JP2022013871A - Atomizer - Google Patents

Abstract

To provide a technique that can cope with liquid having high viscosity and control a spray angle highly accurately.SOLUTION: The atomizer comprises an orifice 3 that is an outlet of chemicals, an introduction part 2 feeding the chemicals toward the orifice, a spiral flow channel 4 provided between the introduction part and the orifice, and a rectification part 5 provided between the spiral flow channel and the orifice. The rectification part has a first rectification member 51 having a circular inner face on the vertical section in the axial direction of the spiral flow channel, and a second rectification member 52 having an outer face arranged in concentric circular with intervals so that the chemicals pass between the inner face and itself.SELECTED DRAWING: Figure 1a

Description

Application for application of Article 30, Paragraph 2 of the Patent Act 1 (Posted on the company's website) Toray Precision Co., Ltd. was published on the following websites on September 30, 2 (1) Toray.・ The sprayer invented by Shingo Takenaka and Koji Shimada was released on the website of Precision Co., Ltd. and (2) the website of Toray Industries, Inc. (1) Toray Precision Co., Ltd. website address https: // www. tpc. toray / https: // www. tpc. toray / solution / index. html https: // www. tpc. toray / product / medical / index. html https: // www. tpc. toray / product / nozzle / nozzle_010. html (2) Toray Industries, Inc. website address html: // www. toray. co. jp / network / 2 (Sales) Toray Precision Co., Ltd. shipped the atomizers and / or parts of the atomizers invented by Shingo Takenaka and Koji Shimada to each contractor as shown in the following table. The arrival date of the shipment to the contractor is, in principle, the day after the shipping date, depending on the mailing circumstances. ■

The present invention provides a device for spraying a drug into the body such as the nose, trachea or lungs of an animal or human.

As a method of injecting a drug into the body for the treatment or prevention of an animal or human disease, or an experiment using an animal, there is a spray of a powder or liquid drug.

Patent Document 1 discloses an intrapulmonary nebulizer suitable for spraying a liquid substance in close proximity to the lungs. The intrapulmonary nebulizer has a sleeve member having a hole extending in the longitudinal direction inside, a spray generator arranged in the hole of the sleeve member, and a pressure generator connected to the sleeve member. The spray generator comprises a spiral insert with a spiral passage or groove on the outer surface. Between the spiral insert and the final orifice is a vortex chamber. In operation, the liquid is introduced from the base end of the sleeve member, where the liquid follows a spiral path established by the spiral passage in the outer wall of the insert and the inner wall of the sleeve member. The liquid enters the vortex chamber as it exits the spiral passage. At the end of the vortex chamber, the swirling liquid encounters a final orifice, which forms the interface between the swirling liquid in the sleeve member and the surrounding atmosphere, usually air. Spray generation is performed at the final orifice (paragraphs 0016-0019).

Patent Document 2 discloses a device that delivers a therapeutic compound to the olfactory epithelium of an animal or human. The device further includes a housing, a fluid reservoir therein, and a rotating chamber defined by the space between the inner surface of the housing and the outer surface of the fluid reservoir. The housing further includes a compressed gas inlet that communicates with the rotary chamber and is hydrodynamically connected to the pneumatic solenoid. The rotary chamber further includes a coiled wire wound around the outside of the fluid chamber, which has a spiral or corkscrew shape and extends from the gas inlet to the proximal orifice (paragraphs 0014, 0015).

Japanese Unexamined Patent Publication No. 2005-66359 Special Table 2011-511674 Gazette

In the technique of Patent Document 1, the accuracy of controlling the spray angle of the drug is not sufficient.

Further, in Patent Document 2, compressed gas is injected from a rotating chamber defined by a space between the inner surface of the housing and the outer surface of the fluid reservoir, and the decompression effect thereof sucks the chemical solution contained in the fluid reservoir. Is sprayed. Such a configuration requires a compressed gas and cannot cope with a highly viscous liquid. An object of the present invention is to provide a technique capable of controlling a spray angle with higher accuracy, which can be applied to a highly viscous liquid.

In order to solve the above problems, the present invention provides the following techniques.

(1) A sprayer for spraying a drug, an orifice which is an outlet of the drug, an introduction section for sending the drug toward the orifice, and a spiral flow path provided between the introduction section and the orifice. A first rectifying member having a circular inner surface in a cross section perpendicular to the axial direction of the spiral flow path, and the rectifying section provided with a rectifying section provided between the spiral flow path and the orifice. A sprayer comprising a second rectifying member having an outer surface arranged concentrically at intervals so that a drug can pass between the inner surface and the inner surface.

