JP2021195324A - External composition - Google Patents

Abstract

To provide an external composition used for improving skin inflammation after shaving.SOLUTION: The external composition comprises (A) ufenamate and (B) lidocaine and/or a salt thereof. The external composition is effective in improving skin inflammation after shaving.SELECTED DRAWING: None

Description

The present invention relates to an external composition used for improving skin inflammation after shaving.

Due to the growing awareness of beauty in recent years, hair removal treatment is being performed in a wide range of people. The methods for removing body hair are usually hair removal, shaving, and hair removal, and it is also widespread that specialized institutions (medical institutions and beauty salons) use specialized equipment for hair removal.

On the other hand, the treatment method that still accounts for the largest proportion is shaving by self-treatment. Even with self-treatment, hair removal and hair removal may be performed using home appliances, tweezers, hair removal cosmetics, etc., but the ease of shaving overwhelms other methods. Furthermore, the fact is that the only means for self-treatment of the delicate zone (lower abdomen, vulva, anus) is practically shaving.

During shaving, the skin is susceptible to contact stimuli such as contact with the blade of the shaving jig and exposure to friction by a protective device such as a guard material for the blade, so that the skin is liable to become inflamed after shaving. In addition, the tips of the hair after shaving have horns, and the hair grows quickly to make the surrounding skin more vulnerable, which also causes inflammation. Generally, for skin such as arms and legs, skin inflammation due to shaving is relatively small (Non-Patent Document 1), but skin in the pubic area is thinner and more sensitive than skin in other parts, and body hair is other. The risk of inflammation due to shaving is extremely high because it is thicker than the site, it is difficult to handle the shaving jig and it is easy to irritate, and after shaving it is pressed by underwear and constantly exposed to the harsh environment of steam. .. For this reason, troubles caused by shaving by self-treatment are endless.

J. Soc. Cosmet. Chem. Jpn. 44 (4) 298-303 (2010)

It is an object of the present invention to provide an external composition used for improving skin inflammation after shaving.

As a result of diligent studies, the present inventors have found that an external composition containing ufenamate and lidocaines has an excellent effect on improving skin inflammation after shaving. The present invention has been completed by further studies based on this finding.

That is, the present invention provides the inventions of the following aspects.
Item 1. An external composition containing (A) ufenamate and (B) lidocaine and / or a salt thereof, which is used for improving skin inflammation after shaving.
Item 2. Item 2. The external composition according to Item 1, which is applied to skin inflammation in the lower abdomen, vulva, and / or anus.
Item 3. Item 2. The external composition according to Item 1 or 2, which is applied to inflammation without itching.
Item 4. Further (C) glycyrrhetinic acid, a derivative of glycyrrhetinic acid and / or a salt thereof, (D) diphenhydramine and / or a salt thereof, (E) tocopherol and / or a derivative thereof, and / or (F) an antibacterial or bactericidal agent. Item 8. The external composition according to any one of Items 1 to 3.

According to the present invention, there is provided an external composition used for improving skin inflammation after shaving.

The composition for external use of the present invention comprises (A) ufenamate (hereinafter, also referred to as "(A) component") and (B) lidocaine and / or a salt thereof (hereinafter, "(B) component" or "lidocaine". ”), And is characterized by being used for improving skin inflammation after shaving. Further, the external composition of the present invention further comprises (C) glycyrrhetinic acid, a derivative of glycyrrhetinic acid, and / or a salt thereof (hereinafter, also referred to as "component (C)" or "glycyrrhetinic acid"), ( D) Diphenhydramine and / or a salt thereof (hereinafter, also referred to as "(D) component" or "diphenhydramines"), (E) tocopherol and / or a derivative thereof (hereinafter, "(E) component" or "tocopherol". It may also contain (also referred to as “class”) and / or (F) a quaternary ammonium-based antibacterial agent (hereinafter, also referred to as “(F) component”). From the viewpoint of further improving the effect of improving skin inflammation after shaving, the external composition of the present invention comprises (A) component, (B) component, (C) component, (D) component, and (E) component. , And (F) component are preferably contained. Hereinafter, the external composition of the present invention will be described in detail.

