulose-based thickener, a vinyl-based thickener, and a mucopolysaccharide-based thickener are preferable from the viewpoint that the effect of the present invention can be obtained more remarkably, and methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, etc. Hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydrophobic hydroxypropylmethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, hyaluronic acid, acetylated hyaluronic acid, oligo hyaluronic acid, hydrolyzed hyaluronic acid, Chondroitin sulfate, alginic acid, sodium hyaluronate, sodium acetylhyaluronate, sodium chondroitin sulfate, sodium alginate are more preferable, and methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobicized hydroxypropylmethylcellulose, carboxymethylcellulose , Carboxymethyl cellulose is more preferred.

The thickener may be used alone or in combination of two or more.

The content of the thickener in the external composition for scalp according to the present embodiment is not particularly limited, and depends on the type of thickener, the type and content of other compounding ingredients, the use of the external composition, the formulation form, and the like. Is set as appropriate. Regarding the content of the thickener, for example, from the viewpoint of exerting the effect of the present invention more remarkably, the total content of the thickener is 0.01 to 3.0 w / w based on the total amount of the external composition, for example. %, More preferably 0.05 to 2.5 w / w%, still more preferably 0.05 to 2.0 w / w%, and 0.1 to 1.5 w / w. % Is particularly preferable.

The content ratio of the thickener to the lower alcohol in the external composition for scalp according to the present embodiment is not particularly limited, and the types of the lower alcohol and the thickener, the types and contents of other compounding components, and the external composition. It is appropriately set according to the intended use, the form of the formulation, and the like. The content ratio of the thickener to the lower alcohol is, for example, from the viewpoint of further enhancing the effect of the present invention, for example, with respect to 1 part by weight of the total content of the lower alcohol contained in the external composition for scalp according to the present embodiment. The total content of the thickener is preferably 0.0001 to 0.6 parts by weight, more preferably 0.0005 to 0.5 parts by weight, and 0.0008 to 0.4 parts by weight. It is more preferably 0.001 to 0.3 parts by weight, and particularly preferably 0.001 to 0.3 parts by weight.

Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, vaseline, gelled hydrocarbon (plastibase, etc.), ozokelite, α-olefin oligomer, and light liquid paraffin; methylpolysiloxane, crosslinked methylpolysiloxane. , Highly polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, cross-linked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, silicone -Silicone oils such as alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicon, phenyl-modified silicone, silicone resin; Higher alcohols such as stearyl alcohol, stearyl alcohol, and behenyl alcohol; sterols such as cholesterol, phytosterol, and phytosteryl hydroxystearate; jojoba oil, meadowfoam oil, sunflower oil, grape seed oil, camellia oil, squalane, shea butter, rice germ oil, etc. Vegetable oils; animal oils such as lanolin, orange raffy oil, squalane, horse oil; polyvinyl butyrate; polyethylene glycol; dioxane; polyester butylene glycol adipate; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononan Esters such as isononyl acid, pentaerythrith tetra2-ethylhexanoate, jojoba oil, tri (capricyl / capric acid) glyceryl; polysaccharides such as dextrin and maltodextrin; 2-6 carbon atoms, 2-4 hydroxyl groups Polyhydric alcohols; organic acids such as succinic acid, glycolic acid, gluconic acid, and citrate; and aqueous bases such as water.

The base or carrier may be used alone or in combination of two or more.

Examples of the additive include an antioxidant, a surfactant, a preservative, a preservative, a pH adjuster, a stabilizer, an irritation reducing agent, a colorant, a fragrance, and a pearl gloss imparting agent.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, sodium pyrosulfite, ascorbic acid, ascorbic acid derivative, tocopherol, tocopherol derivative, erythorbic acid, and L-cysteine hydrochloride.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl acid diglycerol sorbitan and the like. Solbitan fatty acid esters; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor bean paste. Hardened castor oil derivatives such as oil 60 (HCO-60) and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene monolaurylate (20) sorbitan (polysorbate 20), polyoxyethylene monostearate (20) sorbitan (polysorbate 60). ), Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene monooleate (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monopalm oil fatty acid glyceryl; glycerin alkyl ether; seto Alkyl glucoside such as stearyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether and polyoxyethylene behenyl ether; amines such as stearyl amine and oleyl amine; polyoxyethylene / methyl polysiloxane copolymer, lauryl PEG-9 Silicone-based surfactants such as polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone; natural surfactants such as phospholipids, surfactins, and saponins; Examples thereof include fatty acid amidamines; alkylamines such as trilaurylamine, dimethylstearylamine, and di-2-ethylhexylamine; and betaine-based amphoteric surfactants such as dimethylaminopropylamide stearate and laurylhydroxysulfobetaine.

Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxy. Examples thereof include benzyl benzoate, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and salts thereof, chlorhexidine gluconate, alkanediol, and glycerin fatty acid ester.

Examples of the pH adjuster include inorganic acids (hydrochloride, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxylation). (Sodium, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) can be mentioned.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxyanisole.

Examples of the irritation reducing agent include licorice extract, sodium alginate, and 2-methacryloyloxyethyl phosphorylcholine.

Examples of the colorant include inorganic pigments and natural pigments.

Examples of the pearl gloss imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

The additive may be used alone or in combination of two or more.

The pH of the external composition for scalp according to the present embodiment is not particularly limited as long as it is within a physiologically or pharmaceutically acceptable range, but may be, for example, 3 to 9, and may be 3.5 to 8.5. It is preferably present, more preferably 4 to 8, and even more preferably 4 to 7.

The external composition for scalp according to the present embodiment may be, for example, a solubilizing system, an emulsifying system or a powder dispersion system composition. From the viewpoint of exerting the effect of the present invention more remarkably, the composition for external use on the scalp is preferably a solubilizing composition. As used herein, the solubilization system refers to a thermodynamically stable one-phase system in which water and oil do not undergo phase separation and exhibit a uniform and transparent appearance. That is, the solubilization system is a state excluding the emulsification system or the powder dispersion system.

The dosage form of the external composition for scalp according to the present embodiment can be arbitrarily selected according to the use of the external composition for scalp, for example, an external solution, a liniment, a lotion, an ointment, and a cream. , Gel agent, etc. These dosage forms can be formulated according to known methods. The dosage form of the external composition for scalp according to the present embodiment is preferably an external liquid agent, a lotion agent, or a gel agent, and more preferably an external liquid agent or a lotion agent.

The external composition for scalp according to the present embodiment can be applied to the scalp by applying a coating portion formed of a soft porous material over the hair or by pressing it directly against the scalp or spreading it while pressing the coating portion. can. This makes it possible to efficiently deliver the active ingredient or the functional ingredient to the deep part of the hair follicle regardless of whether or not it is a hair growth site. The effective dose of the external composition for scalp according to the present embodiment can be appropriately set according to the type and content of the compounding component, the use and dosage form, the symptom and the like.

The external composition for scalp according to the present embodiment can be used, for example, by applying an appropriate amount to the scalp several times a day or when symptoms (itch, etc.) appear. When applied regularly, it is preferable to apply it to the scalp after washing the scalp and washing the hair. The appropriate amount is not particularly limited, but can be, for example, about 20 to 60 mg / cm ² once per unit area.

Hereinafter, the present invention will be specifically described based on Examples and the like, but the present invention is not limited thereto.

〔Test method〕
(Scalp model with hair follicles)
Silicone sheet (AS ONE, silicone rubber sheet 5t 300 square) with a thickness of 5 mm (corresponding to the depth of hair in human scalp hair follicles) is made into a circular shape of 4.15 cm ² (1.1 cm x 1.1 cm x 3.14). Die-cut. A 1 mm biopsy punch (Kymedical BP-10F, biopsy trepan) was used to form 25 through holes in the thickness direction of the die-cut sheet. This was used as a scalp model with hair follicles.

(Adjustment of discharge amount)
In order to make the discharge amount in the permeation test uniform, the discharge amount was measured in advance for each test product. The test product is one in which the composition (formulation) shown in each table is contained in a narrow-mouthed liquid container (see FIG. 4) or a plug-type container for liquid coating (see FIG. 1) provided with a soft porous coating portion. be. First, the amount of the composition discharged from the container was measured from the change in the weight of the Kim towel before and after pressing the coated portion of the container against the Kim towel 5 times, and this was repeated 5 times to obtain the average value of the measured values. This average value was taken as one discharge amount. From the one-time discharge amount obtained in this way, the number of pressings was adjusted so that the discharge amount was the same (0.4 g) between the test formulations to be compared.

