JP2021104663A - Multilayer film, and package - Google Patents

Abstract

To provide a multilayer film having both vapor barrier properties and tablet taking out nature and a package made of the same.SOLUTION: A multilayer film includes a vapor barrier layer containing polychlorotrifluoroethylene or polyvinylidene chloride and a substrate layer containing polyvinyl chloride. The thickness of the vapor barrier layer is in the range of 10 μm or more and 160 μm or less. The total thickness of the vapor barrier layer and the substrate layer is in the range of 180 μm or more and 300 μm or less. A test piece of a tablet container protruded in the thickness direction is prepared, wherein the test piece is a recess of 10.0 mm inner diameter and 5.0 mm depth. The tablet container has a buckling strength of 20 N or less in the test piece.SELECTED DRAWING: Figure 1

Description

The present invention relates to multilayer films and packages.

Foods, pharmaceuticals, etc. are generally packaged in a packaging body such as a packaging bag or a packaging container at the time of sale. Such a package is required to have various performances for protection of the contents and the like. Therefore, in some packages, a composite (multilayer) multilayer film is used.

The multilayer film used for the packaging is required to have impact resistance and gas barrier properties in order to impart functions such as protection of the contents to the packaging. For example, Patent Document 1 discloses a method of orienting crystals in a multilayer film by stretching a multilayer film made of a polymer material as a means for improving impact resistance and gas barrier properties.

Japanese Unexamined Patent Publication No. 2007-283569

However, in the multilayer film disclosed in Patent Document 1, since the crystals in the multilayer film are oriented, there is a problem that the water vapor barrier property is excellent, but the tablet retrievability of the entire film is inferior. On the contrary, if the thickness of the entire film is reduced, the tablet take-out property is improved, but there is a problem that the water vapor barrier property is lowered. Therefore, there has been a demand for a multilayer film capable of achieving both water vapor barrier properties and tablet removal properties.

As a result of diligent studies to solve the above problems, the present inventor includes a water vapor barrier layer containing polychlorotrifluoroethylene or polyvinylidene chloride and a base material layer containing polyvinyl chloride, and the thickness of the water vapor barrier layer is provided. The total thickness of the water vapor barrier layer and the base material layer is in the range of 180 μm or more and 300 μm or less, and the tablet storage portion is provided so as to project in the thickness direction. By forming a multilayer film in which the buckling strength of the tablet storage portion in the test piece is 20 N or less when a test piece having a recessed portion having an inner diameter of 10.0 mm and a depth of 5.0 mm is produced. We have found that it is possible to achieve both water vapor barrier properties and tablet removal properties. That is, the present invention includes the following aspects.

[1]. A water vapor barrier layer containing polychlorotrifluoroethylene or polyvinylidene chloride and a base material layer containing polyvinyl chloride are provided, and the thickness of the water vapor barrier layer is in the range of 10 μm or more and 160 μm or less, and the water vapor barrier layer is provided. The total thickness of the base material layer is in the range of 180 μm or more and 300 μm or less, and a tablet storage portion protruding in the thickness direction is provided, and the tablet storage portion is a recess having an inner diameter of 10.0 mm and a depth of 5.0 mm. A multilayer film in which the buckling strength of the tablet storage portion of the test piece is 20 N or less when a certain test piece is produced.
[2]. The multilayer film according to [1], wherein the multilayer film is for packaging a drug.
[3]. A package comprising the multilayer film according to [1] or [2].
[4]. The package according to [3], wherein the package is for packaging a drug.
[5]. The package according to [4], wherein the package is a press-through package.

The present invention can provide a multilayer film capable of achieving both a water vapor barrier property and a tablet take-out property, and a package using the multilayer film.

It is sectional drawing which shows typically one Embodiment of the multilayer film of this invention. It is a figure which measured the load change from PTP (press-through package) produced by accommodating a tablet to taking out a tablet using a multilayer film. It is a figure which shows the correlation between the buckling strength and the ease of taking out by a sensory test. It is a figure which shows the correlation between the thickness of a multilayer film, and the buckling strength (easiness of taking out). It is a perspective view which shows typically one Embodiment of the package of this invention. FIG. 5 is a cross-sectional view taken along the line II of the package shown in FIG.