(A) Ufenamart The external composition of the present invention contains Ufenamart as a component (A). Ufenamate, also called butyl flufenamic acid, is a known drug as a fat-soluble non-steroidal anti-inflammatory drug. The component (A) alone does not have much effect of improving skin inflammation after shaving, but the external composition of the present invention can exert an excellent effect of improving skin inflammation after shaving. Is.

In the external composition of the present invention, the content of the component (A) is appropriately set according to the medicinal effect to be exerted, and examples thereof include 1 to 20% by weight. From the viewpoint of further improving the effect of improving skin inflammation after shaving, the content of the component (A) in the external composition of the present invention is preferably 3 to 6% by weight, more preferably 4.5 to 5%. .5% by weight is mentioned.

(B) Lidocaines The external composition of the present invention contains lidocaine and / or a salt thereof as the component (B). Lidocaine, also referred to as xylocaine, is a known drug known to have a local anesthetic effect. The component (B) is a local anesthetic and does not improve inflammation by itself, but when combined with the component (A), it dramatically improves the effect of improving skin inflammation after shaving. ..

The salt of lidocaine is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include inorganic acid salts such as hydrochloride.

In the external composition of the present invention, one kind may be selected from lidocaine and a salt thereof and used alone, or two or more kinds may be used in combination. Among lidocaine and its salts, lidocaine is preferably mentioned from the viewpoint of further improving the effect of improving skin inflammation after shaving.

The content of the component (B) in the external composition of the present invention may be appropriately set according to the medicinal effect to be imparted, and for example, the total amount of the component (B) is 0.1 to 5% by weight. It is preferably 0.2 to 2% by weight, more preferably 0.5 to 1.5% by weight.

In the external composition of the present invention, the ratio of the component (B) to the component (A) is determined according to the contents of the component (A) and the component (B), and is, for example, 1 part by weight of the component (A). The total amount of the component (B) is, for example, 0.01 to 1.5 parts by weight, preferably 0.05 to 1 part by weight, and more preferably 0.1 to 0.5 parts by weight.

(C) Glycyrrhetinic acid The external composition of the present invention contains glycyrrhetinic acid, a derivative thereof, and / or a salt thereof as the component (C) from the viewpoint of further improving the effect of improving skin inflammation after shaving. Can be contained.

Glycyrrhetinic acid is a known drug known to have an anti-inflammatory action, an antiallergic action and the like.

The derivative of glycyrrhetinic acid is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, and monoglucuronide glycyrrhetinate. These derivatives of glycyrrhetinic acid may be used alone or in combination of two or more.

The salt of glycyrrhetinic acid and / or a derivative thereof is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include alkali metal salts such as sodium salt and potassium salt; ammonium salts and the like. These salts may be used alone or in combination of two or more.

The external composition of the present invention may be used by selecting one from glycyrrhetinic acid, a salt of glycyrrhetinic acid, a derivative of glycyrrhetinic acid, and a salt of a derivative of glycyrrhetinic acid as the component (C). You may use a combination of seeds or more.

Among these components (C), glycyrrhetinic acid is preferably mentioned from the viewpoint of further improving the effect of improving skin inflammation after shaving.

In the external composition of the present invention, the content of the component (C) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted. For example, the total amount of the component (C) is 0. 05 to 5% by weight, preferably 0.1 to 1% by weight, more preferably 0.2 to 0.5% by weight, from the viewpoint of further improving the effect of improving skin inflammation after shaving. Can be mentioned.

In the external composition of the present invention, the ratio of the component (C) to the component (A) is determined according to the contents of the component (A) and the component (C), and is, for example, 1 part by weight of the component (A). The total amount of the component (C) is 0.01 to 0.9 parts by weight. From the viewpoint of further improving the effect of improving skin inflammation after shaving, the total amount of the component (C) per 1 part by weight of the component (A) is preferably 0.03 to 0.5 part by weight, more preferably. Examples include 0.05 to 0.1 parts by weight.

