JP2021074465A - Locus coeruleus treatment device and locus coeruleus treatment method - Google Patents

Abstract

To propose a locus coeruleus treatment technology that can simply increase neuron of locus ceruleus.SOLUTION: A locus coeruleus treatment device includes a vibrating member 200. The vibrating member 200 includes an adhesive layer 220, and the vibrating member 200 can be fixed in an eyelid of a subject detachably. The vibrating member 200 is case-shaped, and a vibrating body 210 for generating vibration is built in the inside. The vibrating body 210 is a voice coil and an eccentric motor, and the vibration generated by that has a frequency of around 200 Hz and an amplitude of around 1 mm. When the two vibrating members 200 are fixed in the eyelid of the subject and the vibrating body 210 is made to vibrate, the locus coeruleus is activated, and thereby the neuron of the locus coeruleus is increased.SELECTED DRAWING: Figure 2

Description

The present invention relates to a technique for treating the locus coeruleus in the brain.

Cognitive function is indispensable for a person to live as a person. However, with aging, cognitive function may decline.
There are several reasons for cognitive decline, including dementia caused by Alzheimer's disease called Alzheimer's disease.
There are several causes of Alzheimer's disease, some of which have already been identified or suspected to be the cause. For example, in the brain of a person who develops Alzheimer's disease, neurons are known to decrease in the locus coeruleus. It is still clear whether the phenomenon of locus coeruleus neurons depletion occurred as a result of Alzheimer's dementia for some reason, or whether Alzheimer's dementia developed as a result of locus coeruleus neurons depletion. It has not become.
However, in the brains of depressed patients, it is known that the number of neurons in the locus coeruleus is reduced, so that the decrease in the number of neurons in the locus coeruleus causes Alzheimer-type dementia. The inventor of the present application thinks that it may be the cause.
As is widely known, the locus coeruleus plays a role in activating the function of the sympathetic nerve. When the sympathetic nerve becomes dominant over the parasympathetic nerve, the person becomes tense and excited. Sympathetic dominance occurs, for example, when you wake up and start an activity, when you are working, when you are fighting, when you are playing a game or exercising, and so on.
In short, the locus coeruleus exerts its function during active activity. Therefore, the inventor of the present application considers that when the function of the locus coeruleus is weakened, a person cannot perform active activity, and it is highly possible that Alzheimer-type dementia or depression occurs as one of the symptoms.

As a method for improving the function of the locus coeruleus, it is known to give electrical stimulation to the locus coeruleus by inserting an electrode into the locus coeruleus and energizing the locus coeruleus. It has already been confirmed by experiments by Professor Shoji Nakamura of Yamaguchi University that this method increases the number of neurons in the locus coeruleus.

However, the method of directly electrical stimulation of the locus coeruleus, which contributes to increasing the number of neurons in the locus coeruleus, requires craniotomy and can only be performed under the supervision of a doctor. At least it is not easy to implement under.

An object of the present invention is to propose a therapeutic technique for locus coeruleus, which can easily increase the number of neurons in locus coeruleus.

The present invention is detachable in a state in which a vibrating member including a vibrating body and the vibration generated by the vibrating body can be transmitted to the subject's eyelid, and the vibrating member is in contact with or close to the subject's eyelid. It is a treatment device for locus coeruleus, which comprises a fixing member for fixing to a locus coeruleus.
The inventor of the present application has found that when a mechanical stimulus is applied to the eyelid, the locus coeruleus is stimulated and the number of neurons in the locus coeruleus increases (decreased neurons regenerate). At least according to the experiments conducted by the inventor of the present application, other mechanical stimuli may increase the number of neurons in the locus coeruleus, but by applying vibration to the eyelids, the neurons in the locus coeruleus directly reach the locus coeruleus. It turned out that it increased as much as when electrical stimulation was given.
The locus coeruleus treatment device according to the present invention having an extremely simple configuration including a vibrating member including a vibrating body and a fixing member for fixing the vibrating member in a state of being in contact with or close to the eyelid is provided by a doctor. No treatment is required, and the subject can act while wearing it in a hands-free state, so that the effect of increasing the number of neurons in the locus coeruleus can be easily obtained.

