JP2021066742A5 - Laminated tablets and their manufacturing methods - Google Patents

Claims (12)

A laminated tablet that is substantially columnar and includes a first layer and a second layer adjacent to the first layer at a boundary surface.
The surface of the second layer opposite to the boundary surface and the boundary surface are curved surfaces that bulge in the same direction.
A laminated tablet characterized in that both or one of the first layer and the second layer contains the component (α) which is the following component (B).
( B) Ingredient: At least one selected from loxoprofen and its salts. The laminated tablet according to claim 1, wherein the surface of the second layer opposite to the boundary surface has the same shape as the boundary surface. The laminated tablet according to claim 2, wherein the height of the bulging surface of the second layer opposite to the boundary surface is 1 to 2 mm. The laminated tablet according to any one of claims 1 to 3, wherein the content of the component (α) is 30 to 80% by mass with respect to the total mass of the layer containing the component (α). The laminated tablet according to any one of claims 1 to 4, wherein the tablet has a diameter of 6 to 13 mm and a height of 3 to 10 mm in a plan view. The laminated tablet according to any one of claims 1 to 5, wherein the water content of the layer containing the component (α) is 2 to 13% by mass. A first layer and a second layer adjacent to the first layer at a boundary surface are provided, and both or one of the first layer and the second layer is composed of the following component (B). Production of a substantially columnar laminated tablet containing a certain (α) component and having a surface of the second layer opposite to the boundary surface and a curved surface in which the boundary surface bulges in the same direction. It ’s a method,
A first compression step of compressing the first powder constituting the first layer at an arbitrary pressure, and
The second powder constituting the second layer is placed on the first powder that has undergone the first compression step, and the first powder has a higher pressure than that of the first compression step. A method for producing a laminated tablet, comprising a second compression step of compressing a body and the second powder to form the first layer and the second layer.
(B) Ingredient: At least one selected from loxoprofen and its salt. The method for producing a laminated tablet according to claim 7, wherein the surface of the second layer opposite to the boundary surface has the same shape as the boundary surface. The method for producing a laminated tablet according to claim 8, wherein the height of the bulging surface of the second layer opposite to the boundary surface is 1 to 2 mm. The method for producing a laminated tablet according to any one of claims 7 to 9, wherein the content of the component (α) is 30 to 80% by mass with respect to the total mass of the layer containing the component (α). The method for producing a laminated tablet according to any one of claims 7 to 10, wherein the pressure in the first compression step is 1 to 3 kN and the pressure in the second compression step is more than 3 kN. An intermediate compression step is provided between the first compression step and the second compression step.
The production of the laminated tablet according to any one of claims 7 to 11, wherein the pressure in the intermediate compression step is higher than the pressure in the first compression step and lower than the pressure in the second compression step. Method.