(D) Diphenhydramines The external composition of the present invention can contain diphenhydramine and / or a salt thereof as the component (D) from the viewpoint of further improving the effect of improving skin inflammation after shaving. Diphenhydramine is a known drug known to have antihistamine activity. The component (D) has almost no effect of improving skin inflammation after shaving by itself, but when combined with the components (A) and (B), the effect of improving skin inflammation after shaving is remarkable. It is possible to improve to.

The salt of diphenhydramine is not particularly limited as long as it is pharmaceutically acceptable, but specifically, hydrochloride, citrate, succinate, tartrate, fumarate, maleate, salicylate. , Diphenyldisulfonate, tannate, lauryl sulfate, sulfate and other acid addition salts. These salts may be used alone or in combination of two or more.

The external composition of the present invention may be used by selecting one of diphenhydramine and a salt thereof as the component (D), or may be used in combination of two or more.

Among these components (D), diphenhydramine is preferably mentioned from the viewpoint of further improving the effect of improving skin inflammation after shaving.

In the external composition of the present invention, the content of the component (D) is not particularly limited, and for example, the total amount of the component (D) may be 0.1 to 5% by weight. From the viewpoint of further improving the effect of improving skin inflammation after shaving, the content of the component (D) in the external composition of the present invention is preferably 0.3 to 2% by weight, more preferably 0.5. ~ 1.5% by weight is mentioned.

In the external composition of the present invention, the ratio of the component (D) to the component (A) is determined according to the contents of the component (A) and the component (D), and is, for example, 1 part by weight of the component (A). The total amount of the component (D) is 0.01 to 1.2 parts by weight. From the viewpoint of further improving the effect of improving skin inflammation after shaving, the total amount of the component (D) per 1 part by weight of the component (A) is preferably 0.05 to 0.8 parts by weight, more preferably. 0.1 to 0.5 parts by weight may be mentioned.

(E) Tocopherols The external composition of the present invention can further contain tocopherol and / or a derivative thereof as the component (E) from the viewpoint of further improving the effect of improving skin inflammation after shaving.

Tocopherol is a known compound known as Vitamin E. The tocopherol may be any of d-form, l-form, and dl-form, but dl-form is preferable. Further, the tocopherol may be any of α-form, β-form, γ-form, and δ-form, but α-form is preferable.

The derivative of tocopherol is not particularly limited as long as it is pharmaceutically acceptable, and examples thereof include an ester form with a carboxylic acid such as acetic acid, nicotinic acid, and succinic acid, and a diester form with phosphoric acid. Among these tocopherol derivatives, an ester form with a carboxylic acid is preferable, and tocopherol acetate is more preferable, from the viewpoint of further improving the effect of improving skin inflammation after shaving.

The derivative of tocopherol may be d-form, l-form, or dl-form, but dl-form is preferable. Further, the derivative of tocopherol may be any of α-form, β-form, γ-form, and δ-form, but α-form is preferable.

In the external composition of the present invention, as the component (E), one of tocopherol and its derivative may be selected and used alone, or two or more thereof may be used in combination. Among the components (E), from the viewpoint of further improving the effect of improving skin inflammation after shaving, a derivative of tocopherol, more preferably an ester of tocopherol with a carboxylic acid, still more preferably tocopherol acetate, particularly. Preferred examples thereof include d-α-tocopherol acetate, l-α-tocopherol acetate and dl-α-tocopherol acetate.

The content of the component (E) when the external composition of the present invention contains the component (E) is not particularly limited, but from the viewpoint of further improving the effect of improving skin inflammation after shaving, (E). ) The total amount of the components is, for example, 0.05 to 2% by weight, preferably 0.1 to 1.3% by weight, and more preferably 0.3 to 0.8% by weight.