The number of vibrating members may be one or two. Naturally, when there is one vibrating member, the vibrating member comes into contact with or near the eyelid of one eye, and when there are two vibrating members, both vibrating members hit the eyelids of both eyes, respectively. It will be in contact with or near it.
As described above, the vibrating member includes a vibrating body that vibrates. However, even if the vibrating member is the vibrating body itself, the condition that the vibrating member includes the vibrating body is satisfied in the present application.
The vibrating body vibrates as described above. The vibrating body can be configured by a known or well-known technique, and can be configured by, for example, a voice coil that vibrates by passing an electric current, which is widely used in a speaker that emits sound. Alternatively, a piezoelectric actuator that can form a vibrating body by an eccentric motor, which is widely used to give a vibration function to a smartphone, and is composed by adhering a piezoelectric element to a metal plate of brass or nickel. It is also possible to construct a vibrating body by applying a piezoelectric vibrating plate.
The vibrating body vibrates as described above, and the frequency of vibration of the vibrating body can be between 3 Hz and 1000 Hz. If the frequency of the vibration is in this range, the number of neurons in the locus coeruleus increases. The frequency of vibration of the vibrating body is more preferably between 150 Hz and 250 Hz. Vibrations in this range of frequencies have a better effect of increasing the number of neurons in the locus coeruleus.
The vibrating body vibrates as described above, and the amplitude of the vibration of the vibrating body can be between 0.1 mm and 5 mm. If the amplitude of the vibration is in this range, the number of neurons in the locus coeruleus increases. If the amplitude is the largest, it becomes difficult to increase the frequency of vibration of the vibrating body. Therefore, it seems that the magnitude of the amplitude and the magnitude of the frequency cannot be arbitrarily determined within the above range.
The direction of vibration of the vibrating body is arbitrary. For example, the direction of vibration may be a direction parallel to the skin of the eyelid (for example, a vertical direction or a horizontal direction), or a direction perpendicular to the skin of the eyelid. When the direction of vibration of the vibrating body is perpendicular to the skin of the eyelid, the pressure applied to the eyelid by the vibrating member generally changes with time.

The fixing member may be adapted to position and fix the vibrating member with respect to the eyelid in any way.
The fixing member may be an adhesive body that is detachably adhered to the eyelid.
Further, the fixing member may be a head fixing body that is detachably fixed to the head by locking and tightening at least one of the head of the subject. In this case, the fixing member has, for example, a spectacle-like shape or a goggle-like shape regardless of the presence or absence of a lens.
The fixing member has a spectacle-like head fixing body fixed to the subject's head, its base end fixed to the head fixing body, and its tip fixed to the vibrating member, respectively, to the subject's eyelids. It may have a rod-shaped elastic body having elasticity that gives an upward force such as lifting the subject's eyelid to the vibrating member that comes into contact with the vibrating member. Ptosis-correcting spectacles, which are called "clutch spectacles" for the treatment of ptosis, are known. A rod-shaped elastic body whose base end is fixed near the butterfly plate and whose tip is fixed to the above-mentioned resin rod, and which has elasticity to give an upward force to the resin rod in contact with the subject's eyelid to lift the subject's eyelid. It has. The above-mentioned invention substantially corresponds to the one in which the resin rod of the eyelid ptosis correction spectacles is replaced with a vibrating member. By using such a locus coeruleus therapeutic device, in addition to the therapeutic effect of the locus coeruleus, the therapeutic effect of ptosis can be obtained. Since ptosis is a common disease in the elderly, it is convenient to combine ptosis and locus coeruleus treatment.