(2) The atomizer according to (1) above, wherein the end portion of the second rectifying member on the orifice side has a tapered diameter.

(3) The atomizer according to (1) or (2) above, wherein the inner surface of the first rectifying member has a tapered diameter at least at the end on the orifice side.

(4) The distance L3 from the end of the second rectifying member to the starting end of the tapered portion of the inner surface of the first rectifying member and the inner diameter φD of the first rectifying member are 0.2 ≦. The atomizer according to (3) above, which satisfies L3 / φD ≦ 10.

(5) The above-mentioned (1) to (4), wherein the inner diameter φD of the first rectifying member and the outer diameter φd of the second rectifying member satisfy 1.1 ≦ φD / φd ≦ 2.5. Atomizer.

(6) In the axial direction of the spiral flow path, the length L11 from the end of the spiral flow path to the orifice and the length L21 of the second rectifying member satisfy 1.1 ≦ L11 / L21 ≦ 5.0. ,
The atomizer according to any one of (1) to (5) above.

(7) The atomizer according to any one of (1) to (6) above, further comprising a syringe, a rod, or a plunger connected to the introduction portion.

(8) The atomizer according to any one of (1) to (7) above, wherein the number of spiral flow paths is 2 or more.

According to the present invention, a swirling flow is formed by the drug passing through the spiral flow path from the introduction portion, and the swirling flow passes between the first rectifying member and the second rectifying member, so that the spray angle is more accurate. Be controlled. Further, in the present invention, since the drug itself is extruded from the introduction portion and injected through the spiral flow path, the compressed gas is not indispensable, and it is possible to cope with a highly viscous drug.

It is sectional drawing of the sprayer which concerns on one Embodiment of this invention. It is a side view of the insert member in which the 2nd rectifying member and the spiral member are integrated. It is a schematic sectional drawing which shows the dimension of the rectifying part. It is a schematic cross-sectional view which shows the dimension in another form of a straightening part. (A)-(c) are sectional views showing another form of the 2nd rectifying member. It is a schematic diagram explaining the spray angle evaluation in an Example.

<First form>
The atomizer 1 of FIG. 1 has an introduction portion 2, an orifice 3 which is an outlet of a drug, a spiral flow path 4 provided between the introduction portion 2 and the orifice 3, and a spiral flow path 4 and an orifice 3. It is provided with a rectifying unit 5 provided between the and. The axial direction of the spiral flow path 4 is shown in the figure as x. The introduction unit 2, the spiral flow path 4, and the rectifying section 5 are arranged along the direction x, and the orifice 3 is provided at the end of the rectifying section 5 (on the opposite side of the spiral flow path 4).

In other words, the atomizer 1 has a housing 11 having a hollow inside and an insert member 12 arranged in the housing 11. The outer shape of the housing 11 is substantially cylindrical. Further, the inner diameter of the housing 11 is substantially constant except for the tapered portion described later.

The first end side of the housing 11 forms the introduction portion 2. The introduction unit 2 introduces the drug into the spiral flow path 4.

The second end of the housing 11 has an orifice 3 formed by a thick and open tip portion. The diameter of the orifice 3 can be appropriately changed depending on the use of the atomizer, and can be, for example, 0.01 mm or more and 0.50 mm or less. More preferably, it is 0.03 mm or more and 0.10 mm or less. The length of the orifice 3 in the direction x can be, for example, 0.05 mm or more and 4 mm or less. More preferably, it is 0.05 mm or more and 2 mm or less.

As shown in FIG. 1b, the insert member 12 is a member in which a spiral member 41 having a spiral protrusion on the surface and a second rectifying member 52 described later are integrally formed. A spiral flow path 4 which is a spiral space extending from the introduction portion 2 toward the rectifying portion 5 is formed between the outer surface of the spiral member 41 and the inner surface of the housing 11.

The number of turns of the spiral may be appropriately set according to the properties of the fluid to be sprayed, the purpose of use, etc., but if the number of turns is large, the turning force applied to the drug increases, and if the number of turns is small, the path is short. The time from to spraying can be shortened.

In the case of one row, the number of turns here is the same as the number of ridges. On the other hand, in the case of multiple rows (n rows), it refers to the number of mountains divided by n. The preferred range of the number of turns is 3 or more and 20 or less in the case of 1 row, and 3 / n or more and 20 / n or less in the case of n rows.