Further, when the external composition of the present invention contains the component (E), the ratio of the component (E) to the component (A) is determined based on the range of the content of each component, but after shaving. From the viewpoint of further improving the effect of improving skin inflammation, the total amount of the component (E) is 0.01 to 1 part by weight, preferably 0.03 to 0.5 part by weight, per 1 part by weight of the component (A). More preferably, 0.05 to 0.3 parts by weight is mentioned.

(F) Antibacterial or bactericidal agent The external composition of the present invention may further contain an antibacterial or bactericidal agent as the component (F) from the viewpoint of further improving the effect of improving skin inflammation after shaving.

The antibacterial or bactericidal agent is not particularly limited as long as it is pharmaceutically or cosmetically acceptable. Examples thereof include quaternary ammonium antibacterial agents, isopropylmethylphenol, hinokitiol, chlorhexidine hydrochloride, chlorhexidine gluconate, triclosan, lysozyme chloride, sulfadine and the like. Specific examples of the quaternary ammonium antibacterial agent include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, decalinium chloride, alkyldimethylammonium chloride, alkyltrimethylammonium chloride, methylbenzethonium chloride, and lauroylcolaminoformylmethyl chloride. Examples include pyridinium.

These antibacterial or bactericidal agents may be used alone or in combination of two or more.

Among these antibacterial or bactericidal agents, isopropylmethylphenol is preferable from the viewpoint of further improving the effect of improving skin inflammation after shaving.

When the external composition of the present invention contains the component (F), the content of the component (F) may be appropriately set according to the type of antibacterial or bactericidal agent used, and is, for example, 0.01 to. 1% by weight is mentioned. From the viewpoint of further improving the effect of improving skin inflammation after shaving, the content of the component (C) is preferably 0.03 to 0.5% by weight, more preferably 0.05 to 0.3% by weight. %.

When the external composition of the present invention contains the component (F), the ratio of the component (A) to the component (F) is determined according to the contents of both of these components described above, and is determined by, for example, (A). Examples of the component (F) are 0.001 to 0.5 parts by weight, preferably 0.005 to 0.1 parts by weight, and more preferably 0.01 to 0.05 parts by weight per 1 part by weight of the component.

Other Ingredients The external composition of the present invention may contain other pharmacological components in addition to the above-mentioned components, if necessary. Examples of such pharmacological components include antihistamines (chlorpheniramine maleate, etc.), local anesthetics (dibucaine, procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, meprilcaine or salts thereof), alkyl benzoate. Esters (eg ethyl aminobenzoate, diethylaminoethyl parabutylaminobenzoate), orthokine, oxesazein, oxypolyentoxydecane, funnel extract, percaminpase, tesitdecitin, etc.), anti-inflammatory agents (alantin, salicylic acid, glycol salicylate, methyl salicylate, etc.) Indomethacin, fervinac, diclofenac sodium, loxoprofen sodium, etc.), antipruritic agents (crotamiton, thiantoll, etc.), skin protectants (corodion, castor oil, etc.), blood circulation promoting components (nonyl acid vanillylamide, nicotinic acid benzyl ester, capsaicin, peppermint extract, etc.) ), Cooling agents (menthol, camphor, etc.), vitamins (vitamins A, B, C, D, etc.), mucopolysaccharides (sodium chondroitin sulfate, hyaluronic acid, etc.) and the like.