Hereinafter, a multilayer film according to an embodiment to which the present invention is applied and a package using the multilayer film will be described in detail. In the drawings used in the following description, in order to make the features easier to understand, the featured parts may be enlarged for convenience, and the dimensional ratios of each component may not be the same as the actual ones. do not have.

<< Multilayer film >>
The multilayer film according to this embodiment will be described with reference to the drawings. The multilayer film 1 of FIG. 1 is a laminate of a water vapor barrier layer 11 and a base material layer 12. That is, the multilayer film 1 includes a water vapor barrier layer 11 and a base material layer 12 provided on one surface of the water vapor barrier layer 11.

In the multilayer film 1, the thickness of the water vapor barrier layer 11 is in the range of 10 μm or more and 160 μm or less, and the total thickness of the water vapor barrier layer 11 and the base material layer 12 is in the range of 180 μm or more and 300 μm or less. By setting the thickness of the water vapor barrier layer 11 to 10 μm or more, the water vapor barrier property can be improved. Further, by setting the total thickness of the water vapor barrier layer 11 and the base material layer 12 to 300 μm or less, the tablet retrievability can be improved.

That is, by setting the thickness of the water vapor barrier layer 11 to 10 μm or more and the total thickness of the water vapor barrier layer 11 and the base material layer 12 to 300 μm or less, both the water vapor barrier property and the tablet take-out property can be achieved.

In addition, in this specification, "tablet retrievability" means the ease of pushing in the tablet storage part of a package unless otherwise specified.

The thickness of the water vapor barrier layer 11 is more preferably in the range of 20 μm or more and 120 μm or less, and further preferably in the range of 50 μm or more and 110 μm or less.

By setting the thickness of the water vapor barrier layer 11 to the above lower limit value or more, the water vapor barrier property of the multilayer film 1 can be further improved. On the other hand, by setting the thickness of the water vapor barrier layer 11 to the above upper limit value or less, it is possible to prevent the multilayer film 1 from becoming excessively thick.

The thickness of the base material layer 12 is preferably in the range of 50 μm or more and 300 μm or less, more preferably in the range of 100 μm or more and 280 μm or less, and further preferably in the range of 150 μm or more and 250 μm or less.

By setting the thickness of the base material layer 12 to the above lower limit value or more, the moldability of the multilayer film 1 can be improved. On the other hand, by setting the thickness of the base material layer 12 to the above upper limit value or less, the tablet retrievability of the multilayer film 1 can be further improved.

The total thickness of the water vapor barrier layer 11 and the base material layer 12 is more preferably in the range of 190 μm or more and 280 μm or less, and further preferably in the range of 200 μm or more and 250 μm or less.

When the total thickness of the water vapor barrier layer 11 and the base material layer 12 is not more than the above upper limit value, the tablet retrievability of the multilayer film 1 can be further improved. On the other hand, if the total thickness of the water vapor barrier layer 11 and the base material layer 12 is at least the above lower limit value, the water vapor barrier property of the multilayer film 1 can be improved.

The multilayer film 1 includes a tablet storage portion protruding in the thickness direction, and when the tablet storage portion produces a test piece having a recess having an inner diameter of 10.0 mm and a depth of 5.0 mm, the tablet in the test piece The buckling strength of the storage portion is 20 N or less.

In the present specification, the "buckling strength" means the strength required for the side surface of the tablet storage portion to be crushed.

FIG. 2 is a diagram in which a load change from a PTP (press-through package) produced by accommodating tablets to taking out tablets using a multilayer film is measured. As shown in FIG. 2, a push-in pin is attached to the compression tester, and the tip of the tablet storage portion is pushed vertically with the push-in pin. The buckling strength can be determined by measuring the second peak (indicated by a circle in FIG. 2) of the load applied until the tablet storage portion is sufficiently pushed. The “displacement” on the horizontal axis in FIG. 2 means the displacement of the push-in pin.

FIG. 3 is a diagram showing a correlation between buckling strength and ease of removal by a sensory test. As shown in FIG. 3, the relationship is established that the larger the buckling strength, the more difficult it is to take out the tablet, and the smaller the buckling strength, the easier it is to take out the tablet. This is because at least the side surface of the tablet storage portion must be crushed in order to take out the tablet.