In the present embodiment, the diameter (here, the valley diameter) of the spiral member 41 in the spiral flow path 4 is constant from the introduction portion 2 to the rectifying portion 5, but the closer to the rectifying portion 5, the larger the diameter (valley diameter). It may include parts having different diameters (valley diameters), such as becoming smaller, conversely increasing the diameter (valley diameter), and repeating large and small diameters (valley diameters). In the present embodiment, the maximum outer diameter of the spiral member 41 is equivalent to the inner diameter of the introduction portion 2 (inner diameter of the housing 11).

The rectifying unit 5 has a first rectifying member 51 and a second rectifying member 52. In the present embodiment, the first rectifying member 51 is a part of the housing 11, and the inner surface 51a thereof is circular in a cross section perpendicular to the x direction. The second rectifying member 52 is arranged in the space inside the first rectifying member 51 (housing 11). The second rectifying member 52 has an outer surface 52a that is circular in a cross section perpendicular to the x direction. The outer surface 52a is arranged concentrically with the inner surface 51a at a distance from the inner surface 51a. The second rectifying member 52 has a columnar shape as shown in FIG. 1 in this embodiment, but its shape can be changed as described later.

An enlarged view of the rectifying unit 5 of FIG. 1a is shown in FIG. FIG. 2 is an example of a form in which the inner surface of the first rectifying member has a reduced diameter at the end portion on the orifice side. A cylindrical portion 54 on the spiral flow path 4 side and a tapered portion 55 on the orifice 3 side are provided on the inner surface of the first rectifying member 51. The cylindrical portion 54 is a cylinder having a constant diameter, and the tapered portion 55 is reduced in diameter from the cylindrical portion 54 toward the orifice 3. In this embodiment, the maximum diameter of the tapered portion 55 is set smaller than the diameter of the cylindrical portion 54. The minimum diameter of the tapered portion 55, that is, the diameter of the side end portion of the orifice 3, coincides with the diameter of the orifice 3. The length of the first rectifying member 51 (the sum of the length of the cylindrical portion 54 and the length of the tapered portion 55), that is, the distance from the end of the spiral flow path 4 to the orifice 3 is shown in the figure as L11, and the length of the tapered portion 55 is shown. Is shown as L12.

In the form of FIG. 2, the second rectifying member 52 is a cylinder having a constant diameter. The length of the entire second rectifying member 52 is shown in the figure as L21.

The drug is supplied from the outside of the housing 11 to the space inside the introduction unit 2, or is stored in the introduction unit 2 in advance. The drug is introduced from the introduction unit 2 into the spiral flow path 4. A swirling flow of the drug is formed by the spiral flow path 4, and the drug passes through the rectifying flow path, which is the space between the first rectifying member 51 and the second rectifying member 52 of the rectifying unit 5, and is atomized from the orifice 3. Is sprayed on. The spray angle is controlled by the rectifying unit 5, and the uniformity of spraying is enhanced.

<Second form>
FIG. 3 shows a form in which the orifice side end portion of the second rectifying member 52 is tapered in diameter. The second rectifying member 52 in the form of FIG. 3 has a cylindrical portion 56 on the spiral flow path 4 side and a tapered portion 57 on the orifice 3 side. The tapered portion 57 has a conical shape with a chipped top, and gradually reduces in diameter from the cylindrical portion 56 toward the orifice 3. The length of the tapered portion 57 of the second rectifying member 52 is shown in the figure as L22. In the form of FIG. 2 described above, the length L22 is zero.

Further, in the first rectifying member 51 of the form of FIG. 3, the ratio of the length L12 of the tapered portion 55 to the length L11 of the entire first rectifying member 51 is larger than that of the form of FIG. Further, in the form of FIG. 3, the maximum diameter of the tapered portion 55 is the same as the diameter of the cylindrical portion 54. That is, in this embodiment, the diameter of the tapered portion 55 is reduced from the diameter of the cylindrical portion 54 to the diameter of the orifice 3 along the x direction.

The angle formed by the inner surface of the tapered portion 55 of the first rectifying member 51 is shown as θ1, and the angle formed by the outer surface of the second rectifying member 52 is shown in the figure as θ2. In the form of FIG. 2, θ2 is zero, so it is not shown.