In addition to the above-mentioned components, other bases and additives usually used for external skin preparations and the like may be contained, if necessary. Such base materials and additives are not particularly limited as long as they are pharmaceutically acceptable, but for example, water, lower alcohols (for example, isopropanol), polyhydric alcohols (glycerin, propylene glycol, dipropylene glycol). , 1,3-butylene glycol, etc.); oils (olive oil, saflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, sunflower oil, cottonseed oil, peanut oil, lard, squalane, fish oil, etc.) , Mineral oil (liquid paraffin, paraffin, gelled hydrocarbon, vaseline, etc.), waxes / waxes (mitsurou, carnauba wax, candelilla wax, selecin, rice wax, microcrystallin wax, etc.), ester oil (isopropyl myristate, etc.) Isopropyl adipate, diethyl sebacate, isopropyl sebacate, isopropyl palmitate, cetyl palmitate, ethyl oleate, etc.), fatty acid alkyl esters, fatty acids (stearic acid, oleic acid, palmitic acid, behenic acid, linoleic acid, lanolin, etc.) , Fatty acid esters (cetyl palmitate, isopropyl palmitate, isopropyl myristate, ethyl linoleate, etc.), higher alcohols (stearyl alcohol, cetanol, behenyl alcohol, myristyl alcohol, oleyl alcohol, hexadecyl alcohol, lanolin alcohol, etc.), cholesterol, tri Oily bases such as glyceryl 2-ethylhexanate, cetyl 2-ethylhexanate, silicone oil (dimethylpolysiloxane, cyclic silicone, etc.); POE (10-50 mol) phytosterol ether, POE (10-50 mol) dihydrocholesterol Ether, POE (10-50 mol) 2-octyldodecyl ether, POE (10-50 mol) decyltetradecyl ether, POE (10-50 mol) oleyl ether, POE (2-50 mol) cetyl ether (set macrogol) 1000 etc.), POE (5-50 mol) behenyl ether, POE (5-30 mol) polyoxypropylene (5-30 mol) 2-decyltetradecyl ether, POE (10-50 mol) polyoxypropylene (2-) 30 mol) Polyoxyethylene alkyl ethers such as cetyl ethers, their phosphates and phosphates (POE cetyl ether sodium phosphate, etc.), POE (20-60 mol) sorbitan monoolates, POE (10-60 mol) ) Solbitan monoisostearate, POE (10-80 mol) glyceryl monoisostearate, POE (10-30 mol) glyceryl monostearate, POE (20-100 mol) / polyoxypropylene-modified silicone, POE / alkyl-modified Silicone, Monolaurate Polyethylene Glycol, Monopalmitate Polyethylene Glycol, Monostearate Polyethylene Glycol, Dilaurate Polyethylene Glycol, Dipalmitate Polyethylene Glycol, Distearate Polyethylene Glycol, Dioleate Polyethylene Glycol, Diricinoleate Polyethylene Glycol, Polyoxyethylene Cure Surfactants such as castor oil (5-100), polysorbate (20-85), glycerin fatty acid esters (glycerin monostearate, etc.), hydrogenated soybean phospholipids, hydrogenated lanolin alcohol; refreshing agents (menthol, camphor, etc.) Borneol, peppermint water, peppermint oil, etc.), preservatives (methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), flavoring agents (citral, 1,8-sionel, citronellal, farnesol, etc.), colorants (Tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.), cocoa pigments, chlorophyll, aluminum oxide, etc.), viscous agents (carboxyvinyl polymer, hypromellose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, etc.) Hydroxyethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, carrageenan, etc.), pH adjusters (phosphate, hydrochloric acid, citric acid, sodium citrate, succinic acid, tartrate acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc. ), Wetting agent (dl-pyrrolidone sodium carboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizer (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-asparagine) Acids, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, UV absorbers, chelating agents, adhesives, buffers , Additives such as solubilizers, solubilizers, preservatives and the like.

Properties, formulation form, etc. The properties of the external composition of the present invention are not particularly limited, and examples thereof include an aqueous liquid composition, an aqueous gel composition, an oil gel composition, and an emulsified composition. Among these, an emulsified composition is preferable from the viewpoint of further improving the effect of improving skin inflammation after shaving. The emulsified state of the emulsified composition may be either an oil-in-water type or a water-in-oil type, but the oil-in-water type is preferable from the viewpoint of further improving the effect of improving skin inflammation after shaving. Can be mentioned.