(Penetration test-no hair)
This will be described with reference to FIG. 2 (a). First, a silicon sheet 120 (scalp model with hair follicles) having a through hole 110 is placed on the Kim towel 130, and the test preparation (in FIG. 2A) is a test preparation from the surface opposite to the Kim towel 130 of the scalp model with hair follicles. The liquid coating stopper type container 100) provided with the soft porous coating portion was pressed evenly. The number of pressings was adjusted so that the discharge amount of each test product was 0.4 g. After pressing, the permeation liquid 140 that had passed through the through hole 110 was absorbed by the Kim Towel 130. From the change in the weight of the Kim towel before and after pressing, the amount of the composition permeated into the Kim towel was measured. This measured value was taken as the amount of penetration into hair follicles (without hair).

(Penetration test-with hair)
This will be described with reference to FIG. 2 (b). First, a silicon sheet 120 (scalp model with hair follicles) having a through hole 110 is placed on the Kim towel 130, and a hair sample 150 (Bulux, BM-B15) is placed on the surface opposite to the Kim towel 130 of the scalp model with hair follicles. ) Was placed. The test product (in FIG. 2B, the liquid coating stopper type container 100 provided with the soft porous coating portion) was evenly pressed from the surface on which the hair sample 150 was placed. The number of pressings was adjusted so that the discharge amount of each test product was 0.4 g. After pressing, the permeation liquid 140 that had passed through the through hole 110 was absorbed by the Kim Towel 130. From the change in the weight of the Kim towel before and after pressing, the amount of the composition permeated into the Kim towel was measured. This measured value was taken as the amount of penetration into hair follicles (with hair).

[Test Example 1: Comparison of containers (1)]
Each of the formulations shown in Table 1 was prepared and placed in a liquid coating plug-type container or a liquid narrow-mouthed container equipped with a soft porous coating portion formed of a soft porous natural rubber foam to prepare a test preparation. .. Blue No. 1 is added to improve the visibility of the prescription.

The permeation amount (without hair) and the permeation amount (with hair) of each test preparation were measured by the method described in [Test method]. The results are shown in Table 2 and FIG. FIG. 3A is a graph in which the permeation amount (without hair) is plotted against the ethanol concentration. FIG. 3B is a graph in which the permeation amount (with hair) is plotted against the ethanol concentration.

As shown in Table 2 and FIG. 3, surprisingly, the liquid coating stopper type container provided with the soft porous coating portion in the range of at least the ethanol concentration of 5 to 70 w / w% regardless of the presence or absence of hair. However, the amount of penetration of the scalp into the hair follicles was higher. In particular, in the case of the plug-type container for liquid coating provided with the soft porous coating portion, the amount of permeation of the scalp into the hair follicles was remarkably large in the ethanol concentration range of 5 to 50 w / w% in the case of hair.

[Test Example 2: Comparison of prescriptions (1)]
Each of the formulations shown in Table 3 was prepared and placed in a liquid coating plug-type container or a liquid narrow-mouthed container equipped with a soft porous coating portion formed of a soft porous natural rubber foam to prepare a test preparation. .. Blue No. 1 is added to improve the visibility of the prescription.

The permeation amount (with hair) of each test product was measured by the method described in [Test method]. Formulas 4 and 6, which are the same formulations as Formulas 7 and 8, except that they do not contain prednisolone valerate acetate (PVA), were measured in the same manner. The results are also shown in Table 4.

As shown in Table 4, when the composition contained in the container contained PVA in addition to ethanol, the amount of permeation of the scalp into the hair follicles (with hair) was significantly increased. This effect was more remarkable in the case of a liquid coating stopper type container provided with a soft porous coating portion.

[Test Example 3: Comparison of prescriptions (2)]
Each of the formulations shown in Table 5 was prepared and placed in a liquid coating plug-type container or a liquid narrow-mouthed container equipped with a soft porous coating portion formed of a soft porous natural rubber foam to prepare a test preparation. .. Blue No. 1 is added to improve the visibility of the prescription.

The permeation amount (with hair) of each test product was measured by the method described in [Test method]. Formulation 6 and Formulation 5, which are the same formulas as Formulation 9 (or Formulation 10) and Formulation 11, except that they do not contain l-menthol, were measured in the same manner. The results are shown in Tables 6 and 7.

