JP2021526443A - 被検体により生成されたnoの量を検出するための方法、及び当該方法を実施するためのデバイス - Google Patents
被検体により生成されたnoの量を検出するための方法、及び当該方法を実施するためのデバイス Download PDFInfo
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Abstract
Description
Claims (23)
- 被検体において、所定の活動状態のシーケンスの進行中に当該被検体により生成されたNOの量を検出するための方法において、
前記被検体の表皮(2)の調査ゾーンを選択し、
前記調査ゾーンに取り付けられて防漏性に保持される第1の部分(4)であって電気化学的センサ(14)を用いてNOの検出を行うセンシング要素(5)に取り付けられた第1の部分(4)により構成されたデバイスを用いて、前記表皮に由来する生体液中に溶解したNOの生成を直接的かつ連続的に追跡し、
前記センシング要素(5)に関連付けられたエネルギー発生器を用いて、前記電気化学的センサによって、所望の検出を行える信号を送信する
ことを特徴とする方法。 - 絶縁性のプレーナ型支持部(10)に取り付けられた2つの動作電極(8,9)間の電解質としての前記調査ゾーンにおいて前記被検体により生成された前記生体液を用いて行われる電気化学的測定の結果として前記信号を供給する少なくとも1つの電気化学的センサを使用する、
請求項1記載の方法。 - 参照電極が前記2つの動作電極(8,9)に接続されている、
請求項2記載の方法。 - 前記電気化学的センサは複数の電気化学的センサを含み、
前記複数の電気化学的センサの信号を組み合わせることにより前記出力信号を改善する、
請求項2又は3記載の方法。 - 前記電極(8,9)の支持部(10)の単位面積当たりの前記出力信号のパワーを改善するため、前記支持部(10)との関係における前記電極(8,9)のパターンはヒルベルト曲線に従う、
請求項2から4までのいずれか1項記載の方法。 - 前記測定は、前記電極(8,9)の導電パターンと共に前記プレーナ型支持部に設けられたオリフィス(13)と共に行われる、
請求項2から5までのいずれか1項記載の方法。 - 前記電極は、とりわけ銀(Ag)、金(Au)、白金(Pt)及び白金黒の堆積物などの金属堆積物、又は銀(Ag)若しくは金(Au)のナノ粒子がドープされたグラフェン堆積物から成り、前記ナノ粒子は、NOのバインダ、とりわけグアニリルシクラーゼ又はポルフィリンなどにより機能化されるものである、
請求項2から6までのいずれか1項記載の方法。 - 前記デバイスは、前記第1の部分(4)の上方に配置される第2の部分(6)をさらに備えており、
前記第2の部分(6)は電子装置を備えており、
前記電子装置は、前記電気化学的センサからの原測定結果を受け取って当該原測定結果をNO濃度に変換し、前記信号の伝送を保証するためのものであり、
前記信号は場合によっては、環境に関連する他のパラメータを含む、
請求項1から7までのいずれか1項記載の方法。 - 前記デバイスは、前記被検体の活動状態に依存する周波数で測定を行って測定結果を送信し、
前記活動状態は、前記デバイスの第2の部分(5)のジャイロスコープ及び/又は加速度計モジュールを用いて追跡される、
請求項1から8までのいずれか1項記載の方法。 - 被検体において、所定の活動状態のシーケンスの進行中に当該被検体によって生成されたNOの量を検出するための検出デバイス(1)であって、
前記被検体の表皮(2)の調査ゾーンに取り付けられて防漏性に保持される第1の部分(4)であって、前記表皮に由来する生体液中のNOの生成を直接的かつ連続的に追跡するためのものであり、電気化学的センサ(14)を用いてNOの検出を行うセンシング要素(5)に取り付けられた第1の部分(4)と、
前記センシング要素(5)に関連付けられたエネルギー発生器(5d)を用いて、所望の検出を行える信号を送信するように構成された第2の部分(6)と、
を備えていることを特徴とする検出デバイス(1)。 - 前記センシング要素は、絶縁性のプレーナ型支持部(10)に取り付けられた2つの動作電極(8,9)間の電解質としての前記調査ゾーンにおいて前記被検体により生成された前記生体液を用いて行われる電気化学的測定の結果として、前記信号を供給する、
請求項10記載の検出デバイス。 - 参照電極が前記2つの動作電極に接続されている、
請求項11記載の検出デバイス。 - 前記絶縁性のプレーナ型支持部(10)は、前記生体液を前記電気化学的センサ(14)に導くための少なくとも1つのマイクロチャネル(15,30,31,33)を備えている、
請求項11又は12記載の検出デバイス。 - 前記センシング要素は複数の同様の電気化学的センサを備えており、
前記出力信号を改善するため、前記複数の電気化学的センサの信号が組み合わされる、
請求項10又は13記載の検出デバイス。 - 前記動作電極(8,9)の支持部の単位面積当たりの前記出力信号の強度を改善するため、前記支持部(10)との関係における前記動作電極(8,9)のパターンがヒルベルト曲線に従う、
請求項11から14までのいずれか1項記載の検出デバイス。 - 前記測定は、前記電極(8,9)の導電パターンと共に前記プレーナ型支持部(10)に設けられたオリフィス(13)と共に行われる、
請求項11から15までのいずれか1項記載の検出デバイス。 - 前記動作電極(8,9)は、とりわけ銀(Ag)、金(Au)、白金(Pt)及び白金黒の堆積物などの金属堆積物、又は銀(Ag)若しくは金(Au)のナノ粒子がドープされたグラフェン堆積物から成り、前記ナノ粒子は、NOのバインダ、とりわけグアニリルシクラーゼ又はポルフィリンなどにより機能化されるものである、
請求項11から16までのいずれか1項記載の検出デバイス。 - 前記センシング要素は、複数のセンシングユニット(16,17,18)に分散された複数の電気化学的センサ(14)を備えており、
前記各センシングユニットは、少なくとも1つの化学種を検出するように構成されている、
請求項10又は17記載の検出デバイス。 - 前記絶縁性のプレーナ型支持部は複数のマイクロチャネル(30,31,32)を備えており、
各チャネルはそれぞれセンシングユニットを備えている、
請求項13を引用する請求項18記載の検出デバイス。 - 前記第1の部分は、前記調査ゾーンから前記生体液をキャピラリ力によって前記センシング要素に運ぶため、繊維体を有する、
請求項10から19までのいずれか1項記載の検出デバイス。 - 前記第1の部分は、前記生体液に含まれる干渉要素によるNOの検出の歪みを回避するため、前記センシング要素の流入口において前記生体液をフィルタリングするフィルタ(29)をさらに備えている、
請求項20記載の装置。 - 前記第2の部分は、前記第1の部分(4)の上方に配置されており、
前記第2の部分は、前記電気化学的センサからの原測定結果を受け取るための電子装置を備えており、
前記電子装置は前記原測定結果をNO濃度に変換して、前記信号の伝送を保証するためのものであり、当該信号は場合によっては、環境に関連する他のパラメータを含む、
請求項10から21までのいずれか1項記載の検出デバイス。 - 前記検出デバイスは、前記被検体の活動状態を検出するためのジャイロスコープ及び/又は加速度計モジュールを備えており、
前記検出デバイスは、前記被検体の活動状態に依存する周波数で測定を行って測定結果を送信する、
請求項10から22までのいずれか1項記載の検出デバイス。
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PCT/FR2019/051261 WO2019229380A1 (fr) | 2018-05-28 | 2019-05-28 | Procede pour detecter une quantite de no produite par le sujet etudie et appareil pour la mise en œuvre dudit procede |
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