<Other forms of the second rectifying member>
Various shapes other than those described above can be adopted for the second rectifying member. An example is shown in FIGS. 4 (a) to 4 (c). In the form of FIG. 4A, the second rectifying member does not have a cylindrical portion and is composed of only a conical tapered portion having a chipped top. That is, L21 = L22. The morphology of FIG. 4 (b) is different from that of FIG. 4 (a), and is a conical shape in which the top is not chipped. The form of FIG. 4C is a combination of a cylindrical portion and a tapered portion having a maximum diameter smaller than that of the cylindrical portion.

In the above example, the angle of the tapered portion is constant, but portions having different angles may be combined.

The shape of the tapered portion and the shape of the cylindrical portion shown in each of FIGS. 2 to 4 can be combined with each other.

<Dimensions of each part of the rectifying part>
In any of the above embodiments, the inner diameter φD of the first rectifying member and the outer diameter φd of the second rectifying member satisfy 1.1 ≦ φD / φd ≦ 2.5 over the entire length of the second rectifying member. Is preferable, and it is more preferable to satisfy 1.1 <φD / φd <2.5. By satisfying this condition, the spraying direction can be adjusted accurately.

In the example of FIG. 2, since φD and φd are constant, φD / φd may be calculated. On the other hand, when φD or φd changes as shown in FIG. 3, it is preferable to satisfy this relationship at any position in the x direction of the second rectifying member. FIG. 3 shows the dimensions at position A as an example.

Further, the spray angle can be adjusted by adjusting the distance L3 from the end of the second rectifying member 52 (the right end in FIGS. 2 and 3) to the end of the tapered portion 55 (the right end in FIGS. 2 and 3). can. The longer L3, the narrower the spray angle and the longer the spray distance. Therefore, if it is desired to spray a narrow area, L3 may be lengthened, and if it is desired to be sprayed widely, L3 may be shortened.

The distance between the end of the second rectifying member 52 and the end of the tapered portion 55 may be fixed or variable. When variable, at least one of the positions of the first rectifying member 51 or the second rectifying member 52 is screwed or screwed so that the distance between the second rectifying member 52 and the end of the tapered portion 55 can be relatively changed. It may be possible to change it by another structure.

Further, it is preferable that 0.5 ≦ L3 / φD ≦ 10. When L3 / φD is 0.5 to 2, the spray range can be widened, and when L3 / φD is 5 to 10, the spray range can be narrowed. Further, when L3 / φD is 0.5 or more, mist-like spraying becomes easy. Further, when L3 / φD is 10 or less, the spraying distance can be lengthened to an extent suitable for chemical spraying.

In the x direction, the length L11 of the first rectifying member, that is, the distance between the spiral flow path and the orifice, and the length L21 of the second rectifying member must satisfy 1.1 ≦ L11 / L21 ≦ 5.0. It is preferable to satisfy 1.1 <L11 / L21 <5.0. By satisfying this condition, the spraying direction can be adjusted accurately.

When the length L11 is large, the swirling flow is weakened, so that the spray angle becomes small and the variation in the spray angle becomes small. Therefore, the length L11 may be adjusted according to the desired spray angle.

The larger the ratio L12 / L11 occupied by the length L12 of the tapered portion in the total length L11 of the first rectifying member, the more uniformly the drug is sprayed. L12 / L11 is preferably 0.3 or more and 1 or less.

The ratio L22 / L21 to the length L22 of the tapered portion in the total length L21 of the second rectifying member is the same as the ratio L12 / L11.

It is preferable that the taper angle θ1 on the inner surface of the first rectifying member and the taper angle θ2 on the outer surface of the second rectifying member satisfy 0.5 <θ2 / θ1 ≦ 1. When 0.5 <θ2 / θ1 ≦ 1, the spray angle of the drug can be controlled accurately.

The larger the taper angles θ1 and θ2, the larger the spray angle. Therefore, if you want to control the spray range of the drug narrowly, reduce the angle (for example, 5 ° or more and less than 45 °), and if you spray widely and uniformly, increase the angle (for example). For example, it may be 45 ° or more and 120 ° or less).

The second rectifying member 52 may be arranged so as to provide a gap between the second rectifying member 52 and the first rectifying member 51 in order to secure a flow path through which the drug passes.

When the second rectifying member 52 has a tapered shape as shown in FIG. 3, the flow path between the second rectifying member 52 and the first rectifying member 51 is narrower as a whole as compared with the cylindrical shape as shown in FIG. can do. As a result, the chemical can be discharged while maintaining the turning force, so that it is possible to spray widely while reducing the variation of the mist. That is, it is possible to spray a mist having a smaller variation in particle size over a wider range.