As shown in Tables 6 and 7, the amount of permeation of the scalp into the hair follicles (with hair) was significantly increased by containing menthol in addition to ethanol in the composition contained in the container. This effect was more remarkable in the case of a liquid coating stopper type container provided with a soft porous coating portion.

[Test Example 4: Comparison of prescriptions (3)]
The formulations shown in Table 8 were prepared and placed in a liquid coating stopper type container provided with a soft porous coating portion formed of a soft porous natural rubber foam or a liquid narrow mouth container to prepare a test preparation. Blue No. 1 is added to improve the visibility of the prescription.

The permeation amount (with hair) of Formulation 12 was measured by the method described in [Test method]. Formulation 6, which is the same formula as formula 12 except that it does not contain diphenhydramine hydrochloride, was also measured in the same manner. The results are shown in Table 9.

As shown in Table 9, when the composition contained in the container contained diphenhydramine hydrochloride in addition to ethanol, the amount of permeation of the scalp into the hair follicles (with hair) was significantly increased. This effect was more remarkable in the case of a liquid coating stopper type container provided with a soft porous coating portion.

[Test Example 5: Comparison of containers (2)]
Each of the formulations shown in Table 10 was prepared and placed in a liquid coating stopper type container provided with a soft porous coating portion formed of a soft porous natural rubber foam or a liquid narrow mouth container to prepare a test preparation. .. Blue No. 1 is added to improve the visibility of the prescription.

The permeation amount (with hair) of each test product was measured by the method described in [Test method]. The results are also shown in Table 11.

External compositions containing a thickener (hydrophobicized hydroxypropylmethylcellulose) tend to be less viscous and therefore generally less likely to penetrate into the small hair follicles of the scalp. However, as shown in Table 11, even in the case of an external composition containing a thickener, the amount of permeation of the scalp into the hair follicles by using a plug-type container for liquid coating provided with a soft porous coating portion. (With hair) increased significantly.

[Test Example 6: Comparison of containers (3)]
The formulation 4 shown in Table 1 is housed in a liquid coating stopper type container provided with a soft porous coating portion made of a soft porous polyurethane foam (soft urethane) or a liquid narrow mouth container to be a test preparation. And said. The permeation amount (with hair) of each test product was measured by the method described in [Test method]. The results are also shown in Table 12.

As shown in Table 12, even when a liquid coating plug-type container provided with a soft porous coating portion made of a soft porous polyurethane foam (soft urethane) is used, the amount of penetration into hair follicles is high. Was done.

Separately, the same amount (0.4 g) of the formulation 4 as that used in the container is dropped onto the hair sample 150 shown in FIG. 2 (b), and the mixture is spread with a finger to the container. We also evaluated the case where it was applied without using. As a result, it was confirmed that the test product of Formulation 4 was repelled by the hair and was very difficult to permeate even when it was spread with a finger, and the permeation amount tended to be inferior to that when the liquid narrow-mouthed container was used.

[Example of pharmaceutical prescription]
The following is an example of the pharmaceutical formulation of the present invention. When applied to the scalp, these lotions not only can be applied over a wide area, but also do not easily drip, and even if there is hair, there is a feeling that the liquid has reached the scalp sufficiently, and the effect is excellent.

<Formulation example 1: Lotion agent>
(1) Ion-exchanged water residue (2) Prednisolone valeric acid ester Acetic acid ester 0.15% by weight
(3) l-menthol 3.5% by weight
(4) 1,3-butylene glycol 5% by weight
(5) Paraben 0.1% by weight
(6) Disodium edetate 0.05% by weight
(7) Hydrophobicized hydroxypropylmethylcellulose 0.1% by weight
(8) 45% by weight of absolute ethanol
A formulation containing each of the above ingredients is prepared according to a conventional method. The lotion agent of the present embodiment can be produced by filling the prepared formulation in a container having a coating portion formed of a soft porous material (natural rubber foam).