The buckling strength is preferably 20 N or less, more preferably 18 N or less, and further preferably 15 N or less. By setting the buckling strength to be equal to or lower than the above upper limit value, the tablet removability can be further improved.

FIG. 4 is a diagram showing the correlation between the thickness of the multilayer film and the buckling strength (easiness of taking out). As shown in FIG. 4, the thicker the film, the higher the buckling strength (that is, it becomes difficult to take out the tablet), and the thinner the film, the lower the buckling strength (that is, the tablet is taken out). The relationship is established.

The sheet moisture permeability of the multilayer film 1 is ^{preferably 0.5 g / m 2} · day or less, ^{more preferably 0.4 g / m 2} · day or less, and 0.2 g / m ² · day or less. It is more preferable to have.

By setting the sheet moisture permeability of the multilayer film 1 within the above range, the water vapor barrier property can be further improved.

The sheet moisture permeability can be obtained by measuring the amount of water vapor permeation of the multilayer film of the present embodiment by a known method, as in the case of Examples described later.

The multilayer film 1 is suitable for use in various applications that require good water vapor barrier properties and tablet removability. For example, it is suitable as a packaging bag or a packaging container for packaging foods, pharmaceuticals, etc. It is more preferable that it is for packaging.

<Water vapor barrier layer>
In the multilayer film 1, the water vapor barrier layer 11 contains polychlorotrifluoroethylene (PCTFE) or polyvinylidene chloride (PVDC). When the water vapor barrier layer 11 contains polychlorotrifluoroethylene or polyvinylidene chloride, the water vapor barrier property of the multilayer film 1 can be improved.

The water vapor barrier layer 11 may contain both polychlorotrifluoroethylene and polyvinylidene chloride, or may contain only one of polychlorotrifluoroethylene and polyvinylidene chloride.

From the viewpoint of improving the water vapor barrier property, polychlorotrifluoroethylene is preferable to polyvinylidene chloride.

The water vapor barrier layer 11 may contain a resin other than polychlorotrifluoroethylene and polyvinylidene chloride, additives known in the art, and the like. These may be used individually by 1 type, or may be used in combination of 2 or more type.

Examples of the resin other than the polychlorotrifluoroethylene and polyvinylidene chloride include cyclic polyolefins and the like.

Examples of the additive include antioxidants, antistatic agents, crystal nucleating agents, inorganic particles, organic particles, thickeners, thickeners, heat stabilizers, lubricants, infrared absorbers, ultraviolet absorbers and the like. Can be mentioned.

When the water vapor barrier layer 11 contains polychlorotrifluoroethylene, the content of polychlorotrifluoroethylene in the water vapor barrier layer 11 is in the range of 50 to 100% by mass, in the range of 60 to 100% by mass, and 70 to 100. It may be in the range of% by mass.

When the content of polychlorotrifluoroethylene in the water vapor barrier layer 11 is within the above range, the water vapor barrier property of the multilayer film 1 can be further improved.

When the water vapor barrier layer 11 contains polyvinylidene chloride, the content of polyvinylidene chloride in the water vapor barrier layer 11 ranges from 50 to 100% by mass, 60 to 100% by mass, and 70 to 100% by mass. It may be either.

When the content of polyvinylidene chloride in the water vapor barrier layer 11 is within the above range, the water vapor barrier property of the multilayer film 1 can be further improved.

<Base layer>
In the multilayer film 1, the base material layer 12 contains polyvinyl chloride. Since the base material layer 12 contains polyvinyl chloride, the moldability of the multilayer film 1 can be improved.

The base material layer 12 may contain a resin other than polyvinyl chloride, an additive, or the like. These may be used individually by 1 type, or may be used in combination of 2 or more type.

Examples of the resin other than the polyvinyl chloride include polypropylene, polyethylene and the like.

Examples of the additive include antioxidants, antistatic agents, crystal nucleating agents, inorganic particles, organic particles, thickeners, thickeners, heat stabilizers, lubricants, infrared absorbers, ultraviolet absorbers and the like. Can be mentioned.