The pharmaceutical form of the external composition of the present invention is not particularly limited, and examples thereof include lotions, emulsions, ointments, and creams. Among these, emulsions and creams are preferable from the viewpoint of further improving the effect of improving skin inflammation after shaving and the ease of application.

Specific examples of the external composition of the present invention include pharmaceuticals, quasi-drugs, cosmetics and the like. Among these pharmaceutical forms, pharmaceutical products are preferable.

Uses The external composition of the present invention is used for improving skin inflammation after shaving. The site of inflammation to which the skin is applied is not particularly limited as long as it is a site where the body hair is shaved, but the external composition of the present invention is particularly limited to the lower abdomen (V zone) and the vulva (I zone), which are called delicate zones. , Buttocks, and / or skin inflammation in the anus (O zone).

The mode of skin inflammation is not particularly limited, and examples thereof include pain (tingling sensation), rash, and red lumps. Further, in the present invention, it can be preferably applied to inflammation without itching.

The external composition of the present invention can be applied to the skin having dermatitis after shaving by applying it 1 to 6 times a day. In addition, the external composition of the present invention is preferably applied, for example, for 5 days or more, preferably 1 week or more, in order to more effectively obtain the effect of improving skin inflammation after shaving.

Hereinafter, the present invention will be specifically described with reference to Examples, but the present invention is not limited to these Examples.

The external composition having the composition shown in Test Example Table 1 was prepared as an oil-in-water emulsified composition (cream preparation). Subjects with rash, redness, and tingling inflammation (all without itching) in the lower abdomen (V zone) and vulva (I zone) due to razor loss due to shaving at least once a week (N) = 15), the prepared external composition was applied to the affected area for one week (three times a day). One week later, the degree of satisfaction with the improvement of inflammation was evaluated on a 5-point VAS (satisfied / slightly satisfied / neither / slightly dissatisfied / dissatisfied), and the percentage of subjects who answered "satisfied" out of 15 subjects (%). Was calculated as the "effective rate". First, Comparative Examples 1 and 2 and Example 2 were tested, and then Comparative Examples 3 to 5 and Example 2 were tested after the symptoms due to shaving returned to the same extent as before the test. The results are shown in Table 1.

As shown in Table 1, a small number of subjects answered that they were satisfied with the external composition of Comparative Example 1 containing only ufenamate as an active ingredient, and only a small number of subjects in Comparative Example 2 containing only lidocaine as an active ingredient. However, the external composition of Example 1 containing ufenamate and lidocaine was found to be highly effective in improving inflammation so that more than half of the subjects answered that they were satisfied. In addition, few subjects answered that they were satisfied with the external composition of Comparative Example 3 containing diphenhydramine, glycyrrhetinic acid, tocopherol acetate, and isopropylmethylphenol, and the external compositions of Comparative Examples 4 and 5 containing ufenamate or lidocaine. However, less than half of the subjects answered that they were satisfied. On the other hand, the external composition of Example 2 containing ufenamate and lidocaine together with diphenhydramine, glycyrrhetinic acid, tocopherol acetate, and isopropylmethylphenol was found to be more effective in improving inflammation so that most subjects answered that they were satisfied. Was done.

[Prescription example]
The external composition of the formulation shown in Table 2 was prepared as an oil-in-water emulsified composition (cream preparation). Both external compositions showed excellent ameliorating effects on skin inflammation after shaving.

Claims (4)

An external composition containing (A) ufenamate and (B) lidocaine and / or a salt thereof, which is used for improving skin inflammation after shaving. The external composition according to claim 1, which is applied to skin inflammation in the lower abdomen, vulva, and / or anus. The external composition according to claim 1 or 2, which is applied to inflammation without itching. Further (C) glycyrrhetinic acid, a derivative of glycyrrhetinic acid and / or a salt thereof, (D) diphenhydramine and / or a salt thereof, (E) tocopherol and / or a derivative thereof, and / or (F) an antibacterial or bactericidal agent. The external composition according to any one of claims 1 to 3.