The inventor of the present application also proposes the following method for treating locus coeruleus as one aspect of the present invention. The effect of the present invention is equal to the effect of the above-mentioned method for treating locus coeruleus.
An example of such a method is a vibrating member including a vibrating body and a state in which the vibrating member is in contact with or close to the subject's eyelid in a manner capable of transmitting the vibration generated by the vibrating body to the subject's eyelid. It is a method performed in a locus coeruleus treatment device equipped with a fixing member that is detachably fixed. In this method, the vibration of the vibrating body is controlled so as to satisfy any of the following conditions (A) and (B).
(A) The frequency of vibration of the vibrating body is between 3 Hz and 1000 Hz. (B) The amplitude of vibration of the vibrating body is between 0.1 mm and 5 mm.

The perspective view which shows typically the locus coeruleus treatment apparatus in 1st Embodiment. The perspective view which shows typically the locus coeruleus treatment apparatus in 2nd Embodiment. The graph which shows the state of the change of the diameter of the pupil when using the locus coeruleus treatment apparatus in 2nd Embodiment. The graph which shows the state of the change of the amount of blood flow of the paramedial prefrontal cortex when the locus coeruleus treatment apparatus in the 2nd Embodiment was used.

Hereinafter, the first and second embodiments of the present invention (and examples thereof) will be described in detail with reference to the drawings.
In the description of each embodiment, common objects will be assigned a common reference numeral, and the common description will be omitted in some cases.

<< First Embodiment >>
The locus coeruleus treatment apparatus in this embodiment is shown in the schematic perspective view of FIG.
The locus coeruleus treatment device (hereinafter, may be simply referred to as a “treatment device”) includes a fixing member 100 that detachably fixes the subject's head.
The fixing member 100 is for fixing the vibrating member, which will be described later, immediately before the eyelid of the subject in a state of being positioned as described later. As long as the function can be obtained, the configuration of the fixing member 100 does not matter.
Although not limited to this, the fixing member 100 in this embodiment includes a spectacles portion 110 configured like spectacles. The eyeglass unit 110 is configured in the same manner as general eyeglasses, and locks the left and right eye-like frames 111, the bridge 112 connecting the frames 111, the nose pad 113 connected to the bridge 112, and the eyeglass unit 110 to the ears. The rod-shaped temple 114, the lens 115 attached to the frame 111, and the armor 116 having a hinge for connecting the base end of the temple 114 to the frame 111 in a bendable manner are provided. The eyeglass unit 110 may adopt a configuration that can be adopted for general eyeglasses, such as the bridge 112 also serving as the nose pad 113, omitting the nose pad 113, or adopting a frameless structure without the frame 111. It is possible. Further, the lens 115 may or may not have a degree, and may not be used in relation to the present invention. For example, it is possible to adopt a structure different from that of general spectacles, such as forming both frames 111 and the bridge 112 shown in FIG. 1 in a straight line and further eliminating the lens 115.
Further, the eyeglass unit 110 may have a structure such as goggles for skiing or headgear. When these are adopted, they may usually have an elastic belt or an equivalent thereof, and the portion of the fixing member 100 corresponding to the spectacle portion 110 is placed on the head of the subject. On the other hand, it is highly likely that they will be detachably fixed by tightening rather than locking.