The content of polyvinyl chloride in the base material layer 12 is preferably in the range of 70 to 100% by mass, more preferably in the range of 80 to 100% by mass, and in the range of 90 to 100% by mass. Is even more preferable.

When the content of polyvinyl chloride in the base material layer 12 is within the above range, the moldability of the multilayer film 1 can be further improved.

<Other layers>
The multilayer film 1 may include other layers in addition to the water vapor barrier layer 11 and the base material layer 12 as long as the effects of the present invention are not impaired. The other layer is not particularly limited and may be arbitrarily selected depending on the intended purpose.

The other layer may be provided on the surface of the water vapor barrier layer 11 opposite to the base material layer 12, or may be provided between the water vapor barrier layer 11 and the base material layer 12. It may be provided on the surface of the base material layer 12 opposite to the water vapor barrier layer 11.

For example, the multilayer film 1 may further include an intermediate layer containing a polyolefin resin, and the intermediate layer may be provided between the water vapor barrier layer 11 and the base material layer 12. Since the multilayer film 1 includes the intermediate layer, the impact resistance can be improved.

Specific examples of the polyolefin resin contained in the intermediate layer include polypropylene (PP), polyethylene (PE), ethylene / vinyl acetate copolymer (EVA), ethylene / acrylic acid copolymer (EAA), and the like. Ethylene / methyl methacrylate copolymer (EMAA), ethylene / methyl acrylate copolymer (EMA), ethylene / methyl methacrylate copolymer (EMMA), ethylene / ethyl acrylate copolymer (EEA), ethylene vinyl alcohol (EVOH) and ionomer resin and the like can be mentioned. Examples of polyethylene (PE) include low-density polyethylene (LDPE) and linear low-density polyethylene (LLDPE). These may be used individually by 1 type, or may be used in combination of 2 or more type.

Among the polyolefin resins, polyethylene is preferable. Since polyethylene is a general-purpose resin among polyolefin resins, it is possible to reduce the cost.

The thickness of the intermediate layer is preferably 10 to 100 μm, more preferably 15 to 80 μm, and even more preferably 20 to 60 μm.

Impact resistance can be improved by setting the thickness of the intermediate layer to the above lower limit value or more. By setting the thickness of the intermediate layer to the above upper limit value or less, it is possible to prevent the multilayer film 1 from becoming excessively thick.

<< Manufacturing method of multilayer film >>
Next, an example of the above-mentioned manufacturing method of the multilayer film 1 will be described.
The method for producing the multilayer film 1 described above is not particularly limited, but is a coextrusion T-die method such as a feed block method or a multi-manifold method in which a resin or the like as a raw material is melt-extruded by several extruders. Examples thereof include an air-cooled or water-cooled coextrusion inflation method and a laminating method.

Subsequent steps include a dry laminating method, an extrusion laminating method, a hot melt laminating method, a wet laminating method, a thermal (heat) laminating method, etc., in which a single-layer sheet or film forming each layer is bonded together using an appropriate adhesive. And those methods are used in combination. Further, it may be laminated by a coating method.

<< Packaging >>
The package of the present invention includes the above-mentioned multilayer film of the present invention.
Since the package of the present invention uses the multilayer film of the present invention capable of achieving both water vapor barrier property and tablet take-out property, both water vapor barrier property and tablet take-out property can be achieved.

The package of the present invention is suitable for use in various applications requiring good water vapor barrier properties and tablet take-out properties, and is suitable as, for example, a packaging bag or a packaging container for packaging foods, pharmaceuticals, and the like. , More preferably for packaging of drugs.

FIG. 5 is a perspective view schematically showing an embodiment of the package of the present invention, and FIG. 6 is a cross-sectional view taken along the line II of the package shown in FIG.
In the figures after FIG. 5, the same components as those shown in the already explained figures are designated by the same reference numerals as in the case of the already explained figures, and detailed description thereof will be omitted.

The package 10 shown here includes a molding film 2 and a cover film 101. Then, the molded film 2 is formed with a protruding portion 2c forming a storage portion 10a of the package 10. The molded film 2 is a molded body of the above-mentioned multilayer film (for example, the multilayer film 1 shown in FIG. 1).
The package 10 is a PTP (press-through package) film (packaging container) as a blister pack, and the tablet 102 can be hermetically stored in the storage portion 10a.

