JP2021532095A - 肝臓疾患のミトコンドリア増強療法 - Google Patents

肝臓疾患のミトコンドリア増強療法 Download PDF

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JP2021532095A
JP2021532095A JP2021502870A JP2021502870A JP2021532095A JP 2021532095 A JP2021532095 A JP 2021532095A JP 2021502870 A JP2021502870 A JP 2021502870A JP 2021502870 A JP2021502870 A JP 2021502870A JP 2021532095 A JP2021532095 A JP 2021532095A
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mitochondria
stem cells
mitochondrial
pharmaceutical composition
cells
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JP2021502870A
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Japanese (ja)
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JPWO2020021537A5 (https=
JP2021532095A5 (https=
Inventor
オハナ，ナタリエ イヴギ
ハラヴィー，ウリエル
ブクスファン，シュムエル
シェール，ノア
ブルムキン，モリヤ
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ミノヴィア セラピューティクス リミテッド
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Publication of JPWO2020021537A5 publication Critical patent/JPWO2020021537A5/ja
Publication of JP2021532095A5 publication Critical patent/JP2021532095A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021502870A 2018-07-22 2019-07-22 肝臓疾患のミトコンドリア増強療法 Pending JP2021532095A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862701783P 2018-07-22 2018-07-22
US62/701,783 2018-07-22
US201862753939P 2018-11-01 2018-11-01
US62/753,939 2018-11-01
PCT/IL2019/050824 WO2020021537A1 (en) 2018-07-22 2019-07-22 Mitochondrial augmentation therapy of liver diseases

Publications (3)

Publication Number Publication Date
JP2021532095A true JP2021532095A (ja) 2021-11-25
JPWO2020021537A5 JPWO2020021537A5 (https=) 2022-07-27
JP2021532095A5 JP2021532095A5 (https=) 2022-07-27

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ID=69181382

Family Applications (1)

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JP2021502870A Pending JP2021532095A (ja) 2018-07-22 2019-07-22 肝臓疾患のミトコンドリア増強療法

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US (1) US20210252075A1 (https=)
EP (1) EP3823643A4 (https=)
JP (1) JP2021532095A (https=)
WO (1) WO2020021537A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2741757B1 (en) 2011-09-11 2018-05-16 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
US12551504B2 (en) 2018-07-22 2026-02-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of pancreatic diseases
US12329781B2 (en) 2018-07-22 2025-06-17 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of renal diseases
JP2021531288A (ja) 2018-07-22 2021-11-18 ミノヴィア セラピューティクス リミテッド 眼疾患のミトコンドリア増強療法
WO2020021536A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy for primary mitochondrial diseases
JP7524157B2 (ja) 2018-07-22 2024-07-29 ミノヴィア セラピューティクス リミテッド 脳疾患のミトコンドリア増強療法
JP7458368B2 (ja) 2018-07-22 2024-03-29 ミノヴィア セラピューティクス リミテッド 筋疾患のミトコンドリア増強療法
CA3172402A1 (en) * 2020-03-31 2021-10-07 Minovia Therapeutics Ltd. Mitochondria-enriched genetically engineered cells and uses thereof
TWI780431B (zh) * 2020-05-08 2022-10-11 台灣粒線體應用技術股份有限公司 新穎性醫藥組合物及其於修復肝臟損傷、治療肝臟損傷相關疾病與提升肝臟功能之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018507690A (ja) * 2015-02-26 2018-03-22 ミノヴィア セラピューティクス リミテッド 機能性ミトコンドリアで富化された哺乳動物細胞
WO2018088874A1 (ko) * 2016-11-14 2018-05-17 주식회사 파이안바이오테크놀로지 외래 미토콘드리아를 세포로 전달하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2150117A4 (en) * 2007-05-02 2011-10-05 Mclean Hospital Corp METHODS AND COMPOSITIONS FOR MITOCHONDRIA REPLACEMENT THERAPY
EP2741757B1 (en) * 2011-09-11 2018-05-16 Minovia Therapeutics Ltd. Compositions of functional mitochondria and uses thereof
WO2016008937A1 (en) * 2014-07-16 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the intercellular transfer of isolated mitochondria in recipient cells
US10537594B2 (en) * 2015-02-27 2020-01-21 University Of Connecticut Targeted transplantation of mitochondria to hepatocytes
EP3549589A4 (en) * 2016-11-30 2020-07-15 Paean Biotechnology Inc. PHARMACEUTICAL COMPOSITION CONTAINING MITOCHONDRIA

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018507690A (ja) * 2015-02-26 2018-03-22 ミノヴィア セラピューティクス リミテッド 機能性ミトコンドリアで富化された哺乳動物細胞
WO2018088874A1 (ko) * 2016-11-14 2018-05-17 주식회사 파이안바이오테크놀로지 외래 미토콘드리아를 세포로 전달하는 방법

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOL. PHARM. BULL., vol. 40, JPN6024003454, 2017, pages 1174 - 1182, ISSN: 0005254900 *
EXPERIMENTAL CELL RESEARCH, vol. 336, JPN6024003453, 2015, pages 15 - 22, ISSN: 0005254901 *
J JPN COLL ANGIOL, vol. 46, JPN6024003452, 2006, pages 281 - 288, ISSN: 0005254902 *
MITOCHONDRION, vol. 4, JPN6023025718, 2004, pages 609 - 620, ISSN: 0005254904 *
WORLD J GASTROENTEROL, vol. 14, no. 2, JPN6023025719, 2008, pages 193 - 199, ISSN: 0005254905 *
埼玉医科大学雑誌, vol. 30, no. 4, JPN6024003451, 2003, pages 195, ISSN: 0005254903 *

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Publication number Publication date
US20210252075A1 (en) 2021-08-19
WO2020021537A9 (en) 2020-03-19
EP3823643A4 (en) 2022-06-08
WO2020021537A1 (en) 2020-01-30
EP3823643A1 (en) 2021-05-26

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