A vibrating member 200 is attached to the eyeglass portion 110 via an elastic rod-shaped body 120. The elastic rod-shaped body 120 forms a part of the fixing member 100. In this embodiment, both the vibrating member 200 and the elastic rod-shaped body 120 are two. However, it is also possible to make each of the vibrating member 200 and the elastic rod-shaped body 120 one by one so as to correspond to only one eye of the subject.
The elastic rod-shaped body 120 is made of an elastic material, its base end is fixed to, for example, body armor 116 of the eyeglass portion 110, and its tip is fixed to the vibrating member 200. The elastic rod-shaped body 120 is rod-shaped and has elasticity. The material of the elastic rod-shaped body 120 is metal, resin, or the like. It is easy to construct the elastic rod-shaped body 120 with a metal wire. As will be described later, when the locus coeruleus treatment device is used, the fixing member 100 is attached to the subject's head, but when the fixing member 100 is attached to the subject's head, the vibrating member 200 is attached to the subject. In contact with the eyelids. The fixing member 100 including the elastic rod-shaped body 120 is designed so that the positioning of the vibrating member 200 at such a position is realized when the fixing member 100 is attached to the head of the subject. Further, the vibrating member 200 in this embodiment receives an upward force due to the elastic force of the elastic rod-shaped body 120 when the vibrating member 200 comes into contact with the eyelid, thereby further causing the vibrating member 200. An upward force that pushes up the eyelid also acts on the eyelid that comes into contact with the eyelid. The relative position of the vibrating member 200 with respect to the eyelid when the fixing member 100 is fixed to the head of the subject is set to the eyelid if it is essential for the vibrating member 200 to push up the eyelid as in this embodiment. Although it is necessary to abut, if the vibrating member 200 does not need to push up the eyelid, the vibrating member 200 may be separated from the eyelid within a range that can transmit the vibration generated by the vibrating body 210 described later to the eyelid. .. However, even in that case, the vibrating member 200 is generally located at a position close to the eyelid, and although it is slightly separated from the eyelid, there is a timing at which the vibrating member 200 comes into contact with the eyelid.

The vibrating member 200 has a built-in vibrating body 210 that vibrates. The vibrating body 210 may be the vibrating member 200 itself, but the vibrating body 210 in this embodiment is built in the vibrating member 200 configured in a case shape. The vibrating body 210 is made of, for example, resin, but may be made of metal.
The vibrating body 210 may have any specific configuration as long as it vibrates at the following frequencies and amplitudes. Further, the vibrating member 200 is configured and the fixing member 100 is fixed to the head of the subject as long as the vibration generated by the vibrating body 210 can be transmitted to the eyelids of the subject. It does not matter where the subject is relative to the eyelids.
The vibrating body 210 can be configured by, for example, a known or well-known voice coil. Alternatively, as is well known, the vibrating body 210 can be formed by an eccentric motor or a piezoelectric diaphragm. The power source of the vibrating body 210 can be included in the vibrating member 200 as, for example, a dry battery or other battery. Further, it is also possible to provide the power source outside the treatment device in FIG. 1 and to supply electric power from the power source to the vibrating body 210 by connecting the power source and the vibrating member 200 by wire. .. Further, although not provided in this embodiment, it is also possible to provide, for example, a switch for turning on / off the generation of vibration by the vibrating body 210 in the vibrating member 200, for example. When the power supply is provided outside the treatment device shown in FIG. 1, the switch as described above can be provided in the case for accommodating the power supply. The provision of the switch as described above or the position of the switch may be appropriately determined by a known or well-known technique.
The frequency of vibration generated by the vibrating body 210 can be appropriately determined, for example, between 3 Hz and 1000 Hz. The frequency of vibration generated by the vibrating body 210 does not have to be always the same, and can be made variable by an appropriate method, for example. The technique for varying the frequency of the vibration generated by the vibrating body 210 is a known or well-known technique in any case regardless of how the vibrating body 210 is configured. The frequency of vibration generated by the vibrating body 210 is more preferably between 150 Hz and 250 Hz, particularly about 200 Hz.
The amplitude of the vibration generated by the vibrating body 210 can be appropriately determined, for example, between 0.1 mm and 5 mm. The amplitude of the vibration generated by the vibrating body 210 does not have to be always the same, and can be made variable by an appropriate method, for example. The technique for making the amplitude of the vibration generated by the vibrating body 210 variable is a known or well-known technique, particularly except when the vibrating body 210 is formed by an eccentric motor. In general, the amplitude of the vibration generated by the vibrating body 210 needs to be determined according to the frequency of the vibration generated by the vibrating body 210, and when the amplitude of the vibration is variable, the frequency of the vibration generated by the vibrating body 210 is determined. It may be changed in response to the change.
The direction of vibration of the vibrating body 210 is arbitrary. For example, the direction of vibration may be a direction parallel to the skin of the eyelid (for example, a vertical direction or a horizontal direction), or a direction perpendicular to the skin of the eyelid. When the direction of vibration of the vibrating body 210 is perpendicular to the skin of the eyelid, the pressure applied to the eyelid by the vibrating member 200 generally changes with time.