Further, the larger the radius of the first rectifying member 51, the larger the centrifugal force can be obtained, which is suitable for spraying the drug over a wide range. On the other hand, if the centrifugal force is reduced by reducing the radius, the spraying distance can be lengthened.

When the second rectifying member 52 has a tapered shape as in the second form, the resistance can be reduced, which is suitable for a high-viscosity liquid.

In the first and second embodiments, the number of rows of the spiral member 41 (spiral flow path 4) is assumed to be 1, but in the present invention, the number of rows of the spiral member is not limited to two or more, that is, multiple rows. There may be. From the viewpoint of spiral processing or when spraying a liquid having a relatively low viscosity, the number is preferably 1. When spraying a high-viscosity liquid or when the cross section of the sprayer is small, it is preferable to increase the number of rows, for example, preferably 1 to 16 rows, and more preferably 2 to 4 rows. ..

The smaller the number of rows, the larger the centrifugal force and the larger the spray angle, and the wider the range can be sprayed. In addition, since the pipeline is long, the flow is stable and the rotational force can be increased. In addition, the particle size of the fog tends to be small.

On the other hand, as the number of rows increases, the centrifugal force becomes smaller and the spray angle becomes smaller, so it is easier to aim at the target. Even when spraying the same amount of chemicals, if the number of rows is large, the flow path increases and the flow path can be shortened, so that the resistance becomes small and the spray resistance becomes small. In addition, the particle size of the fog tends to increase.

In the case of multiple rows, the position (phase) at which each groove starts is not particularly limited. For example, it may start from the same phase or from a different phase. In-phase is preferable from the viewpoint of suppressing variation.

As the different phase, for example, if the number of rows is n, it is possible to set the phase to 360 ° / n, specifically, two rows (180 ° phase) or three rows. (Phase 120 °) and the like.

Further, in any form, if the pitch of the spiral flow path 4 (spiral member 41) is fine (the lead is short), the centrifugal force becomes large, so that the sprayed drug is easily diffused and the pitch is coarse (the lead is long). ), The straightness can be increased, the flight distance can be lengthened, and the resistance can be reduced.

That is, the lead is not particularly limited, but in the case of one row, 0.02 mm or more and 3 mm or less is preferable, 0.05 mm or more and 2.5 mm or less is more preferable, 0.08 mm or more and 2.0 mm or less is further preferable, and 0. 10 mm or more and 1.5 mm are particularly preferable. The preferable range of the pitch is not particularly limited and depends on the application, but when the number of rows is n, it is preferably 0.02 mm / n or more and 3 mm / n or less, preferably 0.05 mm so as to fall within the above-mentioned preferable lead range. It is more preferably / n or more and 2.5 mm / n or less, further preferably 0.08 mm / n or more and 2.0 mm or less / n, and particularly preferably 0.10 mm / n or more and 1.5 mm / n.

<How to use>
The atomizer is used in combination with a means capable of pushing the drug out of the introduction unit 2, such as a syringe, rod, or plunger. By these means, the pressure required for spraying is supplied to the drug in the introduction unit 2. Examples of the target of spraying the drug include animals such as humans and mammals, particularly organs such as the oral cavity, nasal cavity, trachea, and lungs. As the drug, a therapeutic drug, a preventive drug, an experimental drug and the like are applied.

According to the configuration of the atomizer, the compressed gas is not essential for extruding the drug from the introduction portion, but the pressure for extruding the drug may be obtained by the compressed gas.

<Structure>
The sprayer of Example 1 had the same structure as that of FIG. 1, and the structures of Examples 2, 3 and 4 had the same structure as that of FIG. 3, and the dimensions of each part were changed.

As a common structure, the length of the introduction portion 2 in the x direction is 20 mm, the length of the spiral flow path 4 (the length of the spiral member 41) is 0.80 mm, and the pitch (lead) of the spiral flow path is 0.15 mm. , The inner diameter of the introduction portion 2 (that is, the maximum diameter of the spiral flow path 4 and the maximum diameter of the inner surface of the first rectifying member 51) is 0.512 mm, and the maximum diameter of the second rectifying member 52 (that is, the outer diameter of the cylindrical portion 56). Was 0.307 mm, and the diameter of the orifice 3 was 0.06 mm.

The length L11 of the first rectifying member 51, the length of the cylindrical portion 54 of the first rectifying member 51, the length L12 and angle of the tapered portion, the length of the second rectifying member L21, the length of the cylindrical portion, and the tapered portion. The length L22 and the angle are as shown in Table 1.