<Pharmaceutical prescription example 2: Lotion agent>
(1) Ion-exchanged water residue (2) Diphenhydramine hydrochloride 1.0% by weight
(3) l-menthol 3.5% by weight
(4) 1,3-butylene glycol 10% by weight
(5) Paraben 0.1% by weight
(6) Disodium edetate 0.05% by weight
(7) Hydrophobicized hydroxypropylmethylcellulose 0.2% by weight
(8) 50% by weight of absolute ethanol
A formulation containing each of the above ingredients is prepared according to a conventional method. The lotion agent of the present embodiment can be produced by filling the prepared formulation in a container having a coating portion formed of a soft porous material (natural rubber foam).

<Pharmaceutical prescription example 3: Lotion agent>
(1) Ion-exchanged water residue (2) Dipotassium glycyrrhizinate 0.1% by weight
(3) Tocopherol acetate 0.05% by weight
(4) 1,3-butylene glycol 5% by weight
(5) Paraben 0.1% by weight
(6) Disodium edetate 0.05% by weight
(7) Carboxyvinyl polymer 0.15% by weight
(8) Potassium hydroxide 0.05% by weight
(9) Absolute ethanol 10% by weight
A formulation containing each of the above ingredients is prepared according to a conventional method. The lotion agent of the present embodiment can be produced by filling the prepared formulation in a container having a coating portion formed of a soft porous material (polyurethane foam).

<Prescription example 4: Emulsifying lotion>
(1) Ion-exchanged water residue (2) Prednisolone valeric acid ester Acetic acid ester 0.15% by weight
(3) Allantoin 0.2% by weight
(4) Dipropylene glycol 3% by weight
(5) Diglycerin 1% by weight
(6) Light liquid paraffin 1.5% by weight
(7) Isopropyl palmitate 0.5% by weight
(8) Sorbitan monostearate 0.5% by weight
(9) Polysorbate 60 1.5% by weight
(10) Paraben 0.2% by weight
(11) Disodium edetate 0.05% by weight
(12) Carboxyvinyl polymer 0.2% by weight
(13) Triethanolamine 0.3% by weight
(14) Absolute ethanol 5% by weight
A formulation containing each of the above ingredients is prepared according to a conventional method. The emulsified lotion of the present embodiment can be produced by filling the prepared formulation in a container having a coating portion formed of a soft porous material (natural rubber foam).

10, 11 ... Container body, 20, 21 ... External composition, 30, 31 ... Cap, 40, 41 ... Screw, 50 ... Coating part, 51 ... Opening (coating part), 100 ... Soft porous coating part Liquid application plug-type container, 110 ... through hole, 120 ... silicon sheet, 130 ... Kim towel, 140 ... penetrant, 150 ... hair sample, 200 ... narrow mouth container for liquid.

Claims (7)

With lower alcohol
Containing at least one selected from the group consisting of steroids, monoterpenes, and antihistamine components,
A container provided with a coating portion made of a soft porous material (provided that the chemical solution coating tool has a coating portion for applying the chemical solution to hair or the scalp and a chemical solution storage section for storing the chemical solution to be supplied to the coating portion. The coating portion includes a discharge passage that communicates with the chemical liquid storage unit to discharge the chemical liquid, a middle rod member that moves by pushing up to open the discharge passage and has a guiding function to discharge the chemical liquid, and the middle rod member is the discharge passage. It has an urging means for urging in the closing direction and applying a load to the pushing force, and the middle rod member moves by pushing up to open the discharge passage to discharge the chemical solution, and the middle rod member is pushed up. External composition for scalp contained in a chemical solution application tool (excluding a chemical solution application tool characterized by changing the discharge amount of the chemical solution according to the movement of the rod member) (provided that the external use contains diphenhydramine hydrochloride and dexamethasone acetate. Excluding the composition.). The external composition for scalp according to claim 1, which is used for a hair growth site. The external composition for scalp according to claim 1 or 2, wherein the content of the lower alcohol is 5 to 70 w / w% based on the total amount of the external composition. 23. To prevent, treat, and / or ameliorate at least one symptom selected from the group consisting of eczema, dermatitis, hair loss, thinning hair, dandruff, itch, dryness, and decreased barrier function in the scalp. The external composition for scalp according to any one of the above. The external composition for scalp according to any one of claims 1 to 4, wherein the lower alcohol is ethanol. The external composition for scalp according to any one of claims 1 to 5, which is a solubilizing composition. The external composition for scalp according to any one of claims 1 to 6, further comprising a thickener.

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