The method of using the locus coeruleus treatment device as described above will be described.
First, the fixing member 100 including the spectacles portion 110 configured like spectacles is attached to the head in the same manner as in the case of wearing ordinary spectacles. In that case, as in the case of ordinary eyeglasses, the two temples 114 are locked to both ears, and both nose pads 113 are brought into contact with both sides of the nose muscle of the subject. As a result, the fixing member 100 is fixed to the head of the subject.
When the fixing member 100 is fixed to the head of the subject, both vibrating members 200 are in contact with the binocular eyelids of the subject. In this state, the binocular eyelids of the subject continue to receive the upward force by the vibrating member 200 that receives the upward force from the elastic rod-shaped body 120.
Depending on whether or not there is a switch, for example, if there is a switch, in this state, for example, the subject operates the switch to vibrate the vibrating body 210 in the vibrating member 200. Then, as described above, the vibrating body 210 vibrates in a predetermined range of frequencies, a predetermined amplitude, and a predetermined direction. Then, the vibration generated by the vibrating body 210 is transmitted to the eyelids of the subject via the vibrating member 200.
When vibration is transmitted to the subject's eyelids, the mechanical stimulus is transmitted to the subject's locus coeruleus and the locus coeruleus is activated. This will increase the number of neurons in the locus coeruleus and treat the locus coeruleus. In addition, the treatment device of this embodiment can also treat ptosis at the same time.

<< Second Embodiment >>
The locus coeruleus treatment device in the second embodiment will be described.
The locus coeruleus treatment device in the second embodiment is shown in FIG. Simply put, it can be said that the treatment device in this embodiment is like taking out only the vibrating member 200 of the treatment device in the first embodiment.
This treatment device includes a vibrating member 200. The vibrating member 200 in this embodiment is hemispherical, and is, for example, a metal or resin case. Of course, the shape of the vibrating member 200 does not have to be hemispherical. Inside the vibrating member 200, a vibrating body 210 similar to that of the first embodiment is built. The configuration and function of the vibrating body 210 are the same as those in the first embodiment. It is the same as the first embodiment that the power source of the vibrating body 210 may be provided inside the vibrating member 200 or may be taken from the outside, and the switch may be provided at an appropriate position.
The vibrating member 200 is provided with an adhesive layer 220 on its flat surface portion corresponding to the lower side in FIG. The vibrating member 200 can be detachably fixed to the subject's eyelid by pressing the exposed lower surface of the adhesive layer 220 against the subject's eyelid. Of course, when the vibrating member 200 is fixed to the eyelid of the subject in this way, the vibration generated by the vibrating body 210 in the vibrating member 200 is transmitted to the eyelid of the subject.
In this embodiment, the treatment device is used as a set of two, and is used in a state of being fixed to the eyelids of both eyes of the subject. To make this possible, the exposed circular surface of the adhesive layer 220 is shaped and sized so that it can be attached to the eyelid.
The adhesive layer 220 may be fixedly provided to the case of the vibrating member 200, or may be detachable from the vibrating member 200 by forming the adhesive layer 220 with double-sided tape or the like. .. Then, when the adhesive strength of the exposed side surface of the adhesive layer 220 is reduced, the adhesive layer 220 can be replaced. Considering that the adhesive layer 220 can be better fixed to the eyelid, the adhesive layer 220 is made thick and elastic, and when the adhesive layer 220 is pressed against the eyelid, it is applied to the eyelid of the adhesive layer 220. The shape of the abutting surface can be made to follow the curved surface of the eyelid well. Alternatively, rather than the adhesive layer 220, the above-mentioned flat surface of the vibrating member 200 may be a curved surface having an appropriate curvature instead of a flat surface.