One surface of the molded film 2 (sometimes referred to as the "second surface" in the present specification) 2b is referred to as one surface of the cover film 101 (in the present specification, the "first surface"). Is adhered to 101a. However, the molded film 2 projects toward the other surface (sometimes referred to as the "first surface" in the present specification) 2a in a part of the region, and the second surface of the projecting portion 2c. The 2b is not adhered to the first surface 101a of the cover film 101, and the storage portion 10a is formed by the second surface 2b of the molded film 2 and the first surface 101a of the cover film 101. ..

Examples of the material of the cover film 101 include aluminum and the like.

A slit 10b is formed in the molding film 2 and the cover film 101. The slit 10b has an arbitrary configuration and does not necessarily have to be formed, but the slit 10b is formed so that the package 10 can be easily divided according to the specific number of tablets 102 stored in the storage portion 10a. Therefore, the convenience of the package 10 is improved.

Here, as the package 10, the outer shape of the storage portion 10a is shown to have a truncated cone shape, but the outer shape of the storage portion 10a is not limited to this, and depends on the shape of the tablet 102 to be stored. Can be selected arbitrarily. For example, the outer shape of the storage portion 10a may be a polygonal shape such as a triangle, a quadrangle, a pentagon, or a hexagon when the package 10 is viewed in a plan view from the molding film 2 side, or an oval shape. And so on.

Further, here, the package 10 includes eight storage portions 10a, but the number of the storage portions 10a is not limited to this, and may be one or two or more (however, however). (Except when the number is eight).

<< Manufacturing method of packaging >>
The package of the present invention can be produced by using the multilayer film and laminating the multilayer films or the multilayer film and another film or the like so as to form a desired storage portion.

For example, the package 10 shown in FIGS. 5 and 6 can be manufactured using a known PTP packaging machine.
More specifically, first, a protrusion is formed on the multilayer film 1 by vacuum forming, compressed air forming, plug forming, or the like to produce a molded film 2.
Next, the protruding portion 2c of the molded film 2 is filled with the tablet 102, which is an object to be stored, and then the cover film 101 is overlapped with the multilayer film 1 to bond the molded film 2 and the cover film 101.
Then, if necessary, the slit 10b is formed in the molding film 2 and the cover film 101 by using a sewing machine blade, a half-cut blade, or the like.
From the above, the package body 10 is obtained.

Hereinafter, the present invention will be described in more detail with reference to specific examples. However, the present invention is not limited to the examples shown below.

<Manufacturing of multilayer film>
[Example 1]
As the multilayer film of Example 1, a multilayer film having the configuration shown in FIG. 1 described above was produced.
As a resin film used for the water vapor barrier layer, polychlorotrifluoroethylene (manufactured by Honeywell, product number: Aclar UltRx 2000) was prepared.
Further, as a resin film used for the base material layer, polyvinyl chloride (manufactured by Sumitomo Bakelite Co., Ltd., product number: VSS-F120) was prepared.

Next, the water vapor barrier layer and the base material layer were dry-laminated in this order to prepare a multilayer film.

The thickness of the water vapor barrier layer was 51 μm, and the thickness of the base material layer was 200 μm. Table 1 below shows the structure of the multilayer film.

(Example 2)
As a resin film used for the water vapor barrier layer, polychlorotrifluoroethylene (manufactured by Honeywell, product number: Aclar UltRx 3000) was prepared, and the same as in Example 1 except that the thickness of the water vapor barrier layer was set to 76 μm. A multilayer film was produced. Table 1 below shows the structure of the multilayer film.

(Comparative Example 1)
As the resin film used for the base material layer, polyvinyl chloride (manufactured by Sumitomo Bakelite Co., Ltd., product number: VSS-F F120) was prepared, and the thickness of the base material layer was set to 250 μm in the same manner as in Example 1. A multilayer film was produced. Table 1 below shows the structure of the multilayer film.