Further, Comparative Example 1 has the same structure as that of Example 1 and is not provided with the second rectifying member.

<Evaluation conditions>
After sucking 200 μL of the drug into the syringe, a needle incorporating a sprayer having each configuration described above was attached to the tip of the syringe, and the rod was sprayed by hand. The drug was a liquid with a density of 1000 kg / m ³ and a viscosity of 1.002 mPa · s. The inflow flow rate was calculated by measuring the time required for the drug to be discharged by hand, and it was 4.286 × 10 ^-5 kg / s.

For each of the examples and comparative examples shown in Table 1, the spray angle and inlet pressure of the liquid from the orifice 3 (pressure of the introduction part 2) are as follows using the numerical fluid analysis software STAR-CCM + (manufactured by SIEMENS). Calculated in. First, an analysis model of only the fluid region was created in consideration of the orifice shape. Next, the density, viscosity coefficient, and inflow flow rate of the target fluid were input, and the fluid analysis was performed. The analysis was stopped when the average flow velocity in the orifice converged to a constant value. From the obtained results, the spray angle was calculated by calculating the angle formed by the velocity vector near the orifice wall surface at the orifice tip (discharge surface) and the axial velocity vector.

Specifically, as shown in FIG. 5, the 3 o'clock and 9 o'clock directions (z-axis direction) when viewed from the x-axis direction are a1, a2, 12 o'clock, and the 6 o'clock direction (y-axis direction) are c1. The directions of 45 ° to the c2 and z-axis were set to b1, b2, d1 and d2, respectively. The angles in the a1-a2, b1-b2, c1-c2, and d1-d2 directions were calculated, respectively. Further, the average value was used as the spray angle of the example for evaluation, and the standard deviation was calculated.

<Result>
In Example 1 provided with the columnar second rectifying member 52, the average value of the spray angles was 25.3 ° and the standard deviation was 0.17. In Comparative Example 1 in which the second rectifying member 52 was not provided, the average angle was 24.6 ° and the standard deviation was 0.409. As described above, by providing the second rectifying member, the uniformity of the spray angle is improved.

Comparing the results of Example 2 and Example 3, the spray angle was larger in Example 3 in which the angle of the first and second rectifying members (that is, the angle of the rectifying flow path) was large. It is considered that this is because the swirling flow in the tapered portion of the rectifying flow path increases as the angle increases.

On the other hand, when comparing Examples 3 and 4 having the same angle, the spray angle was larger and the standard deviation was larger in Example 3 in which the rectifying unit, particularly the first rectifying member 51, was shorter. It is considered that this is because the swirling flow is maintained and sprayed.

The standard deviation became smaller when the tapered portion of the second rectifying member (that is, the tapered portion in the rectifying flow path) was longer.

Claims (8)

A sprayer that sprays chemicals
The orifice that is the outlet of the drug and
An introduction unit that sends the drug toward the orifice, and
A spiral flow path provided between the introduction portion and the orifice,
A rectifying unit provided between the spiral flow path and the orifice is provided.
The rectifying section is arranged concentrically at intervals so that the drug passes between the first rectifying member having a circular inner surface in a cross section perpendicular to the axial direction of the spiral flow path and the inner surface. With a second rectifying member having an outer surface,
Atomizer. The ends of the second rectifying member on the orifice side are tapered in diameter.
The atomizer according to claim 1. The atomizer according to claim 1 or 2, wherein the inner surface of the first rectifying member is tapered in diameter at least at the end portion on the orifice side. The distance L3 from the end of the second rectifying member to the starting end of the tapered portion of the inner surface of the first rectifying member and the inner diameter φD of the first rectifying member are 0.2 ≦ L3 / φD. The atomizer according to claim 3, which satisfies ≦ 10. The inner diameter φD of the first rectifying member and the outer diameter φd of the second rectifying member satisfy 1.1 ≦ φD / φd ≦ 2.5.
The atomizer according to any one of claims 1 to 4. In the axial direction of the spiral flow path, the length L11 from the end of the spiral flow path to the orifice and the length L21 of the second rectifying member satisfy 1.1 ≦ L11 / L21 ≦ 5.0.
The atomizer according to any one of claims 1 to 5. The atomizer according to any one of claims 1 to 6, further comprising a syringe, rod, or plunger connected to the introduction portion. The number of rows of the spiral flow path is 2 or more.
The atomizer according to any one of claims 1 to 7.

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