As described above, this treatment device is used in a state where each of the two treatment devices is detachably fixed to the eyelids of both eyes of the subject. In that state, the vibrating body 210 in the vibrating member 200 is vibrated by, for example, turning on the switch.
Then, the vibration generated by the vibrating body 210 is transmitted to the eyelids. As a result, the locus coeruleus is activated and the number of neurons in the locus coeruleus is increased as in the case of the first embodiment. However, the treatment device according to the second embodiment cannot obtain the effect of treating ptosis.

(Experimental example)
The treatment device according to the second embodiment was attached to the eyelids of both eyes of the subject, and in that state, the vibrating body 210 in the vibrating member 200 was vibrated. The vibrating body 210 is made of a voice coil. The vibration frequency was fixed at 200 Hz. The amplitude of vibration is approximately 1 mm. The direction of vibration is approximately horizontal to the skin of the eyelids in both directions.
Whether or not the locus coeruleus was activated by mechanical stimulation of the eyelids due to the vibration of the vibrating body 210 was measured by two parameters. The degree of locus coeruleus activation is currently said to be measurable with only three parameters. The first is the size of the pupil, the second is the blood flow in the paramedial prefrontal cortex, and the third is the amount of sweating in the palm or sole of the foot. Of these, the parameters of the former two were measured this time.
As for the size of the pupil, the vibration of the vibrating body 210 is started after the state in which the stimulation by the vibrating body 210 has not occurred for a while, the vibration of the vibrating body 210 is continued for a while, and then the vibration of the vibrating body 210 is stopped. Further, the change in the size of the pupil for a while after the vibration of the vibrating body 210 was stopped was measured using a pupillometer.
Blood flow in the paramedial prefrontal cortex was also measured by a cerebral blood flow meter that measures blood flow in the paramedial prefrontal cortex over a similar time range.

The measurement result of the pupil by the pupillometer is shown in FIG.
The graph of FIG. 3 shows the diameter of the pupil that changes over time. The vertical axis is the diameter of the pupil (mm), the horizontal axis is the time (seconds), and the vibration of the vibrating body 210 starts when 45.5 seconds have passed by the number given downward. The stop is when 54.5 seconds have passed.
Obviously, the pupil is enlarged only while the vibrating body 210 is vibrating, and although there is a slight time lag of about 2 seconds from the start of vibration to the enlargement of the pupil, the pupil once enlarged. The diameter of the remains large for the duration of the vibration. When the vibration is stopped, the pupil becomes smaller with a shorter time lag than when the vibration starts.
The measurement result of the blood flow in the paramedial prefrontal cortex by the blood flow meter is shown in FIG.
The graph of FIG. 4 shows the blood flow rate that changes with time. The vertical axis is the hemoglobin concentration (au (or AU)), the horizontal axis is the time (seconds), and the vibration start of the vibrating body 210 has passed 22 seconds with the number given downward. At the time point, the vibration of the vibrating body 210 is stopped when 60 seconds have passed. In the figure, X1 is the blood flow of arterial blood (corresponding to the hemoglobinometry, the same applies hereinafter), X2 is the blood flow of venous blood, and X3 is the blood flow of arterial blood and venous blood combined.
Of the blood flow of arteries, veins, and their sum, the blood volume of arteries, arteries, and veins is clearly increased only while the vibrating body 210 is vibrating. There is a slight time lag from the start of vibration to the increase in blood flow, and from the stop of vibration to the decrease in blood flow, as in the case of the pupil, but the latter is shorter than the former in the case of the pupil. It is common.
Other experiments have shown that activation of the locus coeruleus causes the subsequent increase in neurons in the locus coeruleus, so mechanical stimulation by vibration of the eyelids can be used to stimulate the locus coeruleus. The number of neurons will increase, and the treatment of the locus coeruleus, which is to improve the function of the locus coeruleus, will be performed.