(Comparative Example 2)
Polychlorotrifluoroethylene (manufactured by Honeywell, product number: Aclar UltRx 3000) was prepared as the resin film used for the water vapor barrier layer, and polyvinyl chloride (manufactured by Sumitomo Bakelite Co., Ltd., product number) was prepared as the resin film used for the base material layer. : VSS-F F120) was prepared, and a multilayer film was produced in the same manner as in Example 1 except that the thickness of the water vapor barrier layer was 76 μm and the thickness of the base material layer was 250 μm. Table 1 below shows the structure of the multilayer film.

<Evaluation of multilayer film>
The following items were evaluated for the multilayer film obtained above by the following method. The results are shown in Table 1.

A test piece having the multilayer film prepared in each Example and each Comparative Example was prepared. Specifically, first, a roll-shaped multilayer film having a width of 100 mm was produced. A blister packaging machine (manufactured by CKD, product number: FBP-300E) was used on the multilayer film to form two rows of five tablet storage portions, each protruding in the thickness direction. Then, the multilayer film was cut to a length of about 50 mm to prepare a first test piece. The tablet storage portion was a recess having an inner diameter of 10.0 mm and a depth of 5.0 mm.

(Sheet moisture permeability)
The moisture permeability of the sheet was evaluated by measuring the amount of water vapor permeation of the multilayer films produced in each Example and Comparative Example. The amount of water vapor permeated was measured using PERMATRAN-W (registered trademark) 3/33 manufactured by MOCON, according to the method described in JIS K7129 (Method B) (moisture absorption condition: 40 ° C./90%).

(Buckling strength)
The buckling strength of the tablet storage portion in the first test piece was measured. A columnar indentation pin having a diameter of 5 mm was attached to the compression tester, and the tip of the tablet storage portion was indented vertically with the indentation pin under compression conditions of 10 mm / min. The second peak of the load applied until the tablet storage portion was sufficiently pushed was measured and used as the buckling strength. When the buckling strength was 20 N or less, it was evaluated that the tablet removability was good.

As shown in Table 1, the multilayer films of Examples 1 and 2 and Comparative Examples 1 and 2 in which the thickness of the water vapor barrier layer is 10 μm or more have a sheet moisture permeability of 0.20 g / m ² · day or less. It was confirmed that the water vapor barrier property was good.

Further, the buckling strength of the multilayer films of Comparative Examples 1 and 2 in which the thickness of the multilayer film is more than 300 μm is more than 20 N, whereas the multilayer film of Examples 1 and 2 in which the thickness of the multilayer film is 300 μm or less is more than 20 N. The buckling strength of the film was 20 N or less. Therefore, it was confirmed that the multilayer films of Examples 1 and 2 had improved tablet retrievability as compared with the multilayer films of Comparative Examples 1 and 2.

The present invention can be used for packaging used for storage of foods, pharmaceuticals and the like.

1 ... Multilayer film 11 ... Steam barrier layer 12 ... Base material layer 2 ... Molded film 2a ... First surface of molded film 2b ... Second surface of molded film 2c ... Protruding part of molded film 11 ... Barrier layer 111 ... First film layer 112 ... Second film layer 12 ... First outer layer 13 ... Second outer layer 10 ... Package 10a ...・ Package storage part 10b ・ ・ ・ Package slit 101 ・ ・ ・ Cover film 101a ・ ・ ・ First side of cover film 102 ・ ・ ・ Tablet

Claims (5)

A water vapor barrier layer containing polychlorotrifluoroethylene or polyvinylidene chloride and a base material layer containing polyvinyl chloride are provided.
The thickness of the water vapor barrier layer is in the range of 10 μm or more and 160 μm or less.
The total thickness of the water vapor barrier layer and the base material layer is in the range of 180 μm or more and 300 μm or less.
When a test piece having a tablet storage portion protruding in the thickness direction and the tablet storage portion is a recess having an inner diameter of 10.0 mm and a depth of 5.0 mm is produced, buckling of the tablet storage portion in the test piece is performed. A multilayer film with a strength of 20 N or less. The multilayer film according to claim 1, wherein the multilayer film is for packaging a drug. A package comprising the multilayer film according to claim 1 or 2. The package according to claim 3, wherein the package is for packaging a drug. The package according to claim 4, wherein the package is a press-through package.

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