In addition, the above-mentioned processing is repeated about 2 to 5 minutes (preferably 3 minutes) once, and repeats about 2 to 5 times with an interval of 30 seconds to 2 minutes (preferably about 1 minute). For example, once the circuit for controlling the vibrating body 210 is started to vibrate in the vibrating body 210 inside or outside the vibrating member 200 by pressing a switch or the like, the above-mentioned preferable frequency is used. It is preferable that one set of vibrations of amplitude be automatically executed by the vibrating body 210 under the control of the above circuit. That is, the treatment apparatus of the present invention vibrates for a predetermined time (at a preferable frequency and amplitude). , The same shall apply hereinafter.), The process of not vibrating for a predetermined time, vibrating for a predetermined time, not vibrating for a predetermined time ... It is preferable to include a control device (control circuit) that automatically repeats the frequency a plurality of times after the vibration member 200 is operated. Such a control device may be provided by the vibration member 200, or the treatment of the first embodiment. If it is an apparatus, it may be provided somewhere in the treatment apparatus shown in FIG. 1, or may be provided outside the treatment apparatus shown in FIGS. 1 and 2. Although the description of the configuration of the control device will be omitted, it will be too clear to those skilled in the art that the above-mentioned control device can be easily manufactured by a well-known technique rather than a known technique.
An experiment was conducted in which the above-mentioned treatment was performed 3 sets a day for subjects aged 60 to 70 years, and 10 days after the start of the experiment, before the start of the experiment and 10 days after the start of the experiment. When the size of the pupils of the subjects in normal times was compared, the size of the pupils in normal times, which is generally known to decrease in proportion to age, was 10 years old on average. It became large enough to correspond to the age difference of. Since the locus coeruleus has the function of dilating the pupil, this fact may indicate that the function of the locus coeruleus is improved and the number of neurons is increased.

100 Fixing member 110 Eyeglass part 120 Elastic rod-shaped body 200 Vibrating member 210 Vibrating body

Claims (8)

A vibrating member including a vibrating body and a fixing in which the vibrating member can be detachably fixed in contact with or close to the subject's eyelid in a manner capable of transmitting the vibration generated by the vibrating body to the subject's eyelid. It has parts and
A device for treating locus coeruleus. The frequency of vibration of the vibrating body is between 3 Hz and 1000 Hz.
The locus coeruleus treatment device according to claim 1. The frequency of vibration of the vibrating body is between 150 Hz and 250 Hz.
The locus coeruleus treatment device according to claim 2. The amplitude of vibration of the vibrating body is between 0.1 mm and 5 mm.
The device for treating locus coeruleus according to any one of claims 1 to 3. The fixing member is an adhesive body that is detachably adhered to the eyelid.
The device for treating locus coeruleus according to any one of claims 1 to 4. The fixing member is a head fixing body that is detachably fixed to the head by locking and tightening at least one of the heads of the subject.
The device for treating locus coeruleus according to any one of claims 1 to 4. The fixing member has a spectacle-like head fixing body fixed to the subject's head, its base end fixed to the head fixing body, and its tip fixed to the vibrating member, respectively, to the subject's eyelids. A rod-shaped elastic body having elasticity that gives an upward force that lifts the subject's eyelid to the vibrating member that comes into contact with the vibrating member.
6. The locus coeruleus treatment device according to claim 6. A vibrating member including a vibrating body and a fixing in which the vibrating member can be detachably fixed in contact with or close to the subject's eyelid in a manner capable of transmitting the vibration generated by the vibrating body to the subject's eyelid. A method performed in a locus coeruleus treatment device equipped with a member,
A method for treating locus coeruleus, in which the vibration of the vibrating body is controlled so as to satisfy any of the following conditions (A) and (B).
(A) The frequency of vibration of the vibrating body is between 3 Hz and 1000 Hz. (B) The amplitude of vibration of the vibrating body is between 0.1 mm and 5 mm.

Images